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| 1 | Immune checkpoint inhibitor-related hepatotoxicity:A review显示文摘The application of immune checkpoint inhibitors(ICI)in advanced cancer has been a major development in the last decade.The indications for ICIs are constantly expanding into new territory across different cancers,disease stages and lines of therapy.With this increased use,adverse events including immune checkpoint inhibitor-related hepatotoxicity(ICH)have emerged as an important clinical problem.This along with the introduction of ICI as first-and second-line treatments for advanced hepatocellular carcinoma makes ICH very relevant to gastroenterologists and hepatologists.The incidence of ICH varies between 1%-20%depending on the number,type and dose of ICI received.Investigation and management generally involve excluding differential diagnoses and following a stepwise escalation of withholding or ceasing ICI,corticosteroid treatment and adding other immunosuppressive agents depending on the severity of toxicity.The majority of patients with ICH recover and some may even safely recommence ICI therapy.Guideline recommendations are largely based on evidence derived from retrospective case series which highlights a priority for future research. | Devika Remash David S Prince Catriona McKenzie Simone I Strasser Steven Kao Ken Liu | 2021 | World Journal of Gastroenterology2021，27，32： | 9 |
| 2 | 无放疗史的成人ETV6-NTRK3易位甲状腺乳头状癌的临床和形态学特征显示文摘据报道,ETV6-NTRK3易位甲状腺乳头状癌(PTCs)通常与放疗相关且多发生在小儿。作者描述了12例无放疗史的成人ETV6-NTRK3易位PTCs的临床病理学特征,均为经二代测序技术证实的病例。患者平均年龄为37岁,以女性多见(女:男=10:2)。6例患者行术前细针穿刺,其中4例诊断为恶性,2例诊断为“性质未定的滤泡性病变”。术后病理证实1/3(4/12)的患者有甲状腺外浸润,1/2(5/10)有淋巴结转移,1例出现了脑转移。 | Seethala R R Chiosea S I Liu C Z 黄爱清 余英豪 | 2017 | 临床与实验病理学杂志2017，33，10： | 8 |
| 3 | Monitoring Greenhouses Gases over China Using Space-Based Observations Monitoring Greenhouses Gases over China Using Space-Based Observations显示文摘The atmospheric carbon dioxide(CO 2)concentration has increased to more than 405 parts per million(ppm.1 ppm=10-6 m/s 2)in 2017 due to human activities such as deforestation,land-use change and burning of fossil fuels.Although there is broad scientific consensus on the damaging consequences of the change in climate associated with increasing concentrations of greenhouse gases,fossil CO 2 emissions have continued to increase in recent years mainly from rapidly developing economies and China is now the largest emitter of CO 2 generating about 30%of all emissions globally.To allow more reliable forecast of the future state of the carbon cycle and to support the efforts for mitigation greenhouse gas emissions,a better understanding of the global and regional carbon budget is needed.Space-based measurements of CO 2 can provide the necessary observations with dense coverage and sampling to provide improved constrains on of carbon fluxes and emissions.The Chinese Global Carbon Dioxide Monitoring Scientific Experimental Satellite(TanSat)was established by the National High Technology Research and Development Program of China with the main objective of monitoring atmospheric CO 2 and CO 2 fluxes at the regional and global scale.TanSat has been successfully launched in December 2016 and as part of the Dragon programme of ESA and the Ministry of Science and Technology(MOST),a team of researchers from Europe(UK and Finland)and China has evaluated early TanSat data and contrast it against data from the GOSAT mission and models.In this manuscript,we report on retrieval intercomparisons of TanSat data using two different retrieval algorithms,on validation efforts for the Eastern Asia region using GOSAT CO 2 data and first assessments of TanSat and GOSAT CO 2 data against model calculations using the GEOS-Chem model. | Hartmut BOESCH Yi LIU Paul I PALMER Johanna TAMMINEN Jasdeep S ANAND Zhaonan CAI Ke CHE Huilin CHEN Xi CHEN Liang FENG Janne HAKKARAINEN Pauli HEIKKINEN Nikoleta KALAITZI Rigel KIVI Robert PARKER Peter SOMKUTI Jing WANG Alex WEBB Dongxu YANG Lu YAO You YI | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 2 |
| 4 | 显示文摘 | Liu I S Rempel G L | 1997 | J Appl Polym Sci1997，64，： | 1 |
| 5 | MicroRNA profile analysis of human prostate canc- ers 显示文摘 | Tong A W Fulgham P Jay C Chen P Khalil I Liu S | 2009 | Cancer Gene Ther2009，16，： | 1 |
| 6 | Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMK II 显示文摘 | Liu S Fa M Ninan I Trinchese F Dauer W Arancio O | 2007 | Eur J Neurosci2007，25，12： | 1 |
| 7 | Low-voltage CMOS four-quad- rant multiplier显示文摘 | LIU S I CHANG C C | 1997 | Elec Lett1997，33，3： | 1 |
| 8 | Low-voltage CMOS four-quadrant multiplier显示文摘 | Liu S I | 1996 | Elect ronies Lett1996，30，25： | 1 |
| 9 | Nitrogen regulation of root branching显示文摘 | Walch -Liu P Ivanov I Filleur S | 2006 | Annals of Botany2006，97，： | 1 |
| 10 | The rang suitable for GM (1,1)显示文摘 | Liu S F Deng I L | 1999 | Journal of Greysystem1999，11，1： | 1 |
| 11 | Im- proved two-dimensional electron gas transport characteri- stics in AIGaN/GaN metal-insulator-semiconductor high electron mobility transistor with atomic layer-deposited A1203 as gate insulator 显示文摘 | LIU Z H NG G I ARULKUMARAN S | 2009 | Applied Physics Letters2009，22，95： | 1 |
| 12 | Low-voltage CMOS four-quadrant multiplier based on square-difference identity显示文摘 | Liu S I Chang CC | 1996 | IEEE Proe Cire Dev Svst1996，143，3： | 1 |
| 13 | A spread-spectrum clock generator with triangular modulation显示文摘 | CHANG H H HUA I H LIU S I | 2003 | IEEE J SSC2003，38，4： | 1 |
| 14 | The structurcs of lmpetzine A and B, two new alkaloids exhibiting marked antieholnesterase activity 显示文摘 | Liu J S Zhu Y I Chao MY | 1986 | CanJChem1986，64，4： | 1 |
| 15 | Interpretation of a statistical analysis of variations in the foF2 critical frequency before earthquakes based on data from ChungLi ionospheric station (Taiwan) 显示文摘 | Pulinets S A Liu J Y and Safronova I A | 2004 | Geomagnetism and Aeronomy2004，44，1： | 1 |
| 16 | Non-destructive evaluation of horizontal crack detection in beams using transverse impact显示文摘 | Ishak S I Liu G R Shang H M | 2002 | Journal of Sound and Vibration2002，252，2： | 1 |
| 17 | Highly efficient blue-light-emitting diodes from polyfluorene containing bipolar pendant groups 显示文摘 | SHU C F WU F I LIU M S | 2003 | Macromolecules2003，36，18： | 1 |
| 18 | Impact of ester promoieties on transdermal delivery of ketorolac显示文摘 | Liu K S Hsieh P W Aljuffali I A | 2014 | J Pharm Sci2014，103，3： | 1 |
| 19 | Ginsenoside Rh2 is one of the active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats 显示文摘 | Lee W K Kao S T Liu I M | 2007 | Horm Metab Res2007，39，5： | 1 |
| 20 | Rapid procedure for detection and isola tion of large and small plasmids 显示文摘 | KADO C I LIU S T | 1981 | J Bacteriol1981，145，3： | 1 |
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