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| 1 | Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis显示文摘AIM To investigate of pediatric ulcerative colitis activity index(PUCAI) in ulcerative colitis correlate with mucosal inflammation and endoscopic assessment of disease activity(Mayo endoscopic score).METHODS We reviewed charts from ulcerative colitis patients who had undergone both colonoscopy over 3 years. Clinical assessment of disease severity within 35 d(either before or after) the colonoscopy were included. Patients were excluded if they had significant therapeutic interventions(such as the start of corticosteroids or immunosuppressive agents) between the colonoscopy and the clinical assessment. Mayoendoscopic score of the rectum and sigmoid were done by two gastroenterologists. Inter-observer variability in Mayo score was assessed.RESULTS We identified 99 patients(53% female, 74% pancolitis) that met inclusion criteria. The indications for colonoscopy included ongoing disease activity(62%), consideration of medication change(10%), assessment of medication efficacy(14%), and cancer screening(14%). Based on PUCAI scores, 33% of patients were in remission, 39% had mild disease, 23% had moderate disease, and 4% had severe disease. There was 'moderate-substantial' agreement between the two reviewers in assessing rectal Mayo scores(kappa = 0.54, 95%CI: 0.41-0.68). CONCLUSION Endoscopic disease severity(Mayo score) assessed by reviewing photographs of pediatric colonoscopy has moderate inter-rater reliability, and agreement was less robust in assessing patients with mild disease activity. Endoscopic disease severity generally correlates with clinical disease severity as measured by PUCAI score. However, children with inflamed colons can have significant variation in their reported clinical symptoms. Thus, assessment of both clinical symptoms and endoscopic disease severity may be required in future clinical studies. | Basavaraj Kerur Heather J Litman Julia Bender Stern Sarah Weber Jenifer R Lightdale Paul A Rufo Athos Bousvaros | 2017 | World Journal of Gastroenterology2017，23，18： | 5 |
| 2 | Pumping of drugs by P-glycoprotein:a two-step process显示文摘 | Litman T Skovsgaard T Stein WD | 2003 | J Pharmacol Exp Ther2003，307，3： | 1 |
| 3 | Novel immune-type receptor genes显示文摘 | Litman GW Hawke NA Yoder JA | 2001 | Immunol Rev2001，181，： | 1 |
| 4 | Anesthesia for tracheal or bronchial foreign body removal in children:an analysis of ninety-four cases显示文摘 | Litman RS Ponnuri J Trogan I | | 0，，06： | 1 |
| 5 | A role for phospholipid polyunsaturation in modulating membrane-protein 显示文摘 | Litman B J Mitchell D C | 1996 | Lipids1996，，： | 1 |
| 6 | Early evolution of immunoglobulin genes 显示文摘 | Litman G W | 1991 | Amer Zool1991，31，： | 1 |
| 7 | Postoperative Malignant Hyperthermia:an analysis of cases from the North American Malignant Hyperthermia Registry 显示文摘 | Litman RS Flood CD Kaplan RF | 2008 | Anesthesiology2008，109，5： | 1 |
| 8 | Cloning of two zebrafish cDNA that share domains with the MHC class Ⅱ-associated invariant chain显示文摘 | Yoder J A Harle R N Litman G W | 1999 | Immunogenetics1999，50，： | 1 |
| 9 | Multivariateanalysis of morbidity and mortality from the initial surgical management of obstructing carcinoma of the colon显示文摘 | Litman IM Sullivan JD Brains D | | 0，，06： | 1 |
| 10 | Marked improvement of PAC and BAC cloning is achieved using electroelution of pulsed-field gel-separated partial digests of genomic DNA 显示文摘 | Strong S J Ohtal Y Litman G W | 1997 | Nucleic Acids Research1997，19，25： | 1 |
| 11 | Immunoglobulin heavy chain gene organization and complexity in the skate,Raja erinacea显示文摘 | Cohen N Litman G W | 1990 | Nucl Acids Res1990，18，： | 1 |
| 12 | Autonomy as Competence in 2 - year- olds: Maternal Correlates of Child Defiance, Com- pliance and Self - assertion 显示文摘 | Crockenberg S Litman C | 1990 | Developmental Psychol- ogy1990，，26： | 1 |
| 13 | A randomized trial of urody- namie testing before stress-incontinence surgery 显示文摘 | Nager CW Brnbaker L Litman HJ | 2012 | New England Journal of Medicine2012，366，21： | 1 |
| 14 | Distinct patterns of IgH structure and organization in a divergent lineage of chrondrichthyan fishes 显示文摘 | Amemiya C T Litman R T | 1998 | Immunogenetics1998，47，： | 1 |
| 15 | Valuing transit service quality improvements显示文摘 | Todd Litman | 2008 | Journal of Public Transportation2008，11，2： | 1 |
| 16 | An economic analysis of the US wireless telephone industry: responses to new technologies显示文摘 | Seongcheol Kim Barry Litman | 1999 | Telematics and Informatics1999，16，： | 1 |
| 17 | Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR显示文摘 | de Bruin M Miyake K Litman T | 1999 | Cancer Lett1999，146，2： | 1 |
| 18 | Camptotbecin resistance: role of the ATP-binding cassette ( ABC ), mitoxantrone-resistance half transporter (MXR), and potential for glucuronidation in- MXR-expressing cells显示文摘 | Brangi M Litman T Ciotti M | 1999 | Cancer Res1999，59，23： | 1 |
| 19 | Evolutionary origins of immunoglobulin gene diversity显示文摘 | Rast J P Hulst M A | 1992 | Prog Immunol1992，8，： | 1 |
| 20 | From MDR to MXR; Now understanding of multidrug resistance systems,their properties and clinical significance显示文摘 | Litman T Dnley TE Stein WD | 2001 | Cell Mol Life Sci2001，58，： | 1 |
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