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| 1 | Downregulation of electroacupuncture at ST36 on TNF-α in rats with ulcerative colitis显示文摘AIM: To investigate the regulatory effect of electroacupuncture (EA) at Zusanli (ST36) on tumor necrosis factor-alpha (TNFα) in rats with ulcerative colitis (UC), and further elucidate the therapeutic mechanism of EA on UC.METHODS: Thirty-two male Sprague-Dawley (SD) rats were randomly divided into four groups (n=-8): normal control group, UC control group, UC+ST36 group and UC+nonacupoint group. A solution containing ethanol and 2,4,6-trinitrobenzenesulfonic acid (TNBS) was instilled into the distal colon in the rat (at a dose of 100 mg/kg) to set up UC rat model. Rats in wakefulness state of UC+ST36 group were stimulated at ST36 by EA once a day, while those of UC+nonacupoint group were done at 0.5 cm beside ST36. After 10d treatment, all rats were sacrificed simultaneously. Colon musocal inflammation and damage were assessed by measuring colon mass, morphologic damage score, colonic myeloperoxidase enzyme (MPO) activity, serum TNF-α and colonic TNF-α mRNA level. Morphologic damage score was examined under stereomicroscope. Colonic MPO activity was measured by spectrophotometer method. Serum TNF-αconcentration was determined by radioimmunoassay (RIA).Colonic TNF-α mRNA expression level was analyzed by semiquantitative reverse transcription polymerase chain reaction (RT-PCR).RESULTS: Ratio of colonic mass/body mass (mC/mB) and activity of colonic MPO (μkat/g tissue) markedly increased (8.5±2.6 vs 2.5±0.4; 145±25 vs 24±8, P<0.01 vs normal control group). Compared with normal control rats, serum TNF-α and colonic TNF-α mRNA level in UC control group were increased 2.5 fold (2 278±170 vs 894±248, P<0.01)and 4.3 fold (0.98±0.11 vs 0.23±0.11, P<0.01)respectively. After EA at ST36, mc/mB and MPO activity were reduced significantly (5.3±2.0 vs 8.5±2.6; 104±36 vs145±25, P<0.01, 0.05) compared with those of UC control group. Serum TNF-α and colonic TNF-α mRNA level were inhibited by EA stimulation at ST36 (P<0.01). The inhibitory rate was 16 % and 44 % respectively.Morphologic damage score was also increased markedly in rat with UC (P<0.01), whereas it was decreased by EA at ST36 (P<0.05). There was no significant difference between UC control group and UC+EA at non-acupoint (P>0.05). Furthermore, these parameters were highly correlated with each other (P<0.01).CONCLUSION: Serum TNF-α concentration and colonic TNF-α mRNA expression level are increased significantly in UC rats in correlation with the severity of disease. It indicates that TNF-α is closely involved in the immune abnormalities and inflammatory responses in UC. EA at ST36 has therapeutic effect on UC by downregulating serum TNF-r and colonic TNF-r mRNA expression. High levels of TNF-αand its corresponding mRNA expression seem to be implicated in the pathogenesis of UC. | LiTian Yu-XinHuang MinTian WeiGao QingChang | 2003 | World Journal of Gastroenterology2003，9，5： | 25 |
| 2 | A review on China's constructed wetlands in recent three decades:Application and practice显示文摘Constructed wetlands(CWs)have been introduced to and developed in China for environmental engineering over the most prosperous three decades(1990–2020).To study the origin,development process,and future trend of CWs,this review summarized a wide range of literatures between 1990 and 2020 by Chinese authors.Firstly,the publication number over years,research highlights,and the author contributions with the most published papers in this field were conducted through bibliometric analysis.Secondly,the most principal components of CWs,substrates and macrophytes were summarized and analyzed.Thirdly,the typical application cases from traditional CWs,pond systems to combined pond-wetland systems were presented.In China,CWs were predominately distributed in the east of the so-called'Hu Huanyong Line'.Therefore CWs were limited by the socio-economic level and climatic conditions.It is unquestionable that the overall level of China's CWs has improved significantly,and one of the most prominent features has started towards the plural pattern development.There has been a trend of large-scale or low-cost CW application in the recent years.However,lifecycle research and management are required for better strategies in the future. | Hong Zhang Wenzhong Tang Weidong Wang Wei Yin Honglei Liu Xiaomin Ma Yiqi Zhou Pei Lei Dongyang Wei Litian Zhang Cao Liu Jinmiao Zha | 2021 | Journal of Environmental Sciences2021，33，6： | 13 |
| 3 | OPTIMIZATION DESIGN OF HYDRAULIC MANIFOLD BLOCKS BASED ON HUMAN-COMPUTER COOPERATIVE GENETIC ALGORITHM显示文摘Optimization design of hydraulic manifold blocks (HMB) is studied as a complex solid spatial layout problem. Based on comprehensive research into structure features and design rules of HMB, an optimal mathematical model for this problem is presented. Using human-computer cooperative genetic algorithm (GA) and its hybrid optimization strategies, integrated layout and connection design schemes of HMB can be automatically optimized. An example is given to testify it. | Feng YiLi LiTian ShujunSchool of Mechanical Engineering,Dalian University of Technology,Dalian 116024, China | 2003 | Chinese Journal of Mechanical Engineering2003，16，3： | 10 |
| 4 | Research Status and Progress on Modification of Dietary Fiber at Home and Abroad显示文摘Studies have shown that modified dietary fiber has better physical and chemical properties and functions,and can better play its physiological effects.This paper systematically and comprehensively expounded the application progress of chemical separation method,microbial fermentation method,physical method,enzyme method and steam explosion method in dietary fiber modification,and expounded the development prospect of modified dietary fiber,so as to provide reference for further study on development and application of dietary fiber. | Xiaoran DUAN Suyan GAO Shoumin JIA Litian ZHANG Ruihuan DU Aili XIANG Biao QI Lei WANG | 2019 | Agricultural Biotechnology2019，8，4： | 5 |
| 5 | Low-frequency repetitive transcranial magnetic simulation prevents chronic epileptic seizure显示文摘Although low-frequency repetitive transcranial magnetic simulation can potentially treat epilepsy,its underlying mechanism remains unclear.This study investigated the influence of low-frequency repetitive transcranial magnetic simulation on changes in several nonlinear dynamic electroencephalographic parameters in rats with chronic epilepsy and explored the mechanism underlying repetitive transcranial magnetic simulation-induced antiepileptic effects.An epilepsy model was established using lithium-pilocarpine intraperitoneal injection into adult Sprague-Dawley rats,which were then treated with repetitive transcranial magnetic simulation for 7 consecutive days.Nonlinear electroencephalographic parameters were obtained from the rats at 7,14,and 28 days post-stimulation.Results showed significantly lower mean correlation-dimension and Kolmogorov-entropy values for stimulated rats than for non-stimulated rats.At 28 days,the complexity and point-wise correlation dimensional values were lower in stimulated rats.Low-frequency repetitive transcranial magnetic simulation has suppressive effects on electrical activity in epileptic rats,thus explaining its effectiveness in treating epilepsy. | Yinxu Wang Xiaoming Wang Sha Ke Juan Tan Litian Hu Yaodan Zhang Wenjuan Cui | 2013 | Neural Regeneration Research2013，8，27： | 2 |
| 6 | Realization of a Series Contact MEMS Switch with SiON Dielectric Bridge显示文摘 | HU Guangwei LIU Zewen HOU Zhihao LI Zhijian LIU Litian | 2008 | Chinese Journal of Electronics2008，17，2： | 2 |
| 7 | Major element chemistry of the Changjiang (Yangtze River) 显示文摘 | Chen Jingsheng Wang Feiyue Xia Xinghui Zhang Litian | 2002 | Chem Geol2002，187，34： | 1 |
| 8 | High-tmperature Self-lubricated Properties of AI203/Mo Laminated Composites显示文摘 | Qi Ya-e Zhang Yongsheng Hu Litian | 2012 | Wear2012，，280281： | 1 |
| 9 | Anti-wear and friction-reduction mechanism of Sn and Fe nanoparticles as additives of multialkylated cyclopentanes under vacuum condition显示文摘 | Songwei Zhang Litian Hu Dapeng Feng Haizhong Wang | 2013 | Vacuum2013，，： | 1 |
| 10 | The anti-seizure effect of Ag nanoparticles additive in multialkylated cyclopentanes oil under vacuum condition显示文摘 | Songwei Zhang Litian Hu Haizhong Wang Dapeng Feng | 2012 | Tribology International2012，，： | 1 |
| 11 | Bottom-up copper electroplating using transfer for fabrication of high aspect-ratio through-silicon vias显示文摘 | Song Chongshen Wang Zheyao Liu Litian | 2010 | Journal of Microelectronic Engineering2010，87，： | 1 |
| 12 | A Multiple Negotiations Model Considering Interdependence between Discrete Issues Across Negotiations显示文摘The research of multiple negotiations considering issue interdependence across negotiations is considered as a complex research topic in agent negotiation. In the multiple negotiations scenario, an agent conducts multiple negotiations with opponents for different negotiation goals, and issues in a single negotiation might be interdependent with issues in other negotiations. Moreover, the utility functions involved in multiple negotiations might be nonlinear, e.g., the issues involved in multiple negotiations are discrete. Considering this research problem, the current work may not well handle multiple interdependent negotiations with complex utility functions, where issues involved in utility functions are discrete. Regarding utility functions involving discrete issues, an agent may not find an offer exactly satisfying its expected utility during the negotiation process. Furthermore, as sub-offers on issues in every single negotiation might be restricted by the interdependence relationships with issues in other negotiations, it is even harder for the agent to find an offer satisfying the expected utility and all involved issue interdependence at the same time, leading to a high failure rate of processing multiple negotiations as a final outcome. To resolve this challenge, this paper presents a negotiation model for multiple negotiations, where interdependence exists between discrete issues across multiple negotiations. By introducing the formal definition of “interdependence between discrete issues across negotiations”, the proposed negotiation model applies the multiple alternating offers protocol, the clustered negotiation procedure and the proposed negotiation strategy to handle multiple interdependent negotiations with discrete issues. In the proposed strategy, the “tolerance value” is introduced as an agent’s consideration to balance between the overall negotiation goal and the negotiation outcomes. The experimental results show that, 1) the proposed model well handles the multiple negotiations with interdependence between discrete issues, 2) the proposed approach is able to help agents in the decision-making process of proposing acceptable offers, 3) an agent can choose a proper “tolerance value” to balance between the success rate of multiple negotiations and its expected utility. | Lei Niu Litian Huang Jinhua Zhao Xinguo Yu | 2021 | Journal of Systems Science and Systems Engineering2021，30，4： | 1 |
| 13 | Study of anisotropic etching of (100) Si with ultrasonic agi- tation显示文摘 | Jing Chen Litian Lin Zhiiian Li | 2002 | Sensors and Actuators A: Physical2002，96，23： | 1 |
| 14 | Characterization of microarc oxidation coatings formed on AM60B magnesium alloy in silicate and phosphate electrolytes显示文摘 | Jun Liang Litian Hu Jingcheng Hao | 2007 | Applied Surface Science2007，253，10： | 1 |
| 15 | After ven- ipuncture two needle injection method for the control of the 显示文摘 | Li Quanlei Feng Litian Zhang asylum | 2015 | International Journal of pharmaceutical medicine2015，28，37： | 1 |
| 16 | Topotactic Conversion Route to Mesoporous Quasi‐Single‐Crystalline Co<sub>3</sub>O<sub>4</sub> Nanobelts with Optimizable Electrochemical Performance显示文摘 | LiTian HongliZou JunxiangFu XianfengYang YiWang HongliangGuo XionghuiFu ChaolunLiang MingmeiWu Pei KangShen QiumingGao | 2010 | Adv Funct Mater2010，，4： | 1 |
| 17 | Experimental study on the phase change behavior ofphase change material confined in pores显示文摘 | ZHANG Dong SHENG Litian DE Yanxiao | 2007 | Solar Energy2007，81，： | 1 |
| 18 | An uncooled microbolometer infrared detector based on poly-SiGe thermistor 显示文摘 | DONG Liang YUE Ruifeng LIU Litian | 2003 | Sensors and Actuators A2003，105，： | 1 |
| 19 | Comparative investigation on the wear and transfer behaviors of carbon fiber reinforced polymer composites under dry sliding and water lubrication显示文摘 | Junhong Jia Jianmin Chen Huidi Zhou Litian Hu Lei Chen | 2005 | Composites Science and Technology2005，，7： | 1 |
| 20 | Preparation and characterization of oxide films containing crystalline TiO2 on magnesium alloy by plasma electrolytic oxidation显示文摘 | Jun Liang Litian Hua Jingcheng Hao | 2007 | Electrochimica Acta2007，52，： | 1 |
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