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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Radiographic assessment of leg alignment and grading of knee osteoarthritis:A critical review显示文摘Knee osteoarthritis(OA) is a progressive joint disease hallmarked by cartilage and bone breakdown and associated with changes to all of the tissues in the joint,ultimately causing pain,stiffness,deformity and disability in many people.Radiographs are commonly used for the clinical assessment of knee OA incidence and progression,and to assess for risk factors.One risk factor for the incidence and progression of knee OA is malalignment of the lower extremities(LE).The hipknee-ankle(HKA) angle,assessed from a full-length LE radiograph,is ideally used to assess LE alignment.Careful attention to LE positioning is necessary to obtain the most accurate measurement of the HKA angle.Since full-length LE radiographs are not always available,the femoral shaft-tibial shaft(FS-TS) angle may be calculated from a knee radiograph instead.However,the FS-TS angle is more variable than the HKA angle and it should be used with caution.Knee radiographs are used to assess the severity of knee OA and its progression.There are three types of ordinal grading scales for knee OA:global,composite and individual feature scales.Each grade on a global scale describes one or more features of knee OA.The entire description must be met for a specific grade to be assigned.The KellgrenLawrence scale is the most commonly-used global scale.Composite scales grade several features of knee OA individually and sum the grades to create a total score.One example is the compartmental grading scale for knee OA.Composite scales can respond to change in a variety of presentations of knee OA.Individual feature scales assess one or more OA features individually and do not calculate a total score.They are most often used to monitor change in one OA feature,commonly joint space narrowing.The most commonly-used individual feature scale is the OA Research Society International atlas.Each type of scale has its advantages;however,composite scales may offer greater content validity.Responsiveness to change is unknown for most scales and deserves further evaluation. | Lisa Sheehy T Derek V Cooke | 2015 | World Journal of Rheumatology2015，5，2： | 2 |
| 3 | Regulation of human alveolar macrophage inflammation cytokine production by interleukin-10显示文摘 | MARY J T LISA T | 1996 | Article1996，80，： | 1 |
| 4 | Understanding and Managing the Service Supply Chain 显示文摘 | LISA M ELLRAM WENDY L T COREY B | 2004 | Journal of Supply Chain Management2004，40，4： | 1 |
| 5 | Venous thromboembolism in cervical cancer显示文摘 | Lisa B Gillian T | 2008 | Lancet Oncol2008，9，： | 1 |
| 6 | Quantification of deoxynivalenol in wheat using an immunoaffinity column and liquid chromatography显示文摘 | Scott C Kruger Brian T McAlice | 1999 | Journal of Chromatography A1999，859，： | 1 |
| 7 | Reductive elimination of chlorinated ethylenes by zero-valent metals显示文摘 | ROBERTS A L LISA A T WILLIAM A A | 1996 | Environmental Science and Technol-ogy1996，30，8： | 1 |
| 8 | Pectin induces apoptosis in human prostate cancer cell:correlation of apoptotic function with pectin structure显示文摘 | Crystal L J Tina M D Lisa K T | 2007 | Glyeobiology2007，17，8： | 1 |
| 9 | SPICE model and parameters for fully-depleted SO1 MOSFETS Including self-heating显示文摘 | Dimitri A Antoniadis Narain D Arora | 1994 | IEEE Electron Device Letters1994，15，10： | 1 |
| 10 | Relationship marketing in consunmer markets Rhetoric or reality?显示文摘 | LISA O CAROLINE T | 2000 | European Journal d Marketing2000，34，7： | 1 |
| 11 | Development of a rapid automated influenza A, influenza B, and respiratory syncytial virus A/B multiplex real-time RT-PCR assay and its use during the 2009 H1N1 swine origin influenza virus epidemic in Milwaukee, Wisconsin显示文摘 | Eric T B Lisa A J Sue C K | 2010 | J Mol Diagn2010，12，： | 1 |
| 12 | Matrix metalloproteinases:Pathways of induction by bioactive molecules显示文摘 | TOSHIHIRO T LISA C | 2004 | Heart Fail Rev2004，1，： | 1 |
| 13 | TGF-βinduced repres-sion of CBFα1 by Smad3 decreases cbfαl and osteocalcinexpression and inhibits osteoblast differentiation显示文摘 | Tamara A Lisa C Patricia De t al | 2001 | EM-BO J2001，20，9： | 1 |
| 14 | Orthogonal,convergent syntheses of dendri mers based on melaminewith one or two unique surfacesites for manipulati on显示文摘 | WEN Z DANIELT N LISA M T | 2001 | Journal of the American Chemical Society2001，123，89： | 1 |
| 15 | Applications of array biosensor for detection of food allergens显示文摘 | LISA C CHRIS R T LIGLER S | 2004 | Journal of AOAC International2004，87，6： | 1 |
| 16 | Modeling cognitive adaptation: a longitudinal investigation of the impact of individual differences and coping on college adjustment and performance显示文摘 | Lisa G A Shelley E T | 1992 | Journal of Personality and Social Psychology1992，，6： | 1 |
| 17 | Design of a nonlinear disturbance observer 显示文摘 | LISA Pathfinder drag-free control Classical and Quantum Gravity Chen X K Komada S Fukuda T | 2000 | IEEE Transactions on Industrial Electronics2000，47，2： | 1 |
| 18 | High-performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry and gas chromatography flame ionization detection characterization of △5-polyenoic fatty acids in triacylglycerols from conifer seed oils显示文摘 | Lisa M Holcapek M Rezanka T | 2007 | Journal of Chromatography A2007，1146，1： | 1 |
| 19 | Detergency properties of al- kylated diphenyl oxide disulfonates 显示文摘 | Lisa Quencer T J Loughney | 2001 | Surfactant Science Seriess2001，，98： | 1 |
| 20 | Quantification of deoxynivalenol in wheat using an immunoaffinity column and liquid chromatography显示文摘 | Scott C Kruger Brian T McAlice | 1999 | Journal of Chromatography A1999，859，： | 1 |
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