|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Physical activity as a treatment of non-alcoholic fatty liver disease:A systematic review显示文摘AIM: To review the effectiveness of exercise as a therapy for nonalcoholic fatty liver disease(NAFLD) and potential benefits in treating insulin resistance and atherosclerosis.METHODS: Medline(EBSCOhost) and Pub Med were searched for English-language randomized controlled trials and prospective cohort studies in human adults aged ≥ 18 which investigated the various effects of exercise alone, a combination of exercise and diet, or exercise and diet coupled with behavioral modification on NAFLD from 2010 to Feburary 2015.RESULTS: Eighteen of 2298 available studies were chosen for critical review, which included 6925 patients. Nine(50%) studies were randomized controlled trials. Five(27.8%) studies utilized biopsy to examine the effects of physical activity on hepatic histology. The most commonly employed imaging modality to determine change in hepatic steatosis was hydrogen-magnetic resonance spectroscopy. Only two studies examined the effects of low impact physical activity for patients with significant mobility limitations and one compared the efficacy of aerobic and resistance exercise. No studies examined the exact duration of exercise required for hepatic and metabolic improvement in NAFLD.CONCLUSION: While exercise improved hepatic steatosis and underlying metabolic abnormalities in NAFLD, more studies are needed to define the most beneficial form and duration of exercise treatment. | Maureen Whitsett Lisa B VanWagner | 2015 | World Journal of Hepatology2015，7，16： | 281 |
| 2 | Personalized chemotherapy in clear cell adenocarcinoma of the urethra:A case report显示文摘BACKGROUND Clear cell adenocarcinoma of the urethra is a rare type of aggressive cancer with a poor prognosis.Clear cell carcinoma of the urethra represents less than 0.02%of all malignancies in women.Adenocarcinomas account for 10%of female urethral carcinomas,of which 40%are the clear cell variant.Determining the presence or absence of certain mutations through genetic testing may predict whether a patient with cancer may benefit from a particular chemotherapy regimen.CASE SUMMARY A 40-year-old woman presented with a 3-year history of slow urinary flow and a 3-mo history of urinary urgency and frequency as well as gross hematuria.An abdominal and pelvic computed tomography scan demonstrated enlarged lymph nodes in the abdomen and pelvis.A biopsy of a left inguinal lymph node microscopically confirmed a metastatic adenocarcinoma of the urethra.Specialized genetic testing determined personalized chemotherapy.She was treated successfully with a non-platinum-based chemotherapy consisting of paclitaxel and bevacizumab.Following 3 cycles of paclitaxel and bevacizumab,she attained significant clinical improvement,and response by FDG-Positron emission tomography(PET)imaging showed a definite improvement in size and metabolic activity.She achieved complete response after 6 cycles of therapy by PET scan.The patient concluded 11 cycles of paclitaxel and bevacizumab,and a subsequent PET scan confirmed progression of metastatic disease.The patient was then treated with two cycles of doxorubicin after which a PET scan revealed a mixed response to the treatment.CONCLUSION We report the first case of a patient with metastatic clear cell adenocarcinoma of the urethra who underwent personalized chemotherapy after testing for cancer gene alterations.Our unique case represents the safe and effective use of nonplatinum-based chemotherapy in clear cell adenocarcinoma of the urethra. | Lisa B E Shields Arash Rezazadeh Kalebasty | 2020 | World Journal of Clinical Oncology2020，11，4： | 3 |
| 3 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 4 | Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study显示文摘 | Daniel J Drucker John B Buse Kristin Taylor David M Kendall Michael Trautmann Dongliang Zhuang Lisa Porter | 2008 | The Lancet2008，，9645： | 2 |
| 5 | Differential expression of components of the cardiomyocyte adrenomedullin/intermedin receptor system following blood pressure red-uction in Nodeificient hypertension显示文摘 | Abdelrahman A M David B Lisa R S | 2005 | JPET Fast Forward2005，12，3： | 1 |
| 6 | Leptin is a four - helix bundle:secondary structure by NMR显示文摘 | Allen D K Gerald W B Lisa M C | 1997 | FEBS Letters1997，407，2： | 1 |
| 7 | Understanding and Managing the Service Supply Chain 显示文摘 | LISA M ELLRAM WENDY L T COREY B | 2004 | Journal of Supply Chain Management2004，40，4： | 1 |
| 8 | Venous thromboembolism in cervical cancer显示文摘 | Lisa B Gillian T | 2008 | Lancet Oncol2008，9，： | 1 |
| 9 | Determination of the oxidation states of manganese in brain, liver, and heart mitochondria 显示文摘 | Thomas E G Lisa M M Claire E G Roman E Jason S Linas B Andrei A Sean H Karlene K G | 2004 | Journal of Neuroehemistry2004，88，： | 1 |
| 10 | A survey of image registration techniques 显示文摘 | LISA G B | 1992 | ACM Computing Surveys1992，24，4： | 1 |
| 11 | Development of a rapid automated influenza A, influenza B, and respiratory syncytial virus A/B multiplex real-time RT-PCR assay and its use during the 2009 H1N1 swine origin influenza virus epidemic in Milwaukee, Wisconsin显示文摘 | Eric T B Lisa A J Sue C K | 2010 | J Mol Diagn2010，12，： | 1 |
| 12 | Ontogeny of me- tabolizing enzymes in the neonate 显示文摘 | MICHAEL J B LISA C B J STEVEN L | 2005 | Semin Fetal Neonatal Med2005，10，2： | 1 |
| 13 | Computational and experimental study of axisymmetric coflow partially premixed methane/air flames显示文摘 | Beth A V B Charles S M Lisa D P | 2000 | Combustion and Flame2000，123，4： | 1 |
| 14 | Whole blood optical biosensor 显示文摘 | Lisa M B Lisa A D | 2007 | Biosensors and Bioelectronics2007，23，3： | 1 |
| 15 | Ovomucoid is not Superior to egg white testing in Predicting Tolerance to Baked Egg显示文摘 | Lisa M B William J S Wanda P | 2013 | The Journal of Allergy and Clinical Immunology:In Practice2013，1，4： | 1 |
| 16 | Relations of hyperuricemia to longitudinal blood pressure tracking and hypertension incidence显示文摘 | Johan Sundstrom Lisa Sullivan Ralph B | 2005 | Hypertension2005，45，： | 1 |
| 17 | The Effects of Driver Training on Simulated Driving Performance 显示文摘 | Lisa D David B | 2005 | Accident Analysis and Prevention2005，37，1： | 1 |
| 18 | Schizophrenia: Etiology and course显示文摘 | Elaine W Lisa K Annie B | 2004 | Annual Review Psychology2004，55，： | 1 |
| 19 | Riparian woody plant diversity and forest structure along an urban-rural gradient显示文摘 | Michele L B Lisa J S Shufen P | 2005 | Urban E- cosystems2005，8，： | 1 |
| 20 | Marcinkeviciene mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin ( BMS-477118 ) 显示文摘 | Young B Kim Lisa M Kopcho Mark S Kirby | 2006 | Arch Biochem Biophys2006，445，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员