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| 1 | Helicobacter pylori vac A genotype is a predominant determinant of immune response to Helicobacter pylori CagA显示文摘AIM To evaluate the frequency of Helicobacter pylori(H. pylori) Cag A antibodies in H. pylori infected subjects and to identify potential histopathological and bacterial factors related to H. pylori Cag A-immune response.METHODS Systematic data to H. pylori isolates, blood samples, gastric biopsies for histological and molecular analyses were available from 99 prospectively recruited subjects. Serological profile(anti-H. pylori, anti-Cag A) was correlated with H. pylori isolates(cag A, EPIYA, vac A s/m genotype), histology(Sydney classification) and mucosal interleukin-8(IL-8) m RNA and protein expression. Selected H. pylori strains were assessed for H. pylori Cag A protein expression and IL-8 induction in co-cultivation model with AGS cells.RESULTS Thirty point three percent of microbiologically confirmed H. pylori infected patients were seropositive for Cag A. Majority of H. pylori isolates were cag A gene positive(93.9%) with following vac A polymorphisms: 42.4% vac A s1m1, 23.2% s1m2 and 34.3% s2m2. Anti-Cag AIg G seropositivity was strongly associated with atrophic gastritis, increased mucosal inflammation according to the Sydney score, IL-8 and cag A m RNA expression. V a c A s a n d m p o l y m o r p h i s m s w e r e t h e m a j o r determinants for positive(vac A s1m1) or negative(vac A s2m2) anti-Cag A serological immune response, which also correlated with the in vitro inflammatory potential in AGS cells. In vitro co-cultivation of representative H. pylori strains with AGS cells confirmed functional Cag A translocation, which showed only partial correlation with Cag A seropositivity in patients, supporting vac A as major co-determinant of the immune response.CONCLUSION Serological immune response to H. pylori cag A + strain in H. pylori infected patients is strongly associated with vac A polymorphism, suggesting the crucial role of bacterial factors in immune and clinical phenotype of the infection. | Alexander Link Cosima Langner Wiebke Schirrmeister Wiebke Habendorf Jochen Weigt Marino Venerito Ina Tammer Dirk Schlüter Philipp Schlaermann Thomas F Meyer Thomas Wex Peter Malfertheiner | 2017 | World Journal of Gastroenterology2017，23，26： | 12 |
| 2 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 3 | AtHsp70-15-deficient Arabidopsis plants are characterized by reduced growth, a constitutive cytosolic protein response and enhanced resistance to TuMV 显示文摘 | Jungkunz I Link K Vogel F Voll L M Sonnewald S Sonnewald U | 2011 | Plant Journal2011，66，： | 1 |
| 4 | Estimating the benefits from collaboration:the case of SEMATECH显示文摘 | LINK A N TEECE D J FINAN W F | 1996 | Review of Industrial Organization1996，11，5： | 1 |
| 5 | Fecal MicroRNAs as novel biomarkers for colon cancer screening显示文摘 | Link A Balaguer F Shen Y | 2010 | Cancer Epidemiol Biomarkers Prev2010，19，7： | 1 |
| 6 | New vessel analysis tool for morphometric quantification and visualization of vessels in CT and MR imaging data sets显示文摘 | Boskamp T Rinck D Link F | 2004 | Radiographics2004，24，1： | 1 |
| 7 | Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor显示文摘 | Thomas J Liu F Link DC | 2002 | Curr Opinion Hematol2002，9，3： | 1 |
| 8 | Optical properties and chemistry of graptolite periderm following labo- ratory simulated maturatin 显示文摘 | Bustin R M Link C Goodarzi F | 1989 | Org Geochem1989，14，： | 1 |
| 9 | Quantitative MRS:comparison of time domain and time domain frequency domain methods using a novel test procedure显示文摘 | Elster C Link A Schubert F | 2000 | Magn Reson Imaging2000，18，5： | 1 |
| 10 | The endometrium as a novel target forleptin: differences in fertility and subfertility显示文摘 | Alfer J Muller - Schottle F Classen - Linke I | 2000 | Mol Hum Reprod2000，6，： | 1 |
| 11 | Fecal MicroRNAs as novel biomarkers for colon cancer screening 显示文摘 | Link A Balaguer F Shen Y | 2010 | Cancer Epidemiol Biomarkers Prey2010，19，7： | 1 |
| 12 | Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis显示文摘 | Balaguer F Link A Lozano J J | 2010 | Cancer Res2010，70，16： | 1 |
| 13 | Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor显示文摘 | Thomas J Liu F Link DC | 2002 | Curt Opin Hematol2002，9，3： | 1 |
| 14 | Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis显示文摘 | Balaguer F Link A Lozano JJ | 2010 | Cancer Res2010，70，16： | 1 |
| 15 | Basics for in-process roundness error improvement by a functional workrest blade显示文摘 | Klocke F Friedrich D Linke B | 2004 | CIRP Annals-Manufacturing Technology2004，53，1： | 1 |
| 16 | Effect of specimen size on fracture toughness of a titanium alloy显示文摘 | Munz D Galda K H Link F | 1976 | Mechanics of Crack Growth ASTM STP 590 ASTM International West Conshohocken PA1976，1976，： | 1 |
| 17 | Is follow-up of colorectal cancer patients worthwhile?显示文摘 | Safi F Link KH Beger HG | 1993 | Dis Colon Rectum1993，36，7： | 1 |
| 18 | Concept study for a high-efficiency nanowire based thermoelectric显示文摘 | O'DWYER M F HUMPHREY T E LINKE H | 2006 | Nanotechnology2006，17，： | 1 |
| 19 | Effects of chromium propionate supplementation on growth performance,serum traits and immune response in weaned pigs显示文摘 | LIEN T F YANG K H LINK K J | 2005 | Asian-Australasian Journal of Animal Sciences2005，18，3： | 1 |
| 20 | DREAM is a Ca2+ -regula- ted transcriptional repressor 显示文摘 | Carrion AM Link WA Ledo F | 1999 | Nature1999，398，： | 1 |
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