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| 1 | Diffusion tensor imaging detects Wallerian degeneration of the corticospinal tract early after cerebral infarction显示文摘To investigate the feasibility and time window of early detection of Wallerian degeneration in the corticospinal tract after middle cerebral artery infarction,23 patients were assessed using magnetic resonance diffusion tensor imaging at 3.0T within 14 days after the infarction.The fractional anisotropy values of the affected corticospinal tract began to decrease at 3 days after onset and decreased in all cases at 7 days.The diffusion coefficient remained unchanged.Experimental findings indicate that diffusion tensor imaging can detect the changes associated with Wallerian degeneration of the corticospinal tract as early as 3 days after cerebral infarction. | Ruiman Xie Min Fang Linjiang Zhou Shanghua Fan Jianying Liu Hongbo Quan Man Luo Dongying Qiu | 2012 | Neural Regeneration Research2012，7，12： | 20 |
| 2 | Application of Clays in Fire Retardant Materials of Polymers显示文摘Because of the dispersion at the nanometer level, polymer-clay nanocomposites exhibit superior properties in comparison with pure polymer or conventional composites; this includes properties such as barrier properties , improved thermal stability and flame retardancy. The outstanding properties of polymer-clay nanocomposites are achieved at a much lower volume fraction, compared with conventional composites. Polymer-clay nanocomposites can be processed using common techniques, such as extrusion and casting, which are superior to the cumbersome techniques used for the conventional composites. Hence, polymer-clay nanocomposites have important potential commercial value. | WANG Linjiang XIE Xiangli Charles A.Wilkie | 2013 | 矿物学报2013，33，S1： | 0 |
| 3 | Logformer: Cascaded Transformer for System Log Anomaly Detection显示文摘Modern large-scale enterprise systems produce large volumes of logs that record detailed system runtime status and key events at key points.These logs are valuable for analyzing performance issues and understanding the status of the system.Anomaly detection plays an important role in service management and system maintenance,and guarantees the reliability and security of online systems.Logs are universal semi-structured data,which causes difficulties for traditional manual detection and pattern-matching algorithms.While some deep learning algorithms utilize neural networks to detect anomalies,these approaches have an over-reliance on manually designed features,resulting in the effectiveness of anomaly detection depending on the quality of the features.At the same time,the aforementioned methods ignore the underlying contextual information present in adjacent log entries.We propose a novel model called Logformer with two cascaded transformer-based heads to capture latent contextual information from adjacent log entries,and leverage pre-trained embeddings based on logs to improve the representation of the embedding space.The proposed model achieves comparable results on HDFS and BGL datasets in terms of metric accuracy,recall and F1-score.Moreover,the consistent rise in F1-score proves that the representation of the embedding spacewith pre-trained embeddings is closer to the semantic information of the log. | Feilu Hang Wei Guo Hexiong Chen Linjiang Xie Chenghao Zhou Yao Liu | 2023 | Computer Modeling in Engineering & Sciences2023，，7： | 0 |
| 4 | Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma显示文摘Glioblastoma(GBM)is the most common and aggressive malignant brain tumor in adults and is poorly controlled.Previous studies have shown that both macrophages and angiogenesis play significant roles in GBM progression,and co-targeting of CSF1R and VEGFR is likely to be an effective strategy for GBM treatment.Therefore,this study developed a novel and selective inhibitor of CSFIR and VEGFR,SYHA1813,possessing potent antitumor activity against GBM.SYHA1813 inhibited VEGFR and CSFIR kinase activities with high potency and selectivity and thus blocked the cell viability of HUVECs and macrophages and exhibited anti-angiogenetic effects both in vitro and in vivo.SYHA1813 also displayed potent in vivo antitumor activity against GBM in immune-competent and immune-deficient mouse models,including temozolomide(TMZ)insensitive tumors.Notably,SYHA1813 could penetrate the blood-brain barrier(BBB)and prolong the survival time of mice bearing intracranial GBM xenografts.Moreover,SYHA1813 treatment resulted in a synergistic antitumor efficacy in combination with the PD-1 antibody.As a clinical proof of concept,SYHA1813 achieved confirmed responses in patients with recurrent GBM in an ongoing first-in-human phase I trial.The data of this study support the rationale for an ongoing phase I clinical study(ChiCTR2100045380). | Yingqiang Liu Zhengsheng Zhan Zhuang Kang Mengyuan Li Yongcong Lv Shenglan Li Linjiang Tong Fang Feng Yan Li Mengge Zhang Yaping Xue Yi Chen Tao Zhang Peiran Song Yi Su Yanyan Shen Yiming Sun Xinying Yang Yi Chen Shanyan Yao Hanyu Yang Caixia Wang Meiyu Geng Wenbin Li Wenhu Duan Hua Xie Jian Ding | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 5 | A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy显示文摘Oncogenes are critical factors in tumorigenesis of diverse cancer types and play essential roles in tumor immune escape.Mutations in Kirsten rat sarcoma viral oncogene homolog(KRAS)and epidermal growth factor receptor(EGFR)are among the most frequent gain-of-function alterations[1].After many years of in-depth research,inhibitors targeting EGFR or KRAS mutations have been successfully developed,however,their clinical benefit is relatively limited,and they will inevitably encounter the challenge of drug resistance.The emergence of resistance is attributed to secondary mutations in driver genes and other complicated factors. | Yingqiang Liu Linjiang Tong Mengge Zhang Qi Zhang Qiupei Liu Fang Feng Yan Li Mengzhen Lai Haotian Tang Yi Chen Meiyu Geng Wenhu Duan Jian Ding Hua Xie | 2024 | Cancer Communications2024，44，3： | 0 |
| 6 | 2-Oxo-3,4-dihydropyrimido[4,5-d] pyrimidines as new reversible inhibitors of EGFR C797S(Cys797 to Ser797)mutant显示文摘Extensive structure-activity relationships(SARs)study of JND3229 was conducted to yield a series of new reve rsible 2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidine privileged scaffold as EGFRC797 S inhibitors.One of the most potent compound 6 i potently suppressed EGFRL858 R/T790 M/C797 S kinase with an IC50 value of 3.1 nmol/L,and inhibited the proliferation of BaF3 cells harboring EGFRL858 R/T790 M/C797 S and EGFR19 D/T790 M/C797 S mutants with IC50 values of 290 nmol/L and 316 nmol/L,respectively.Further,6 i dose-dependently induced suppression of the phosphorylation of EGFRL858 R/T790 M/C797 S and EGFR19 D/T790 M/C797 S in BaF3 cells.Compound 6 i may serve as a promising lead compound for further drug discovery overcoming the acquired resistance of non-small cell lung cancer(NSCLC)patients. | Xianglong Hu Qiuju Xun Tao Zhang Su-Jie Zhu Qian Li Linjiang Tong Mengzhen Lai Tao Huang Cai-Hong Yun Hua Xie Ke Ding Xiaoyun Lu | 2020 | Chinese Chemical Letters2020，31，5： | 0 |
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