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| 1 | Ginsenoside Rb1 attenuates activated microglia-induced neuronal damage显示文摘The microglia-mediated inflammatory reaction promotes neuronal damage under cerebral ischemia/hypoxia conditions. We therefore speculated that inhibition of hypoxia-induced microglial activation may alleviate neuronal damage. To test this hypothesis, we co-cultured ginsenoside Rb1, an active component of ginseng, and cortical neurons. Ginsenoside Rb1 protected neuronal morphology and structure in a single hypoxic culture system and in a hypoxic co-culture system with microglia, and reduced neuronal apoptosis and caspase-3 production. The protective effect was observable prior to placing in co-culture. Additionally, ginsenoside Rb1 inhibited levels of tumor necrosis factor-α in a co-culture system containing activated N9 microglial cells. Ginsenoside Rb1 also significantly decreased nitric oxide and superoxide production induced by N9 microglia. Our findings indicate that ginsenoside Rb1 attenuates damage to cerebral cortex neurons by downregulation of nitric oxide, superoxide, and tumor necrosis factor-α expression in hypoxia-activated microglia. | Lining Ke Wei Guo Jianwen Xu Guodong Zhang Wei Wang Wenhua Huang | 2014 | Neural Regeneration Research2014，9，3： | 11 |
| 2 | Increased expression of human T-cell immunoglobulin-and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus显示文摘全身的豺狼座 erythematosus (SLE ) 是 prototypic 自体免疫的疾病。天生、适应的免疫合作地贡献 SLE 的发展。介绍抗原的房间(APC ) 被建议了连接天生、适应的免疫。T 房间 immunoglobulin-domain-containing 和 mucin-domain-containing molecule-4 (Tim-4;另外作为 Timd4 知道) ,首先在 APC 的表面上表示了,是 TIM 家庭,的一个成员作为免疫系统的潜在的管理者收到了许多注意的分子的一个最近描述的组。在这研究,我们使用了量的即时反向的抄写聚合酶链反应从 SLE 病人在外部血 mononuclear 房间( PBMC )检验 Tim-4 的 mRNA 表示并且进一步在 PBMC 和浆液肿瘤坏死因素( TNF )分析了在 Tim-4 和 Tim-1 (为 Tim-4 的潜在的 ligand )的表示之间的关联-伪层次。结果证明在 PBMC 的那个 Tim-4 mRNA 表达式比在健康控制在 SLE 病人是显著地更高的,特别在疾病的活跃阶段的那些病人。而且, Tim-4 mRNA 层次密切在 SLE 病人然而并非在控制组在 PBMC 并且与浆液 TNF- 伪层次与 Tim-1 mRNA 层次被相关。一起拿,这些结果证明 Tim-4 可以涉及 SLE 的致病。 | Peiqing Zhao Liyun Xu Piming Wang Xiaohong Liang Jianni Qi Peng Liu Chun Guo Lining Zhang Chunhong Ma Lifen Gao | 2010 | Cellular & Molecular Immunology2010，7，2： | 11 |
| 3 | Metabolomic Profiling in Selaginella lepidophylla at Various Hydration States Provides New Insights into the Mechanistic Basis of Desiccation Tolerance显示文摘Selaginella lepidophylla 是仅仅一些之一发展了干燥忍耐(DT ) 或从一个 air-dried 状态复兴的能力的尖铁苔藓(Selaginellaceae ) 的种类。以便理解 DT 的新陈代谢的基础, S。lepidophylla 受到一五阶段, rehydration/dehydration 周期,然后分析了使用基于 GC/MS 和 UHLC/MS/MS2 平台介绍技术的非偏导的、全球 metabolomics。包括 167 说出的 251 代谢物(66.5%) 的一个总数并且 84 (33.4%) 未命名的混合物被描绘。仅仅 42 (16.7%) 并且(29.5%) 74 混合物显示出显著地增加或减少的丰富分别地,显示大多数混合物组成地被生产包括高度丰富的 trehalose,蔗糖,和葡萄糖。几 glycolysis/gluconeogenesis 和 tricarboxylic 酸(TCA ) 周期中介在 100% 亲戚水内容(RWC ) 和 50% RWC 显示出增加的丰富。Vanillate,一种有势力抗氧化剂,也更充满含水的状态。许多不同的糖白酒和糖酸更充满含水的状态。这些 polyols 多半速度率在水和期间在弄干的过程以及慢水吸收期间浇损失,稳定蛋白质,并且清除反应的氧种类(ROS ) 。相反,充满氮并且 -glutamyl 氨基酸,瓜氨酸,和核苷酸分解代谢产品(例如 allantoin ) 更充满干燥状态,建议这些混合物可能在水和期间或在清除的 ROS 在氮动员起重要作用。紫外保护的混合物象 3-(3-hydroxyphenyl ) 那样 propionate, apigenin,和 naringenin,更充满干燥状态。大多数类脂化合物组成地被生产,与胆碱磷酸盐的例外,它更充满干燥状态并且多半在膜水和和稳定起一个作用。相反,几多元不堡和丰满的酸更充满含水的状态,建议这些混合物多半帮助在脱水期间维持膜流动性。最后, S。lepidophylla 包含了显示了双重或更大的丰富在的七未命名的混合物干燥或 rehydrating 状态,建议这些混合物可能在 DT 起适应作用。 | Abou Yobi Bernard W.M. Wone Wenxin Xu Danny C. Alexander Lining Guo John A. Ryals Melvin J. Oliver John C. Cushman | 2013 | Molecular Plant2013，6，2： | 9 |
| 4 | Perioperative factors related to prognosis of regular hepatectomy in comparison with irregular hepatectomy显示文摘 | Feng Zhiqiang Li Hongqi Zhang Jinqian Xu Lining Xiao Mei Huang Zhiqiang Zhang Hongyi | 2014 | Chinese Medical Journal2014，，2： | 4 |
| 5 | Pitting Corrosion of 13Cr Steel in Oxygen-free Completion Fluids of Organic Salt显示文摘Corrosion behavior of 13Cr steel in oxygen-free completion fluids of the organic salt at 180 ℃ was studied. Cross-sectional morphologies of the corrosion products were observed by scanning electron microscopy. Energy dispersive spectrum (EDS) was used to study the element distribution of the corrosion product inside and outside the pits. The results show that the organic salt causes severe pitting corrosion of 13Cr steel. The width and depth of the pits increase simultaneously when the test duration prolongs, and potassium enriches inside the pits. | Lining XU Yao MENG Yunguang SHI Yan LIU | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，3： | 2 |
| 6 | Corrosion of Cr Bearing Low Alloy Pipeline Steel in CO2 Environment at Static and Flowing Conditions 显示文摘 | Xu Lining Guo Shaoqiang Chang Wei | 2013 | Applied Surface Science2013，270，4： | 1 |
| 7 | Rapid determination of telmisartan in pharmaceuticals and serum by the parallel catalytic hydrogen wave method显示文摘 | XU Mao-tian SONG Jun-feng LINing | 2003 | A- nal Bioanal Chem2003，377，： | 1 |
| 8 | Establishment of a risk assessment system for complications of hepatectomy based on preoperative variables显示文摘Background and aims:To reduce the incidence of postoperative complications,it is important to predict them and intervene before surgery if necessary.However,there is no ideal system to evaluate the overall risk of post-operative complications of liver surgery on the basis of preoperative variables.Therefore,this study aimed to design and validate a risk assessment system to predict postoperative complications of hepatectomy on the basis of preoperative variables.Methods:Binomial logistic regression was used to derive the“hepatectomy overall risk formula”(HORF)for predicting postoperative complications on the basis of preoperative variables.Results:Multivariate analysis revealed that Child–Pugh grade B–C(odds ratio[OR]=1.984,p=0.002),medical diseases requiring drug treatment(OR=1.883,p=0.003),major hepatectomy(OR=1.947,p<0.001),adjacent organ invasion(OR¼3.616,p¼0.023),and preoperative hospital stay>7 days(OR=1.565,p=0.004)were independent risk factors for postoperative complications of hepatectomy.The area under the curve for the HORF was 0.736.The optimal cut-off value for predicting complications was 0.32(32%).The area under the curve for the HORF in the validation dataset was 0.727.Conclusion:The HORF can accurately predict postoperative complications of hepatectomy on the basis of pre-operative variables,and thus enables the determination of the necessity for intervention before surgery. | Lining Xu Guiping Li Bo Yang | 2022 | iLIVER2022，1，4： | 1 |
| 9 | Corrosion of alloy steelscontaining 2% chromium in C02 environments显示文摘 | Shaoqiang Guo Lining Xu Lei Zhang | 2012 | Corrosion Science2012，63，： | 1 |
| 10 | Chronological constraints on multi-staged rapid cooling of the Tianshan Mountains inferred from apatite fission track analysis of modern river sands显示文摘The extreme modern elevation of the Tianshan Mountains reflects the Cenozoic deformation.Apatite Fission Track(AFT)chronometry is widely used to study the latest cooling stages caused by tectonic process or by exhumation in the uppermost crust.However,uncertainties remain over timing constraints on thermal history of the Tianshan Mountains since the Cenozoic though a great mount of dating work had been done in this area.To address this issue,modern river sands from the drainage basin on the piedmont of the Tianshan Mountains were sampled to integrate regional information.Single grains were dated with the AFT method,and then different grain-age components were identified to provide thermochronological constraints of their sources.Combined with discussion of previous dataset,our results show the multi-staged rapid cooling cluster at 46–32,25–24,19–13,8–6,and^3 Ma,respectively.We interpreted these cooling events as a result of interplays between the Cenozoic tectonic uplift of the mountains and regional climate change. | WANG LiNing JI JianQing SUN DongXia XU QinQin HAN BaoFu | 2015 | Science China Earth Sciences2015，58，8： | 1 |
| 11 | Fast Discrimination of Traditional Chinese Medicine According to Geographical Origins with FTIR Spectroscopy and Advanced Pattern Recognition Techniques 显示文摘 | LINing WANG Yan XU Ke-xin | 2006 | Optics Express2006，14，17： | 1 |
| 12 | Anxiety and depression in older adult patients undergoing elective liver surgery in allopatry medical treatment显示文摘Background:Allopatry medical treatment is common in China.However,allopatry medical therapy can result in many problems,including a negative psychological impact on patients.Patients undergoing liver surgery often experience anxiety and depression.To understand the psychological status of older adult patients undergoing surgery better,this study was designed to investigate the incidence of anxiety and depression in older adult patients undergoing elective liver surgery and to analyze factors associated with it in allopatry medical therapy.Methods:A total of 173 older adult patients undergoing elective liver surgery were included in the study.Patients were evaluated using the hospital anxiety and depression scale(HADS).The contributing factors affecting the psychological state of older adult patients undergoing elective surgery were analyzed using a linear regression method.Results:The HADS-A(hospital anxiety and depression scale-anxiety).The correlation(scale)score of the older adult patients undergoing elective liver surgery was(8.692.38),including 53 asymptomatic patients,86 suspicious patients,and 34 symptomatic patients.The HADS-D(hospital anxiety and depression scale-depression)score was(8.312.90),including 83 asymptomatic patients,56 suspicious patients,and 34 symptomatic patients.Multivariate analysis showed that residence and complication grade(Clavien–Dindo Classification of Surgical Complications or Accordion Severity Grading System)significantly correlated with the anxiety level of patients undergoing elective surgery.Residence,a requirement of blood transfusion,total transfusion volume,and Accordion complication grade showed a significant correlation with depression in patients undergoing elective surgery.Conclusions:Anxiety and depression in older adult patients undergoing elective liver surgery were common.Regional differences(local patients vs non local patients)and the severity of complications were the risk factors for anxiety and depression in older adult patients undergoing elective liver surgery.Reducing both regional differences and the severity of complications would be beneficial to alleviate the risk of anxiety and depression in older adult patients undergoing elective liver surgery and thus promote their physical and mental health. | Lining Xu Yingying Xu Guiping Li Bo Yang | 2022 | iLIVER2022，1，2： | 0 |
| 13 | How did the Tonga volcanic tsunami on January 15,2022,affect Chinese coasts?显示文摘At 12:15 on January 15,2022(Beijing time),a massive eruption of the Hunga Tonga-Hunga Ha'apai volcano produced violent atmospheric fluctuations,which in turn generated a global tsunami through an abrupt air pressure shock upon the sea surface.Two main components of tsunami waves,phase-locked waves and free gravity waves,were identified by significant differences in propagating speeds across the deep ocean.The phase-locked wave propagated through the ocean basin synchronously with the atmospheric Lamb wave at an average speed of approximately 306 m/s,followed by the free gravity wave at a slower speed.The locked wave reached the coast of eastern Taiwan Island at about 20:00 on January 15,in coincidence with the Lamb wave arrival.However,on the coast of Chinese mainland,tidal gauges did not record tsunami signals until at least 2 h after the Lamb wave arrivals.Theoretical analyses and numerical experiments both suggested that as a result of the incoming wave shoaling above the vast continental shelf of Chinese mainland,the locked wave was no longer trapped by the air pressure shock and gradually transformed into freely-propagating shallow water waves by slowing down its propagation.Due to the longlasting planetary atmospheric fluctuations circling the earth many times,the sea level oscillations continuously propagated onto the Chinese shelf,which resulted in the tsunami waves excited along the Chinese coasts for at least 36 h.The maximum wave amplitude recorded on the coast of eastern Taiwan Island was 44 cm at Wushi,while on the coasts of eastern and southern Chinese mainland,the maximum amplitudes were 22 cm at Shipu and 13 cm at Zhuhai.Fourier and wavelet analyses were performed to identify the major components of the tsunami waves on the Chinese coasts.The results indicated that eastern Taiwan Island was impacted mainly by the waves with periods of approximately 10-40 min.Chinese mainland was hit by the evolved shallow water waves and subsequent free waves,with periods of approximately 40-100 and 16-20 min,respectively. | Zongchen WANG Zhiguo XU Ye YUAN Huaiwei YANG Lining SUN Peitao WANG Tingting FAN | 2023 | Science China Earth Sciences2023，66，5： | 0 |
| 14 | Soxllb regulates the migration and fate determination of Müller glia-derived progenitors during retina regeneration in zebrafish显示文摘The transcription factor Sox11 plays important roles in retinal neurogenesis during vertebrate eye development.However,its function in retina regeneration remains elusive.Here we report that Sox11 b,a zebrafish Sox11 homolog,regulates the migration and fate determination of Müller glia-derived progenitors(MGPCs)in an adult zebrafish model of mechanical retinal injury.Following a stab injury,the expression of Sox11 b was induced in proliferating MGPCs in the retina.Sox11 b knockdown did not affect MGPC formation at 4 days post-injury,although the nuclear morphology and subsequent radial migration of MGPCs were alte red.At 7 days post-injury,Sox11 b knockdown res ulted in an increased proportion of MGPCs in the inner retina and a decreased propo rtion of MGPCs in the outer nuclear layer,compared with controls.Furthermore,Sox11 b knockdown led to reduced photoreceptor regeneration,while it increased the numbe rs of newborn amacrines and retinal ganglion cells.Finally,quantitative polymerase chain reaction analysis revealed that Sox11 b regulated the expression of Notch signaling components in the retina,and Notch inhibition partially recapitulated the Sox11 b knockdown phenotype,indicating that Notch signaling functions downstream of Sox11 b.Our findings imply that Sox11 b plays key roles in MGPC migration and fate determination during retina regeneration in zebrafish,which may have critical im plications for future explorations of retinal repair in mammals. | Kaida Song Zihao Lin Lining Cao Bowen Lu Yuxi Chen Shuqiang Zhang Jianfeng Lu Hui Xu | 2023 | Neural Regeneration Research2023，18，2： | 0 |
| 15 | Atmosphere CO2 increased concentration against lush membrane sponge stay显示文摘under lab conditions , studied the atmosphere CO2 effect of elevated concentrations on the filtration function of the lowest-equal multicellular animal sponge . in mock atmosphere CO2 Elevated concentrations of ecosystems , review CO2 concentration for 387, 750, 1000 mg/l under the environment , Lush film Sponge Hymeniacidonperlevis Stop sterilization of total organic carbon in seawater ( TOC) Capabilities . results show : in impersonation CO 2 concentration is 387 , 750, 1000 mg/l under the condition of Lush film sponge in H Clear seawater inside TOC The efficiency of IS 8%,67.6%, 50.0% and 15.4%, in the 24h to TOC The average drag retention rate for is (1.90±0.20 ,( 2.13±0.06 ,( 1.69±0.08 ,( 0.43± 0.11 mgkh-g Sponge ), The average purge rate is ( 0.025±0.002 ,( 0.033±0.001 ,( 0.019±0.001 ,( 0.004±0.001 mlkh.g sponge ), See Atmospher CO2 concentration from approximately 387 mg/l elevated to mg/l ,promotes lush film sponges prevent seawate from being in the sea TOC Ability , When the concentration is elevated to 750 mg/l suppresses the lush membrane sponge to stay TOC Capabilities , When the concentration is further elevation to 1000 mg/l , The causes the lush membrane sponge to almost lose its resistance to the seawater.TOC Capabilities . This study can be used for atmospheric 一: concentration The elevation of the effect of the sponge filtration function of intertidal zone and its possible ecological problems in nearshore waters . | Xu Hui Liu Hongwen Anzongfo Sheng Yu Line Du Yingxia | 2018 | Journal of Atmosphere and Oceanography Environment2018，6，1： | 0 |
| 16 | Research on Material and Morphological Structure of Venus Flytrap Trigger Hair显示文摘Venus flytrap can sense the very small insects that touch its tactile receptors,known as trigger hairs,and thus capture prey to maintain its nutrient demand.However,there are few studies on the trigger hair and its morphological structure and material properties are not fully understood.In this study,the trigger hair is systematically characterized with the help of diff erent instruments.Results show that trigger hair is a special cantilever beam structure and it has a large longitudinal diameter ratio.Besides,it is composed of a hair lever and a basal podium,and there is a notch near the hair base.The crosssection of the trigger hair is approximately a honeycomb structure,which is composed of many holes.Methods to measure mechanical properties of trigger hair are introduced in this paper.Based on the mechanical tests,trigger hair proved to be a variable stiff ness structure and shows a high sensitivity to the external force.These features can provide supports for the understanding of the high-sensitivity sensing mechanism of trigger hairs from the perspective of structure and material,and off er inspirations for the development of high-performance tactile sensors. | Qian Wang Kun Xu Cheng Fan Lining Sun Lei Zhang Kejun Wang | 2021 | Journal of Bionic Engineering2021，18，5： | 0 |
| 17 | Palladium nanoplates scotch breast cancer lung metastasis by constraining epithelial-mesenchymal transition显示文摘Metastasis accounts for the majority of cancer deaths in many tumor types including breast cancer.Epithelial-mesenchymal transition(EMT)is the driving force for the occurrence and progression of metastasis,however,no targeted strategies to block the EMT program are currently available to combat metastasis.Diverse engineered nanomaterials(ENMs)have been reported to exert promising anti-cancer effects,however,no ENMs have been designed to target EMT.Palladium(Pd)nanomaterials,a type of ENM,have received substantial attention in nanomedicine due to their favorable photothermal performance for cancer therapeutics.Herein,Pd nanoplates(PdPL)were found to be preferentially biodistributed to both primary tumors and metastatic tumors.Importantly,PdPL showed a significant inhibition of lung metastasis with and without near-infrared(NIR)irradiation.Mechanistic investigations revealed that EMT was significantly compromised in breast cancer cells upon the PdPL treatment,which was partially due to the inhibition of the transforming growth factor-beta(TGF-β)signaling.Strikingly,the PdPL was found to directly interact with TGF-βproteins to diminish TGF-βfunctions in activating its downstream signaling,as evidenced by the reduced phosphorylation of Smad2.Notably,TGF-β-independent pathways were also involved in undermining EMT and other important biological processes that are necessary for metastasis.Additionally,NIR irradiation elicited synergistic effects on PdPL-induced inhibition of primary tumors and metastasis.In summary,these results revealed that the PdPL remarkably curbed metastasis by inhibiting EMT signaling,thereby indicating the promising potential of PdPL as a therapeutic agent for treating breast cancer metastasis. | Shunhao Wang Jingchao Li Mei Chen Liting Ren Wenya Feng Lining Xu Xiaolan Chen Tian Xia Nanfeng Zheng Sijin Liu | 2021 | National Science Review2021，8，7： | 0 |
| 18 | Blockade of CD28 by a synthetical peptoid inhibits T-ce proliferation and attenuates graft-versus-host disease显示文摘 | Na Li Faliang Zhu Fei Gao Qun Wang Xiaoyan Wang Haiyan Li Chunhong Ma Wensheng Sun Wenfang Xu Chaodong Wang Lining Zhang | 2010 | Cellular & Molecular Immunology2010，7，2： | 0 |
| 19 | Anticorrosion performance of the coating/metal system by electrochemical impedance spectra显示文摘In order to investigate the anticorrosion performance of the organic coating/metal system, electrochemical impedance spectra (EIS) were measured in the 3.5wt% NaCl solution, the chemical component and the formation of corrosion products scale were analyzed by laser Raman microspectroscopy, and the pattern of the organic coating/metal system was observed by scanning electron microscopy (SEM). The characteristics and the delamination process of the organic coating/metal system were investigated systematically, and the emphases were on the transportation of the corrosive medium and the changes of the coating/metal interface. The results show that the impedance decreases at the initial immersion, then increases at the middle-immersion, and again decreases at last, which is related to the corrosion products scale. The concentration of Cl- in the coating, which destroys the corrosion products scale, increases with the immersion time. | Yinghuai Zhang Lining Xu Minxu Lu Pu Zhang | 2008 | Journal of University of Science and Technology Beijing2008，15，4： | 0 |
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