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| 1 | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection显示文摘AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.METHODS Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/G, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 G contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. | Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong Christian G Meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 2 | Delay and discontinuity-a survey of TB patients's search of a diagnosis in a diversified health care system显示文摘 | Thuong L M Linh P D | 1999 | Int J Tuberc Lung Dis1999，3，： | 1 |
| 3 | Quantitative determination of eLeutheroside B and E from Acanthopanax species by high performance Liquid chromatography 显示文摘 | Kang J S Linh P T Cai X F etal | 2001 | Arch Pharm Res2001，24，5： | 1 |
| 4 | Strategic human resource management as ethi-cal stewardship显示文摘 | CALDWELL C TRUONG D X LINH P T | 2011 | Journal of Business Ethics2011，98，1： | 1 |
| 5 | Radio-over-fiber architecture for seamless wireless indoor communication in the 60 GHz band 显示文摘 | LINH B D GARCIA L M VENKATESHA P R | 2007 | Computer Communication2007，30，： | 1 |
| 6 | Enantioselective preparation of metoprolol and its major metabolites 显示文摘 | JUNG S H LINH P T LIM H K | 2000 | Arch Pharm Res2000，23，3： | 1 |
| 7 | Quantitative determination of eleutheroside B and E from Acanthopanax species by high performance liquid chromatography显示文摘 | Kang J S Linh P T Cai X F | 2001 | Arch Pharm Res2001，24，5： | 1 |
| 8 | Magnetic Properties of Fe3O4 Nanoparticles Synthesized by Coprecipitation Method显示文摘 | Linh P Manh D Phong P | 2014 | Journal of Superconductivity & Novel Mag- netism2014，27，9： | 1 |
| 9 | Impacts of rising food prices on poverty and welfare in Vietnam显示文摘 | Linh V Glewwe P | 2011 | Journal of Agricul- tural and Resource Economics2011，，1： | 1 |
| 10 | Enantioselective preparation of metoprolol and its major metabolites显示文摘 | Jung S H Linh P T Lim H K | 2000 | Arch Pharm Res2000，23，3： | 1 |
| 11 | Direct catalytic asymmetric enolexo aldolizations 显示文摘 | Chandrakala P Linh H Benjamin L | 2003 | Angew Chem Int Ed2003，42，24： | 1 |
| 12 | Magnetic nanoparticles:Study of magnetic heating and adsorption/desorption for biomedicaland environmental applications 显示文摘 | Linh P H Manh D H Lam T D ei al | 2011 | International Journal ofNanotechnology2011，8，345： | 1 |
| 13 | Real-time eyetracking using a smart camera 显示文摘 | MEHRUBE M LINH M P HUNG TL | 2011 | Applied Imagery Pat-tern Recognition Workshop (AIPR)2011，，10： | 1 |
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