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| 1 | Protective effects of DIDS against ethanol-induced gastric mucosal injury in rats显示文摘复合 4,4-diisothiocyanostilbene-2,2-disulfonic 酸(DIDS ) 是能堵住阴离子 exchanger 的活动的一个有效阴离子 exchanger 禁止者 2 (AE2 ) ,它在胃的酸起一个不可缺少的作用分泌物。DIDS 们也有抗氧化的有势力和 anti-apoptosis 活动。这研究试图在老鼠在导致乙醇的 mucosal 损坏上调查 DIDS 的效果并且评估调停的内在的机制混合物的行动。老鼠收到了绝对乙醇的 1 ml 或盐口头上地。DIDS [50 mg/kg 静脉内(i.v )] 在乙醇管理前被给 5 min。胃的损害肉眼可见地被评估,在在乙醇以后的 60 min 的用显微镜,和电子用显微镜质问。胃的 myeloperoxidase (军邮局) 活动, malonyldialdehyde (MDA ) 水平,前列腺素 E2 (PGE2 ) 合成,和 cyclooxygenase-2 (COX-2 ) 表示被估计。为胃的酸分泌物上的 DIDS 的效果的评估, histamine-stimulatory 胃的酸分泌物被检验与或没有 DIDS 的预告的处理(50 mg/kg;i.v ) 。导致乙醇的胃的损害被增加胃的 MDA 水平,军邮局活动,和 COX-2 表示描绘,并且减少 PGE2 合成。DIDS 们显著地减少了胃的 mucosal 损坏的程度并且颠倒了织物 MDA 水平和军邮局活动,这被发现。DIDS 们进一步提高了 COX-2 的表示并且颠倒了 PGE2 的减少。我们的结果建议 DIDS 们在通过涉及禁止煽动性的房间渗入和类脂化合物 peroxidation 的机制的胃的损害的老鼠模型是有益的并且起来调整 COX-2/PGE2 小径。 | Wei Zhao Feng Zhu Weiwei Shen Aifen Fu Lin Zheng Zhaowen Yan Lingzi Zhao Guohui Fu | 2009 | Acta Biochimica et Biophysica Sinica2009，41，4： | 6 |
| 2 | Analysis of the binding sites with NL-101 to amino acids and peptides by HPLC/MS/MS显示文摘The binding between NL-101, a novel nitrogen mustard anti-cancer drug, with amino acids and peptides has been investigated by high performance liquid chromatography electrospray tandem mass spectrometry(HPLC/ESI-MS/MS). This study offers supporting data of the interaction among drug and amino acids and peptides, which could potentially explain the cytotoxic and mutagenic effects of the drug. Collision-induced dissociation(CID) experiment demonstrated that under the same collision energy, the amino group combined with NL-101 adducts are sensitive and often produce more fragment ions; the carboxyl group combined with NL-101 adducts are hard to break and display fewer fragment ions. In addition, when other group(like sulfhydryl group) of amino acids binds to NL-101, CID spectra show different fragmentation pattern. These differences could display structural information about the drug adducts and be utilized as location of the authentic binding sites. | Lingzi Dai Nian Guo Yaqin Liu Shanshan Shen Qiufu Ge Yuanjiang Pan | 2019 | Chinese Chemical Letters2019，30，1： | 4 |
| 3 | Graphene oxide as a photocatalytic nuclease mimicking nanozyme for DNA cleavage显示文摘Developing nanomaterial-based enzyme mimics for DNA cleavage is an interesting challenge and it has many potential applications.Single-layered graphene oxide(GO)is an excellent platform for DNA adsorption.In addition,GO has been employed for photosensitized generation of reactive oxygen species(ROS).Herein,we demonstrate that GO sheets could cleave DNA as anuclease mimicking nanozyme in the presence of UV or blue light.For various DNA sequences and lengths,well-defined product bands were observed along with photobleaching of the fluorophore label on the DNA.Different from previously reported GO cleavage of DNA,our method did not require metal ions such as Cu^2+.Fluorescence spectroscopy suggested a high adsorption affinity between GO and DNA.For comparison,although zero-dimensional fluorescent carbon dots(C-dots)had higher photosensitivity ir terms of producing ROS,their cleavage activity was much lower and only smeared cleavage products were observed,indicatingthat the ROS acted on the DNA in solution.Based on the results,GO behaved like a classic heterogeneous catalyst following substrate adsorption,reaction,and product desorption steps.This simple strategy may help in the design of new nanozymes by introducing light. | Jinyi Zhang Shihong Wu Lingzi Ma Peng Wu Juewen Liu | 2020 | Nano Research2020，13，2： | 4 |
| 4 | Inhibiting effect of melittin on pathogens of crops显示文摘The spectrum of antimicrobial effects of melittin were investigated on 19 pathogens by using a cylin-der-plate method with serial dilutions. Bacteriostatic efficiency and possible mechanistic effects were monitored via growth curves. The mechanism of inhibition was further analyzed by SDS-PAGE, flow cytometry and electron microscopy. Melittin had a wide inhibition spectrum and killed pathogens ef-fectively, and bacteriostatic action was influenced by factors such as pH and temperature. We eluci-dated three inhibitory mechanisms: melittin integrated with the cell membrane causing cell bursting and cytoplasm release, inhibited the synthesis of proteins and caused the cytoplasm to condense, and delayed pathogens in phase I (or phase G1) so that they could not complete the cell cycle. These re-sults suggest that melittin could serve as a broad-spectrum biological pesticide with fast-action and high-efficiency. | PAN LingZi NA Jie XING Zhuo FANG HongJun WANG GuanLin | 2007 | Chinese Science Bulletin2007，52，5： | 3 |
| 5 | Study on implicit composite element method for seepage analysis in underground engineering显示文摘Based on the basic principle of the finite element method, the implicit composite element method for numerical simulation of seepage in underground engineering is proposed. In the simulation, the faults and drainage holes are set implicitly in the model elements without adding additional elements. Elements containing fault or drainage-hole data are termed composite elements. Then, their information data in model could be obtained. By determining the osmotic transmission matrix of the composite elements, the permeability coefficient matrix is then obtained. The method was applied to the numerical simulation of the seepage field around the underground powerhouse of the Ganhe Pumping Station in Yunnan, China, using a compiled three-dimensional finite element method calculation program. The rock mass around the site includes two faults. The seepage field in the rock mass was analyzed at different stages of the engineering project. The results show that, before the excavation of the underground caverns, the rock mass seepage is affected by the faults and the groundwater permeated down along the tangential fault plane. After the excavation of the caverns during the operation period, the groundwater is basically drained away and the underground caverns are mostly above the groundwater level. Thus, the calculation results of the engineering example verify the implicit composite method for the simulation of faults and drainage holes. This method can well meet the calculation demands of practical engineering. | LI LingZi XIAO Ming | 2015 | Science China(Technological Sciences)2015，58，10： | 3 |
| 6 | Influence of TiCl_4 treatment on performance of dye-sensitized solar cell assembled with nano-TiO_2 coating deposited by vacuum cold spraying显示文摘Titanium tetrachloride (TiCl4) treatment was employed to TiO2 coating deposited on fluoride-doped tin oxide (FTO) conducting glass and indium oxide doped tin oxide (ITO) conducting glass, respectively. The nano-crystalline TiO2 coating was deposited using a composite powder composed of polyethylene glycol (PEG) and 25 nm TiO2 particles by vacuum cold spraying (VCS) process. A commercial N-719 dye was used to adsorb on the surface of TiO2 coating to prepare TiO2 electrode, which was applied to assemble dye-sensitized solar cell (DSC). The cell performance was measured under simulated solar light at an intensity of 100 mW·cm-2. Results show that with an FTO substrate the DSC composed of a VCS TiO2 electrode untreated by TiCl4 gives a short-circuit current density of 13.1 mA·cm-2 and an open circuit voltage of 0.60 V corresponding to an overall conversion efficiency of 4.4%. It is found that after TiCl4 treatment to the VCS TiO2 electrode with an FTO substrate, the short circuit current density of the cell increases by 31%, the open-circuit voltage increases by 60 mV and a higher conversion yield of 6.5% was obtained. However, when an ITO substrate is used to deposit TiO2 coating by VCS, after TiCl4 treatment, the conversion efficiency of the assembled cell reduces slightly due to corrosion of the conducting layer on the ITO glass by TiCl4. | FAN Shengqiang LI Changjiu YANG Guanjun ZHANG Lingzi | 2006 | Rare Metals2006，25，z1： | 3 |
| 7 | Coculture of Escherichia coli O157:H7 with a Nonpathogenic E. coli Strain Increases Toxin Production and Virulence in a Germfree Mouse Model显示文摘 | Goswami Kakolie Chen Chun Xiaoli Lingzi Eaton Kathryn A. Dudley Edward G | 2015 | Infection and Immunity2015，，11： | 1 |
| 8 | Ultrastructural observation on sterilization of melittin显示文摘The effects of melittin on growth and bacteriostasis of four pathogens were extensively investigated using scanning electron microscopy(SEM) and transmission electron microscopy(TEM).The results indicated that the melittin had a marked bacteriostatic effect on the four pathogenic bacteria.Among these,E.cacotowora was influenced most powerfully and quickly,the yeast and F.fulva were the second,and the S.aureus was inhibited by a low concentration but was killed by a high concentration.It was observed in the experiments that melittin killed pathogenic bacteria in three ways.One was by pore formation.After integrating melittin into the plasma membrane,a vacuole was formed then penetrated,resulting in bacterial content leakage.The vacuole also experienced plasmolysis and the growing cavity destroyed the membrane.A third effect was the formation of vacuoles in the cells which induced the pycnosis of the cytoplasm resulting in a cell death.The mechanism of melittin bacteriostasis was the result of integrating melittin with phospholipod double layers of the plasmalemma and the endomembranes. | WANG GuanLin NA Jie PAN LingZi XING Zhuo FANG HongJun | 2011 | Science China(Life Sciences)2011，54，2： | 1 |
| 9 | New strategy for the evaluation of CdTe quantum dot toxicity targeted to bovine serum albumin 显示文摘 | Lingzi Zhao Rutao Liu Xingehen Zhao | 2009 | Sci Total Environ2009，407，： | 1 |
| 10 | Evidence base of randomized controlled trials and guideline recommendations of patent Traditional Chinese Medicines for uncomplicated acute lower respiratory tract infections in adults显示文摘OBJECTIVE:To compare clinical practice guideline recommendations on the use of oral patent Traditional Chinese Medicines(PTCMs) for uncomplicated acute lower respiratory tract infections(ALRTIs)in adults with the existing evidence using results of a systematic review of randomized controlled trials(RCTs).METHODS:A systematic review on RCTs and a systematic review of current guidelines on orally taken PTCMs for uncomplicated ALRTIs were performed.Pub Med,Cochrane Library,EMBASE and four Chinese databases were searched from inception to September 2016 for RCTs testing orally taken PTCMs for uncomplicated ALRTIs(excluding pneumonia).Two reviewers independently screened each study,extracted study data,and assessed risk of bias.Disagreements were resolved through discussion or by consultation with a third reviewer.Clinical practice guidelines for uncomplicated ALRTIs containing PTCM recommendations were identified and quality appraised.The quality of pooled evidence of the RCTs and the guidelines was assessed with GRADE and AGREE Ⅱ respectively.The consistency of the evidence base in RCTs and the guideline recommendations were then compared.RESULTS:For the systematic review of RCTs,4810 papers were identified,among which 29 RCTs(5093 patients) were included in the review.PTCMs compared to placebo increased the effective treatment rate of cough(3 trials,949 patients,risk ratio(RR) 2.50,1.16 to 5.43;low certainty);improved assessment of global health(3 trials,948 patients,RR1.70,1.44 to 2.01;low certainty);and increased the effective rate of specific symptom relief(1 trial,478 patients,RR 4.01,2.76 to 5.81;moderate certainty).21 trials(3432 patients) compared effects of different PTCMs.For the guideline evaluation,29 PTCMs were recommended for the use of uncomplicated ALRTIs,of which27 had no supportive evidence from RCTs.CONCLUSION:The evidence base of PTCMs for uncomplicated ALRTIs is weak and the guideline recommendations were based on almost no clinical trial evidence.Rigorous clinical research is urgently needed to inform the clinical use of these herbal medicines.Further training in evidence-based medicine methods for Traditional Chinese Medicine guideline developers is essential. | Xia Ruyu Hu Xiaoyang Wang Di Wang Ying Merlin Willcox Liu Jianping Michael Moore Andrew Flower Li Xun Lily Lai Hu Ruixue Wen Lingzi Zhang Lishan Wang Qi Fei Yutong | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 1 |
| 11 | Combined forest and soil management after a catastrophic event显示文摘At the end of October 2018,a storm of unprecedented strength severely damaged the forests of the eastern sector of the Italian Alps.The affected forest area covers 42,500 ha.The president of one of the damaged regions asked for help from the University of Padua.After eight months of discussion,the authors of this article wrote a consensus text.The sometimes asper debate brought to light some crucial aspects:1)even experienced specialists may have various opinions based on scientific knowledge that lead to conflicting proposals for action.For some of them there is evidence that to restore a destroyed natural environment it is more judicious to do nothing;2)the soil corresponds to a living structure and every ecosystem’s management should be based on it;3)faced with a catastrophe,people and politicians find themselves unarmed,also because they rarely have the scientific background to understand natural processes.Yet politicians are the only persons who make the key decisions that drive the economy in play and therefore determine the near future of our planet.This article is an attempt to respond directly to the governor of a region who formally and prudently asked a university department called'Land,Environment,Agriculture and Forestry'for help before taking decisions;4)the authors also propose an artistic interpretation of facts(uncontrolled storm)and conclusions(listen to the soil).Briefly,the authors identify the soil as an indispensable source for the renewal of the destroyed forest,give indications on how to prepare a map of the soils of the damaged region,and suggest to anchor on this soil map a series of silvicultural and soil management actions that will promote the soil conservation and the faster recovery of the natural dynamic stability and resilience. | Augusto ZANELLA Jean-Francois PONGE Anna ANDREETTA Michael AUBERT Nicolas BERNIER Eleonora BONIFACIO Karine BONNEVAL Cristian BOLZONELLA Oleg CHERTOV Edoardo A.C.COSTANTINI Maria DE NOBILI Silvia FUSARO Raffaello GIANNINI Pascal JUNOD Klaus KATZENSTEINER Jolantha KWIATKOWSK-MALINA Roberto MENARDI Lingzi MO Safwan MOHAMMAD Annik SCHNITZLER Adriano SOFO Dylan TATTI Herbert HAGER | 2020 | Journal of Mountain Science2020，17，10： | 0 |
| 12 | Classification of aviation incident causes using LGBM with improved cross-validation显示文摘Aviation accidents are currently one of the leading causes of significant injuries and deaths worldwide. This entices researchers to investigate aircraft safety using data analysis approaches based on an advanced machine learning algorithm.To assess aviation safety and identify the causes of incidents, a classification model with light gradient boosting machine (LGBM)based on the aviation safety reporting system (ASRS) has been developed. It is improved by k-fold cross-validation with hybrid sampling model (HSCV), which may boost classification performance and maintain data balance. The results show that employing the LGBM-HSCV model can significantly improve accuracy while alleviating data imbalance. Vertical comparison with other cross-validation (CV) methods and lateral comparison with different fold times comprise the comparative approach. Aside from the comparison, two further CV approaches based on the improved method in this study are discussed:one with a different sampling and folding order, and the other with more CV. According to the assessment indices with different methods, the LGBMHSCV model proposed here is effective at detecting incident causes. The improved model for imbalanced data categorization proposed may serve as a point of reference for similar data processing, and the model’s accurate identification of civil aviation incident causes can assist to improve civil aviation safety. | NI Xiaomei WANG Huawei CHEN Lingzi LIN Ruiguan | 2024 | Journal of Systems Engineering and Electronics2024，35，2： | 0 |
| 13 | HAND2-AS1,PRKAA2 and VLDLR predict the risk of peritoneal metastasis in gastric cancer of different Lauren types based on STEPP analysis显示文摘The peritoneum is the most common site of recurrence of gastric cancer(GC).Early occult peritoneal metastasis is difficult to detect by imaging examination.Stratifying the risk of peritoneal metastasis in patients with different Lauren subtypes is of great clinical value.We performed a univariate Cox regression to identify those genes with prognostic value of overall survival(OS)and peritoneal-specified disease-free survival(psDFS)from the Gene Expression Omnibus database.The candidate genes were screened by the Subpopulation Treatment Effect Pattern Plot(STEPP)method.Propensity score matching(PSM)analysis was used to reduce the interference of confounders on the results.Based on the optimal cut-off values determined by the STEPP method,we found overexpression of three genes(HAND2-AS1,PRKAA2,and VLDLR)was correlated with shorter 1-year psDFS among patients with diffuse-type than that of patients with intestinal-type GC,and it is highly significant.Gene Set Enrichment Analysis(GSEA)potentially suggested that the three genes promote the early occurrence of peritoneal metastasis in patients with diffuse-type GC through glucose metabolism-related pathways.These three genes may be potential biomarkers.They can be used to assess the risk of peritoneal metastases to guide treatment decisions and follow-up strategies. | HUI QU RUICHUAN SHI BOWEN YANG XI CHEN YUJIA SONG LINGZI HE YITING SUN YUJING YANG ZHI LI XIUJUAN QU | 2022 | BIOCELL2022，46，3： | 0 |
| 14 | Carbon enhanced nucleophilicity of Na_(3)V_(2)(PO_(4))_(3):A general approach for dendrite-free zinc metal anodes显示文摘Zincophilic property and high electrical conductivity are both very important parameters to design novel Zn anode for aqueous Zn-ion batteries(AZIBs).However,single material is difficult to exhibit zincophilic property and high electrical conductivity at the same time.Herein,originating from theoretical calculation,a zincophilic particle regulation strategy is proposed to address these limitations and carbon coated Na_(3)V_(2)(PO_(4))_(3)is taken as an example to be a protective layer on zinc metal(NVPC@Zn).Na_(3)V_(2)(PO_(4))_(3)(NVP)is a common cathode material for Zn-ion batteries,which is zincophilic.Carbon materials not only offer an electron pathway to help Zn deposition onto NVPC surface,but also enhance the zinc nucleophilicity of Na_(3)V_(2)(PO_(4))_(3).Hence,this hybrid coating layer can tune zinc deposition and resist side reactions such as hydrogen generation and Zn metal corrosion.Experimentally,a symmetrical battery with NVPC@Zn electrode displays highly reversible plating/stripping behavior with a long cycle lifespan over 1800 h at2 mA cm^(-2),much better than carbon and Na_(3)V_(2)(PO_(4))_(3)solely modified Zn electrodes.When the Na_(3)V_(2)(PO_(4))_(3)is replaced with zincophobic Al2O3or zincophilic V2O3,the stability of the modified zinc anodes is also prolonged.This strategy expands the option of zincophilic materials and provides a general and effective way to stabilize the Zn electrode. | Sijun Wang Lingzi Hu Xiaohui Li Dan Qiu Shunhang Qiu Qiancheng Zhou Wenwen Deng Xiaoying Lu Ze Yang Ming Qiu Ying Yu | 2024 | Journal of Energy Chemistry2024，91，4： | 0 |
| 15 | Speech enhancement method combining amplitude spectrum and power spectrum dictionaries显示文摘An improved speech enhancement method based on sparse representation of spec-tral features is proposed from the perspective of dual dictionary learning,noise power spectrum estimation and speech amplitude spectrun reconstruction.In the dictionary learning stage,the power spectrun and amplitude spectrum features are combined,and the discriminative dictionary learning method is used to reduce the coherence of the spech dictionary and the noise dictionary.In the speech enhancement stage,a noise power spectrum estimation method is proposed to track and estimate the nonstationary noise.Considering the inconsistency be-tween the amplitude spectrum and the power spectrum characteristics for different noises,the corresponding reconstruction weight cofficient is designed.The two-channel signals recovered from the amplitude spectrum and the power spectrum are adaptively weighted,and the en-hanced speech signal is obtained by combining the phase compensation function.As shown in experimental results,compared with the single spectral feature speech enhancement method,the proposed method improves the performance of speech enhancement method by 31.6%on average under stationary and nonstationary noise environments. | NIE Lingzi CHEN Xueqin ZHAO Heming | 2021 | Chinese Journal of Acoustics2021，40，4： | 0 |
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