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| 1 | Resveratrol Induces Apoptosis and Autophagy in T-cell Acute Lymphoblastic Leukemia Cells by Inhibiting Akt/mTOR and Activating p38-MAPK显示文摘Objective To explore the effects of resveratrol-induced apoptosis and autophagy in T-cell acute lymphoblastic leukemia(T-ALL) cells and potential molecular mechanisms. Methods The anti-proliferation effect of resveratrol-induced, apoptosis and autophagy on T-ALL cells were detected by using MTT test, immunofluorescence, electronic microscope, and flow cytometry, respectively. Western blotting was performed for detecting changes of apoptosis-associated proteins, cell cycle regulatory proteins and state of activation of Akt, mTOR, p70S6K, 4E-BP1, and p38-MAPK. Results Resveratrol inhibited the proliferation and induced apoptosis and autophagy in T-ALL cells in a dose and time-dependent manner. It also induced cell cycle arrest at G0/G1 phase via up regulating cyclin-dependent kinase(CDK) inhibitors p21 and p27 and down regulating cyclin A and cyclin D1. Western blotting revealed that resveratrol significantly decreased the expression of antiapoptotic proteins(Mcl-1 and Bcl-2) and increased the expression of proapoptotic proteins(Bax, Bim, and Bad), and induced cleaved-caspase-3 in a time-dependent manner. Significant increase in ratio of LC3-II/LC3-I and Beclin 1 was also detected. Furthermore, resveratrol induced significant dephosphorylation of Akt, mTOR, p70S6K, and 4E-BP1, but enhanced specific phosphorylation of p38-MAPK which could be blocked by SB203580. When autophagy was suppressed by 3-MA, apoptosis in T-ALL cells induced by resveratrol was enhanced.Conclusion Our findings have suggested that resveratrol induces cell cycle arrest,apoptosis,and autophagy in T-ALL cells through inhibiting Akt/mTOR/p70S6K/4E-BP1 and activating p38-MAPK signaling pathways.Autophagy might play a role as a self-defense mechanism in T-ALL cells treated by resveratrol.Therefore,the reasonable inhibition of autophagy in T-ALL cells may serve as a promising strategy for resveratrol induced apoptosis and can be used as adjuvant chemotherapy for T-ALL. | GE Jiao LIU Yan LI Qiang GUO Xia GU Ling MA Zhi Gui ZHU Yi Ping | 2013 | Biomedical and Environmental Sciences2013，26，11： | 38 |
| 2 | Dynamic Prediction Method of Production Logistics Bottleneck Based on Bottleneck Index显示文摘In modern manufacturing pattern,there are many uncertain factors in the modern manufacturing process,such as changes of product attribute,changes of manufacturing resources' state,and so on,which cause production logistics bottleneck frequently shift,and make decisions of production planning and control based on formed bottleneck deviated from practical production process.Considering these factors,present researches mainly apply afterwards control to optimize production process to passively adapt to bottleneck changes.If the direction of bottleneck shifting can be accurately forecasted,the transition from afterwards control of chasing bottleneck to beforehand control can be realized.Therefore,aiming at the phenomenon of production logistics bottleneck shifting under uncertain manufacturing circumstances,this paper starts off with dynamic property of capability and requirement and then builds the concepts of bottleneck degree and bottleneck index to describe dynamic bottleneck characteristic of production unit;taken production capability,production load and quality assurance capability into consideration,mathematical model of bottleneck index is established to measure bottleneck degree accurately,consequently,quantitative research on mechanism of production logistics shifting is achieved.Based on bottleneck index,the prediction model of production logistics bottleneck is founded to predict dynamic change of bottleneck accurately.Finally,an example of forecasting and monitoring the production logistics bottleneck in one manufacturing shop is given to testify the validation and practicability of the prediction method. | LIU Mingzhou TANG Juan GE Maogen JIANG Zengqiang HU Jing LING Lin | 2009 | Chinese Journal of Mechanical Engineering2009，22，5： | 22 |
| 3 | Effects of long-term,low-dose sex hormone replacement therapy on hippocampus and cognition of postmenopausal women of different apoE genotypes显示文摘瞄准:学习效果长期,体积和在带 apolipoprotein E ( apoE )的绝经后的女人的马头鱼尾的怪兽的生物化学的变化上的低剂量的性荷尔蒙代替治疗( HRT )基因 epsilon 3 或 epsilon 4 .Methods :使用 HRT 的低剂量超过 4 年了的 83 个绝经后的女人作为 HRT 组被选择,并且当控制 group.ApoE 等位基因被 PCR.Magnetic 回声成像分析,有匹配的年龄和教育的 99postmenopausal 女人被注册被执行决定 brainhippocampus.Proton 的卷磁性的回声光谱学被用来在 apoE epsilon 在前面的 cingulate 外皮和马头鱼尾的怪兽检测生物化学的变化 4 并且 epsilon 3 个搬运人。六普通认知测试被用来做认知 function.Results 的全面评估: 有 4 个搬运人显示出的 apoE epsilon 的分析控制组的马头鱼尾的怪兽的卷是比 HRT 组的那些显著地低的。生物化学的分析证明有 N-acetylaspartate (NAA )/total 肌酸(tCr ) 和 myoinositol (mI ) 的减少的增加在在 HRT 的 4 个搬运人组织的 apoE epsilon 的马头鱼尾的怪兽的 /tCr,与控制组相比。为 apoEepsilon 3 个搬运人, HRT 组的最少的广场工具(LSMEAN ) 比控制 group.Conclusion 的高: 这研究证明长期的、低剂量 HRT 可能为在脆弱的绝经后的女人减少广告开发的风险是有益的。同时, HRT 能增加 apoE epsilon 的 LSMEAN 3 个搬运人。 | Yun YUE Ling HU Qin-jie TIAN Jing-mei JIANG Yi-long DONG Zheng-yu JIN yu-hang CHENG Xia HONG Qin-sheng GE Ping-ping ZUO | 2007 | Acta Pharmacologica Sinica2007，28，8： | 15 |
| 4 | Comparison of combined phacotrabeculectomy with trabeculectomy only in the treatment of primary angle-closure glaucoma显示文摘 | WANG Mei FANG Min BAI Yu-jing ZHANG Wei-zhong LIN Ming-kai LIU Bing-qian HAO Yuan-tao LING Yun-lan ZHUO Ye-hong GE Jian | 2012 | Chinese Medical Journal2012，，8： | 15 |
| 5 | The Predictive Value of Baseline HBs Ag Level and Early Response for HBs Ag Loss in Patients with HBe Ag-positive Chronic Hepatitis B during Pegylated Interferon Alpha-2a Treatment显示文摘Objective To explore the predictive value of baseline HBsAg level and early response for HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. Methods A total of 121 patients with HBeAg-positive chronic hepatitis B who achieved HBsAg loss were enrolled; all patients were treated with PEG-IFNα-2a 180 μg/week. Serum HBV DNA and serological indicators(HBsAg, anti-HBs, HBeAg, and anti-HBe) were determined before and every 3 months during treatment. Results The median treatment time for HBsAg loss was 84 weeks(7-273 weeks), and 74.38%(90 cases) of the patients needed extended treatment(> 48 weeks). The correlation between baseline HBsAg levels and the treatment time of HBsAg loss was significant(B = 14.465, t = 2.342, P = 0.021). Baseline HBsAg levels together with the decline range of HBsAg at 24 weeks significantly correlated with the treatment time of HBsAg loss(B = 29.862, t = 4.890, P = 0.000 and B = 27.993, t = 27.993, P = 0.005). Conclusion Baseline HBsAg levels and extended therapy are critical steps toward HBsAg loss. Baseline HBsAg levels together with early response determined the treatment time of HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. | LI Ming Hui ZHANG Lu QU Xiao Jing LU Yao SHEN Ge LI Zhen Zhen WU Shu Ling LIU Ru Yu CHANG Min HU Lei Ping HUA Wen Hao SONG Shu Jing WAN Gang XIE Yao | 2017 | Biomedical and Environmental Sciences2017，30，3： | 14 |
| 6 | Human carboxylesterases:a comprehensive review显示文摘Mammalian carboxylesterases(CEs) are key enzymes from the serine hydrolase superfamily.In the human body, two predominant carboxylesterases(CES1 and CES2) have been identified and extensively studied over the past decade. These two enzymes play crucial roles in the metabolism of a wide variety of endogenous esters, ester-containing drugs and environmental toxicants. The key roles of CES in both human health and xenobiotic metabolism arouse great interest in the discovery of potent CES modulators to regulate endobiotic metabolism or to improve the efficacy of ester drugs. This review covers the structural and catalytic features of CES, tissue distributions, biological functions, genetic polymorphisms, substrate specificities and inhibitor properties of CES1 and CES2, as well as the significance and recent progress on the discovery of CES modulators. The information presented here will help pharmacologists explore the relevance of CES to human diseases or to assign the contribution of certain CES in xenobiotic metabolism. It will also facilitate medicinal chemistry efforts to design prodrugs activated by a given CES isoform, or to develop potent and selective modulators of CES for potential biomedical applications. | Dandan Wang Liwei Zou Qiang Jin Jie Hou Guangbo Ge Ling Yang | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 14 |
| 7 | Recent progress and challenges in screening and characterization of UGT1A1 inhibitors显示文摘Uridine-diphosphate glucuronosyltransferase 1 A1(UGT1 A1) is an important conjugative enzyme in mammals that is responsible for the conjugation and detoxification of both endogenous and xenobiotic compounds. Strong inhibition of UGT1 A1 may trigger adverse drug/herb–drug interactions, or result in metabolic disorders of endobiotic metabolism. Therefore, both the US Food and Drug Administration(FDA)and the European Medicines Agency(EMA) have recommended assaying the inhibitory potential of drugs under development on the human UGT1 A1 prior to approval. This review focuses on the significance,progress and challenges in discovery and characterization of UGT1 A1 inhibitors. Recent advances in the development of UGT1 A1 probes and their application for screening UGT1 A1 inhibitors are summarized and discussed in this review for the first time. Furthermore, a long list of UGT1 A1 inhibitors, including information on their inhibition potency, inhibition mode, and affinity, has been prepared and analyzed. Challenges and future directions in this field are highlighted in the final section. The information and knowledge that are presented in this review provide guidance for rational use of drugs/herbs in order to avoid the occurrence of adverse effects via UGT1 A1 inhibition, as well as presenting methods for rapid screening and characterization of UGT1 A1 inhibitors and for facilitating investigations on UGT1 A1–ligand interactions. | Xia Lv Yangliu Xia Moshe Finel Jingjing Wu Guangbo Ge Ling Yang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 14 |
| 8 | MyD88-independent activation of a novel actin-Cdc42/Rac pathway is required for Toll-like receptor-stimulated phagocytosis显示文摘吞噬作用和由巨噬细胞的病原体的随后的降级在主人起一个枢轴的作用对微生物引起的感染的天生的有免疫力的回答。最近的研究证明了像使用费的受体(TLR ) 在支持细菌的清理由起一个重要作用起来调整巨噬细胞的吞噬细胞的活动。然而,关于调停 TLR 的吞噬作用的发信号的机制的信息仍然是有限的。这里,我们提供有 LPS 的 TLR4 的刺激在鼠科的像巨噬细胞的房间线 RAW264.7 包括地图 kinases, phosphatidylinositide 3-kinase (PI3K ) ,和小 GTPases 导致多重发信号的小径的激活的证据。Cdc42/Rac 或 p38 地图 kinase 的特定的抑制,然而并非 PI3K,细菌的减少的导致 TLR4 的吞噬作用。而且,我们由 cytochalasin D 发现了那肌动朊聚合的任何一个抑制或由显著地减少的 RNAi 的肌动朊击倒由 LPS 的 Cdc42 和 Rac 的激活。Cdc42 和 Rac 的导致 TLR4 的激活看起来独立于 MyD88。一起拿,我们的结果描述了 TLR 能明确地通过挑起吞噬作用的一条新奇 actin-Cdc42/Rac 小径。 | Ling Kong Bao-Xue Ge | 2008 | Cell Research2008，18，7： | 13 |
| 9 | Soil Nutrient Status and Leaf Nutrient Diagnosis in the Main Apple Producing Regions in China显示文摘Soil and leaf nutrient analysis are widely used as effective methods of diagnosing nutrient deficiency in fruit trees,the results of which are used to properly manage fertilizer application.Therefore,a survey was conducted for assessment of the soil nutrient status and leaf nutrient concentration in 2 827 apple orchards in the Bohai Bay and Loess Plateau apple production regions of China.The soil organic matter,alkali hydrolyzable N,available P,and available K were 10.91 g·kg^(-1),73.21 mg·kg^(-1),70.22 mg·kg^(-1),and 169.23 mg·kg^(-1)in the Bohai Bay region,respectively,and 11.72 g·kg^(-1),56.46 mg·kg^(-1),14.91 mg·kg^(-1),and 135.78 mg·kg^(-1)in the Loess Plateau region,respectively.Soil organic matter was at a medium-to-low level in both regions,whereas the soil alkali hydrolyzable N was low.In the Bohai Bay region,soil available P was high,but soil available K was deficient.In contrast,both soil available P and K were insufficient in the Loess Plateau region.The Diagnosis and Recommendation Integrated System(DRIS)diagnostic results indicated that the most deficient elements were Ca and K in low-yielding orchards(<35 t·hm(-2))of the Bohai Bay region followed by Fe,N,and Zn;however in the Loess Plateau region,the most deficient elements were P and K followed by N,Zn,and Cu.The findings imply that the application of Ca,K,Fe,N,and Zn fertilizer should be increased in the Bohai Bay region,whereas P,K,N,Zn,and Cu fertilizer should be enhanced in the Loess Plateau region.Meanwhile,use of organic manure is recommended to improve soil quality in the two apple producing regions. | GE Shunfeng ZHU Zhanling PENG Ling CHEN Qian JIANG Yuanmao | 2018 | Horticultural Plant Journal2018，4，3： | 12 |
| 10 | Clinical practice guidelines for breast cancer implantable intravenous infusion ports:Chinese Society of Breast Surgery practice guidelines 2021显示文摘To standardize the clinical application of implantable intravenous(IV)ports,the Chinese Society of Breast Surgery(CSBrS)of the Chinese Medical Association has identified the key clinical issues through literature research and expert discussion and evaluated the relevant evidence with reference to the grading of recommendations assessment,development,and evaluation.The CSBrS formulated the clinical practice guidelines to provide a reference for physicians specializing in breast cancer and other fields. | Li Ma Zhi-Cheng Ge Ling Xin Ying-Xin Wang Yan-Shou Zhang Tian-Tian Tang Guo-Xuan Gao Qian Liu Xuan Zhao Yun-Jiang Liu Xiang Qu 无 | 2021 | Chinese Medical Journal2021，，16： | 11 |
| 11 | Inhibition of autophagy induced by proteasome inhibition increases cell death in human SHG-44 glioma cells显示文摘 | Peng-fei GE Ji-zhou ZHANG Xiao-fei WANG Fan-kai MENG Wen-chen LI Yong-xin LUAN Feng LING Yi-nan LUO | 2009 | Acta Pharmacologica Sinica2009，30，7： | 11 |
| 12 | Differentiation of embryonic stem cells into corneal epithelium显示文摘Our project was to determine whether embryonic stem (ES) cells could be induced to differentiate into corneal epithelia by superficial corneoscleral limbal stroma. To achieve this goal, ES-GFP cell line D3 was pre-induced by retinoic acid (RA). The pre-induced cells were seeded on deepithelialized superficial corneoscleral slices (SCSS) to form a monolayer, and di-vided into three groups. Group 1 was cultured and passaged in vitro for direct detection. Group 2 was exposed to air-liquid interfaces for 10 days and implanted into the subcutaneous layer of nude mice for 2 weeks for further induction in vivo. Group 3 was cultured in vitro without any in-ducing factors for control. There were no teratomas found in nude mice which were implanted with differentiated ES cells after two weeks. The differentiated cells showed an appearance of epithelia both in vitro and in vivo. Expression of CK3, P63 and PCNA was detected by immuno-histochemical staining in the differentiated cells in group 1 and 2. Microvillis and zonula oc-cludens were observed on the surface of the differentiated cells under an electron microscope. In the control group, ES cells differentiated freely without any inducing factors. Most cells were shed and formed a neuronal dendrite-like structure, and a minority of cells appeared polymorphic. These results demonstrate that ES cells can differentiate into corneal epithelia on the surface of SCSS under the controlled condition. Differentiated ES cells could be used as epithelial seeding cells for the reconstruction of ocular surface and corneal tissue engineering in the future. | WANG Zhichong GE Jian HUANG Bing GAO Qianying LIU Bingqian WANG Linghua YU Ling FAN Zhigang LU Xiaoming LIU Jingbo | 2005 | Science China(Life Sciences)2005，48，5： | 10 |
| 13 | Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility显示文摘瞄准:在 ubiquitin 特定的朊酶学习单个核苷酸多型性的发生 26 (USP26 ) 在在中国的自发的男不孕的基因和它的参与。方法:平淡的精液分析被执行。不孕因素象免疫学的那样,传染、生物化学的混乱被检验与自发的不孕选择病人。DNA 从选择病人和控制人口的外部血被孤立,它用聚合酶链反应单人赛海滨符合构造多型性分析为变化被检验。而且,核苷酸序列在一些病人和控制被定序。结果:41 个不肥沃的人, 9 (22.0% , P = 0.01 ) 在 X 染色体上的 USP26 基因的有的变化。一个复合变化(364insACA;460G → A ) 在 8 个病人被检测(19.5% , P = 0.01 ) 并且 1044T → A 替换在 1 个病人被发现(2.4% , P >
0.05 ) 。所有三个变化在编码氨基酸导致了变化。二替换预言一些变化:460G → A 把缬氨酸变成异白氨酸,并且 1044T → A 用白氨酸代替本氨基丙酸。三核苷酸 ACA 的另一插入引起 threonine 的插入。没有另外的变化在留下的病人和肥沃的控制被发现。结论:USP26 基因可能具有在男复制的重要性。在这基因的变化可能与男不孕被联系,并且可能否定地影响阴囊的功能。关于这个问题的进一步的研究在进行中。 | Jie Zhang Shu-Dong Qiu Sheng-Bin Li Dang-Xia Zhou Hong Tian Yong-Wei Huo Ling Ge Qiu-Yang Zhang | 2007 | Asian Journal of Andrology2007，9，6： | 10 |
| 14 | Comprehensive profiling and characterization of the absorbed components and metabolites in mice serum and tissues following oral administration of Qing-Fei-Pai-Du decoction by UHPLC-Q-Exactive-Orbitrap HRMS显示文摘Qing-Fei-Pai-Du decoction(QFPDD)is a Chinese medicine compound formula recommended for combating corona virus disease 2019(COVID-19)by National Health Commission of the People's Republic of China.The latest clinical study showed that early treatment with QFPDD was associated with favorable outcomes for patient recovery,viral shedding,hospital stay,and course of the disease.However,the effective constituents of QFPDD remain unclear.In this study,an UHPLC-Q-Orbitrap HRMS based method was developed to identify the chemical constituents in QFPDD and the absorbed prototypes as well as the metabolites in mice serum and tissues following oral administration of QFPDD.A total of 405 chemicals,including 40 kinds of alkaloids,162 kinds of flavonoids,44 kinds of organic acids,71 kinds of triterpene saponins and 88 kinds of other compounds in the water extract of QFPDD were tentatively identified via comparison with the retention times and MS/MS spectra of the standards or refereed by literature.With the help of the standards and in vitro metabolites,195 chemical components(including 104 prototypes and 91 metabolites)were identified in mice serum after oral administration of QFPDD.In addition,165,177,112,120,44,53 constituents were identified in the lung,liver,heart,kidney,brain,and spleen of QFPDD-treated mice,respectively.These findings provided key information and guidance for further investigation on the pharmacologically active substances and clinical applications of QFPDD. | LIU Wei HUANG Jian ZHANG Feng ZHANG Cong-Cong LI Rong-Sheng WANG Yong-Li WANG Chao-Ran LIANG Xin-Miao ZHANG Wei-Dong YANG Ling LIU Ping GE Guang-Bo | 2021 | Chinese Journal of Natural Medicines2021，19，4： | 10 |
| 15 | Design and application of a small electrode experimental installation for resistivity measurement of mineral and solid insulating material显示文摘There has not been an effective method to measure the resistivity of small-size sample of mineral and solid insulating material until now.According to the Chinese National Standard(GB/T1410-2006) and features of digital high resistance meter,a small electrode experimental installation was developed;it can work with current high resistance meter;the sample decreases to 18 mm from standard size 100 mm in diameter and reduces by 30.86 times in area.A three-electrode system is supported and precisely positioned by two insulating bases whose diameter is 60 mm and height is 20 mm,which ensures accuracy of device structure and reliability of measuring results.The key technological parameters are as follows:diameter of high voltage electrode is 18mm;diameter of measuring electrode is 14.6 mm;internal diameter and external diameter of guard electrode are 16 and 18 mm,respectively;the gap between guard electrode and measuring electrode is set at 0.6 mm.These parameters are adequate for the measurement of flat specimen of mineral and solid insulating material whose diameter is 18 mm.According to the confirmatory experiment on the volume resistivity and surface resistivity,the measuring results are almost the same,using a small electrode experimental installation and a standard electrode. | WANG Ling LUO Ke LI ZiQiang GUAN SongYun GE Wei ZHANG JunYuan | 2011 | Science China(Technological Sciences)2011，54，4： | 8 |
| 16 | Predictors of adherence to home-based cardiac rehabilitation program among coronary artery disease outpatients in China显示文摘Background Cardiac rehabilitation (CR) has proven beneficial for patients with coronary artery disease. However, adherence to CR programs is the key to the health improvement in those patients. Identifying predictors for adherence, which is very much unknown in China, would be valuable for effective rehabilitation. This study aims to determine the adherence to home-based CR programs in Chinese coronary artery disease patients and determine predictors of adherence. Methods The current study included 1033 outpatients with coronary heart disease in the First Medical Center of Chinese PLA General Hospital in Beijing from July 2015 to June 2017. Participants were given an exercise prescription and took part in home-based exercise training lasting for 3–24 months. A questionnaire was used to evaluate the completion of the CR program, understanding of the program, motivation of the patients, and family/peer support. Results Two thirds of the patients adhered well to the home-based CR program. Elder patients (≥ 65-year-old) adhere to the program better, while men adhered better than women. Patients who used to exercise (B = 6.756, P < 0.001), understood the program (B = 0.078, P = 0.002), with stronger motivation to participate (B = 0.376, P < 0.001), and received better family support (B = 0.487, P < 0.001) also adhere better to the program. Conclusions Understanding the program, self-motivation of patients, and family support help to keep patients engaged in a home-based CR program. Improvement of family support by educating both patients and families may be helpful in improving adherence to home-based CR programs. | Cheng GE Jing MA Yong XU Ya-Jun SHI Cheng-Hui ZHAO Ling GAO Jing BAI Yu WANG Zhi-Jun SUN Jun GUO Yun-Dai CHEN | 2019 | Journal of Geriatric Cardiology2019，16，10： | 8 |
| 17 | Myocardial bridging detection by non-invasive multislice spiral computed tomography: comparison with intravascular ultrasound显示文摘背景:侵略血管内超声(IVUS ) 是为心肌的衔接的当前的诊断标准(MB ) 。非侵略多切冠的血管造影术(MSCT ) 技术提供了的计算机化的断层摄影术隧道动脉的一个好解剖看法现在。方法:有为 IVUS 安排的不正常或典型的咽峡炎的 51 个连续病人的一个总数在这研究被注册, MSCT 被执行在 IVUS 前的 7 天。冠的成像用 IVUS 和 MSCT 被确定。四个主要容器(左主要动脉(LMA ) ,左前面的下降(男孩) ,左降声调符号(LCX ) ,恰好冠的动脉(RCA )) 被检验。结果:41 (80%) 从 51,病人们在 MSCT 扫描前收到了 metaprolol (25 mg ) ,他们中的 25 个是当前的贝它块用户。吝啬的心搏率是(64 +/- 3 ) 每分钟跳动。51 个病人的一个总数经历了 IVUS 检查(30 与 MB 并且 21 没有 MB ) 为这研究被选择。28 被 MSCT 正确地从 30 个 MB 盒子诊断,有 MB 的 2 个病人没被检测。有 IVUS 的比较,由 MSCT 的察觉的敏感是 93% ,特性是 100% 。显著地从 MSCT 和 IVUS 导出的隧道动脉的腔直径减少了从(2.9 +/- 0.3 ) 公里到(2.4 +/- 0.4 ) 公里(P <
0.001 ) 并且从(3.3 +/- 0.3 ) 公里到(2.6 +/- 0.5 ) 公里(P <
0.001 ) 分别地。从 MSCT 导出的 MB 的最小、最大的直径是比从 IVUS 的那些显著地小的((2.4 +/- 0.4 ) 公里对(2.6 +/- 0.5 ) 公里, P <
0.05 并且(2.9 +/- 0.3 ) 公里对(3.3 +/- 0.3 ) 公里, P <
0.05 ) 分别地。结论:MSCT 与与侵略 IVUS 可比较的诊断精确性在男孩和动脉粥样硬化诊断为 MB 提供一个可靠非侵略的方法。 | WANG Ming-hui SUN Ai-jun QIAN Ju-ying LING Qing-zhi ZENG Meng-su GE Lei WANG Ke-qiang FAN Bing YAN Wei ZHANG Feng | 2008 | Chinese Medical Journal2008，，1： | 7 |
| 18 | Research progresses on Cherenkov and transit-time high-power microwave sources at NUDT显示文摘Research progresses on Cherenkov and transit-time high-power microwave(HPM)sources in National University of Defense Technology(NUDT)of China are presented.The research issues are focused on the following aspects.The pulse-shortening phenomenon in O-type Cerenkov HPM devices is suppressed.The compact coaxial relativistic backward-wave oscillators(RBWOs)at low bands are developed.The power efficiency in M-Type HPM tubes without guiding magnetic field increased.The power capacities and power efficiencies in the triaxial klystron amplifier(TKA)and relativistic transit-time oscillator(TTO)at higher frequencies increased.In experiments,some exciting results were obtained.The X-band source generated 2 GW microwave power with a pulse duration of 110 ns in 30 Hz repetition mode.Both L-and P-band compact RBWOs generated over 2 GW microwave power with a power efficiency of over 30%.There is approximately a 75% decline of the volume compared with that of conventional RBWO under the same power capacity conditions.A 1.755 GHz MILO produced 3.1 GW microwave power with power efficiency of 10.4%.A 9.37 GHz TKA produced the 240 MW microwave power with the gain of 34 dB.A 14.3 GHz TTO produced 1 GW microwave power with power efficiency of 20%. | Jiande Zhang Xingjun Ge Jun Zhang Juntao He Yuwei Fan Zhiqiang Li Zhenxing Jin Liang Gao Junpu Ling Zumin Qi | 2016 | Matter and Radiation at Extremes2016，1，3： | 7 |
| 19 | P300 change and cognitive behavioral therapy in subjects with Internet addiction disorder A 3-month follow-up study显示文摘Event-related potential studies of cognitive function in addiction behaviors have focused on the P300 event-related potential component. The current study investigated the association between P300 component and Internet addiction disorder. We found that individuals with Internet addiction disorder exhibited significantly longer P300 latencies than controls (N2: P = 0.035; P3a: P = 0.031; P3b: P = 0.043) and similar P300 amplitudes compared to control participants. After 3 months of cognitive behavioral therapy, P300 latencies decreased significantly in the P3a and P3b (P3a: P = 0.045; P3b: P = 0.062). These results suggest that deficits in cognitive function may be involved in Internet addiction disorder, and that clinical psychological treatment may be effective. | Ling Ge Xiuchun Ge Yong Xu Kerang Zhang Jing Zhao Xin Kong | 2011 | Neural Regeneration Research2011，6，26： | 7 |
| 20 | C5a/C5a R pathway is essential for up-regulating Sph K1 expression through p38-MAPK activation in acute liver failure显示文摘AIM To investigate the role of the complement 5a(C5a)/C5 a receptor(C5a R) pathway in the pathogenesis of acute liver failure(ALF) in a mouse model.METHODS BALB/c mice were randomly assigned to different groups, and intraperitoneal injections of lipopolysaccharide(LPS)/D-galactosamine(D-Gal N)(600 mg/kg and 10 μg/kg) were used to induce ALF. The KaplanMeier method was used for survival analysis. Serum alanine aminotransferase(ALT) levels, at different time points within a 1-wk period, were detected with a biochemistry analyzer. Pathological examination of liver tissue was performed 36 h after ALF induction. Serum complement 5(C5), C5 a, tumor necrosis factor-α(TNF-α), interleukin(IL)-1β, IL-6, high-mobility group protein B1(HMGB1) and sphingosine-1-phosphatelevels were detected by enzyme-linked immunosorbant assay. Hepatic morphological changes at 36 h after ALF induction were assessed by hematoxylin and eosin staining. Expression of C5 a R, sphingosine kinase 1(Sph K1), p38-MAPK and p-p38-MAPK in liver tissue, peripheral blood mononuclear cells(PBMCs) and peritoneal exudative macrophages(PEMs) of mice or RAW 264.7 cells was analyzed by western blotting. C5 a R m RNA levels were detected by quantitative real-time PCR.RESULTS Activation of C5 and up-regulation of C5 a R were observed in liver tissue and PBMCs of mice with ALF. Blockade of C5 a R with a C5 a R antagonist(C5a Ra C5 a Ra) significantly reduced the levels of serum ALT, inflammatory cytokines(TNF-α, IL-1β and IL-6) and HMGB1, as well as the liver tissue damage, but increased the survival rates(P < 0.01 for all). Blockade of C5 a R decreased Sph K1 expression in both liver tissue and PBMCs significantly at 0.5 h after ALF induction. C5 a Ra pretreatment significantly downregulated the phosphorylation of p38-MAPK in liver tissues of ALF mice and C5 a stimulated PEMs or RAW 264.7 cells. Moreover, inhibition of p38-MAPK activity with SB203580 reduced Sph K1 protein production significantly in PEMs after C5 a stimulation.CONCLUSION The C5a/C5 a R pathway is essential for up-regulating Sph K1 expression through p38 MAPK activation in ALF in mice, which provides a potential immunotherapeutic strategy for ALF in patients. | Yan-Chang Lei Chun-Lei Lu Ling Chen Ke Ge Ling-Ling Yang Wen Li Yuan-Hua Wu | 2016 | World Journal of Gastroenterology2016，22，46： | 7 |
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