| 14 | Effect of glutathion on cadmiuminduced cytotoxicity in nasopharyngeal carcinoma cell显示文摘To study the possible role of glutathion (GSH) in cadmium-induced anti-tumor effects on human nasopharyngeal carcinoma(NPC).CNE1 cell line was treated with CdCl2,and together with N-acetyl cysteine(NAC),the predecessor of GSH,or with L-buthionine-[S,R]-sulfoximine (BSO),a selective inhibitor of GSH synthesis.The intracellular GSH level,the LDH leakage and MTT assay were measured.Results showed that there was remarkable proliferation in NAC+CdCl2 treated CNE1 cells,with high activity of GSH.However,in BSO+CdCl2 exposed cells,with low level GSH,the proliferation was significantly inhibited.It was indicated that GSH depletion would sensitize the inducible cytotoxicity in NPC cell,which correlated with cadmium-induced anticancer effects. | LinZN LinYC | 2002 | 中国药理学与毒理学杂志2002，16，6： | 0 |
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