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| 1 | Mutation analysis of the FOXL2 gene in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome显示文摘 | Tang SJ Wang XK Lin LX Sun Y Wang YL Yu HB | 2006 | 中国生物学文摘2006，20，4： | 15 |
| 2 | VIP immunoreactive nerves and somatostatin and serotonin containing cellsin Crohn′s disease显示文摘 | Lu SJ Liu YQ Lin JS Wu HJ Sun YH Tan YB | 1999 | World Journal of Gastroenterology1999，5，6： | 4 |
| 3 | Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma显示文摘AIM To explore factors associated with persistent hepatitis B virus(HBV) infection in a cohort of hepatocellular carcinoma(HCC)-affected families and then investigate factors that correlate with individual viral load among hepatitis B surface antigen(HBsA g)-positive relatives. METHODS We evaluated non-genetic factors associated with HBV replication in relatives of patients with HCC. Relatives of 355 HCC cases were interviewed using a structuredquestionnaire. Demographics, relationship to index case, HBs Ag status of mothers and index cases were evaluated for association with the HBV persistent infection or viral load by generalized estimating equation analysis. RESULTS Among 729 relatives enrolled, parent generation(P = 0.0076), index generation(P = 0.0044), mothers positive for HBs Ag(P = 0.0007), and HBs Ag-positive index cases(P = 5.98 × 10-8) were associated with persistent HBV infection. Factors associated with HBV viral load were evaluated among 303 HBs Ag-positive relatives. Parent generation(P = 0.0359) and sex(P = 0.0007) were independent factors associated with HBV viral load. The intra-family HBV viral load was evaluated in families clustered with HBs Ag-positive siblings. An intra-family trend of similar HBV viral load was found for 27 of 46(58.7%) families. Male offspring of HBsA gpositive mothers(P = 0.024) and older siblings were associated with high viral load.CONCLUSION Sex and generation play important roles on HBV viral load. Maternal birth age and nutritional changes could be the reasons of viral load difference between generations. | Ai-Ru Hsieh Cathy SJ Fann Chau-Ting Yeh Hung-Chun Lin Shy-Yi Wan Yi-Cheng Chen Chia-Lin Hsu Jennifer Tai Shi-Ming Lin Dar-In Tai | 2017 | World Journal of Gastroenterology2017，23，5： | 2 |
| 4 | LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer显示文摘Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with NPC.We prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth weeks.Specific responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth weeks.Local clinicians performed the follow-up and tracking of patients.Results We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical assay.Twenty-nine patients with NPC were enrolled in this clinical trial.The LMP2-DCs vaccine was well tolerated in all of the patients.Boosted responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with NPC.The follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in non-responders.Conclusion In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with NPC.Specific CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing. | ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHOU Ling TANG Min Zhong SJ O`Brien LAN Jiao ZHOU Xiang Yang WANG Yong Li TANG Juan ZHOU Zhi Xiang DU Hai Jun LIN Hui | 2020 | Biomedical and Environmental Sciences2020，33，11： | 2 |
| 5 | Comparative studies of types 1 and 2 herpes siruplex virus infection of cultured normal keratinocytes显示文摘 | Su SJ Wu HH Lin YH | 1995 | J Clin Pathol1995，48，： | 1 |
| 6 | Salvianolic acid B attenuates VCAM-1 and ICAM-1 expression in TNF-alpha-treated human aortic endothelial cells显示文摘 | CHEN YH LIN SJ KU HH | 2001 | J Cell Biochem2001，82，： | 1 |
| 7 | Manifested strabismus in a case of Apert syndrome显示文摘 | Hsu CM Lin MC Sheu SJ | 2011 | J Chin Med Assoc2011，74，2： | 1 |
| 8 | Enterovirus 71 out-breaks, Tai- wan: occurrence and recognition 显示文摘 | Lin TY Twu SJ Ho MS | 2003 | Emerg hffect Dis2003，9，3： | 1 |
| 9 | Relationship between plasma leptin lev?els and clinical outcomes of pediatric traumatic brain injury显示文摘 | Lin C Huang SJ Wang N | 2012 | Peptides2012，35，2： | 1 |
| 10 | The relation between ankle impairments and gait velocity and symmetry in people with stroke显示文摘 | Lin P Yang YR Cheng SJ | 2006 | Arch Phys Med Rehabil2006，87，4： | 1 |
| 11 | A pilot study of vasculogenicmimicry immunohistochemical expression in hepatocellularcarcinoma显示文摘 | Guzman G Cotler SJ Lin AY | 2007 | Arch Pathol Lab Med2007，131，12： | 1 |
| 12 | Expression and functional analysis of pituitary tumor transforming gene - 1 in uterine leiomyomas 显示文摘 | Tsai SJ Lin SJ Cheng YM | 2005 | J Clin Endocrinol Metab2005，90，： | 1 |
| 13 | Enhanced angiogenesis with dl-3n-ba- tylphthalide treatment after focal cerebral ischemia in RHRSP 显示文摘 | Liao SJ Lin JW Pci Z | 2009 | Brain Res2009，1289，： | 1 |
| 14 | Clinical suppression of precocious puberty with cetrorelix after failed tretment with GnRH agonist in a girl with gonadotrophin-independent precocious puberty显示文摘 | Wu MH Lin SJ Cheng YC | 2005 | Reprod Biomed Online2005，11，1： | 1 |
| 15 | Comparison of outcomes of Taxol Cisplatin and Taxol Nedaplatin chemotherapy regimens for advanced non-samll cell lung cancer显示文摘 | Cai YP Xu S Lin SJ | 2010 | Zhonghua Zhong Liu Za Zhi2010，1，32： | 1 |
| 16 | In vivo tension sustained by fascial sling in pubovaginal sling surgery for female stress urinary incontinenee显示文摘 | Lin AT Wang SJ Chen KK | 2005 | J Urol2005，173，3： | 1 |
| 17 | The relationship between nutritional status and physical function,admission frequency,length of hospital stay,and mortality in old people living in long-term care facilities显示文摘 | Lin SJ Hwang SJ Liu CY | 2012 | Nurs Res2012，20，2： | 1 |
| 18 | The miR-92b functions as a potential oncogene by targeting on Smad3 in glioblastomas显示文摘 | Wu ZB Cai L Lin SJ | 2013 | Brain Res2013，1529，1： | 1 |
| 19 | The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro显示文摘 | Yeh CC Kao SJ Lin CC | 2007 | Life Sci2007，80，： | 1 |
| 20 | A randomized controlled trialcomparing octeotide and vasopressin in the conteolof acute esopha geal variceal bleeding显示文摘 | Huang SJ Lin HC Chang CF | 2007 | J H epatol2007，16，2： | 1 |
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