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| 1 | Augmented cellular uptake and homologous targeting of exosome-based drug loaded IOL for posterior capsular opacification prevention and biosafety improvement显示文摘Posterior capsular opacification(PCO),the most common complication after cataract surgery,is caused by the proliferation,migration and differentiation of residual lens epithelial cells(LECs)on the surface of the intraocular lens(IOL).Although drug-loaded IOLs have been successfully developed,the PCO prevention efficacy is still limited due to the lack of targeting and low bioavailability.In this investigation,an exosome-functionalized drug-loaded IOL was successfully developed for effective PCO prevention utilizing the homologous targeting and high biocompatibility of exosome.The exosomes derived from LECs were collected to load the anti-proliferative drug doxorubicin(Dox)through electroporation and then immobilized on the aminated IOLs surface through electrostatic interaction.In vitro experiments showed that significantly improved cellular uptake of Dox@Exos by LECs was achieved due to the targeting ability of exosome,compared with free Dox,thus resulting in superior anti-proliferation effect.In vivo animal investigations indicated that Dox@Exos-IOLs effectively inhibited the development of PCO and showed excellent intraocular biocompatibility.We believe that this work will provide a targeting strategy for PCO prevention through exosome-functionalized IOL. | Siqing Zhu Huiying Huang Dong Liu Shimin Wen Liangliang Shen Quankui Lin | 2022 | Bioactive Materials2022，7，9： | 1 |
| 2 | Bayesian heuristic approach for learning Bayesian networks显示文摘 | Lin Shimin Hu Zhenyu Lu Yuchang | 2003 | Asia Journal of Information Technology2003，2，1： | 1 |
| 3 | Learningstructures 显示文摘 | Lin Shimin Lu Yuchang | 2000 | Science(in Chinese)2000，27，10： | 1 |
| 4 | Bayesian heuristic approach for learning bayesian networks显示文摘 | Lin Shimin Hu Zhengyu Lu Yuchang | 2003 | Asia Journal of Information Technology2003，2，1： | 1 |
| 5 | Flame retardant epoxy polymers based on all phosphorus-containing components 显示文摘 | Jeng RuJong Shau ShiMin Lin JiangJen | 2002 | European Polymer Journal2002，38，： | 1 |
| 6 | Heat Insulation and Dissipation Processes in Nordic Seas in the Summer显示文摘The Nordic Seas have a significant impact on the climate system.Here 23-day air-sea heat fluxes were analyzed from an in situ air-sea coupled buoy deployed in the Lofoten Basin from 5 August 2012 to 27 August 2012.The buoy captured two stages of strong south and north winds.The observations indicate that warm and wet air transported by the south wind can lead to decreased sensible and latent heat fluxes and net longwave radiation.The total oceanic heat loss was 50-60Wm−2.Thus,this stage was called the heat insulation process.By contrast,the heat dissipation process occurred with the north wind condition dur-ing advection of the cold and dry air.During this process,sensible and latent heat fluxes and net longwave radiation notably in-creased.The total oceanic heat loss during the heat dissipation process reached 240Wm−2,which was four-fold greater than that in the heat insulation process.Given that the heat insulation process is dominant in summertime,the ocean lost minimal heat but absorbed strong solar energy.Thus,a large quantity of energy was stored in the ocean.Heat was transported to the Arctic Ocean and accelerated Arctic warming.The heat dissipation process is dominant in autumn and winter when the ocean releases consid-erably more energy.The two processes revealed in this paper can be applied to warm-water areas in high latitudes. | GAO Lin ZHAO Jinping LI Shimin FAN Xiutao LIU Shixuan | 2021 | Journal of Ocean University of China2021，20，6： | 1 |
| 7 | Inactivation of OslRX10 Leads to Decreased Xylan Content in Rice Culm Cell Walls and Improved Biomass Saccharification显示文摘Dear Editor, Xylan polysaccharides constitute the major non-cellulosic components in secondary cell walls of dicots and in both primary and secondary cell walls of grasses (Scheller and Ulvskov,2010).Xylan is composed of a linear backbone of 13(1-4)-linked xylose (Xyl).In grasses,the xylan backbone is substituted with O3-1inked and O2-1inked arabinose residues and,to a lesser extent,α(1-3)-Iinked glucuronic acid residues.A unique feature of grass xylans is the presence of hydroxycinnamate esters (ferulic and p-coumaric acid residues)attached to C5 of some of the arabinosyl residues (Carpita,1996;Vogel,2008;Scheller and Ulvskov,2010).Xylan contributes to the recalcitrance of plant cell walls to enzymatic degradation probably through direct interaction with cellulose microfibrils and also through formation of ferulate cross-links (liyama et al.,1994;Yin et al.,2011). | Xuewei Chen Miguel E. Vega-Sanchez Yves Verhertbruggenb Dawn Chiniquy Patrick E. Canlas Alexandra Fagerstrom Lina Prak Ulla Christensen Ai Oikawa Mawsheng Chern Shimin Zuo Fan Lin Manfred Auer William G.T. Willats Laura Bartley Jesper Harholt Henrik V. Scheller Pamela C. Ronald | 2013 | Molecular Plant2013，6，2： | 1 |
| 8 | DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice显示文摘Dear Editor,Male subfertility,a multifactorial disease affecting~7%of the global male population,is usually caused by abnormalities in sperm flagella.The flagella and motile cilia have similar“9+2”axonemes and are evolutionarily conserved,being widely distributed in bacteria,archaea and eukaryotes1.Cilia defects also lead to primary ciliary dyskinesia(PCD),which affects approximately 1/10,000 individuals worldwide. | Shushu Zhou Shimin Yuan Jintao Zhang Lanlan Meng Xin Zhang Siyu Liu Guangxiu Lu Ge Lin Mingxi Liu Yue-Qiu Tan | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 9 | Magnesium incorporation activates perovskite cobaltites toward efficient and stable electrocatalytic oxygen evolution显示文摘Cobalt-rich perovskite oxides play a paramount role in catalyzing oxygen evolution reaction(OER)on account of their acceptable intrinsic activity but are still challenging due to the high costs and undesired stability.In response to the defects,herein,the Mg-incorporated perovskite cobaltite SrCo_(0.6)Fe_(0.3M)g_(0.1)O_(3-δ)(SCFM-0.1)is proposed as a novel earth-abundant and durable OER electrocatalyst.A well-consolidated cubic-symmetry structure and more active oxygen intermediates are enabled upon Mg substitution.Hence,the optimized SCFM-0.1 perovskite oxide achieves prominent OER electrocatalytic performance,that is,a low overpotential of only 320 mV at 10 mA cm^(-2),a small Tafel slope of 65 mV dec^(-1),as well as an outstanding durability within 20 h,substantially outperforming that of the pristine SrCo_(0.7)Fe_(0.3)O_(3-δ)and benchmark Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ)and IrO_(2) catalysts.The strong pHdependent behavior associated with lattice oxygen activation mechanism for SCFM-0.1 catalyst is also confirmed.This work paves a unique avenue to develop cost-effective and robust perovskite cobaltites for efficient OER electrocatalysis. | Siyu Pan Zilin Ma Wenying Yang Biaokui Dongyang Huizhi Yang Shimin Lai Feifei Dong Xixian Yang Zhan Lin | 2023 | Materials Reports(Energy)2023，3，3： | 0 |
| 10 | ULK1/2所构成的信号节点除控制细胞自噬外还控制葡萄糖代谢通路显示文摘在细胞感受到环境中营养物质和生长因子的提供量发生改变后,代谢通路的重编程对于维持此时胞内的稳态是非常重要的过程。ULK1和ULK2是传递外界应激信号至自噬发生的重要整合因子。 | Terytty Yang Li Yu Sun Yu Liang Qing Liu Yuzhe Shi Chen-Song Zhang Cixiong Zhang Lintao Song Pu Zhang Xianzhong Zhang Xiaotong Li Tao Chen Hui-Ying Huang Xiadi He Yi Wang Yu-Qing Wu Shaoxuan Chen Ming Jiang Canhe Chen Changchuan Xie James Y.Yang Yan Lin Shimin Zhao Zhiyun Ye Shu-Yong Lin Daniel Tsun-yee Chiu 林圣彩 | 2017 | 科学新闻2017，19，4： | 0 |
| 11 | LncRNA-AP006284.1 promotes prostate cancer cell growth and motility by forming RNA-DNA triplexes and recruiting GNL3/SFPQ complex to facilitate RASSF7 transcription显示文摘Long noncoding RNAs(lncRNAs)are known to be involved in transcriptional regulation and their deregulation is associated with the development of human diseases such as cancer.1,2 LncRNA can directly bind to purine-rich double-stranded DNA sequences through Hoogsteen base pairing to form an RNA-DNA triplex motifs and regulate gene expression.3,4,5 However,its regulatory mechanisms and functions in tumors remain unclear.Here,we report that the LMNTD2 antisense RNA 1(LMNTD2-AS1,also known as AP006284.1)is highly expressed in prostate cancer(PCa)and positively correlated with the expression of its adjacent coding gene N-terminal Ras-association domain family 7(RASSF7).Mechanistically,AP006284.1 tethers to the RASSF7 promoter via RNA-DNA triplexes in cis-acting manner,which enhances chromatin accessibility and recruits the transcription factor complex GNL3/SFPQ to activate the expression of RASSF7,a repressor of the Hippo signaling pathway.Consistently,overexpression of either AP006284.1 or RASSF7 inactivated the Hippo signaling and malignant proliferation of PCa cells. | Yali Lu Yan Lin Xiaoyang Zhang Jun Yan Zhe Kong Lu Zhang Chenji Wang Yan Huang Shimin Zhao Yao Li | 2023 | Genes & Diseases2023，10，2： | 0 |
| 12 | Inappropriate Activation of TLR4/NF-κB is a Cause of Heart Failure显示文摘Significance:Heart failure,a disease with extremely high incidence,is closely associated with inflammation and oxidative stress.The Toll-like receptor 4(TLR4)/nuclear factor kappa-B(NF-κB)pathway plays an important role in the occurrence and development of heart failure.Recent advances:Previous studies have shown that TLR4/NF-κB causes heart failure by inducing oxidative stress and inflammation;damaging the endothelia;promoting fibrosis;and inducing myocardial hypertrophy,apoptosis,pyroptosis,and autophagy.Critical issues:Understanding the pathogenesis of heart failure is essential for the treatment of this disease.In this review,we outline the mechanisms underlying TLR4/NF-κB pathway-mediated heart failure and discuss drugs that alleviate heart failure by regulating the TLR4/NF-κB pathway.Future directions:During TLR4/NF-κB overactivation,interventions targeting specific receptor antagonists may effectively alleviate heart failure,thus providing a basis for the development of new anti-heart failure drugs. | Jiedong Zhou Hui Lin Tingting Lv Jinjin Hao Hanlin Zhang Shimin Sun Juntao Yang Jufang Chi Hangyuan Guo | 2022 | Cardiovascular Innovations and Applications2022，7，3： | 0 |
| 13 | Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation显示文摘Oxidative phosphorylation(OXPHOS)consumes oxygen to produce ATP.However,the mechanism that balances OXPHOS activity and intracellular oxygen availability remains elusive.Here,we report that mitochondrial protein lactylation is induced by intracellular hypoxia to constrain OXPHOS.We show that mitochondrial alanyl-tRNA synthetase(AARS2)is a protein lysine lactyltransferase,whose proteasomal degradation is enhanced by proline 377 hydroxylation catalyzed by the oxygen-sensing hydroxylase PHD2.Hypoxia induces AARS2 accumulation to lactylate PDHA1 lysine 336 in the pyruvate dehydrogenase complex and carnitine palmitoyltransferase 2(CPT2)lysine 457/8,inactivating both enzymes and inhibiting OXPHOS by limiting acetyl-CoA influx from pyruvate and fatty acid oxidation,respectively.PDHA1 and CPT2 lactylation can be reversed by SIRT3 to activate OXPHOS.In mouse muscle cells,lactylation is induced by lactate oxidation-induced intracellular hypoxia during exercise to constrain high-intensity endurance running exhaustion time,which can be increased or decreased by decreasing or increasing lactylation levels,respectively.Our results reveal that mitochondrial protein lactylation integrates intracellular hypoxia and lactate signals to regulate OXPHOS. | Yunzi Mao Jiaojiao Zhang Qian Zhou Xiadi He Zhifang Zheng Yun Wei Kaiqiang Zhou Yan Lin Haowen Yu Haihui Zhang Yineng Zhou Pengcheng Lin Baixing Wu Yiyuan Yuan Jianyuan Zhao Wei Xu Shimin Zhao | 2024 | Cell Research2024，34，1： | 0 |
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