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| 1 | Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels显示文摘Brachydactyly 打 A1 (BDA1 ) ,第一在人记录了孟德尔的正染色体的主导的混乱,被弄短或中间的指骨的缺席描绘。在印度刺猬(IHH ) 基因的异质接合的错误感觉变化作为 BDA1 的一个原因被识别了;然而,这些变化的生物化学的后果是不清楚的。在这份报纸,我们在印度刺猬(IhhN ) 的 N 终端碎片分析了三个 BDA1 变化(E95K, D100E,和 E131K ) 。结构的分析证明 E95K 变化在一条钙绑定沟把一个否定地控告的区域改变到一个断然控告的区域,并且 D100E 变化改变本地第三级的结构。而且,我们证明 E95K 和 D100E 变化导致了一温度敏感并且 IhhN 的钙依赖者不稳定性,它可能经由 lysosome 贡献变异的蛋白质的提高的细胞内部的降级。尤其是,所有三个变化影响了对受体 Patched1 (PTC1 ) 有约束力的 Hh,减少它的能力导致细胞的区别。我们建议这些是引起 BDA1 的变化的普通特征,影响 Hh 第三级的结构,细胞内部的命运,到受体 / 搭挡的绑定,和到细胞外的部件的绑定。这些特征的联合改变发信号的能力和范围,但是影响是可能的是变量和变化依赖者。在发信号的范围的潜在的变化被和 heparan 硫酸盐的一个提高的相互作用与 E95K 变化,然而并非 E131K 变化为 IHH 描绘。一起拿,我们的结果建议这些 IHH 变化影响在多重层次,引起的反常骨头发展和反常的位形成发信号的 Hh。 | Gang Ma Jiang Yu Yue Xiao Danny Chan Bo Gao Jianxin Hu Yongxing He Shengzhen Guo Jian Zhou Lingling Zhang Linghan Gao Wenjuan Zhang Yan Kang Kathryn SE Cheah Guoyin Feng Xizhi Guo Yujiong Wang Cong-zhao Zhou Lin He | 2011 | Cell Research2011，21，9： | 6 |
| 2 | Clinicopathologic significance of GLUT1 expression and its correlation with Apaf-1 in colorectal adenocarcinomas显示文摘AIM:To investigate the role of glucose transporter 1 (GLUT1) expression in colorectal carcinogenesis and evaluate the correlation with clinicopathological parameters and apoptosis-activating factor-1 (Apaf-1) expression in colorectal adenocarcinomas. METHODS:We used tissue microarrays consisting of 26 normal mucosa,50 adenomas,515 adenocarcinomas,and 127 metastatic lesions. Medical records were reviewed and clinicopathological analysis was performed. RESULTS:GLUT1 expression was absent in normal mucosa and low or moderately apparent in 19 cases (38.0%) of 50 adenomas. However,GLUT1 expression was detected in 423 (82.1%) of 515 adenocarcinomas and in 96 (75.6%) of 127 metastatic lesions. GLUT1 expression was significantly correlated with female gender (P = 0.009),non-mucinous tumor type (P = 0.045),poorer differentiation (P = 0.001),lymph node metastasis (P < 0.001),higher AJCC and Dukes stage (P < 0.001 and P < 0.001,respectively). There was a significant inverse correlation between GLUT1 expression and Apaf-1 expression (P = 0.001). In univariate survival analysis,patients with GLUT1 expression demonstrated poor overall survival and disease-free survival (P = 0.047 and P = 0.021,respectively,log-rank test). CONCLUSION:GLUT1 expression was frequently increased in adenocarcinomas and metastatic lesions. GLUT1 expression was significantly correlated with poorer clinicopathologic phenotypes and survival of patients with colorectal adenocarcinomas. | Young Jin Jun Se Min Jang Hu lin Han Ki-Seok Jang Seung Sam Paik Kang Hong Lee | 2011 | World Journal of Gastroenterology2011，17，14： | 2 |
| 3 | Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen 显示文摘 | Lupold SE Hicke BJ Lin Y Coffey D | 2002 | Cancer Res2002，62，14： | 1 |
| 4 | Steroidogenic factor-1 and endometriosis显示文摘 | Bulun SE Utsunomiya H Lin Z | 2009 | Mol Cell Endocfinol2009，300，12： | 1 |
| 5 | Very early stage adenocarcinoma arising from adenomyosis in the uterus显示文摘 | Hsu MI Chou SY Lin SE | 2006 | Taiwan J Obstet Gynecol2006，45，4： | 1 |
| 6 | Demonstration of mixed properties of RU486 in progesterone receptor (PR)-transfected MDA-MB-231 cells: a model for studying the functions of progesterone analogues显示文摘 | Lin VC Aw SE Ng EH | 2001 | Br-J-Cancer2001，85，12： | 1 |
| 7 | Inflammatory cytokines and cell response in surgery显示文摘 | Lin E Calvano SE Lowry SF | 2000 | Surgery2000，127，： | 1 |
| 8 | Patient - related barriers to cancer pain management in Taiwan 显示文摘 | Lin CC Ward SE | 1995 | Cancer Nurs1995，18，1： | 1 |
| 9 | Identificaiton of new human mas- termind proteins defines a family that consists of positive regulators for notch signaling 显示文摘 | Lin SE Oyama T Nagase T | 2002 | J Biol Chem2002，277，50： | 1 |
| 10 | The impact of hepatitis C in- fection on ischemic heart disease via ischemic electrocardiogram 显示文摘 | Lin MS Guo SE Chen MY | 2014 | Am J Med Sci2014，347，6： | 1 |
| 11 | Regulation of retinal hemodynamics in diabetic rats by increased expression and action of endothlin-1显示文摘 | Takagi C Bursell SE Lin YW | 1996 | Invest Ophthalmol Vis Sci1996，37，12： | 1 |
| 12 | Effect of cancer pain on performance status, mood states, and level of hope among Taiwanese cancer patients 显示文摘 | Lin CC Lai YL Ward SE | 2004 | J Pain Symptom Manag2004，25，： | 1 |
| 13 | Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma显示文摘 | Lin F Zheng SE Shen Z | | 0，，02： | 1 |
| 14 | Disinfection of water distribution systems for Legionella显示文摘 | Lin Y SE Stout J E Yu VL | 1998 | Semin Respir Infect1998，13，2： | 1 |
| 15 | Corneal topography of keratoconus显示文摘 | Wilson Se Lin DT Klyce SD | 1991 | Comea1991，10，： | 1 |
| 16 | Topographic changes in contact lens- induced corneal warpage 显示文摘 | Wilson SE Lin DT Kkyce SD | 1990 | Ophthalmology-1990，6，： | 1 |
| 17 | Bioactive sesterterpenes and triterpenes from marine sponges: occurrence and pharmacological significance显示文摘 | Sherif SE Lin WH Proksch P | 2010 | Mar Drugs2010，8，2： | 1 |
| 18 | Inflammatory cytokines and cell response in surgery显示文摘 | Lin E Calvano SE Lowry SF | 2000 | Surgery2000，127，2： | 1 |
| 19 | Cx43 CT domain influencesinfarct size and susceptibility to ventricular tachyarrhythmias inacute myocardial infarction 显示文摘 | Maass K Chase SE Lin X | 2009 | Cardiovasc Res2009，84，3： | 1 |
| 20 | Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma显示文摘 | Lin F Zheng SE Shen Z | 2010 | Med Oncol2010，23，6： | 1 |
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