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| 1 | The biological function of type I receptors of bone morphogenetic protein in bone显示文摘Bone morphogenetic proteins(BMPs) have multiple roles in skeletal development, homeostasis and regeneration. BMPs signal via type I and type II serine/threonine kinase receptors(BMPRI and BMPRII). In recent decades, genetic studies in humans and mice have demonstrated that perturbations in BMP signaling via BMPRI resulted in various diseases in bone, cartilage, and muscles. In this review, we focus on all three types of BMPRI, which consist of activin-like kinase 2(ALK2, also called type IA activin receptor), activinlike kinase 3(ALK3, also called BMPRIA), and activin-like kinase 6(ALK6, also called BMPRIB). The research areas covered include the current progress regarding the roles of these receptors during myogenesis,chondrogenesis, and osteogenesis. Understanding the physiological and pathological functions of these receptors at the cellular and molecular levels will advance drug development and tissue regeneration for treating musculoskeletal diseases and bone defects in the future. | Shuxian Lin Kathy KH Svoboda Jian Q Feng Xinquan Jiang | 2016 | Bone Research2016，4，2： | 10 |
| 2 | Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia显示文摘 | Wang HK Fung HC Hsu WC Wu YR Lin JC Ro LS Chang KH Hwu FJ Hsu Y Huang SY Lee-Chen GJ Chen CM | 2006 | 中国生物学文摘2006，20，8： | 8 |
| 3 | Downregulation of Hes1 expression in experimental biliary atresia and its effects on bile duct structure显示文摘AIM To analyze the expression and function of the notchsignaling target gene Hes1 in a rhesus rotavirusinduced mouse biliary atresia model. METHODS The morphologies of biliary epithelial cells in biliary atresia patients and in a mouse model were examined by immunohistochemical staining. Then, the differential expression of Notch signaling pathway-related molecules was investigated. Further, the effects of the si RNAmediated inhibition of Hes1 expression were examined using a biliary epithelial cell 3 D culture system.RESULTS Both immature(Ep CAM+) and mature(CK19+) biliary epithelial cells were detected in the livers of biliary atresia patients without a ductile structure and in the mouse model with a distorted bile duct structure. The hepatic expression of transcripts for most Notch signaling molecules were significantly reduced on day 7 but recovered to normal levels by day 14, except for the target molecule Hes1, which still exhibited lower m RNA and protein levels. Expression of the Hes1 transcriptional co-regulator, RBP-Jκ was also reduced. A 3 D gel culture system promoted the maturation of immature biliary epithelial cells, with increased expression of CK19+ cells and the formation of a duct-like structure. The administration of Hes1 si RNA blocked this process. As a result, the cells remained in an immature state, and no duct-like structure was observed.CONCLUSION Our data indicated that Hes1 might contribute to the maturation and the cellular structure organization of biliary epithelial cells, which provides new insight into understanding the pathology of biliary atresia. | Rui-Zhong Zhang Xin-Hao Zeng Ze-Feng Lin Ming-Fu Yan-Lu Tong Vincent CH Lui Paul KH Tam Jonathan R Lamb Hui-Min Xia Yan Chen | 2018 | World Journal of Gastroenterology2018，24，29： | 5 |
| 4 | In vitro synelgi c antimi- crobial elect of imipenem and cohsdn against an isolate of mt- dtidrug-resistant Enterobacter cloacae显示文摘 | Lin KH Chuang YC Lee SH | 2010 | J Mierobiol Immu- nol Infect2010，43，4： | 1 |
| 5 | RAS signaling pro- motes resistance to JAK inhibitors by suppressing BAD-mediat- ed apoptosis显示文摘 | Winter PS Sarosiek KA Lin KH | 2014 | Sci Signal2014，7，357： | 1 |
| 6 | High prevalence of immunoglobulin a antibody against epstein-barr virus capsid antigen in abult patients with lupus with disease flare:case control studies显示文摘 | Chen CJ Lin KH Lin SC | 2005 | J Rheumatol2005，32，1： | 1 |
| 7 | Molecular epidemiol- ogy of enteroviras 71 in Taiwan 显示文摘 | Chu PY Lin KH Hwang KP Chou LC Wang CF Shih SR Wang JR Shimada Y lshiko H | 2001 | Arch Virol2001，146，3： | 1 |
| 8 | Uric acid and the development of hypertenion显示文摘 | Hwu CM Lin KH | | 0，，10： | 1 |
| 9 | RAPD markers for the identi-fication of yield traits in tomatoes under heat stress via bulked segregant analysis显示文摘 | Lin KH Lo HF Lee SP | 2006 | Hereditas2006，143，4： | 1 |
| 10 | Genetic analysis of enterovirus 71 iso- lated from fatal and non-fatal cases of hand, foot and mouth disease during an epidemic in Taiwan, 1998 显示文摘 | Shih SR Ho MS Lin KH Wu SL Chen YT Wu CN Lin TY Chang LY Tsao KC Ning HC Chang PY Jung SM Hsueh C Chang KS | 2000 | Virus Res2000，68，2： | 1 |
| 11 | Laparoscopic appendectomy in pregnancy显示文摘 | Wu JM Chen KH Lin HF | 2005 | J Laparoendosc Adv Surg Tech A2005，15，5： | 1 |
| 12 | Clinical features and risk factors of pulmonary odema after enterovirus-71-related hand, foot, and mouth disease显示文摘 | Chang LY Lin TY Hsu KH | 1999 | Lancet1999，354，9191： | 1 |
| 13 | Improved survival in severe paraquat poisoning with repeated pulse therapy of cyclophos- phamide and steroids 显示文摘 | Lin JL Lin-Tan DT Chen KH | 2011 | Intensive Care Med2011，37，6： | 1 |
| 14 | Awareness of memory impair-ment increases the adherence to immunosuppressants in kidney trans-plant recipients 显示文摘 | Cheng CY Lin BYJ Chang KH e? al | 2012 | Transplant Proceed Elsevi2012，44，3： | 1 |
| 15 | Uric acid and the development of hypertension 显示文摘 | Hwu CM Lin KH | 2010 | Med Sci Monit2010，16，10： | 1 |
| 16 | Structural and cognitive deficitsin remit-ting and non-recurrent depression : a voxel-basedmorphometric study显示文摘 | Li CT Lin CP Chou KH | 2010 | Neuroi-mage2010，50，1： | 1 |
| 17 | Mechanobiology of MG63 osteo- blast-like ceils adaptation to static magnetic forces显示文摘 | Lin SL Chang WJ Chiu KH | 2008 | Electromagn Biol Med2008，27，1： | 1 |
| 18 | Repeated pulse of methylprednisolone and cyclophosphamide with Continuous dexamethasone therapy for patients with severe paraquat poisoning显示文摘 | Lin JL Lin-Tan DT Chen KH | 2006 | Crit Care Med2006，34，2： | 1 |
| 19 | Repeated pulse of methylprednisolone and cyclophosphamide with continuous dexamethasone therapy for patients with severe paraquat poisoning显示文摘 | Lin JL Lin-Tan DT Chen KH | | 0，，： | 1 |
| 20 | Chemical Constit- uents in Particulate Emissions from an Integrated Iron and Steel Facility 显示文摘 | Tsai JH Lin KH Chen CY | 2007 | J Hazard Mater2007，147，1： | 1 |
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