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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia显示文摘 | Wang HK Fung HC Hsu WC Wu YR Lin JC Ro LS Chang KH Hwu FJ Hsu Y Huang SY Lee-Chen GJ Chen CM | 2006 | 中国生物学文摘2006，20，8： | 8 |
| 3 | Over-expression of fibroblast growth factor receptor 3 in human hepatocellular carcinoma显示文摘AIM: To describe the significant over-expression of fibroblast growth factor receptor 3 (FGFR3), which is a signal transduction and cell proliferation related gene in hepatocellular carcinoma (HCC).METHODS: Following DNA microarray, Northern blot and quantitative real-time PCR were employed to confirm FGFR3 expression difference in HCC tissues and surrounding non-neoplastic liver tissue. FGFR3 expression levels were further determined by immunohistochemical study in 43 cases of HCC.RESULTS: Northern blot results showed the significant over-expression of FGFR3 in HCC tissues, which was consistent with that from DNA microarray. Quantitative real-time PCR demonstrated that the mean ratio of FGFR3 mRNA to glyceraldehyde-3-phosphate dehydrogenase (GADPH) mRNA in HCC tissue was 0.250, whereas the ratio in non-neoplastic liver tissue was 0.014. Statistical analyses of 43 cases of HCC revealed that HCC scored higher than the matched non-neoplastic liver tissues.Examination of clinicopathological features revealed a strong correlation of over-expression of FGFR3 with poor tumor differentiation and high nuclear grade.CONCLUSION: Over-expression of FGFR3 may play an important role in liver carcinogenesis. FGFR3 may be an ideal candidate as a molecular marker in the diagnosis of HCC and a potential therapeutic target. | Wei-Hua Qiu Bing-Sen Zhou Peiguo G. Chu Wen-Gang Chen Christopher Chung Jennifer Shih Paul Hwu Christopher Yeh Richard Lopez Yun Yen | 2005 | World Journal of Gastroenterology2005，11，34： | 8 |
| 4 | Effectsof thermal therapy on uremic pruritus and biochemical parameters in patients having haemodialysis显示文摘 | Mei-Chi Hsu Hsiu-Wen Chen Yueh-Juen Hwu | 2009 | Journal of AdvancedNursing2009，65，11： | 1 |
| 5 | Phase transformation temperatures of an ultra-low carbon steel显示文摘 | Hwu Y J Lenard J G | 1988 | Trans ASME1988，110，： | 1 |
| 6 | Poor response of ovaries with endometrioma previously treated with cystectomy to controlled ovarian hyperstimulation显示文摘 | Ho HY Lee RK Hwu YM | 2002 | J Assist Reprod Genet2002，19，11： | 1 |
| 7 | Early detection of glutaric aciduria type I by newborn screening in Taiwan 显示文摘 | Hsieht CT Hwu WL Huang YT | 2008 | J Formos Med Assoc2008，107，2： | 1 |
| 8 | Green' s funktions of two-dimeesional anisotropic plates containing an elliptic hole显示文摘 | Yen W J Hwu C | 1991 | International Journal of Solids and Structures1991，27，13： | 1 |
| 9 | Reverse microemulsion- mediated synthesis and structural evolution of barium hexaaluminate nanoparticles 显示文摘 | Zarur A J Hwu H H Ying J Y | 2000 | Langmuir2000，16，： | 1 |
| 10 | Stabilization of blood meth- ylmalonic acid level in methylmalonie acidemia after liver transplantation显示文摘 | Chen PW Hwu WL Ho MC | 2010 | Pediatr Transplant2010，14，3： | 1 |
| 11 | Uric acid and the development of hypertenion显示文摘 | Hwu CM Lin KH | | 0，，10： | 1 |
| 12 | Using Antenna Array Redundancy and Channel Diversity for Secure Wireless Transmissions显示文摘 | LI X HWU J RATAZZI E P | 2007 | Journal of Communications2007，2，3： | 1 |
| 13 | Capacity and power fading mechanism identification from a commercial cell evaluation显示文摘 | Dubarry M Svoboda V Hwu R | 2007 | Journal of Power Source2007，165，2： | 1 |
| 14 | Treatment of metastatic melanoma in the brain with temozolomide and thalidomide显示文摘 | Hwu WJ Raizer J Panageas KS | 2001 | Lancet Oncol2001，2，10： | 1 |
| 15 | Molecular genetics of glyco- gen-storage disease type I a in Chinese patients of Taiwan 显示文摘 | Wong LJ Hwu WL Dai P Chen TJ | 2001 | Mol Genet Metab2001，72，2： | 1 |
| 16 | Incidence of NIDDM and the effects of gender, obesity and hyperinsulinemia in Taiwan 显示文摘 | Wang SL Pan WH Hwu CM | 1997 | Diabetologia1997，40，12： | 1 |
| 17 | Advances in the treatment of metastatic melanoma: Adoptive T-cell therapy 显示文摘 | Bernatchez C Radvanyi LG Hwu P | 2012 | Semin Oncol2012，39，2： | 1 |
| 18 | Parallel vertical compression sutures:a technique to control bleeding from placenta praevia or accreta during caesarean section显示文摘 | Hwu Y M Chen C P Chen H S | | 0，，10： | 1 |
| 19 | Dopa-responsive dystonia is induced by a dominant-negative mechanism 显示文摘 | Hwu WL Chiou YW Lai SY et ai | 2000 | Ann Neurol2000，48，4： | 1 |
| 20 | Parallel vertical compression sutures:a technique to control bleeding from placenta previa or accreta during cesarean section显示文摘 | Hwu YM Chen CP Chen HS | 2005 | BJOG2005，112，10： | 1 |
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