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65篇 您的检索式：作者名="Lin KR"

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	题名	作者	年代	出处	被引量
1	Estrogen-mediated downregulation of HIF-1αsignaling in B lymphocytes influences postmenopausal bone loss显示文摘In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment. How B cells functionally influence osteoclasts and bone architecture is poorly understood. Using genetically modified mice and highthroughput analyses, we demonstrate that prolonged HIF-1α signaling in B cells leads to enhanced RANKL production and osteoclast formation. In addition, deletion of HIF-1α in B cells prevents estrogen deficiency-induced bone loss in mice.Mechanistically, estrogen controls HIF-1α protein stabilization through HSP70-mediated degradation in bone marrow B cells.The stabilization of HIF-1α protein in HSP70-deficient bone marrow B cells promotes RANKL production and osteoclastogenesis.Induction of HSP70 expression by geranylgeranylacetone(GGA) administration alleviates ovariectomy-induced osteoporosis.Moreover, RANKL gene expression has a positive correlation with HIF1 A expression in human B cells. In conclusion, HIF-1αsignaling in B cells is crucial for the control of osteoclastogenesis, and the HSP70/HIF-1α axis may serve as a new therapeutic target for osteoporosis.	Xianyi Meng Zhen Lin Shan Cao Iga Janowska Koshiro Sonomoto Darja Andreev Knab Katharina Jinming Wen Karl Xaver Knaup Michael Sean Wiesener Gerhard Krönke Marta Rizzi Georg Schett Aline Bozec	2022	Bone Research2022，10，2：	6
2	Isolation and manipulation of rostral mesencephalic tagnental progenitor cells from rat 显示文摘	Hart Kr Lin D	1995	CellTransplant1995，4，：	1
3	Cervical squamous dysplasias and carcinoma with immunodetectable p53 frequently contain HPV显示文摘	Mittal KR Lin Oscar Chan Wai	1995	Gynecol Oncol1995，58，：	1
4	Resveratrol and ischemic preconditioning in the brain显示文摘	Raval AP Lin HW Dave KR	2008	Curr Med Chem2008，15，15：	1
5	Killing of brain tumor cells by hypoxia-responsive element mediated expression of BAX 显示文摘	Wang J Hu L Lin CS Lamborn KR Deen DF	1999	Neoplasia1999，1，5：	1
6	Epstein2Barr virus and P16 INK4A met hylation in squamous cell carcinoma and precancer ous lesions of the cervix uteri显示文摘	Kim NR Lin Z Kim KR	2005	J Korean Med Sci2005，20，4：	1
7	Identification of n- (deoxyguanosin-8-yl)-2-amino- 1-methyl-6-phenylimidazo pyridine as the major adduct formed by the food-borne carcinogen , 2- amino-l-methyl-6-phenylimidazo pyridine,with DNA 显示文摘	Lin D Kaderlik KR Turesky RJ et 81	1992	C hem Res Toxicol1992，5，：	1
8	Can current technology be integrated to facilitate laparoscopic living donor hepatectomy? 显示文摘	Lin E Gonzalez R Venkatesh KR	2003	Surg Endosc2003，17，5：	1
9	Risk factors for conversion to open surgery in patients with acute cholecystitis undergoing interval laparo- scopic cholecystectomy 显示文摘	Lin KR Ibrahim S Tan NC	2007	Surg Endosc2007，36，8：	1
10	Ep stein-Barr virus and p16INK4A methylation in squamous cell carcinoma and precaneerous lesions ofthe cervix uteri 显示文摘	Kim NR LIN Z Kim KR	2005	J KoreanMed Sci2005，20，4：	1
11	Can current technology be integrated to facilitate laparoscopic living donor hepatectomy?显示文摘	Lin E Gonzalez R Venkatesh KR	2003	Surg Endosc2003，17，：	1
12	Can current technology be integrated to facilitate laparoscopic living donor hepatectomy显示文摘	Lin E Gonzalez R Venkatesh KR	2003	Surg Endosc2003，17，5：	1
13	The effect of intensified low density lipoprotein cholesterol reduction on recurrent myocardial infarction and cardiovascular mortality显示文摘	Huang WC Lin TW Chiou KR	2013	Acta Cardiologica Sinica2013，29，5：	1
14	Epstein-Barr virus and pl6INK4A methylation in squamous cell carcinoma and pre- cancerous lesions of the cervix uteri显示文摘	Kim NR Lin Z Kim KR	2005	Korean Med Sci2005，20，4：	1
15	Constitutive phosphorylation ofGATA-1 at serine26 attenuates the colony-forming activity oferythrocyte-committed progenitors 显示文摘	LIN KR LI CL YEN JJ	2013	PLoS One2013，8，64：	1
16	Neuroimaging in hu man immunodeficiency virus infection显示文摘	Tucker KA Robertson KR Lin WL	2004	J Neuroimmunology2004，157，8：	1
17	Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection 显示文摘	Fried MW Shiffman ML Reddy KR Smith C Marinos G Goncales FL Jr H/iussinger D Diago M Carosi G Dhumeaux D Craxi A Lin A Hoffman J Yu J	2002	N Engl J Med2002，347，13：	1
18	Resveratrol and ischemic preconditioning in the brain显示文摘	Raval AP Lin HW Dave KR	2008	Curr Med Chem2008，15，：	1
19	Budd-Chiari syndrome: evalu- atio with multiphase contrast-enhanced three-dimensional MR an- giography显示文摘	Lin J Chen XH Zhou KR	2003	World J Gastroenterol2003，9，10：	1
20	Epstein - Barr virus and p16INK4A methylation in squamous cell carcinoma and precancerous lesions of the cervix uteri显示文摘	Kim NR Lin Z Kim KR	2005	J Korean Med Sci2005，20，4：	1

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