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| 1 | Routine defunctioning stoma after chemoradiation and total mesorectal excision:A single-surgeon experience显示文摘AIM:To investigate the 10-year results of treating low rectal cancer by a single surgeon in one institution.METHODS:From Oct 1998 to Feb 2009,we prospectively followed a total of 62 patients with cT2-4 low rectal cancer with lower tumor margins measuring at 3 to 6 cm above the anal verge.All patients received neoadjuvant chemoradiation(CRT) for 6 wk.Among them,85% of the patients received 225 mg/m2/d 5-fluorouracil using a portable infusion pump.The whole pelvis received a total dose of 45 Gy of irradiation in 25 fractions over 5 wk.The interval from CRT completion to surgical intervention was planned to be approximately 6-8 wk.Total mesorectal excision(TME) and routine defunctioning stoma construction were performed by one surgeon.The distal resection margin,circumferential resection margin,tumor regression grade(TRG) and other parameters were recorded.We used TRG to evaluate the tumor response after neoadjuvant CRT.We evaluated anal function outcomes using the Memorial Sloan-Kettering Cancer Center anal function scores after closure of the defunctioning stoma.RESULTS:The median distance from the lower margin of rectal cancer to the anal verge was 5 cm:6 cm in 9 patients,5 cm in 32 patients,4 cm in 10 patients,and 3 cm in 11 patients.Before receiving neoadjuvant CRT,45 patients(72.6%) had a cT3-4 tumor,and 21(33.9%) patients had a cN1-2 lymph node status.After CRT,30 patients(48.4%) had a greater than 50% clinical reduction in tumor size.The final pathology reports revealed that 33 patients(53.2%) had a ypT3-4 tumor and 12(19.4%) patients had ypN1-2 lymph node involvement.All patients completed the entire course of neoadjuvant CRT.Most patients developed only Grade 1-2 toxicities during CRT.Thirteen patients(21%) achieved a pathologic complete response.Few post-operative complications occurred.Nearly 90% of the defunctioning stomas were closed within 6 mo.The local recurrence rate was 3.2%.Pathologic lymph node involvement was the only prognostic factor predicting disease recurrence(36.5% vs 76.5%,P = 0.006).Nearly 90% of patients recovered sphincter function within 2 year after closure of the defunctioning stoma.CONCLUSION:Neoadjuvant CRT followed by TME,combined with routine defunctioning stoma construction and high-volume surgeon experience,can provide excellent surgical quality and good local disease control. | Shao-Chieh Lin Po-Chuan Chen Chung-Ta Lee Hong-Ming Tsai Peng-Chan Lin Helen HW Chen Yuan-Hwa Wu Bo-Wen Lin Wen-Pin Su Jenq-Chang Lee | 2013 | World Journal of Gastroenterology2013，19，11： | 3 |
| 2 | Sparganosis, Henan Province, central China 显示文摘 | Cui J Lin XM Zhang HW | 2010 | Emerg Infect Dis2010，17，1： | 1 |
| 3 | Impact of head and neck radiotherapy for patients with nasopharyngeal carcinoma on sleep-related breathing disorders显示文摘 | Lin HC Friedman M Chang HW | 2014 | JAMA Otolaryngol Head Neck Surg2014，140，12： | 1 |
| 4 | Effects of epidural fentanyl on labor pain during the early period of the first stage of induced labor in nulliparous women 显示文摘 | Chen LK Hsu HW Lin C J | 2000 | J Formos Med Assoc2000，99，7： | 1 |
| 5 | Impact of age on the in- jury pattern and survival of people with cervical cord injuries显示文摘 | Liang HW Wang YH Lin YN | 2001 | Spinal Cord2001，39，： | 1 |
| 6 | Grassland responses to grazing:effects of grazing intensity and management system in an Inner Mongolian steppe ecosystem显示文摘 | Sch(o)nbach P Wan HW Gierus M Bai YF Müller K Lin LJ Susenbeth A Taube F | | 0，，： | 1 |
| 7 | Assessment of genetic damage by methyl methacrylate employing in vitro mammalian test system显示文摘 | Yang HW Lin SS Chou MY | 2003 | Biomateria2003，24，2： | 1 |
| 8 | Resveratrol and ischemic preconditioning in the brain显示文摘 | Raval AP Lin HW Dave KR | 2008 | Curr Med Chem2008，15，15： | 1 |
| 9 | Prevalence and risk factorsof middle cerebral artery stenosis in asymptomatic residents in Rongqi County,Guangdong显示文摘 | Huang HW Guo MH Lin RJ | | 0，，01： | 1 |
| 10 | Finite element a- nalysis of plantar fascia under stretch-the relative con- tribution of windlass mechanism and achilles tendon force 显示文摘 | Cheng HY Lin CL Wang HW | 2008 | J Biomech2008，11，2： | 1 |
| 11 | Hyperhomocysteinemia is a risk factor of middle cerebral artery stenosis显示文摘 | Huang HW Guo MH Lin RJ | 2007 | J Neurol2007，254，3： | 1 |
| 12 | Sparganosis, Henan Province, centralChina显示文摘 | Cui J Lin XM Zhang HW | 2010 | Emerg Infect Dis2010，17，1： | 1 |
| 13 | Prevalence and risk factors of middle cerebral artery stenosis in asymptomatic residents in Rongqi County, Guangdong显示文摘 | Huang HW Guo MH Lin RJ | 2007 | Cerebrovasc Dis2007，24，： | 1 |
| 14 | Risk of ovarian cancer in women with pelvic inflammatory disease: a population-based study 显示文摘 | Lin HW Tu YY Lin SY | 2011 | Lancet Oncol2011，12，9： | 1 |
| 15 | The efficacy of multilevel surgery of the upper airway in adults with obstructive sleep apnea/ hypopnea syndrome显示文摘 | Lin HC Friedman M Chang HW | 2008 | Laryngoscope2008，118，5： | 1 |
| 16 | Effects of epiduralfentany on la- bor pain during the early period of the first stage of induced labor in nulliparous women显示文摘 | Chen LK Hsu HW Lin CJ | 2000 | J Formosa Med Assoc2000，99，7： | 1 |
| 17 | Neuroprotective effects of glyceryl nonivamide against microglia like cells and 6 hydroxydopamine-induced neurotoxicity in SH-SYSY human dopaminergic neuroblastoma cells显示文摘 | Lin YC Uang HW Lin RJ | 2007 | J Pharmacol Exp Ther2007，323，： | 1 |
| 18 | Must metabolic acidosis be associated with malnutrition in hemedialysis patients? 显示文摘 | Lin SH Lin YF Chin HW | 2002 | Nephrol Dial Transplant2002，17，9： | 1 |
| 19 | Air impingement drying characteristics and quality of carrot cubes 显示文摘 | Xiao HW Gao Z J Lin H | 2010 | Journal of Food Process Engineering2010，33，5： | 1 |
| 20 | Grassland responses to grazing:effects of grazing intensity and management system in an Inner Mongolian steppe ecosystem显示文摘 | Sch(o)nbach P Wan HW Gierus M Bai YF Müller K Lin LJ Susenbeth A Taube F | | 0，，： | 1 |
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