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| 1 | Viral and host causes of fatty liver in chronic hepatitis B显示文摘AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P<0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P<0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P>0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P<0.05). No significant difference was found in the other parameters between the groups (P>0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage. | Emin Altiparmak Seyfettin K(o|¨)klü Mesut Yalinkilic Osman Yüksel Bahattin Cicek Ertugrul Kayacetin Tülin Sahin | 2005 | World Journal of Gastroenterology2005，11，20： | 52 |
| 2 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 3 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 4 | TLR4 signaling attenuates ongoing allergic inflammation 显示文摘 | Hollingsworth JW Whitehead GS Lin KL | 2006 | Immunol2006，176，10： | 1 |
| 5 | Intravital imaging of donor allogeneic effector and regulatory T cells with host dendritic cells during GVHD显示文摘 | Lin KL Fulton LM Berginski M | 2014 | Blood2014，123，： | 1 |
| 6 | Transcranial Doppler sonography in the early stage of critical enteroviral infection显示文摘 | Chen KS Lin KL Wang HS | 2003 | J Ultrasound Med2003，22，10： | 1 |
| 7 | Neuroimaging correlation with neurological severity in tuberous sclerosis complex 显示文摘 | Chou IJ Lin KL Wong AM | 2008 | Eur J Paedi- atr Neurol2008，12，2： | 1 |
| 8 | Origin, distribution and morphology of galaninergic fibers in the rodent trigeminal system显示文摘 | Waterhouse BD Lin RC | 1999 | J Comp Neurol1999，411，： | 1 |
| 9 | Multiple signaling pathways are activated during insulin-like growth factor-Ⅰ (IGF-Ⅰ) stimulated breast cancer cell migration显示文摘 | Zhang X Lin M van Golen KL | 2005 | Breast Cancer Res Treat2005，93，2： | 1 |
| 10 | Comparative assessment of published atrial fi- brillation stroke risk stratification schemes for predicting stroke, in a non-atrial fibrillation population: The Chin-Shah Community Cohort Study显示文摘 | Lip GY Lin HJ Chien KL | 2013 | Int J Cardi- ol2013，168，1： | 1 |
| 11 | The BRAF mutation is predictive of aggressive clinicopathological characteris- tics in papillary thyroid microcarcinoma显示文摘 | Lin KL Wang OC Zhang XH | 2010 | Ann Surg On- col2010，17，12： | 1 |
| 12 | Central nervous system manifesta- tions of neonatal lupus :a systematic review显示文摘 | Chen CC Lin KL Chen CL | 2013 | Lupus2013，22，14： | 1 |
| 13 | Total white blood cell count or neutrophil count predict ischemic stroke events among adult Taiwanese: report from a community-based cohort study 显示文摘 | Wn TH Chien KL Lin H J | 2013 | BMC Neurol2013，13，7： | 1 |
| 14 | Otitis media with effusion in Patients with Nasopharyngeal carcinoma, postirradiation显示文摘 | Young YH Lin KL Ko JY | 1995 | Arch Otolaryngol Head Neck sury1995，121，7： | 1 |
| 15 | Activation of complement and neutrophils increases vascular permeability during air embolism显示文摘 | Huang KL Lin YC | 1997 | Aviat Space Environ Med1997，68，4： | 1 |
| 16 | Elevation of High-mobility group protein box-1 in serum correlates with severity of acute intracerebral hemorrhage 显示文摘 | Zhou Y Xiong KL Lin S | 2010 | Mediators Inflamm2010，2010，14： | 1 |
| 17 | Neurobiology of HIV,psychiatric and substance abuse comorbidity research:Workshop report显示文摘 | Kopnisky KL Bao J Lin YW | 2007 | Brain Behav Immun2007，21，4： | 1 |
| 18 | Outcome of enterovirus 71 infections with or without stage-based management:1998 to 2002显示文摘 | Cheng LY Hsla SH Wu CT Huang YC Lin KL Fang TY Lin TY | 2004 | Pediatr Infect Dis J2004，23，3： | 1 |
| 19 | Diagnosis and surgical treatmentof multiple endocrine neoplasia type 2A 显示文摘 | Tang KL Lin Y Li LM | 2014 | World J SurgOncol2014，12，： | 1 |
| 20 | Morphologic characteristics of atlantoaxial complex in rheumatoid arthritis and surgical consideration among Chinese显示文摘 | Chen TY Lin KL Ho HH | 2004 | Spine2004，29，9： | 1 |
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