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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Hough transform on reconfigurable meshes显示文摘 | Chung K L Lin H Y | 1995 | Computer Vision and Image Understanding1995，61，2： | 2 |
| 3 | Modeling and High -precision Control of a Ball-screw-drive Stage 显示文摘 | Chen C L Jang M J Lin K C | 2004 | Precision Engineering2004，28，： | 1 |
| 4 | Bench-scale membrane degumming of crude vegetable oil : process optimization 显示文摘 | Lin L Rhee K C | 1997 | Journal of Membrane Science1997，134，1： | 1 |
| 5 | Bi-directional dc to dc converters for fuel cell systems显示文摘 | Wang K Lin C Y Zhu L | 1998 | Power Electronics in Transportation1998，4751，： | 1 |
| 6 | Highly efficient expression of fish growth hormone by Escherichia coli cells显示文摘 | Tsai H J Lin K L Kuo J C | 1995 | Applied and Environmental Microbiology1995，61，11： | 1 |
| 7 | Newcastle disease virus isolated from recent outbreaks in Taiwan phylogenetically related to viruses (genotype VII) from recent outbreaks in western Europe显示文摘 | Cheng-Yao Yang Shieh H K lin Y L | 1999 | Avian Disease1999，43，： | 1 |
| 8 | Seismic slope behavior in a large-scale shaking table model test显示文摘 | LIN M L WANG K L | 2006 | Engineering Geology2006，86，23： | 1 |
| 9 | Use of thin film transistor liquid crystal display ( TFT-LCD) waste glass in the production of ceramic tiles 显示文摘 | LIN K L | 2007 | J HazardMater2007，148，： | 1 |
| 10 | Genome-wide atlas of transcription through maize development显示文摘 | Sekhon R S Lin H Childs K L Hirsch C N Buell C R de Leon N Kaeppler S M | 2011 | The Plant Journal2011，66，4： | 1 |
| 11 | Preparation and properties of nano-silica modified nega- tive acrylate photoresist 显示文摘 | Lee C K Don T M Lai W C Chert C C Lin D J Cheng L P | 2008 | Thin Solid Films2008，516，23： | 1 |
| 12 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 13 | Predicting parameters of degradation succession processes of Tibetan kobresia grasslands显示文摘 | LIN L LI Y K XU X L | 2015 | Solid Earth2015，6，4： | 1 |
| 14 | Preclinical efficacy of the PARP inhibitor rucaparib (CO-338/AG014699/ PF-01367338) in pancreatic cancer models with homologous recombination deficiencies (HRD) 显示文摘 | Robillard L Lin K Lopez-Casas P P | 2014 | Eur J Cancer2014，50，6： | 1 |
| 15 | Theaflavin-3,3'-digallat from black tea blocks the nitric oxide synthase by down-regulating the aetivation of NF- kappaB in macrophages 显示文摘 | Lin Y L Tsai S H Lin-Shiau S Y Ho C T Lin J K | 1999 | Eur J Pharmaeol1999，367，： | 1 |
| 16 | CO2 reforming of methane to synthesis gas over sol-gel-made Co/γ-Al2O3 catalysts from organometallic precursors显示文摘 | JI L TANG S ZENG H C LIN J TAN K L | 2001 | Appl Catal A2001，207，12： | 1 |
| 17 | Dissolved and particulate organic carbon in the southern East China Sea显示文摘 | HUNG J J LIN P L LIU K K | 2000 | Continental Shelf Re search2000，20，： | 1 |
| 18 | A screening assay for antiviral compounds targeted to the HIV- 1 gp41 core structure using a conformation-specific monoclonal antibody显示文摘 | Jiang S B Lin K Zhang L | 1999 | Virol Methods1999，80，： | 1 |
| 19 | Expression of p63 (TA and △ N isoforms) in human primary well differentiated buccal carcinomas显示文摘 | Chen Y K Hsue S S Lin L M | 2004 | Int J Oral Maxillolfacial Surg2004，33，： | 1 |
| 20 | Highly efficient expression of fish growth hormone by Escherichia coli cells显示文摘 | TSAI H J LIN K L KUO J C | 1995 | Appl Environ Microbiol1995，61，11： | 1 |
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