|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Up-regulation of PIK3CA promotes metastasis in gastric carcinoma显示文摘AIM:To explore expressions of PIK3CA in the progression of gastric cancer from primary to metastasis and its effects on activation of phosphatidylinositol 3-kinase(PI3K)/Akt pathway.METHODS:mRNA and protein levels of PIK3CA were assessed,respectively,by real-time quantitative polymerase chain reaction and immunohistochemistry in specimens of normal gastric mucosa,primary foci and lymph node and distant metastasis of gastric cancer.Akt and phosphorylated Akt protein were also examined by Western blotting in these tissues,in order to analyze the effect of PIK3CA expression level changes on the activation of PI3K/Akt signaling pathway.RESULTS:PIK3CA mRNA in lymph node metastasis were approximately 5 and 2 folds higher,respectively,than that in the corresponding normal gastric mucosa and primary gastric cancer tissues(P<0.05),while no statistical significance was found compared with distant metastasis.Immunohistochemically,PIK3CA protein expression was discovered in 7(35%)specimens of 20 primary foci vs 10(67%)of 15 of lymph node metastasis or 11(61%)of 18 of distant metastasis(35%vs 67%,P=0.015;35%vs 61%,P=0.044).With the increased level of PIK3CA expression,the total Akt protein expression remained almost unchanged,but p-Akt protein was upregulated markedly.CONCLUSION:Increased expression of PIK3CA is expected to be a promising indicator of metastasis in gastric cancer.Up-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling. | Liu JF Zhou XK Chen JH Yi G Chen HG Ba MC Lin SQ Qi YC. | 2010 | World Journal of Gastroenterology2010，16，39： | 20 |
| 2 | Overexpression of P-glycoprotein in hepatocellular carcinoma and its clinical implication显示文摘INTRODUCTIONMost advanced hepatocellular garcinoma (HCC) isinsensitive to most anticancer drugs which might berelated to the high frequency of expression of themultidrug resistance-1(MDR1) gene and itsproduct,P-glycoprotein (p-gp).p-gp expressionmay also be concerned with tumor progression anddifferentiation.In the present study。 | Kong XB Yang ZK Liang LJ Huang JF Lin HL | 2000 | World Journal of Gastroenterology2000，6，1： | 13 |
| 3 | Study and Application of Polarographic Catalytic Wave of Chlordiazepoxide in the Presence of Persulfate显示文摘Polarographic catalytic wave of chlordiazepoxide in the presence of K2S2O8 was studied in aqueous and DMF/H2O mixed solutions,The results showed that a single reduction wave in alkaline medium was the reduction of the N=C bond in 1,2-position of chlordiazepoxide via an intermediate free radical in two one-electron successive additions,When K2S2O8 was present,the free radical of the N=C bond was oxidized to regenerate the original,producing a parallel catalytic wave of chlordiazepoxide,It was determined that the apparent rate constant kf of the oxidation reaction was 3.2×10^3 mol^-1.L.s^-1,Using the catalytic wave the trace of chlordiazepoxide can be determined by linear-potential scan polarography,In NH3/NH4Cl(pH 10.2±0.1,0.12mol/L)/K2S2O8(0.016mol/L)supporting electrolyte,the second-order derivative peak current of the catalytic wave was rectilinear to chlordiazepoxide concentration in the range of 3.20×10^-8-1.60×10^-7,1.60×10^-7-1.44×10^-6 and 1.44×10^-6-1.44×10^-5mol/L,respectively.The limit of detection was 9.0×10^-9mol/L. | Guo, W Lin, H Liu, LM Guo, ZA Song, JF | 2002 | Chinese Journal of Chemistry2002，20，5： | 3 |
| 4 | SUPERCONVERGENCE OF DISCONTINUOUS GALERKIN METHOD FOR NONSTATIONARY HYPERBOLIC EQUATION显示文摘AbstractFor the first order nonstationary hyperbolic equation taking the piecewise linear discontinuous Galerkin solver, we prove that under the uniform rectangular partition, such a discontinuous solver, after postprossesing, can have two and half approximative order which is half order higher than the optimal estimate by Lesaint and Raviart under the rectangular partition. | Chen, Y Lin, JF Lin, Q | 2002 | Journal of Computational Mathematics2002，20，4： | 2 |
| 5 | Partitioning regularity of nonionic organic mixtures in organic phase/water system显示文摘The partitioning regularity of nonionic organic mixtures in organic phase/water system is revealed. The equation for calculating the partition coefficients of mixtures (KMD), together with the determination model, is derived from the equilibrium partitioning models (EPMs). Based on these derived equations, the KMD values of 20 mixtures containing halogenated benzenes are obtained. The results show that stronger hydrophobidty of an individual chemical in the mixture results in the stronger hydrophobidty of the mixture and the greater the proportion of this chemical, the stronger the hydrophobidty of the mixture will be. This partitioning regularity is helpful to the study of the toxicity for mixtures and the environmental behavior, such as transfer or accumulation, for mixed organic pollutants. | Lin, ZF Yu, HX Huang, LM Feng, JF Wang, LS | 2001 | Chinese Science Bulletin2001，46，17： | 2 |
| 6 | A comparison of corneal endothelial changes after use of Healon or Viscoat during phacoemulsification 显示文摘 | Koch DD Lin JF Glasser DB | 1993 | Am J Ophthalmol1993，115，： | 1 |
| 7 | Pathogenetic role of eNOSuncoupling in cardiopulmonary disorders显示文摘 | Gielis JF Lin JY Wingler K | 2011 | Free Radic BiolMed2011，50，7： | 1 |
| 8 | Changes in levels of hope after diagnostic disclosure among Talwanese patients with cancer显示文摘 | Lin CC Tsai HF Chiou JF | 2003 | Cancer Nursing2003，26，2： | 1 |
| 9 | Combination of diane-35 andmetformin to treat early endometrial carcinoma in PCOSwomen with insulin resistance显示文摘 | Li X Guo YR Lin JF | 2014 | J Cancer2014，5，3： | 1 |
| 10 | Contents of fluoride, lead, copper, chromium, arsenic and cadmium in Chinese Pu-erhtea 显示文摘 | LV HP LIN Z TAN JF | 2013 | Food Research International2013，53，： | 1 |
| 11 | Clinical characteristicsand surgical management of familial exudativevitreoretinopathy -associated rhegmatogenous retinaldetachment 显示文摘 | Chen SN Hwang JF Lin CJ | 2012 | Retina2012，32，2： | 1 |
| 12 | Prediction of Alzheimer's disease in mild cognitive impairment: A prospective study in Taiwan显示文摘 | Wang PN Limg JF Lin KN Chang FC Liu HC | 2006 | 中国生物学文摘2006，20，8： | 1 |
| 13 | Management of blunt major pancreatic injury显示文摘 | Lin BC Chen RJ Fang JF | 2004 | J Trauma2004，56，4： | 1 |
| 14 | Laparoscopic decompression of abdominal compartment syndrome after blunt hepatic trauma显示文摘 | Chen RJ Fang JF Lin BC | 2000 | Surg Endosc2000，14，10： | 1 |
| 15 | Solitary S-100-positive congenital granular cell tumor of the tongue: a case report and literature review显示文摘 | He JF Lin Y Liu JH | 2014 | Ann Plast Surg2014，72，6： | 1 |
| 16 | Method to detect only viable cells in microbial ecology 显示文摘 | Luo JF Lin WT Guo Y | 2009 | Applied Microbiology and Bioteehnology2009，86，1： | 1 |
| 17 | Macrophages regulate the angiogenic switch in a mouse model of breast cancer 显示文摘 | Lin 15Y Li JF Gnatovskiy L Deng Y Zhu L Grzesik DA | 2006 | Cancer Res2006，66，11： | 1 |
| 18 | Changes in levels of hope after diagnostic disclosure among Taiwanese patients with cancer显示文摘 | Lin CC Tai HF Chou JF | 2003 | Cancer Nursing2003，26，2： | 1 |
| 19 | Reverse of progestin-resistant atypical endometrial hyperplasia by metformin and oral contraceptives显示文摘 | Shen ZQ Zhu HT Lin JF | 2008 | Obstet Gyuecol2008，112，2： | 1 |
| 20 | Moderate hypothermia significantly decreases hippocampal cell death involving autophagy pathway alter moderate traumatic brain injury 显示文摘 | Jin Y Lin Y Fang JF | 2015 | J Neurotrauma2015，32，14： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员