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| 1 | MicroRNA-21 as a potential colon and rectal cancer biomarker显示文摘Colorectal cancer(CRC)is one of the most common malignant diseases worldwide and the prognosis is still poor although much progress has been achieved in recent years.In order to reduce CRC-related deaths,many studies are aimed at identifying novel screeningand prognosis-related biomarkers.MicroRNAs(miRNAs)are a class of 18-27-nucleotide single-stranded RNA molecules that regulate gene expression at the posttranscriptional level.It has been demonstrated that miRNAs regulate a variety of physiological functions,including development,cell differentiation,proliferation,and apoptosis.They play important roles in various physiologic and developmental processes and in the initiation and progression of various human cancers.It has been shown that miRNAs can critically regulate tumor cell gene expression,and evidence suggests that they may function as both oncogenes and tumor suppressor genes.In CRC,miRNAs-21 is one of the most important miRNAs and is rapidly emerging as a novel biomarker in CRC,with good potential as a diagnostic and therapeutic target.In this review,we summarize the latest research findings of the clinicopathological relevance of miRNAs-21 in CRC initiation,development,and progress,highlighting its potential diagnostic,prognostic,and therapeutic application,as well as discuss-ing future prospects. | Tao Li Mei Ha Leong Bruce Harms Gregory Kennedy Lin Chen | 2013 | World Journal of Gastroenterology2013，19，34： | 16 |
| 2 | Altered serum level of cartilage oligomeric matrix protein and its association with coronary calcification in patients with coronary heart disease显示文摘BackgroundCartilage oligomeric 矩阵蛋白质(COMP ) 主要在骨胳的系统和脉管的光滑的肌肉房间被发现。最近的研究证明它在血容器上有保护的功能并且能也禁止脉管的石灰化。我们在冠的心疾病( CHD )调查了浆液 COMP 病人,并且在浆液 COMP 和首先经历了多片跟随的冠的 angiography 的 233 个连续的胸疼痛病人全部的冠的 artery.MethodsA 的石灰化之间的关系在六个月以内计算了断层摄影术( MSCT )被招募并且根据缩小百分比的冠的 angiography 钠直径划分了成二个组:CHD 组(缩小 50% 的直径, n = 194 ) 并且控制组(直径变窄 <50% , n = 39 ) 。Gensini 分数,句法分数和冠的动脉钙分数(CAC ) 是计算的。浆液 COMP 水平用 COMP 的 ELISA.ResultsThe 层次被决定比在控制组在 CHD 组是显著地更高的 155.7 (124.5-194.5 ) ng/mL 对 128.4 (113.0-159.9 ) ng/mL, P = 0.019。在 COMP, Gensini 分数,句法分数,冠的狭窄的严厉和有狭窄的冠的动脉的数字之间没有关联 >50% 。浆液 COMP 与年龄被相关(r = 0.294, P < 0.001 ) , fasting 葡萄糖(r = 0.163, P = 0.015 ) , HbA1c (r = 0.194, P = 0.015 ) 并且 CAC (r = 0.137, P = 0.037 ) 。逐步的线性回归分析显示出那 COMP 水平,年龄是在 CHD 病人的 CAC 的独立预言者(= 0.402, t = 2.612, P = 0.015;= 0.472, t = 3.077, P = 0.005 ) 。为预言 CHD 的 COMP 的性能在曲线(AUC ) 下面作为区域被显示出:0.632, 95% CI:0.549-0.715 和上面的 tertile CAC 是 AUC:0.602, 95% CI:在操作冠的动脉的特征(巨鸟) 曲线 analysis.ConclusionCalcification 的接收装置的 0.526-0.678 是浆液 COMP 的一个独立预言者。 | Fang-Fang WANG Lahati HA Hai-Yi YU Lin MI Jiang-Li HAN Wei GAO | 2017 | Journal of Geriatric Cardiology2017，14，2： | 15 |
| 3 | Regional eco-efficiency evaluation and spatial pattern analysis of the Yangtze River Economic Zone显示文摘The environmental ecology of the Yangtze River Economic Zone(YREZ)faces ecological function decline,deterioration and degradation under intense human activities,long-term development and utilization and its economy has developed rapidly over recent decades.Eco-efficiency is considered as a measure of coordinated development of economy,resources,environment and ecology,and is currently considered a very important issue.In this paper,based on the slack-based measure and data envelope analysis model,we take 129 prefecture-level cities of the YREZ as the study unit and measure the eco-efficiency of the YREZ in 2000,2005,2010 and 2015,which considers undesired output.The evaluation of the status quo of the regional eco-efficiency development was carried out at provincial,prefectural and city scales.The spatial autocorrelation test model and standard deviation ellipse were used to analyze the spatially distributed characteristics and the evolutionary regularity of eco-efficiency.Our study suggested that the eco-efficiency value varied significantly at different spatiotemporal scales and the overall distribution presented an'N-shaped'pattern,the value is the largest downstream and the smallest upstream.Regional eco-efficiency presented certain volatility in growth and a clear spatial positive agglomeration trend from 2000 to 2015.The spatial distribution of each agglomeration area was also significantly different,forming some high-high agglomeration areas at the center of the shaft with Shanghai and surrounding cities,and some low-low agglomeration areas at the center with middle reaches and upstream cities.The low-high over-aggregation and high-low polarization clusters were fewer.At the same time,with the change of the research period,the degree of positive agglomeration became increasingly pronounced and the eco-efficiency gap of the neighborhoodunit reduced.The regional eco-efficiency value of the YREZ presented a spatial distribution pattern in the northeast-southwest axis and the evolutionary pattern of the regional eco-efficiency similarly showed a northeast-southwest orientation. | HA Lin TU Jianjun YANG Jianping XU Chunhai PANG Jiaxing LU Debin YAO Zuolin ZHAO Wenyu | 2020 | Journal of Geographical Sciences2020，30，7： | 8 |
| 4 | Late Cenozoic Sedimentary Evolution of Pagri-Duoqing Co graben, Southern End of Yadong-Gulu Rift, Southern Tibet显示文摘The north trending rifts in southern Tibet represent the E-W extension of the plateau and confirming the initial rifting age is key to the study of mechanics of these rifts. Pagri-Duoqing Co graben is located at southern end of Yadong-Gulu rift, where the late Cenozoic sediments is predominately composed of fluvio-lacustrine and moraine. Based on the sedimentary composition and structures, the fluviolacustrine could be divided into three facies, namely, lacustrine, lacustrine fan delta and alluvial fan. The presence of paleo-currents and conglomerate components and the provenance of the strata around the graben indicate that it was Tethys Himalaya and High Himalaya. Electron spin resonance(ESR) dating and paleo-magnetic dating suggest that the age of the strata ranges from ca. 1.2 Ma to ca. 8 Ma. Optically stimulated luminescence(OSL) dating showed that moraine in the graben mainly developed from around181-109 ka(late Middle Pleistocene). Combining previous data about the Late Cenozoic strata in other basins, it is suggested that 8-15 Ma may be the initial rifting time. Together with sediment distribution and drainage system, the sedimentary evolution of Pagri could be divided into four stages. The graben rifted at around 15-8 Ma due to the eastern graben-boundary fault resulting in the appearance of a paleolake.Following by a geologically quiet period about 8-2.5 Ma, the paleolake expanded from east to west at around 8-6 Ma reaching its maximum at ca. 6 Ma. Then, the graben was broken at about 2.5 Ma. At last,the development of the glacier separated the graben into two parts that were Pagri and Duoqing Co since the later stages of the Middle Pleistocene. The evolution process suggested that the former three stages were related to the tectonic movement, which determined the basement of the graben, while the last stage may have been influenced by glacial activity caused by climate change. | HA Guanghao WU Zhonghai HE Lin WANG Shubing | 2018 | Acta Geologica Sinica(English Edition)2018，92，3： | 3 |
| 5 | Spatiotemporal patterns and influencing factors of human migration networks in China during COVID-19显示文摘The social lockdowns and strict control measures initiated to combat the COVID-19 pandemic have had an impact on human migration.In this study,big data was used to analyze spatial patterns of population migration in 369 Chinese cities during the COVID-19 outbreak and to identify determinants of population migration.We found that the overall migration intensity decreased by 39.87%compared to the same period in 2019 prior to the COVID-19 outbreak.COVID-19 severely affected human migration.The public holidays and weekends have impacted human migration from the perspective of time scale.The spatial pattern of China’s population distribution presents a diamond structure that is dense in the east and sparse in the west,which is bounded by the Hu line and the cities such as Beijing,Shanghai,Guangzhou and Chengdu as nodes to connect.There is a strong consistency between the population distribution center and the level of urban development.The urban human migration network is centered on provincial capitals or municipalities at the regional scale,showing a prominent'center-periphery'structure.COVID-19 dispersed the forces of human migration in time and changed the direction of human migration in space.But it did not change the pattern of national migration.The most critical factors influencing mass migration are income levels and traditional culture.This study reveals the impacts of major public health emergencies on conventional migration patterns and provides a scientific theoretical reference for COVID-19 prevention and control. | Debin Lu Wu Xiao Guoyu Xu Lin Ha Dongyang Yang | 2021 | Geography and Sustainability2021，2，4： | 2 |
| 6 | Broadband omnidirectional light detection in flexible and hierarchical ZnO/Si heterojunction photodiodes显示文摘灵活光电探测器的开发包括灵活图象传感器,生物医学的成像,和聪明的、便携系统为未来 optoelectronic 应用程序收到了大注意。以前,全向的光电探测器由多重光电探测器上的一个半球的 microlens 集会的集成仅仅是可完成的。此处,组织蜂房的 Si ( H-Si )膜上的 ZnO nanowires ( NW )的一个层次光电二极管图案被表明展出优秀全向的轻吸收的能力并且因此在女人上维持高光电流光谱为宽事件角度的范围( 365~1,100 nm )( 0io 是超过 6.00~10 个病人和 35 age-/gender-matched 控制吗(吝啬的 s ?? | Seongdong Lim Doo-Seung Um Minjeong Ha Qianpeng Zhang Youngsu Lee Yuanjing Lin Zhiyong Fan Hyunhyub Ko | 2017 | Nano Research2017，10，1： | 2 |
| 7 | Initial Rifting Age of the Nearly N–S Rifts in Southern Tibetan Plateau:New Evidence from the Age limit of the Early Sediments显示文摘Objective The nearly parallel N–S-trending rifts in southern Tibet represent the E–W extension of the Tibet Plateau.Most data which constrained the age of the extensional deformation come from isotopic dating of the dikes probably related to the activity of the nearly N–S faulting and micas from hydrothermal activity and the lowtemperature thermochronology of plateau uplift. | HA Guanghao WU Zhonghai HE Lin WANG Shubing | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 2 |
| 8 | Current status and trends in forest genomics显示文摘Forests are not only the most predominant of the Earth's terrestrial ecosystems,but are also the core supply for essential products for human use.However,global climate change and ongoing population explosion severely threatens the health of the forest ecosystem and aggravtes the deforestation and forest degradation.Forest genomics has great potential of increasing forest productivity and adaptation to the changing climate.In the last two decades,the field of forest genomics has advanced quickly owing to the advent of multiple high-throughput sequencing technologies,single cell RNA-seq,clustered regularly interspaced short palindromic repeats(CRISPR)-mediated genome editing,and spatial transcriptomes,as well as bioinformatics analysis technologies,which have led to the generation of multidimensional,multilayered,and spatiotemporal gene expression data.These technologies,together with basic technologies routinely used in plant biotechnology,enable us to tackle many important or unique issues in forest biology,and provide a panoramic view and an integrative elucidation of molecular regulatory mechanisms underlying phenotypic changes and variations.In this review,we recapitulated the advancement and current status of 12 research branches of forest genomics,and then provided future research directions and focuses for each area.Evidently,a shift from simple biotechnology-based research to advanced and integrative genomics research,and a setup for investigation and interpretation of many spatiotemporal development and differentiation issues in forest genomics have just begun to emerge. | Dulal Borthakur Victor Busov Xuan Hieu Cao Qingzhang Du Oliver Gailing Fikret Isik Jae-Heung Ko Chenghao Li Quanzi Li Shihui Niu Guanzheng Qu Thi Ha Giang Vu Xiao-Ru Wang Zhigang Wei Lin Zhang Hairong Wei | 2022 | Forestry Research2022，2，1： | 2 |
| 9 | Mesomorphic behavior of new benzothiazole liquid crystals having Schiff base linker and terminal methyl group显示文摘heterocycles 的一个相应系列, 6-methyl-2-(4-alkoxybenzylidenamino ) benzothiazoles,被综合并且描绘了使用英尺红外, 1H 和 13C NMR 和集体度谱的分析。二形互变的 nematic 阶段为更矮的成员被观察。近晶的 A 阶段仅仅向前从 octyloxy 衍生物出现了。在 benzothiazole 碎片和 Schiff 基础连接的终端甲基组影响了现在的系列的具有由中胚叶发达的行为。 | Sie Tiong Ha Kok Leei Foo Hong Cheu Lin Masato M.Ito Kazuma Abe Kenji Kunbo S.Sreehari Sastry | 2012 | Chinese Chemical Letters2012，23，7： | 2 |
| 10 | Steam reforming of methanol using supported Moo C catalysts 显示文摘 | LIN S S Y THOMSON W J HAGENSEN T J HA S Y | 2007 | Appl Catal A: Gen2007，318，： | 1 |
| 11 | Reduction of hospi- tal stay and cost after the implementation of a clinical pathway for radical gestrectomy for gastric cancer 显示文摘 | Jimmy BY Ziliang LL Lin HA | 2008 | Gastric Cancer2008，11，1： | 1 |
| 12 | The effects of blood glucose control upon fracture heating in the BB Wistar rat with diabetes mellitus显示文摘 | BEAM HA PARSONS JR LIN SS | 2002 | J Orthop Res2002，20，6： | 1 |
| 13 | Chronic Achilles tendon rupture treated with two turndown flaps and flexor halhicis longus augmentation-two-year clinical outcome显示文摘 | Tay D Lin HA Tan BS | 2010 | Ann Acad Med Singapore2010，39，1： | 1 |
| 14 | Delayed cochlear implantation after surgical mlabyrinthectomy显示文摘 | Osborn HA Yeung R Lin VY | 2012 | J Laryngol Oto12012，126，1： | 1 |
| 15 | SF3B1 mutations in patients with myelodysplastic syndromes: the mutatio- nis stable during disease evolution显示文摘 | Lin CC Hou HA Chou WC | 2014 | Am J Hematol2014，89，8： | 1 |
| 16 | Comparative study between use of arthroscopy lavage and arthrocentesis of temporomandibular joint based on computational fluid dynamics analysis 显示文摘 | XuYue Y Lin Han HA | 2012 | Journal of maxillofacial and oral surgery2012，11，1： | 1 |
| 17 | The effects of blood glu- cose control upon fracture healing in the BB Wistar rat with diabetes mellitus 显示文摘 | Beam HA Parsons JR Lin SS | 2002 | J Orthop Res2002，20，6： | 1 |
| 18 | Assessment of left and right ventricularsystolic and diastolic synchronicity in normal subjects by tissueDoppler echocardiography and the effects of age and heart rate显示文摘 | Yu CM Lin H Ha PC | 2003 | Echocardiography2003，20，1： | 1 |
| 19 | WT1 mutation in470adult patients with acute myeloid leukemia:stability during disease evolution and implication of its incorporation into a survival scoring system显示文摘 | Hou HA Huang TC Lin LI | 2010 | Blood2010，115，： | 1 |
| 20 | Serum bilirubin and genes controlling bilirubin concentrations as biomarkers for cardiovascular disease显示文摘 | Lin JP Vitek L Schwertner HA | | 0，，10： | 1 |
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