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| 1 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009,19,3: | 9 |
| 2 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018,26,4: | 3 |
| 3 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016,0,12: | 2 |
| 4 | The gene for an abundant parasite coat protein predicts tandemly repetitive mental binding domains 显示文摘 | Clark T G Lin Tian-Long Jackwood D A | 1999 | Gene1999,229,: | 2 |
| 5 | The role of the surgeon in the evolution of flexible endoscopy显示文摘 | Morgenthal C B Richards W O Dunkin B J Forde K A Vitale G Lin E | 2007 | Surg Endosc2007,21,6: | 1 |
| 6 | Selective oxidation of gas phase ammonia over copper chromites catalysts prepared by the sol-gel process显示文摘 | Kaddouri A Dupont N Gélin P | | 0,,01: | 1 |
| 7 | Selective constraint on human pre-mRNA splicing by protein structural properties显示文摘 | GELLY J C LIN H Y DE BREVERN A G et ol | 2012 | Genome Biology and Evolution2012,4,9: | 1 |
| 8 | Developmental potential of Gcn5^-/- embryonic stem cells in vivo and in vitro 显示文摘 | Lin W Srajer G Evrard Y A | 2007 | Dev Dyn2007,236,6: | 1 |
| 9 | Photoassisted bleaching of dyes utilizing TiO2 and visible light 显示文摘 | Eqling G A Lin C | 2002 | Chemosphere2002,46,: | 1 |
| 10 | Adhesion of olefin block copolymers to polypropylene and high density polyethylene and their effectiveness as compatibilizers in blends 显示文摘 | Lin Y Marchand G R Hiltner A | 2011 | Polymer2011,52,7: | 1 |
| 11 | Adhesion of olefinblock copolymers to polypropylene and high density polyethyleneand their effectiveness as compatibilizers in blends显示文摘 | Lin Yijian Marchand G R Hiltner A | 2011 | Polymer2011,52,16: | 1 |
| 12 | Agency cost and owner- ship structure 显示文摘 | Ang G S Cole R A Lin J W | 2000 | Journal of Finance2000,55,: | 1 |
| 13 | Photoassisted bleaching of dyes utilizing TiO2 and visible light 显示文摘 | Epling G A Lin C | 2002 | Chemosphere2002,46,: | 1 |
| 14 | Nucleotide sequence of porcine circovirus associated with postweaning multisystemic wasting syndrome in pigs显示文摘 | Hamel A L Lin L L Nayar G P | 1998 | J Virol1998,72,6: | 1 |
| 15 | Nucleotide sequence of porcine circovirus associated with postweaning multisystemic wasting syndrome in pigs显示文摘 | Hamel A L Lin L L Nayar G P | 1998 | J Virol1998,72,: | 1 |
| 16 | Detection of specific and constitutive antibody secreting cells in the gills, head kidney and peripheral blood leucocytes of dab (Limanda limanda)显示文摘 | Davidson G A Lin S H Secombes C J | 1997 | Vet Immunol Immuno- pathol1997,58,34: | 1 |
| 17 | Postmorten examination of the blood supply and vascular pattern of small liver metastases in man显示文摘 | Lin G Lunderquist A Hagerstrand I | 1984 | Surgery1984,96,: | 1 |
| 18 | Differential expression of insulin receptor tyrosine kinase inhibitor(fetuin) gene in a model of diet-induced obesity 显示文摘 | Lin X Braymer H D Bray G A | 1998 | Life Sci1998,63,2: | 1 |
| 19 | Planning of tool orientation for five-axis cavity machining显示文摘 | Robert G Lin T W Lin A C | 2003 | The International Jour- nal of Advanced Manufacturing Technology2003,22,12: | 1 |
| 20 | Middle ear endoscopy and trans-tympanic drug delivery using an interventional sialendoscope:a feasibility study in human cadaveric temporal bones显示文摘 | PETERS G LIN J ARRIAGA M A | 2010 | Laryngoscope2010,1204,: | 1 |