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5篇 您的检索式：作者名="Lin Chenmin"

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		题名	作者	年代	出处	被引量
	1	Manipulation of single DNA molecules by using optically projected images 显示文摘	Lin Yenheng Chang Chenmin Lee Gwobin	2009	Opt Express2009，17，15：	1
	2	Noise reduction using compensation capacitance for bend discontinuities of differential transmission lines 显示文摘	Shiue Guanghwa Guo Weida Lin Chenmin	2006	IEEE Transactions on Ad- vanced Packaging2006，29，3：	1
	3	Aqueous Ammonia Solution Cooling Absorption Refrigeration Driven by Fishing Boat Diesel Exhaust Heat显示文摘	Chen Yaping Lin Chenmin Tian Ying	2010	Journal of Southeast University2010，26，2：	1
	4	Manipulation of single DNA molecules by using optically projected images 显示文摘	Lin Yenheng Chang Chenmin Lee Gwobin	2009	Opt Express2009，17，15：	1
	5	CREB1 contributes colorectal cancer cell plasticity by regulating lnc RNA CCAT1 and NF-κB pathways显示文摘The CREB1 gene encodes an exceptionally pleiotropic transcription factor that frequently dysregulated in human cancers.CREB1 can regulate tumor cell status of proliferation and/or migration;however,the molecular basis for this switch involvement in cell plasticity has not fully been understood yet.Here,we first show that knocking out CREB1 triggers a remarkable effect of epithelial-mesenchymal transition(EMT)and leads to the occurrence of inhibited proliferation and enhanced motility in HCT116colorectal cancer cells.By monitoring 45 cellular signaling pathway activities,we find that multiple growth-related pathways decline significantly while inflammatory pathways including NF-κB are largely upregulated in comparing between the CREB1wild-type and knocked out cells.Mechanistically,cells with CREB1 knocked out show downregulation of MYC as a result of impaired CREB1-dependent transcription of the oncogenic lnc RNA CCAT1.Interestingly,the unbalanced competition between the coactivator CBP/p300 for CREB1 and p65 leads to the activation of the NF-κB pathway in cells with CREB1 disrupted,which induces an obvious EMT phenotype of the cancer cells.Taken together,these studies identify previously unknown mechanisms of CREB1 in CRC cell plasticity via regulating lnc RNA CCAT1 and NF-κB pathways,providing a critical insight into a combined strategy for CREB1-targeted tumor therapies.	Bin Li Lisi Zheng Jiayi Ye Chenmin Zhang Jie Zhou Qiaojuan Huang Yanhua Guo Luqin Wang Peng Yu Shurong Liu Qiao Lin Yuxia Luo Hui Zhou Jianhua Yang Lianghu Qu	2022	Science China(Life Sciences)2022，65，8：	0

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