|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 2 | Alterations in DNA methylation and genome structure in two rice mutant lines induced by high pressure显示文摘By using high-pressure treatment, two mutant lines were obtained from a genetically stable japonica rice cultivar Bijing38. Genomic DNA of the mutant lines, together with the original line (Bijing38), was either undigested or digested by Hpa II/Msp I, and then subjected to molecular analy-sis using two markers, ISSR and RAPD. Results indicated that changes in the PCR amplification pro-files of both markers are apparent in the two mutant lines compared with the original rice cultivar, suggesting that there had been both sequence changes and DNA methylation modifications in the mutant lines. Southern blot analysis using diverse sequences, including two cellular genes (S2 and S3), a set of retrotransposons (Osr7, Osr36, Tos19 and more), and a MITE transposon family (mPing and Pong), confirmed the results, and indicated that changes in DNA methylation pattern, genomic structure, and possible activation of some transposons indeed occurred in the mutant lines. Moreover, these changes are stably maintained through selfed generations and in different organs. Thus, our results indicate that it is possible to obtain stable mutants in rice by high pressure treatments, and the molecular basis of the mutants may include both genetic and epigenetic changes. Therefore, high hydrostatic pressure seems a promising approach for plant mutagenesis. | SHEN Sile1,3, WANG Zhenwei3, SHAN Xiaohui2, WANG Hua3, LI Ling3, LIN Xuyun2, LONG Likun2, WENG Kenan4, LIU Bao2 & ZOU Guangtian1 1. National Laboratory of Superhard Materials, Jilin University, Changchun 130012, China 2. Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China 3. College of Life Science, Jilin University, Changchun 130012, China 4. Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China | 2006 | Science China(Life Sciences)2006，49，2： | 6 |
| 3 | Detection and characterization of diverse alpha-and betacoronaviruses from bats in China显示文摘Bats have been implicated as important reservoir hosts of alpha- and betacoronaviruses. In this study, diverse coronaviruses(CoVs) were detected in 50 of 951(positive rate 5.3%) intestinal specimens of eight bat species collected in four provinces and the Tibet Autonomous Region of China by pan-coronavirus RT-PCR screening. Based on 400-nt RNA-dependent RNA polymerase(Rd RP) sequence analysis, eight belonged to genus Alphacoronavirus and 42 to Betacoronavirus.Among the 50 positive specimens, thirteen gave rise to CoV full-length Rd RP gene amplification for further sequence comparison, of which three divergent sequences(two from a unreported province) were subjected to full genome sequencing. Two complete genomes of betacoronaviruses(JTMC15 and JPDB144) and one nearly-complete genome of alphacoronavirus(JTAC2) were sequenced and their genomic organization predicted. The present study has identified additional numbers of genetically diverse bat-borne coronaviruses with a wide distribution in China. Two new species of bat CoV, identified through sequence comparison and phylogenetic analysis, are proposed. | Lin Xu Fuqiang Zhang Weihong Yang Tinglei Jiang Guanjun Lu Biao He Xingyu Li Tingsong Hu Gang Chen Yun Feng Yuzhen Zhang Quanshui Fan Jiang Feng Hailin Zhang Changchun Tu | 2016 | Virologica Sinica2016，31，1： | 6 |
| 4 | Preparing Nano-ZnS by Solid State Reaction at Room Temperature显示文摘ZnS nanoparticles were prepared by using solid-state reaction method at room temperature in agate mortar for the first time. The average particle size was about 20nm. This reaction is affected by the structure of reactant, crystal water and defects. | Xiao Lin SUN, Guang Yan HONG* Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry,Changchun 130022 | 2001 | Chinese Chemical Letters2001，12，2： | 5 |
| 5 | Theoretical calculation of the finishing rolling impact work in non-quenched and tempered Si-Mn steel显示文摘Based on the hot-continuous rolling technology, the finishing rolling impact work α k of the non-quenched and tempered Si-Mn steel is theoretically calculated with the covalent electron number nA of the strongest bond in alloying phases, and the smallest interface electron density difference Δρ of alloying phase interface and the number of atom states σ which keep the interface electron density continuous. Calculations show that the solution strengthening, the precipitation strengthening, and the interface strengthening will result in the decrease of the finishing rolling impact work α k, and the effects of the number of atom states σ which keep the interface electron density continuous on the finishing rolling impact work α k are different. Taking the impact work and the number of atom states σ 0 keeping the electron density continuous of the phase interface α-Fe/α-Fe-C between α-Fe and α-Fe-C as reference values, the impact work of the interface will increase when σ of some interface is larger than σ 0; otherwise, the impact will decrease. Therefore, the finishing rolling impact work α k can be calculated with the impact value of the refined α-Fe matrix and the influence amounts caused by the solution strengthening, the precipitation strengthening, the interface strengthening, and the number of atom states σ which keep the interface electron density continuous. The calculated results agree well with the measured ones. In this paper, the effect of S on the impact work is also discussed. | LIU Zhilin1, LIN Cheng1 & WANG Ping2 1. Department of Materials and Chemical Engineering, Liaoning Institute of Technology, Jinzhou 121001, China 2. Mechanical Department, Armor technique Institute of PLA, Changchun 130117, China | 2006 | Science China(Technological Sciences)2006，49，2： | 5 |
| 6 | The Discovery and Study of Mantle-Derived Dunite Inclusions in Hornblende-Diorite in the Handan-Xingtai Area,Hebei显示文摘Phlogopiie-and diopside-bearing dunite occurs as rounded inclusions in hornblende-diorite. Thepetrofabrics, mineral composition and abundances of the trace elements in the dunite indicate that the inclu-sions were derived from the upper mantle and are the residues of high-degree partial melting of mantlepeirdotite. The study of trace elements in the inclusions and their host rocks shows that the magma was origi-nated from the mantle which was enriched in incompatible elements by mantle metasomatism prior to the par-tial melting. | Xu Wenliang Lin Jingqian Changchun Universily of Earth Sciences, Changchun, Jilin Jiang Minxi | 1991 | Acta Geologica Sinica(English Edition)1991，65，3： | 3 |
| 7 | CSF-Based Analysis for Identification of Potential Serum Biomarkers of Neural Tube Defects显示文摘The protein composition of cerebrospinal fluid(CSF) in neural tube defects(NTDs) remains unknown. We investigated the protein composition of CSF from 9 infants with NTDs using isobaric tags for relative and absolute quantitation(iTRAQ). We identified 568 proteins in the CSF of infants with spina bifida, which is the most common type of NTD. Among these, 18 proteins were associated with neural tube closure in the CSF during human embryonic neurulation and 5 were involved in NTDs. Based on these results, an animal model was further utilized to investigate early serum biomarkers for NTDs.We found that the myristoylated alanine-rich C-kinase substrate, Kunitz-type protease inhibitor 2, andapolipoprotein B-100 protein levels were decreased in both embryos and the sera of pregnant Sprague-Dawley rats carrying embryos with NTDs. CSF proteins may be useful in the discovery of potential serum biomarkers for NTDs. | Xinyu Yan Lixin Mai Changchun Lin Wenji He Gengsheng Yin Jiakang Yu Lian Huang Sanqiang Pan | 2017 | Neuroscience Bulletin2017，33，4： | 3 |
| 8 | Dose-dependent Cytotoxicity and Oxidative Stress Induced by 'Naked' Fe_3O_4 Nanoparticles in Human Hepatocyte显示文摘The dose-dependent cytotoxicity effect on human hepatocyte(HL-7702 cells) induced by 'naked' Fe3O4 nanoparticles was assessed through cell viabilities and lactate dehydrogenase(LDH) activities. Three important oxi dative indexes of the cells by glutathione peroxidase(GSH-Px), superoxide dismutase(SOD) and malondialde hyde(MDA) were determined. The good correlation of the cell viabilities with their GSH-Px, SOD and MDA levels indicated that the cytotoxicity is related to activation of oxidative stress induced by Fe3O4 nanoparticles. The oxida tive stress also leads to corresponding DNA damage in a similar dose-dependent manner, followed by the changes of cell cycle and cell apoptosis. Such work provides important experimental data for the safety evaluation of superpa ramagnetic Fe3O4 nanoparticles. | LIN Xin-li1, ZHAO Shu-hua1, ZHANG Long1, HU Gui-qin1, SUN Zhi-wei1,3 and YANG Wen-sheng2 1. School of Public Health, Jilin University, Changchun 130021, P. R. China 2. College of Chemistry, Jilin University, Changchun 130012, P. R. China 3. School of Public Health and Family Medicine, Capital Medical University, Beijing 100069, P. R. China | 2012 | Chemical Research in Chinese Universities2012，28，1： | 3 |
| 9 | The Site Symmetry of Eu^(3+) in ZnS:Eu Nanoparticle显示文摘Nanosized ZnS doped with different concentrations of Eu3+ were prepared andanalyzed by x-ray diffraction technique. The experimental results show that ZnS belongs to thecubic structure. From the photoluminescence (PL) emission spectra, it can be seen that the ratioof the emission intensity of Eu3+ at 616 nm to that at 590 nm increases as the increasing of Eu3+.This phenomenon reveals that the site symmetry of Eu3+ reduces as the increasing of Eu3+. | Xiao Lin SUN Gut Lan ZHANG Guo Qing TANG Wen Ju CHEN(Opto-electronic Information Science and Technology Lab, MOE., Institute of Modern Optics,Nankai University, Tianjin 300071)Guang Yan HONG(Changchun Institute of Applied Chemistry, Changchun 130022) | 1999 | Chinese Chemical Letters1999，10，9： | 3 |
| 10 | Nonlinear analysis on the coupling process of electromagnetic vibrator and earth显示文摘The linear model based on the hydraulic pressure vibrator has been no longer adaptable to the electromagnetic vibrator. In order to realize the effective transmission of the limited energy from the vibrator to the ground, it is important to study the coupling model of the electromagnetic vibrator and the earth. In this paper, a nonlinear restore term was introduced to the coupling model because of the existence of a large amount of harmonics in the vibrator baseplate. The nonlinear vibration analysis was applied to the model by the multiscale method. In the course of energy transmission from the vibrator to the ground, ultraharmonic resonance was used to explain the generation of harmonics. An improved scheme was advanced to select the cross correlation reference signal in the vibrator seismic exploration. Good application results were obtained in field experiments. | CHEN Zubin1,2, TENG Jiwen2, LIN Jun1, ZHANG Linhang1 & JIANG Zhongjin1 1. Institute of Intelligent Instrument & Measurement Control Technology, Jilin University, Changchun 130026, China 2. Institute of Geology & Geophysics, Chinese Academy of Sciences, Beijing 100029, China | 2005 | Science China Earth Sciences2005，48，8： | 3 |
| 11 | Organic ammonium ion-occluded flexible coordination polymers:Thermal activation,structure transformation and proton transfer显示文摘Solvothermal reactions of 1,3,5-benzenetricarboxylic acid (H3btc) with cadmium acetate or zinc acetate yielded two compounds formulated as (Me2NH2)[Cd(btc)]·DMA (1) (btc = 1,3,5-benzenetricarboxylate, DMA = N,N-dimethylacetamide) and (Me2NH2)[Zn(btc)]·DMF (2) (DMF = N,N-dimethylformamide). Both are 3-D frameworks with the rutile topology, which are constructed from six-connected dimeric metal cores and three-connected btc linkers. The solvent molecules and counter cations are located in the 1-D channels of the frameworks. A slight difference between the two compounds is the different connectivity modes of the metal atoms with the carboxylate groups of the ligands. However, this slight difference results in distinct flexibilities of the two frameworks. Variable-temperature powder X-ray diffraction studies revealed that the framework of 1 collapses when heated at 180 °C with loss of the guest species, but compound 2 undergoes two structural transformations below 380 °C. Thermogravimetry-infrared spectroscopy analysis for 2 showed that the two structural transformations are induced by separate losses of solvent molecules and counter cations, and that the dimethylammonium cations are eliminated as neutral dimethylamine molecules. IR spectroscopy demonstrated that the protons are transferred from the counter cations onto the uncoordinated carboxylate oxygen atoms on the channel walls. Sorption and proton conduction studies have also been performed for the compounds. | XIE LinHua1, LIN JianBin1, LIU XiaoMin1, XUE Wei1, ZHANG WeiXiong1, LIU ShuXia2, ZHANG JiePeng1 & CHEN XiaoMing1 1MOE Key Laboratory of Bioinorganic and Synthetic Chemistry State Key Laboratory of Optoelectronic Materials and Technologies School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China 2Key Laboratory of Polyoxometalates Science of Ministry of Education College of Chemistry, Northeast Normal University, Changchun 130024, China | 2010 | Science China Chemistry2010，53，10： | 3 |
| 12 | A Novel Dimer──Heteropolytungstate with a Vanadium Atom as the Centre ──Synthesis and Structural Characterization of (H_3O)_4[VW_(12)O_(40)Na(H_2O)_4]_2显示文摘A novel dimer tungstovanadate, (H 3O) 4[VW 12 O 40 Na(H 2O) 4] 2, was hydrothermally synthesized and structurally characterized by single crystal X ray diffraction, IR spectra, TGA DSC thermal analysis and polarograpy. The yellowish crystal crystallized in the triclinic system, space group P1, a =1 464 5(3) nm, b =1 468 6(3) nm, c =1 411 1(3) nm, α=111 82(2)°, β=93 17(3)°, γ=117 47(3)°, V =2 210 6(8) nm 3, Z=1, D c=4 552 g·cm -3 , λ (Mo Kα )=0 071 073 nm, μ =31 402 mm -1 , F(000)=2 648, R =0 078 0. The title compound consists of two Keggin structure units linked together with two hydrated sodium cations to form a dimer with a porous structure with the pore dimension of 0 766 nm×0 778 5 nm. [WT5FZ] | LIU Zong rui 1,2 , XU Lin 1, WANG En bo 1,** , PENG Jun 1, HU Chang wen 1 XING Yan 3, LIN Yong hua 3 and JIA Heng qing 3 (1. Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China 2. Inner Mongolia Teac | 2000 | Chemical Research in Chinese Universities2000，16，3： | 2 |
| 13 | Development of an Experimental EUVL System显示文摘The authors have developed an experimental system for the studies of extreme ultraviolet projection lithography at 13.0nm wavelength, which includes a laser plasma source, an ellipsoidal condenser, a transmission mask and a Schwarzschild optics. The optical system is optimized to achieve 0.1μm resolution over a 0.1mm diameter image field of view and the mirrors of the objective were coated with Mo/Si multilayer to provide 60% reflectance at near normal incidence angle for 13.0nm radiation. | JIN Chun shui, MA Yue ying, PEI Shu,CAO Jian lin (Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130022, China) | 2001 | 光学精密工程2001，9，5： | 2 |
| 14 | Bioreducible crosslinked low molecular weight branched PEI-PBLG as an efficient gene carrier显示文摘Low molecular weight polyethylenimine-poly(gamma-benzyl L-glutamate) (PEI-PBLG) was crosslinked by N,N'-cystaminebisacrylamide (CBA) to get the polymer named as CBA-PEI-PBLG (CPP).CPP not only inherits PEI-PBLG's amphiphilic advantages,but also possesses reducible properties.CPP can complex with DNA to form nanoparticles.CPP/DNA complex particles were characterized by particle size and zeta potential analysis.The result showed that the complex particles have suitable size and surface charges for gene delivery.And gel retardation assay also prove CBA-PEI-PBLG has proper condensing ability for DNA.CPP has good reducible property,and also has good biocompatibility because of introducing PBLG segment.The cytotoxicity of CPP was evaluated using MTT assay,and the results showed CPP has lower cytotoxicity compared with PEI 25 K.The transfection properties were characterized in different cells by using plasmid DNA as a reporter.CPP showed higher transfection efficiencies and lower cytotoxicity in HeLa cells.This was attributed to bioreducible and biocompatibility properties of the CPP.These results suggested that CPP is a promising low-toxic,highly effective non-viral gene carrier. | GUO ZhaoPei 1,TIAN HuaYu 1,XIA JiaLiang 1,2,CHEN Jie 1,LIN Lin 1 & CHEN XueSi 1 1 Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China 2 Graduate University of Chinese Academy of Sciences,Beijing 100049,China | 2010 | Science China Chemistry2010，53，12： | 2 |
| 15 | Effect of methylmercury on LPO levels, SH groups and activities of GSH-Px, SOD, XOD in liver of rats显示文摘In recent years, lipid peroxidation has been considered as the initial step for foreign toxic substances to damage cells. In this paper, the effects of methylmercury (MeHg) on LPO (lipid peroxide) levels, SH (sulfhydryl) groups and activities of GSH\|Px (glutathione peroxidase), SOD (superoxide dismutase), XOD (xanthine oxidase) in liver of rats treated with doses of MeHg at different intervals were studied by TBA, Ellman Reagent, NBT colorimetric methods and chemilluminescence. Meanwhile, the contents of FR (free radical)and MeHg in the liver of female rats were measured by ESR and GC. Results showed that the LPO levels in the experimental group increased significantly over those of the control group ( p<0.05— p<0.001) , reaching maximum point on the first poisoning day. Both male and female rats showed marked positive dose\|effect relations (Male: Y=261.4±49.4X, r=0.94, p<0.02; Female : Y=255.0±73.0X, r=0.99, p<0.001 ). N-SH (nonprotein sulfhydryl), P\|SH (protein sulfhydryl), T-SH (total sulfhydryl) contents and GSH\|Px activities decreased significantly (p<0.05-p<0.001). For GSH\|Px, both groups reached minimum value on the first poisoning day. In female rats, activities of SOD and XOD increased markedly ( p<0.02-p<0.01 ) although the contents of FR showed no significant changes. The contents of MeHg was determined by GC, and it ranged from 0.0081—0.0191 ppm. | LIU Jin\|yu 1, GUAN Ming 1, SUN Zhi\|wei 1, LIN Xiu\|wu 1, CAO Peng\|yuan 2, MENG Xiang\|dong 2 (1. Norman Bethune University of Medical Sciences, Changchun 130021, China 2. Sanitation and Antiepidemic Station of Jilin Province, Changchun, Chin | 2000 | Journal of Environmental Sciences2000，12，S1： | 2 |
| 16 | The Controllability of Cartesian Flexible Robot System | WANG Zheng LIN Xianning HOU Xuezhang(Department of Mathematics, Northeast NOrmal University, Changchun, 130024) | 1996 | Systems Science and Systems Engineering1996，6，2： | 2 |
| 17 | Simulation of the Tree Algorthm in ATM Networks显示文摘This paper proposes an algorithm for multicast routing in ATM networks. We define the network cost of a routing as the combination of the cost. If establishing connections, the cost of the overall bandwidth and overall switchings, our routing algorithm works on the original topology of ATM networks with physical switches and physical links, and different switching functionalities of Virtual Path( VP ) switches and Virtual Channel( VC ) switches in the networks. It generates an optimal multicast routing with the minimal overall network cost. Simulations with MATLAB have been made to compare the quality of the routing generated by our algorithm with those of other two major algorithms. | WANG Lin zhu (Institute of Communication Engineer, Jilin University, Changchun 130012) | 2002 | The Journal of China Universities of Posts and Telecommunications2002，9，1： | 2 |
| 18 | CRH Public Encryption - the Study on High Intensity Data Encryption Algorithm显示文摘Encrypted Communication technique is an important measure to the information safety. Based on the advantages of two public encryption algorithm RSA & DES, a novel high intensity public encryption algorithm Chaos Random High Intensity (CHR) is proposed in this paper. The principle of CRH is described and analyzed in detail, and the results of computer simulation has proved its effectiveness and correctness. | LIN Zi, XU Yong, LI Kui-jun (Department of Telecommunication Engineering, Changchun Institute of Posts and Telecommunications, Changchun 130012, P.R. China) | 2000 | The Journal of China Universities of Posts and Telecommunications2000，7，1： | 2 |
| 19 | Hydrothermal Synthesis, Structural Characterization and Properties of Mixed Valent Decavanadium Oxide [Co_2Cl_8V_(10) O_(18)(H_2O)]Cl_2·6H_2O with Novel Three-dimensional Framework显示文摘Decavanadium oxide [Co 2Cl 8V 10 O 18 (H 2O)]Cl 2·6H 2O was synthesized hydrothermally with NH 4VO 3, Na 2MoO 4·2H 2O, H 3PO 4(85%), CoCl 2·6H 2O and hexamethylenetetraamine. The X ray diffraction analysis showed that [Co 2Cl 8V 10 O 18 (H 2O)]Cl 2·6H 2O crystallized in a monoclinic crystal system, the space group was C2/m with cell parameters a =1 6065(3) nm, b =2 2699(5) nm, c =1 3897(3) nm, β = 125.29(3)°, V =4 1363(14) nm 3, Z =2 and the final R =0 06, wR =0 1926. Its crystal structure is a 3 D open framework constructed by VO x polyhedra and CoCl 4 tetrahedra with channels along the crystallographic axes a, b, and c . | WU Ping song, XU Lin, WANG En bo ** and HU Chang wen Faculty of Chemistry, Northeast Normal University, Changchun 130024, P. R. China | 2003 | Chemical Research in Chinese Universities2003，19，2： | 2 |
| 20 | Detection and Characterization of a Novel Norovirus in Bats,China显示文摘Dear Editor,Noroviruses(No Vs)are second only to the rotaviruses as etiologic agents of acute fulminant gastroenteritis in infants and young children worldwide,with an estimated 200,000deaths per year in children younger than 5 years of age in developing countries(Patel et al.2008).No Vs are classified within the genus Norovirus of the family Caliciviridae with Norwalk virus as its prototype member(ICTV 2017).The virions are small(38–40 nm in diameter)nonenveloped,with an icosahedral capsidanda linear,positive- | Ling'en Yang Quanxi Wang Lin Xu Changchun Tu Xiaohong Huang Biao He | 2018 | Virologica Sinica2018，33，1： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员