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| 1 | 曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文--长链非编码RNA1nc-DC通过STAT3调控人DC的分化和功能显示文摘树突状细胞(DC)是免疫系统中重要的抗原提呈细胞,其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物基因组能够转录产生大量的长链非编码RNA(long noncoding RNA,IncRNA),其在免疫系统中的功能还知之甚少。
曹雪涛院十科研团队王品副教授课题组采用了转录组芯片二代测序高通量筛选方法、RNA-pulldown、ChIP-seq等技术展开了对IncRNA在DC分化和功能中作用的研究,发现并鉴定了特异性高表达于DC的1ncRNA,命名为1nc-DC,其可通过抑制STAT3去磷酸化,从而促进DC分化和功能。该研究成果发表于Science杂志[2014,344(6181):310-313],并于2015年12月被评为“中国百篇最具影响国际学术论文”。 | wang p xue y han y lin l wu c xu s jiang z xu j liu q cao x | 2016 | 中国肿瘤生物治疗杂志2016，23，1： | 10 |
| 2 | Zebrafish as a model for developmental neurotoxicity testing 显示文摘 | TON C LIN Y X WILLETT C | 2006 | Birth Defects Res A Clin Mol Teratol2006，76，7： | 1 |
| 3 | Twelve-connected porous metal-organic frameworks with high H: adsorption 显示文摘 | JIA J H LIN X WILSON C | 2007 | Chem Commun2007，8，： | 1 |
| 4 | New bisabolane sesquiterpenes and coumarin from Leontopodium longifolium 显示文摘 | LI J X LIN C J YANG X P | 2006 | Chemistry Biodiversity2006，3，7： | 1 |
| 5 | Anodic dissolution of spongy titanium in ethanol solution for preparation of nano-sized Tio2 powder显示文摘 | Zhou X F Chu D B Lin C J | 2002 | Electrochim Acta2002，47，： | 1 |
| 6 | Conditional Expression of Parkinson 's Disease-Related Mutant alpha-Synuelein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1 显示文摘 | Lin X Parisiadou L Sgobio C | 2012 | J Neurosci2012，32，27： | 1 |
| 7 | Apatite-inducing ability of titanium oxide layer on titanium surface:the effect of surface energy显示文摘 | Wang X J Li Y C Lin J G | | 0，，6： | 1 |
| 8 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 9 | Expression of Wnt/13-catenin signaling, stem-cell markers and proliferating cell markers in rat whisker hair follicles 显示文摘 | LIN C M YUAN Y P CHEN X C | 2015 | l Mol Histo12015，46，3： | 1 |
| 10 | Analysis of outer membrane proteome of Escherichia coli related to resistance to ampicillin and tetracycline显示文摘 | XU C LIN X REN H | 2006 | Proteomics2006，6，2： | 1 |
| 11 | Effects of flue gas desulphurization sludge on the pozzolanic reaction of reject-fly-ash- blended cement pastes显示文摘 | Poon C S Qiao X C Lin Z S | 2004 | Cement and Concrete Research2004，34，10： | 1 |
| 12 | Prevalence, isolation, and partial sequence analysis of hepatitis E virus from domestic animals in China 显示文摘 | Wang Y C Zhang H Y Xia N S Peng G Lan H Y Zhuang H Zhu Y H Li S W Tian K G Gu W J Lin W J Wu J X Li X Harrison T J | 2002 | Journal of Medical Virology2002，67，4： | 1 |
| 13 | Platinum/Carbon nanotube nanocomposite synthesized in supercritical fluid as electro- catalysts for low-temperature fuel cells显示文摘 | Lin Y Cui X Yen C | 2005 | J Phys Chem B2005，109，14： | 1 |
| 14 | Determination of Chloramphenicol in eye drops by optical rotation method 显示文摘 | Lin C X | 1997 | J Shanton Univ Med Coll1997，10，4： | 1 |
| 15 | Involvement of the cerebellum in semantic discrimination:an fMRI study显示文摘 | Xiang H Lin C Ma X | 2003 | Hum Brain Mapp2003，18，3： | 1 |
| 16 | Some advanced plastic processing technologies and their numerical simulation显示文摘 | Yang H Zhan M Liu Y L Xian F J Sun Z C Lin Y Zhang X G | 2004 | J Mater Process Technol2004，151，13： | 1 |
| 17 | Role of melatonin in the prevention of morphine-induced hyperalgesia and spinal glial activation in rats: protein kinase C pathway involved显示文摘 | Wei X Wang C Lin L | 2012 | Intern J Neurosc2012，3，122： | 1 |
| 18 | Air temperature comparison between the MMTS and the USCRN temperature systems 显示文摘 | Hubbard K G Lin X Baker C B | 2004 | J Atmos Oceanic Technol2004，21，： | 1 |
| 19 | A dual quaternion solution to attitude and position control for rigid-body coordination显示文摘 | Wang X Yu C Lin Z | 2012 | IEEE Trans on Robotics2012，28，5： | 1 |
| 20 | Characterization of a novel envelope protein(VP281)of shrimp white spot syndrome virus by mass spectrometry显示文摘 | HUANG C ZHANG X LIN Q | | 0，，： | 1 |
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