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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | Dexmedetomidine and meperidine additively reduce the shivering threshold in humans显示文摘 | Doufas AG Lin CM Suleman MI | 2003 | Stroke2003，34，5： | 1 |
| 3 | Dexmendetomidine and meperidine additively reduce the shivering threshold in humans 显示文摘 | Doufas AG Lin CM Suleman MI | 2003 | Stroke2003，34，5： | 1 |
| 4 | Abietane diterpene alkaloids from Salvia yunnanensis显示文摘 | LIN FW DAMU AG WU TS | 2006 | J Nat Prod2006，69，1： | 1 |
| 5 | Dexmedetomidineand meperidine additively reduce the shivering threshold inhumans显示文摘 | Donfas AG Lin CM Sdeman MI | 2003 | Stroke2003，34，5： | 1 |
| 6 | Neither arm nor face warming reduces the shivering threshold in unanesthetized humans显示文摘 | Doufas AG Wahhwa A Lin C | 2003 | Stroke2003，34，7： | 1 |
| 7 | Cumulative incidence of colorectal and extracolonic cancers in MLH1 and MSH2 mutation carrics of hereditary nonpolyposis colorectal cancer显示文摘 | Lin KM Shashidharan M Thorson AG | 1998 | J Gastrintest Surg1998，2，1： | 1 |
| 8 | A baseline study on the importance of bovines for human Schistosoma japonicum infection around Poyang Lake, China显示文摘 | Guo JG Ross AG Lin DD | 2001 | Am J Trop Med Hyg2001，65，4： | 1 |
| 9 | Dexmedetomidine and me-peridine additively reduce the shivering threshold in hu- mans 显示文摘 | DONFAS AG LIN CM SULEMAN MI | 2003 | Stroke2003，34，5： | 1 |
| 10 | Attenuation of TGF- ]3 signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells显示文摘 | Lin S Yang J Elkahloun AG | 2012 | Mol Biol Ce112012，23，8： | 1 |
| 11 | Dexmedetomidine and meperidine additively reduce the shivering threshold in humans显示文摘 | Doufas AG Lin CM Suleman MI | 2003 | Stroke2003，34，5： | 1 |
| 12 | dexmedetonidine and meperidine additively reduce the shivering threshoulld in humans显示文摘 | Doufas AG Lin CM Suleman MI | | 0，，： | 1 |
| 13 | Dexmedetomidine and meperidine additively reduce the shivering threshold in humans显示文摘 | Doufas AG Lin CM Suleman MI | 2003 | Stroke2003，34，5： | 1 |
| 14 | Dexmedetomidine and meperidine additively reduce the shivering threshold in humans显示文摘 | Donfas AG Lin CM Sdeman MI | 2003 | Stroke2003，34，： | 1 |
| 15 | Risk factors for failure after open reduction for DDH: a matched cohort analysis显示文摘 | Sankar WN Young CR Lin AG | 2011 | J Pediatr Orthop2011，31，3： | 1 |
| 16 | Dexmedetomidine and meperi- dine additively reduce the shivering threshold in humans 显示文摘 | Doufas AG Lin CM Suleman MI | 2003 | Stroke2003，34，5： | 1 |
| 17 | Systemic lupus erythematosus-associated optic neuritis:clinical experience and literature review显示文摘 | Lin YC Wang AG Yen MY | 2009 | Acta Ophthalmol2009，87，2： | 1 |
| 18 | Heparin-surface-modified intraocular lens implantation in patients with glaucoma, diabetes, or uveitis 显示文摘 | Lin CL Wang AG Chou JC | 1994 | J Cataract Refract Surg1994，20，5： | 1 |
| 19 | Intraocular pressure and ocular pulse amplitude compari-sons in different types of glaucoma using dynamic contour to-nometry显示文摘 | Punjabi OS Ho HK Kniestedt C Bostrom AG Stamper RL Lin SC | 2006 | Curr Eye Res2006，31，10： | 1 |
| 20 | Systemic lupus erythematosus-associated optic neuritis:clinical experience and literature review显示文摘 | Lin YC Wang AG Yen MY | | 0，，02： | 1 |
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