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| 1 | Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism显示文摘Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domaincontaining 5(FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue(WAT) and uncoupling protein 1(UCP1) expression, leading to an increase in total body energy expenditure by augmented UCP1-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones,including growth plate, trabecular bone, cortical bone, articular cartilage, and bone–tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal(IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-k B ligand(RANKL)-induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice. | Jin Zhang Paloma Valverde Xiaofang Zhu Dana Murray Yuwei Wu Liming Yu Hua Jiang Michel M Dard Jin Huang Zhiwei Xu Qisheng Tu Jake Chen | 2017 | Bone Research2017，5，1： | 23 |
| 2 | Identification of Stress-inducible Proteins in Lactobacillus delbrueckii subsp, bulgaricus 显示文摘 | LIME M EHRLICH S D and MAGUIN E | 2000 | Electrophoresis2000，21，： | 1 |
| 3 | 显示文摘 | Ying Liming Bruckbauer A Rothery A M | 2002 | Anal Chem2002，74，： | 1 |
| 4 | Simian immunodeficiency virus SIVagm from African green monkeys does not antagonize endogenous levels of African green monkey tetherin/ BST-2显示文摘 | LIME S EMERMAN M | 2009 | JVirol2009，83，11： | 1 |
| 5 | Laser-tungsten inert gas hybrid welding of dissimilar AZ based magnesium alloys显示文摘 | Liming Liu Song G Chi M S | 2005 | Materials Science and Technology2005，21，9： | 1 |
| 6 | Microstructure and mechanical properties of Fe-Cr-C euteetie composites 显示文摘 | Liming L Hiroshi S Alexander M | 2003 | Materials Science and Engineering2003，347，12： | 1 |
| 7 | Identification of Mycobacterium tuberculosis DNA Sequences Encoding Exported Proteins by Using phoA Gene Fusions显示文摘 | LIME M UZIER J TIMM J | 1995 | Journal of Bacteriology1995，177，1： | 1 |
| 8 | Carbon nanotube arrays with strong shear binding-on and easy normal lifting-off显示文摘 | Qu Liangti Dai Liming Stone M | 2008 | Science2008，322，5899： | 1 |
| 9 | MDM2, P53P21WAF1 and pAKT protein levels in genesis and behaviour of adenoid cystic carcinoma 显示文摘 | De lime Mde D Marques Y M Alves sde M Jr | 2009 | Cancer Epidemiology2009，33，2： | 1 |
| 10 | 显示文摘 | Zong Liming Kempel L C Hawley M G | 2005 | Polymer2005，46，8： | 1 |
| 11 | Dielectric studies of three epoxy resin system during microwave cure显示文摘 | Zong Liming Kempel L C Hawley M C | 2005 | Polymer2005，46，8： | 1 |
| 12 | Genetic analysis of the TBX1 gene promoter in ventricular septal defects显示文摘 | Haihua W Dongfeng C Liming M | 2012 | Mol Cell Biochem2012，370，12： | 1 |
| 13 | Characterizing the influence of past experience on recreation behavior显示文摘 | Schreyer R M Lime D W Williams D R | 1984 | Journal of Leisure Research1984，16，： | 1 |
| 14 | Degradation of paracetamol in aqueous solutions by TiO2 photocatalysis显示文摘 | YANG Liming Yu L E Ray M B | 2008 | Water Research2008，42，13： | 1 |
| 15 | Suitability of novel galactomannans as edible coatings for tropical fruits显示文摘 | CREQUE1RA M A LIME A M TEIXEIRA J A | 2009 | Journal of Food Engineering2009，94，34： | 1 |
| 16 | Visualization of landscape by VRML system显示文摘 | HONJO T LIME M | 2000 | Landscape and Urban Planning2000，55，3： | 1 |
| 17 | Microstructure and mechanical properties of Fe-Cr-C eutectic composites 显示文摘 | Lu Liming Hiroshi Soda Alexander M | 2003 | Materials Science and Engineering A2003，347，： | 1 |
| 18 | Mierostructure and mechanical properties of Fe-Cr-C eutectie composites 显示文摘 | Liming L Hiroshi S Alexander M | 2003 | Materials Science and Engineering A2003，347，12： | 1 |
| 19 | Modeling the forces of cutting with scissors 显示文摘 | MAHVASH M MOHSEN V LIMING M K | 2008 | IEEE Transactions on Biomedical Engineering2008，55，3： | 1 |
| 20 | Instore Music and Consumer-brand Relationships :Relational Transformation Following Experiences of (Mis) Fit 显示文摘 | BEVERLAND M LIME MORRISON M | 2006 | Journal of Business Research2006，59，9： | 1 |
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