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| 1 | Do probiotics have a therapeutic role in gastroenterology?显示文摘Several hundred species of bacteria inhabit the gut, and affect its cell biology, morphology and homeostasis. Many bacteria are however potential pathogens, especially if the integrity of the epithelial barrier is physically or functionally breached. Conversely, the interaction between host and commensal microbes can confer important health benefits. This has led to commercial and public interest in ’probiotics’, live microbes principally taken as food supplements. Might probiotics also be used in disease therapy? Experimental evidence that probiotics modulate gut physiology, particularly barrier integrity and immunological function, underpins exciting new gastroenterological research. We discuss below the scienti?c basis for probiotic effects and present a critical perspective for their use in relation to gastrointestinal disease. | Jimmy K Limdi Catherine O’Neill John McLaughlin | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 2 | Elderly patients and inflammatory bowel disease显示文摘The incidence and prevalence of inflammatory bowel disease(IBD) is increasing globally. Coupled with an ageing population, the number of older patients with IBD is set to increase. The clinical features and therapeutic options in young and elderly patients are comparable but there are some significant differences. The wide differential diagnosis of IBD in elderly patients may result in a delay in diagnosis. The relative dearth of data specific to elderly IBD patients often resulting from their exclusion from pivotal clinical trials and the lack of consensus guidelines have made clinical decisions somewhat challenging. In addition, age specific concerns such as co-morbidity; locomotor and cognitive function, poly-pharmacy and its consequences need to be taken into account. In applying modern treatment paradigms to the elderly, the clinician must consider the potential for more pronounced adverse effects in this vulnerable group and set appropriate boundaries maximising benefit and minimising harm. Meanwhile, clinicians need to make personalised decisions but as evidence based as possible in the holistic, considered and optimal management of IBD in elderly patients. In this review we will cover the clinical features and therapeutic options of IBD in the elderly; as well as addressing common questions and challenges posed by its management. | Danielle Nimmons Jimmy K Limdi | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 3 |
| 3 | First United Arab Emirates consensus on diagnosis and management of inflammatory bowel diseases:A 2020 Delphi consensus显示文摘Ulcerative colitis and Crohn’s disease are the main entities of inflammatory bowel disease characterized by chronic remittent inflammation of the gastrointestinal tract.The incidence and prevalence are on the rise worldwide,and the heterogeneity between patients and within individuals over time is striking.The progressive advance in our understanding of the etiopathogenesis coupled with an unprecedented increase in therapeutic options have changed the management towards evidence-based interventions by clinicians with patients.This guideline was stimulated and supported by the Emirates Gastroenterology and Hepatology Society following a systematic review and a Delphi consensus process that provided evidence-and expert opinion-based recommendations.Comprehensive up-to-date guidance is provided regarding diagnosis,evaluation of disease severity,appropriate and timely use of different investigations,choice of appropriate therapy for induction and remission phase according to disease severity,and management of main complications. | Maryam Alkhatry Ahmad Al-Rifai Vito Annese Filippos Georgopoulos Ahmad N Jazzar Ahmed M Khassouan Zaher Koutoubi Rahul Nathwani Mazen S Taha Jimmy K Limdi | 2020 | World Journal of Gastroenterology2020，26，43： | 2 |
| 4 | Warfarin pharmaco-genetics: a single VKOECI polymorphism is predictive of dose across 3 racial groups 显示文摘 | Limdi NA Wadelius M Cavallari L | 2010 | Blood2010，115，18： | 1 |
| 5 | Influence of CYP2C9 and VKORC1 on warfarin dose,anticoagulation at- tainment and maintenance among European-Americans and African-Americans显示文摘 | Limdi N A Amett D K Goldstein J A | 2008 | Pharmacogenomics2008，9，5： | 1 |
| 6 | Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans显示文摘 | Limdi N A Arnett D K Goldstein J A | 2008 | Pharmacogenomics2008，9，5： | 1 |
| 7 | Warfarin dosing in patients with impaired kidney function显示文摘 | Limdi NA Limdi MA Cavallari L | 2010 | Am J Kid-ney Dis2010，56，5： | 1 |
| 8 | Warfarin pharmaeoge- netics:a single VKORC1 polymorphism is predictive of dose across 3 racial groups显示文摘 | Limdi NA Wadelius M Cavallari L | 2010 | Blood2010，115，18： | 1 |
| 9 | Evaluation of abnormal liver function tests显示文摘 | Limdi JK Hyde GM | 2003 | Postgrad Med J2003，79，： | 1 |
| 10 | Warfarin phar- macogenetics: a single VKORC1 polymorphism is predic- tive of dose across 3 racial groups显示文摘 | Limdi NA Wadelius M Cavallari L | 2010 | Blood2010，115，18： | 1 |
| 11 | Evaluation of abnormal liver function tests 显示文摘 | Limdi JK Ilyde GM | 2003 | Postgrad Med J2003，79，932： | 1 |
| 12 | Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Ameri- cans显示文摘 | Limdi NA Arnett DK Goldstein JA | 2008 | Pharmacogenomics2008，9，5： | 1 |
| 13 | Influence of CYP2C9 and VKORC1 1173C/T genotype on the risk of hemorrhagic complications in African-American and European-American patients on warfarin显示文摘 | Limdi NA McGwin G Goldstein JA Beasley TM Arnett DK Adler BK | | 0，，02： | 1 |
| 14 | Influence of CYP2C9 and VKORC1 on warfarin dose,anticoagulation attainment and maintenance among European-Americans and African-Americans显示文摘 | Limdi NA Arnett DK Goldstein JA Beasley TM McGwin G Adler BK | | 0，，05： | 1 |
| 15 | Genetic variants associated with warfarin dose in African-American individuals:a genome-wide association study显示文摘 | Perera MA Cavallari LH Limdi NA | 2010 | Lancet2010，382，9894： | 1 |
| 16 | Morphological control of Fe3O4 particles via glycothermal process显示文摘 | ChoSB NohJS ParkSJ LimDY ChoiSH | 2007 | Journal of Materials Science2007，42，： | 1 |
| 17 | Warfarin pharmacogenomics显示文摘 | Cavallari LH Limdi NA | | 0，，03： | 1 |
| 18 | The use of thrombin injections in the management of bleeding gastric varices: a single-center experience显示文摘 | Jayapal Ramesh Jimmy K. Limdi Vikram Sharma Alistair J. Makin | 2008 | Gastrointestinal Endoscopy2008，，5： | 1 |
| 19 | Influence of CYP2C9 and VKORC1 polymorphisms on warfarin dose, anticoagulation attainment and maintenance among European American and African Americans 显示文摘 | Limdi N A Arnett D K Goldstein J A | 2008 | Pharmacogenomics2008，9，5： | 1 |
| 20 | Effect of epilepsy magnetic source imaging on intraeranial electrode placement 显示文摘 | Krtowlton RC Razdan SN Limdi N | 2009 | Ann Neural2009，65，： | 1 |
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