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| 1 | Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature显示文摘Ulcerative colitis(UC) is one of the main types of inflammatory bowel disease, which is caused by dysregulated immune responses in genetically predisposed individuals. Several genetic factors, including interleukin and interleukin receptor gene polymorphisms and other inflammation-related genes play central role in mediating and modulating the inflammation in the human body, thereby these can be the main cause of development of the disease. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but summarized literature is exiguous for challenge health specialist that can used in the clinical practice nowadays. This review summarizes the current literature on inflammationrelated genetic polymorphisms which are associated with UC. We performed an electronic search of Pubmed Database among publications of the last 10 years, using the following medical subject heading terms: UC, ulcerative colitis, inflammation, genes, polymorphisms, and susceptibility. | Patricia Sarlos Erzsebet Kovesdi Lili Magyari Zsolt Banfai Andras Szabo Andras Javorhazy Bela Melegh | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 15 |
| 2 | 溃疡性结肠炎基因单核苷酸多态性的研究进展显示文摘溃疡性结肠炎(ulcerative colitis,UC)属于炎症性肠病(inflammatory bowel disease,IBD)范畴,是一种主要侵及结肠黏膜的慢性非特异性炎症性疾病,常始自左半结肠,可向结肠近端乃至全结肠,以连续方式扩展,临床症状轻重不一,缓解与发作交替进行.患者可仅有结肠局部症状,如黏液脓血便、腹痛腹泻、里急后重等;也可伴发全身症状,如消瘦、贫血、低蛋白血症等;还会出现肠外表现,如结节性红斑、外周关节炎、口腔溃疡等. | 王银君 郑学宝 朱宇珍 吕汝西 | 2013 | 广东医学2013，34，18： | 1 |
| 3 | 药物治疗对溃疡性结肠炎大鼠组织中CTLA-4、TNF-α表达的影响显示文摘目的:利用三种药物:美沙拉嗪、康复新液、益生菌来治疗溃疡性结肠炎大鼠(UC),探究UC大鼠体内细胞毒T淋巴细胞相关抗原4(CTLA-4)、肿瘤坏死因子-α(TNF-a)在结肠黏膜组织、血清中的表达情况,分析这三种药物在治疗溃疡性结肠炎的疗效。方法:选取40只SD大鼠,按随机的原则,平均分成五组:正常组(A),模型组(B),美沙拉嗪组(C),康复新液(D),益生菌组(E),动物大鼠进行溃疡性结肠炎模型造模。造模成功后,A组、B组大鼠给与生理盐水(2m L,2次/天),C组、D组、E组进行相应药物灌肠治疗(2m L,2次/天),共7d。每日记录体重变化。五组大鼠均在一周后进行心脏采血,分离结肠组织,观察组织变化,留取血清,通过流式细胞术、酶联免疫吸附实验(ELISA)分别检测CTLA-4、TNF-a在大鼠组织中的表达水平。结果:将模型组与正常组比较,CTLA-4、TNF-a的水平增高(P<0.05);而治疗组(美沙拉嗪组、康复新液组、益生菌组)上述指标与模型组相比均有下降(P<0.05),美沙拉嗪组下降最少,其次康复新液组,益生菌组指标下降最多。结论:美沙拉嗪、康复新液、益生菌均可降低UC大鼠血清中CTLA-4、TNF-a的浓度水平,控制炎症,益生菌的效果最明显。 | 贺海龙 颜玉 | 2015 | 黑龙江医药科学2015，38，6： | 1 |
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