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| 1 | GRAIN INCOMPLETE FILLING 2 regulates grain filling and starch synthesis during rice caryopsis development显示文摘Rice grain filling determines grain weight,final yield and grain quality.Here,a rice defective grain filling mutant,gif2,was identified.Grains of gif2 showed a slower filling rate and a significant lower final grain weight and yield compared to wild-type.The starch content in gif2 was noticeably decreased and its physicochemical properties were also altered.Moreover,gif2 endosperm cells showed obvious defects in compound granule formation.Positional cloning identified GIF2 to encode an ADP-glucose pyrophosphorylase(AGP) large subunit,AGPL2;consequently,AGP enzyme activity in gif2 endosperms was remarkably decreased.GIF2 is mainly expressed in developing grains and the coded protein localizes in the cytosol.Yeast two hybrid assay showed that GIF2 interacted with AGP small subunits Os AGPS1,Os AGPS2a and Os AGPS2 b.Transcript levels for granule-bound starch synthase,starch synthase,starch branching enzyme and starch debranching enzyme were distinctly elevated in gif2 grains.In addition,the level of nucleotide diversity of the GIF2 locus was extremely low in both cultivated and wild rice.All of these results suggest that GIF2 plays important roles in the regulation of grain filling and starch biosynthesis during caryopsis development,and that it has been preserved during selection throughout domestication of modern rice. | Xiangjin Wei Guiai Jiao Haiyan Lin Zhonghua Sheng Gaoneng Shao Lihong Xie Shaoqing Tang Qingguo Xu Peisong Hu | 2017 | Journal of Integrative Plant Biology2017，59，2： | 20 |
| 2 | Acupuncture treatment of lung-spleen Qi deficiency in stable chronic obstructive pulmonary disease: a randomized, open-label, controlled trial显示文摘OBJECTIVE:To evaluate the effectiveness and safety of acupuncture that reinforces the spleen to strengthen the lung in patients with stable chronic obstructive pulmonary disease(COPD).METHODS:This was a randomized,open-controlled trial in which the acupuncturist and the participants were not blinded,but the outcome evalu-ators and data analysts were blinded.One-hundred-and-two patients with stable COPD were randomly divided into two groups in a 1∶1 ratio.The acupuncture group received 30-minute sessions of acupuncture therapy at the same acupoints three times weekly for 6 weeks in addition to routine conventional Western Medicine treatment;the control group received routine conventional Western Medicine treatment alone.The primary outcome was the Borg scale score,which was assessed immediately after the 6-minute walk test.The secondary outcomes were the 6-minute walk distance,lung function,and oxygen saturation.Measurements were obtained at baseline and after 6 weeks of treatment.RESULTS:After 6 weeks of treatment,the Borg scale score in the acupuncture group was significantly better than that in the control group(2.02±0.71 versus 5.01±0.34,P<0.05).Furthermore,the post-treatment improvements in the 6-minute walk distance,lung function,and oxygen saturation were significantly greater in the acupuncture group than in the control group,showing that the acupuncture group had better exercise tolerance.CONCLUSION:The findings suggest that acupuncture that aims to reinforce the spleen to strengthen the lung is a safe and effective adjuvant therapy that effectively improves the exercise capacity of patients with stable COPD. | Li Yu Xiong Chan Zeng Yan Wei Hua Zhuang Guangtong Zhao Lihong Li Chenyi Li Lin Qin Erqi Chen Xiaoqin Fu Juanjuan | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 13 |
| 3 | Features and origin time of Mesozoic strike-slip structures in the Yilan-Yitong Fault Zone显示文摘The NE-striking Yilan-Yitong Fault Zone(YYFZ) with a length of ca. 900 km is an important major fault zone in northeastern China. Its origin has been a controversial issue for a long time. Detailed field investigation and comprehensive analyses show that strike-slip faults or ductile shear belts exist as the origination structures on the both shoulders of the Cretaceous-Paleogene grabens. These strike-slip structures are dominated by brittle transcurrent faults, and appear as ductile shear belts only in the Weiyuanpu-Yehe and Shulan parts in the south and middle of the fault zone, respectively. The shear belts strike NE-SW and show steep mylonitic foliation and gentle mineral elongation lineation. Outcrop structures, microstructures and quartz c-axis fabrics demonstrate a sinistral shear sense with minor reverse component for the ductile shear belts. The microstructures suggest deformation temperatures of 400–450°C for the Weiyuanpu-Yehe shear belts and 350–400°C for the Shulan shear belt. A series of zircon U-Pb dating results for deformed and undeformed plutons or dikes in the shear belts constrain the strike-slip motion to the time between 160 and 126 Ma. It is further inferred from ages of main geological events in this region that the fault zone originated in the earliest Early Cretaceous. It is suggested therefore that the southern and middle parts of the Tan-Lu Fault Zone, which originated in Middle Triassic, propagated into northeastern China along the sinistral YYFZ under the earliest Early Cretaceous regional compression that is referred to as the Yanshan B event. The earliest Early Cretaceous initiation of the YYFZ results from both the high-speed oblique subduction of the Izanagi Plate and the final closure of the Mongol-Okhotsk Ocean, but the Izanagi Plate subduction played a major dynamic role in the fault zone origin. | GU ChengChuan ZHU Guang ZHAI MingJian LIN ShaoZe SONG LiHong LIU Bei | 2016 | Science China(Information Sciences)2016，59，12： | 10 |
| 4 | Fate of Basal N Under Split Fertilization in Rice with ^(15)N Isotope Tracer显示文摘Split fertilization strategy is popularly adopted in rice to synchronize soil nitrogen(N) supply and crop N demand. Attention has been paid more on mid-season topdressing N, but limited on basal N. A clearer understanding of the basal N fate under split fertilization is crucial for determining rational basal N split ratio to improve the yield and reduce the loss to environment. A two-year field experiment with two N rates of 150 and 300 kg Nha^(-1), two split ratios of basal N, 40% and 25%, and two rice varieties,Wuyunjing 23(japonica) and Y-liangyou 2(super hybrid indica), was conducted. Labelled ^(15) N urea was supplied in micro-plots as basal fertilizer to determine the plant uptake, translocation, soil residual, and loss of basal N fertilizer. The results showed that basal N absorbed by rice was only 1.6%–11.5% before tillering fertilization(8–10 d after transplanting), 6.5%–21.4% from tillering fertilization to panicle fertilization, and little(0.1%–4.4%) after panicle fertilization. The recovery efficiency of basal N for the entire rice growth stage was low and ranged from 18.7% to 24.8%, not significantly affected by cultivars or N treatments. Soil residual basal N accounted for 10.3%–36.4% and decreased with increasing total N rate and basal N ratio, regardless of variety and year. 43.8%–70.4% of basal N was lost into the environment based on the N balance. Basal N loss was significantly linearly positive related with the basal N rate and obviously enhanced by the increasing basal N ratio for both varieties in both 2012 and 2013. The N use efficiency and yield was significantly improved when decreasing the basal N ratio from 40% to 25%. The results indicated that the basal N ratio should be reduced, especially with limited N inputs, to improve the yield and reduce the N loss to the environment. | LI Ganghua LIN Jingjing XUE Lihong DING Yanfeng WANG Shaohua YANG Linzhang | 2018 | Pedosphere2018，28，1： | 9 |
| 5 | Effects of morphology and concentration of CuS nanoparticles on alignment and electro-optic properties of nematic liquid crystal显示文摘Nanoparticles (NP ) 与象花并且框架形态学从 CuS 被综合,显著转变金属硫化物。我们介绍了二种 CuS NP 进 nematic 液体晶体(LC ) 4-cyano-4-n-pentylbiphenyl (5CB ) 并且调查了形态学依赖者和集中依赖者排列并且电镀物品眼(E-O ) 在 5CB 上 CuS 完成 NP。象花的 CuS NP 的踪迹数量导致了 LC 分子的一致 homeotropic 取向;这对获得的理想的紧缩的 nanosheet 结构可归因。而且,象花并且框架 CuS NP 在 5CB 的 E-O 性质导致了显著改进,并且象花的 CuS/5CB 系统展出了更好的表演。在 LC 主人的做的 CuS NP 压制了防护效果并且加强了电场,导致突出的 E-O 性质。在 0.05 wt.% 的做的集中, CuS NP 是分散得好的并且完成了最佳 E-O 表演。这研究为由与非凡的 CuS NP 做导致一致取向和 LC 分子的提高的 E-O 性质提供一个新奇方法,导致在建立灵活 LC 显示器的潜在的应用程序。 | Bin Liu Yiran Ma Dongyu Zhao Lihong Xu Fashun Liu Wei Zhou Lin Guo | 2017 | Nano Research2017，10，2： | 9 |
| 6 | Assessment and Comparison of in vitro Immunoregulatory Activity of Three Astaxanthin Stereoisomers显示文摘In recent years,the immune-modulatory role of all-trans astaxanthin from different pigment sources has been studied.It was reported that all-trans astaxanthin might exist as three stereoisomers,and the composition of all-trans stereoisomers in natural materials differs from that of synthetic products.However,the different biological effects of various all-trans stereoisomers still remain unclear.In the present study,we evaluated the bioactivity of three astaxanthin stereoisomers,(3S,3'S)-trans-,(3R,3'R)-transand meso-trans-astaxanthin,in regulating cell-mediated immune response using mice lymphocytes and peritoneal exudates cells(PECs) systems.After the treatment with three astaxanthin stereoisomers(20 μmol L-1),the lymphocyte proliferation capacity,neutral red phagocytosis of PECs and natural killer(NK) cell cytotoxic activity were comparatively assessed.The results showed that all three astaxanthin stereoisomers significantly promoted lymphocyte proliferation,phagocytic capacity of PECs,and cytotoxic activity of NK cells.Moreover,the(3S,3'S)-trans-astaxanthin exhibited a much higher response than others. | SUN Weihong XING Lihong LIN Hong LENG Kailiang ZHAI Yuxiu LIU Xiaofang | 2016 | Journal of Ocean University of China2016，15，2： | 7 |
| 7 | Efficacy of Bushenjianpi prescription on autoimmune premature ovarian failure in mice显示文摘OBJECTIVE: To assess the efficacy of Bushenjianpi prescription(BSJPP), a formula from Traditional Chinese Medicine, on a mouse model of autoimmune premature ovarian failure(POF) induced by mouse zona pellucida(ZP3) and to investigate the mechanisms underlying the action.METHODS: After randomization, POF was induced in the model mice by immunization with ZP3. One week later, mice received low(8.1 mg/kg), moderate(16.2 mg/kg) and high(32.4 mg/kg) doses of BSJPP by gastrogavage once daily for 90 days. Premarin(0.03 mg/kg) served as the positive group. Serum samples were collected 1 week after the last dose and stored at-20 ℃ for analysis. After cervical dislocation, the uterus and ovaries were collected aseptically for evaluation by histological assessment, scanning electron microscopy, immunohistochemical staining, and Western blot and reverse transcription-polymerase chain reaction analyses.RESULTS: Serum E2 levels in POF model mice were decreased, whereas follicle-stimulating hormone(FSH) and luteinizing hormone(LH) levels were dramatically increased. Serum levels of E2,LH and FSH were reduced in POF model mice treated with BSJPP(moderate and high doses) and premarin. Anti-bone morphogenetic protein 15(BMP-15) and connexin 43(Cx43) were repressed in autoimmune POF model mice, whereas high expression was observed in control mice and those treated with BSJPP(moderate and high doses)and premarin.CONCLUSION: BSJPP is effective in treating ZP3-induced POF in mice and the increase in the expression of BMP-15 and Cx43 may be implicated in the mechanism underpinning the action. | Feng Guilin Lin Meijiao Zhou Xiaolin Zhang Lihong Li Jing Ouyang Jingfeng | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 6 |
| 8 | Melatonin enhances radiofrequency-induced NK antitumor immunity,causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor development显示文摘Surgery is the comm on treatme nt for early lung cancer with multiple pulm onary no dules,but it is often accompanied by the problem of significant malignancy of other nodules in non-therapeutic areas.In this study,we found that a combined treatment of local rad iofreq ue ncy ablati on(RFA)and melatonin(MLT)greatly improved clinical outcomes for early lung cancer patie nts with multiple pulmonary nodules by minimizing lung function injury and reducing the probability of malignant transformation or enlargement of nodules in non-ablated areas.Mechanically,as demonstrated in an associated mouse lung tumor model,RFA not only effectively remove treated tumors but also stimulate antitumor immunity,which could inhibit tumor growth in non-ablated areas.MLT enhanced RFA-stimulated NK activity and exerted synergistic antitumor effects with RFA.Transcriptomics and proteomics analyses of residual tumor tissues revealed enhanced oxidative phosphorylation and reduced acidification as well as hypoxia in the tumor microenvironment,which suggests reprogrammed tumor metabolism after combined treatment with RFA and MLT.Analysis of residual tumor further revealed the depressed activity of MAPK,NF-kappa B,Wnt,and Hedgehog pathways and upregulated P53 pathway in tumors,which was in line with the inhibited tumor growth.Combined RFA and MLT treatment also reversed the Warburg effect and decreased tumor malignancy.These findings thus demonstrated that combined treatment of RFA and MLT effectively inhibited the malignancy of non-ablated nodules and provided an innovative non-invasive strategy for treating early lung tumors with multiple pulmonary nodules.Trial registration:www.chictr.org.cn,identifier ChiCTR2100042695,http://gffzz62a03ee25e6f4a77hc05o6o5c65kk6f05.ffgz.tsg.suse.edu.cn/showproj.aspx?proj=120931. | Ming Li Bingjie Hao Menghuan Zhang Russel J.Reiter Shumeng Lin Tiansheng Zheng Xiangyun Chen Yanbei Ren Liduo Yue Baigenzhin Abay Guojie Chen Xiao Xu Yufeng Shi Lihong Fan | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 9 | In vivo superresolution photoacoustic computed tomography by localization of single dyed droplets显示文摘Photoacoustic(PA)computed tomography(PACT)is a noninvasive hybrid imaging technique that combines optical excitation and acoustic detection to realize high contrast,high resolution,and deep penetration in biological tissues.However,the spatial resolution of PACT is limited by acoustic diffraction.Here,we report in vivo superresolution PACT,which breaks the acoustic diffraction limit by localizing the centers of single dyed droplets that are flowing in blood vessels.The droplets were prepared by dissolving hydrophobic absorbing dye in oil,followed by mixing with water.The dyed droplets generate much higher-amplitude PA signals than blood and can flow smoothly in vessels;thus,they are excellent tracers for localization-based superresolution imaging.The in vivo resolution enhancement was demonstrated by continuously imaging the cortical layer of a mouse brain during droplet injection.The droplets that were flowing in the vessels were localized,and their center positions were used to construct a superresolution image that exhibits sharper features and more finely resolved vascular details.An improvement in spatial resolution by a factor of 6 has been realized in vivo by the droplet localization technique. | Pengfei Zhang Lei Li Li Lin Junhui Shi Lihong V.Wang | 2019 | Light(Science & Applications)2019，8，1： | 6 |
| 10 | Expert consensus on regenerative endodontic procedures显示文摘Regenerative endodontic procedures(REPs)is a biologic-based treatment modality for immature permanent teeth diagnosed with pulp necrosis.The ultimate objective of REPs is to regenerate the pulp-dentin complex,extend the tooth longevity and restore the normal function.Scientific evidence has demonstrated the efficacy of REPs in promotion of root development through case reports,case series,cohort studies,and randomized controlled studies.However,variations in clinical protocols for REPs exist due to the empirical nature of the original protocols and rapid advancements in the research field of regenerative endodontics.The heterogeneity in protocols may cause confusion among dental practitioners,thus guidelines and considerations of REPs should be explicated.This expert consensus mainly discusses the biological foundation,the available clinical protocols and current status of REPs in treating immature teeth with pulp necrosis,as well as the main complications of this treatment,aiming at refining the clinical management of REPs in accordance with the progress of basic researches and clinical studies,suggesting REPs may become a more consistently evidence-based option in dental treatment. | Xi Wei Maobin Yang Lin Yue Dingming Huang Xuedong Zhou Xiaoyan Wang Qi Zhang Lihong Qiu Zhengwei Huang Hanguo Wang Liuyan Meng Hong Li Wenxia Chen Xiaoying Zou Junqi Ling | 2022 | International Journal of Oral Science2022，14，4： | 5 |
| 11 | Dynamic network embedding via incremental skip-gram with negative sampling显示文摘Network representation learning,as an approach to learn low dimensional representations of vertices,has attracted considerable research attention recently.It has been proven extremely useful in many machine learning tasks over large graph.Most existing methods focus on learning the structural representations of vertices in a static network,but cannot guarantee an accurate and efficient embedding in a dynamic network scenario.The fundamental problem of continuously capturing the dynamic properties in an efficient way for a dynamic network remains unsolved.To address this issue,we present an efficient incremental skip-gram algorithm with negative sampling for dynamic network embedding,and provide a set of theoretical analyses to characterize the performance guarantee.Specifically,we first partition a dynamic network into the updated,including addition/deletion of links and vertices,and the retained networks over time.Then we factorize the objective function of network embedding into the added,vanished and retained parts of the network.Next we provide a new stochastic gradient-based method,guided by the partitions of the network,to update the nodes and the parameter vectors.The proposed algorithm is proven to yield an objective function value with a bounded difference to that of the original objective function.The first order moment of the objective difference converges in order of O(1/n^2),and the second order moment of the objective difference can be stabilized in order of O(1).Experimental results show that our proposal can significantly reduce the training time while preserving the comparable performance.We also demonstrate the correctness of the theoretical analysis and the practical usefulness of the dynamic network embedding.We perform extensive experiments on multiple real-world large network datasets over multi-label classification and link prediction tasks to evaluate the effectiveness and efficiency of the proposed framework,and up to 22 times speedup has been achieved. | Hao PENG Jianxin LI Hao YAN Qiran GONG Senzhang WANG Lin LIU Lihong WANG Xiang REN | 2020 | Science China(Information Sciences)2020，63，10： | 4 |
| 12 | Factors Affecting Small Axial Cooling Fan Performance显示文摘Many factors such as outer diameter,hub ratio,blade numbers,shape and stagger angle affect the performance of small cooling fans.A small cooling fan was simulated using CFD software for three blade stagger angles (30.5°,37.5°,44.5°)and obtained the internal flow field and the static characteristics.Research indicated that the stagger angle has an obvious effect on the static characteristics of a fan.For flow rates below 0.0104 m3/s,total pressure is the greatest when the stagger angle is 37.5°;flow rates higher than 0.0104 m3/s,the total pressure is greatest when the stagger angle is 44.5° For the same flow rates,the velocity at inlet of pressure surface increases with increasing stagger angle,but the change of velocity on the suction surface is very small.For one model,vortices and the speed of revolution surfaces decrease with tip clearance increasing.But for other three models,increasing the stagger angle,the vortex intensity and speed of revolution surfaces at same height tip clearance increases,simultaneously,the position of vortex offset from the top of the rotor blade to the suction surface. | Lihong Wang,Yingzi Jin,Baoling Cui,Yuzhen Jin,Jin Lin,Yanping Wang and Chuanyu Wu College of Mechanical Engineering & Automation,Zhejiang Sci-Tech University,Xiasha Education Zone,Hangzhou 310018,China | 2010 | Journal of Thermal Science2010，19，2： | 4 |
| 13 | The Oncoprotein HBXIP Uses Two Pathways to Up-regulate S100A4 in Promotion of Growth and Migration of Breast Cancer Cells显示文摘 | Shuangping Liu Leilei Li Yingyi Zhang Yiwen Zhang Yu Zhao Xiaona You Zhenhua Lin Xiaodong Zhang Lihong Ye | 2012 | Journal of Biological Chemistry2012，，36： | 3 |
| 14 | Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice显示文摘亲爱的编辑, | Dekun Wang Qingwen Meng Lihong Huo Meng Yang Lingling Wang Xinyu Chen JianchaoWang Zhiguo Li Xiaoying Ye Na Liu Qiuyan Li Zhen Dai Hongsheng Ouyang Ning Li Jun Zhou Lingyi Chen Lin Liu | 2015 | Protein & Cell2015，6，2： | 3 |
| 15 | Recent Advances in Carbon Nanodots:Properties and Applications in Cancer Diagnosis and Treatment显示文摘Cancer is a serious threat to human health.Survival rates of cancer patients are highly dependent on the early diagnosis and treatment.Carbon nanodots(CDs),a rising star of carbon nanomaterial family,can be developed as a promising terrace for cell labeling,bioimaging,drug delivery,diagnosis,and therapy by virtue of many superior properties including unique photo-luminescence properties,low toxicity,excellent biocompatibility,and easy functionalization.In this mini review,we present the recent progress in fundamental properties of CDs,and highlight their bioapplications in cancer diagnosis and treatment. | Xiaofeng Li Lihong Shi Lin Li Chuan Dong Chen-zhong Li Shaomin Shuang | 2019 | Journal of Analysis and Testing2019，3，1： | 2 |
| 16 | Facet-dependent electro-optical properties of cholesteric liquid crystals doped with Cu2O nanocrystals显示文摘 | Dongyu Zhao Lihong Xu Yang Shang Xiaoxia Li Lin Guo | 2018 | Nano Research2018，11，9： | 2 |
| 17 | Ultrasound-induced biophysical effects in controlled drug delivery显示文摘Ultrasound is widely used in biomedical engineering and has applications in conventional diagnosis and drug delivery.Recent advances in ultrasound-induced drug delivery have been summarized previously in several reviews that have primarily focused on the fabrication of drug delivery carriers.This review discusses the mechanisms underlying ultrasound-induced drug delivery and factors affecting delivery efficiency,including the characteristics of drug delivery carriers and ultrasound parameters.Firstly,biophysical effects induced by ultrasound,namely thermal effects,cavitation effects,and acoustic radiation forces,are illustrated.Secondly,the use of these biophysical effects to enhance drug delivery by affecting drug carriers and corresponding tissues is clarified in detail.Thirdly,recent advances in ultrasound-triggered drug delivery are detailed.Safety issues and optimization strategies to improve therapeutic outcomes and reduce side effects are summarized.Finally,current progress and future directions are discussed. | Lulu Zhang Zhuohua Lin Lan Zeng Fan Zhang Lihong Sun Suhui Sun Ping Wang Menghong Xu Jinxia Zhang Xiaolong Liang Huiyu Ge | 2022 | Science China(Life Sciences)2022，65，5： | 2 |
| 18 | 人骨肉瘤鸡胚移植瘤模型的建立及其生物学特性研究(英文)显示文摘Objective: We established a transplantation tumor model of human osteosarcoma in chick embryo, studied its morphological and biological characteristics, and observed its dynamic process of angiogenesis induction so that a simple and practical model can be provided for studying osteosarcoma. Methods: Human osteosarcoma cells at different concentrations were inoculated in chorioallantoic membrane (CAM) of chick embryos at different embryonic ages to observe the factors affecting the survival of the transplanted osteosarcoma in chick embryo, growth characteristics of the transplantation tumor, and the morphological characteristics and biological characteristics of the transplantation tumor. Results: The transplantation tumor model of human osteosarcoma in chick embryo was successfully established. It was found that the transplantation tumor was easy to grow and it showed strong angiogenesis-inducing effects. Under the light microscope, the transplantation tumor showed a similar tissue structure to human osteosarcoma. Conclusion: It is feasible to establish a transplantation tumor model of human osteosarcoma in chick embryo. The model can be easily duplicated with a simple operation, which provides a useful animal model for studying osteosarcoma. | Jianping Wang Lihong Wang Lin Cai | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，9： | 2 |
| 19 | Electronic structure of exfoliated millimeter-sized monolayer WSe2 on silicon wafer显示文摘The mono layer WSe2 is in teresting and important for future application in nanoelectronics,spintronics and valleytronics devices,because it has the largest spin splitting and Ion gest valley coherence time among all the known monolayer transition-metal dichalcogenides(TMDs).Toobtain the large-area monolayer TMDs'crystal is the first step to manu facture scalable and high-performance electronic devices.In this letter,we have successfully fabricated millimeter-sized mono layer WSe2 single crystals with very high quality,based on our improved mecha nicalexfoliation method.With such superior samples,using standard high resolution angle-resolved photoemission spectroscopy,we didcomprehe nsive electronic band structure measurements on our mono layer WSe2.The overall band features point it to be a 1.2 eV direct bandgap semico nductor.Its spin splitting of the valence band at K point is found as 460 meV,which is 30 meV less than the corresponding band splitting in its bulk counterpart.The effective hole masses of valence bands are determined as 2.344 me atГ,and 0.529 me as well as 0.532 meat K for the upper and lower branch of splitting ban ds,respectively.And screening effect from substrate is shown to substa ntially impact onthe electronic properties.Our results provide importa nt insights into band structure engineering in mono layer TMDs.Our mono layer WSe2 crystals may constitute a valuable device platform. | Wenjuan Zhao Yuan Huang Cheng Shen Cong Li Yongqing Cai Yu Xu Hongtao Rong Qiang Gao Yang Wang Lin Zhao Lihong Bao Qingyan Wang Guangyu Zhang Hongjun Gao Zuyan Xu Xingjiang Zhou Guodong Liu | 2019 | Nano Research2019，12，12： | 2 |
| 20 | Deciphering the chromatin spatial organization landscapes during BMMSC differentiation显示文摘The differentiation imbalance in bone marrow mesenchymal stem cells(BMMSCs)is critical for the development of bone density diseases as the population ages.BMMSCs are precursor cells for osteoblasts and adipocytes;however,the chromatin organization landscapes during BMMSC differentiation remain elusive.In this study,we systematically delineate the four-dimensional genome and dynamic epigenetic atlas of BMMSCs by RNA sequencing,assay for transposase-accessible chromatin sequencing,and highthroughput chromosome conformation capture.The structure analyses reveal 17.5%common and28.5%-30%specific loops among BMMSCs,osteoblasts,and adipocytes.The subsequent correlation of genome-wide association studies and expression quantitative trait locus(e QTL)data with multi-omics analysis reveal 274 genes and 3634 single nucleotide polymorphisms(SNPs)associated with bone degeneration and osteoporosis(OP).We hypothesize that SNP mutations affect transcription factor(TF)binding sites,thereby affecting changes in gene expression.Furthermore,26 motifs,260 TFs,and 291SNPs are identified to affect the e QTL.Among these genes,DAAM2,TIMP2,and TMEM241 are found to be essential for diseases such as bone degeneration and OP and may serve as potential drug targets. | Zhaowei Teng Yun Zhu Da Lin Qinggang Hao Qiaoning Yue Xiaochao Yu Shuo Sun Lihong Jiang Sheng Lu | 2023 | Journal of Genetics and Genomics2023，50，4： | 1 |
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