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| 1 | Robust semi-global leader-following practical consensus of a group of linear systems with imperfect actuators显示文摘This paper considers the problem of semi-global leader-following consensus of a multi-agent system whose agent dynamics are represented by linear systems. The input output characteristics of the follower agent actuators, such as those of saturation and dead-zone, are imperfect, not precisely known, and subject to the effect of disturbances. Two consensus control algorithms, of the low-and-high gain feedback type and the low gain based variable structure control type, are proposed for solving the consensus problem. It is shown that both of these control algorithms achieve semi-global leader-following practical consensus in the presence of the imperfectness of the actuators when the communication topology among the follower agents is represented by a strongly connected and detailed balanced directed graph and the leader agent is a neighbor of at least one follower agent. The theoretical results are illustrated by numerical simulation. | Liangren SHI Zhiyun ZHAO Zongli LIN | 2017 | Science China(Information Sciences)2017，60，7： | 8 |
| 2 | Robust Semi-Global Leaderless Consensus and Containment Control of Identical Linear Systems with Imperfect Actuators显示文摘这份报纸两个都与有瑕疵的致动器为一组相同线性系统调查柔韧的半全球的无领袖的一致问题和柔韧的半全球的抑制控制问题。有瑕疵的致动器被象浸透和死了的地区那样的非线性描绘,在那里,输入输出关系精确不被知道。追随者代理人的动力学被输入添加剂骚乱也影响。Low-and-high 获得反馈一致协议被构造解决这些问题。更明确地,每个追随者代理人什么时候存取至少一个领导人代理人的信息,被显示出柔韧的半全球的无领袖的一致能在一张连接的未受指导的图上被完成,柔韧的半全球的抑制控制能被完成。数字模拟说明理论结果。 | SHI Liangren ZHAO Zhiyun LIN Zongli | 2018 | Journal of Systems Science & Complexity2018，31，1： | 3 |
| 3 | Orthogonal testdesign foroptimization of the extraction of polysaccharides from phascolosoma esulenta and evaluation of its immunity activity显示文摘 | Liangren Jie | | 0，，： | 1 |
| 4 | A comparison among four tract dilation methods of percutaneous nephrolithotomy:a systematic review and meta-analysis显示文摘 | Dehong C Liangren L Huawei L | 2013 | Urolithiasis2013，41，： | 1 |
| 5 | A comparison among four tract dilation methods of percutaneous nephrolithotomy:a systematic review and metaanalysis显示文摘 | Dehong C Liangren L Huawer L | 2013 | Urolithiasis2013，41，6： | 1 |
| 6 | Synthesis and activity of novel indole derivatives as inhibitors of CD38显示文摘CD38 is a multifunctional enzyme/receptor expressed in a variety of mammalian tissues,regulating a wide range of physiological functions.Beginning with the previously reported compound 1,an inhibitor of human CD38 NADase,we synthesized a series of indole-based NH-substituted derivatives with modifications on alkyl chains,changes in substituent groups on aromatic rings,and differences in carbon chain lengths.Compounds 10,13,16 and 34 exhibited moderate inhibition of human CD38 NADase.Analysis of the structure-activity relationships showed that the phenylpropionyl moiety was very important for the inhibitory activity.This study provides information for the rational design of CD38 inhibitors. | Dongying Wu Kaiyiu Ting Yaokai Duan Na Li Jianguo Li Liangren Zhang Honcheung Lee Lihe Zhang | 2013 | Acta Pharmaceutica Sinica B2013，3，4： | 1 |
| 7 | A comparison among four tract dilation methods of percutaneous nephrolithotomy:a systematic review and meta-analysis显示文摘 | Dehong C Liangren L Huawei L | 2013 | Urolithiasis2013，，： | 1 |
| 8 | Unfolding and Conformational Variations of Thrombin‐Binding DNA Aptamers: Synthesis, Circular Dichroism and Molecular Dynamics Simulations显示文摘 | Lidan Sun Hongwei Jin Xiaoyang Zhao Zhenming Liu Yifu Guan Zhenjun Yang Liangren Zhang Lihe Zhang | 2014 | ChemMedChem2014，，5： | 1 |
| 9 | Synchronization method based on a new constant envelop preamble for OFDM systems 显示文摘 | GUANG liangren YI linchang | 2007 | IEEE Transaction on Broadcasting2007，51，01： | 1 |
| 10 | Carbazole and tetrahydro-carboline derivatives as dopamine D_(3) receptor antagonists with the multiple antipsychotic-like properties显示文摘Dopamine D_(3) receptor(D_(3)R)is implicated in multiple psychotic symptoms.Increasing the D_(3)R selectivity over dopamine D_2 receptor(D_2R)would facilitate the antipsychotic treatments.Herein,novel carbazole and tetrahydro-carboline derivatives were reported as D_(3)R selective ligands.Through a structure-based virtual screen,ZLG-25(D_(3)R K_i=685 nmol/L;D_2R K_i>10,000 nmol/L)was identified as a novel D_(3)R selective bitopic ligand with a carbazole scaffold.Scaffolds hopping led to the discovery of novel D_(3)R-selective analogs with tetrahydro-β-carboline or tetrahydro-γ-carboline core.Further functional studies showed that most derivatives acted as h D_(3)R-selective antagonists.Several lead compounds could dose-dependently inhibit the MK-801-induced hyperactivity.Additional investigation revealed that 23j and 36b could decrease the apomorphine-induced climbing without cataleptic reaction.Furthermore,36b demonstrated unusual antidepressant-like activity in the forced swimming tests and the tail suspension tests,and alleviated the MK-801-induced disruption of novel object recognition in mice.Additionally,preliminary studies confirmed the favorable PK/PD profiles,no weight gain and limited serum prolactin levels in mice.These results revealed that 36b provided potential opportunities to new antipsychotic drugs with the multiple antipsychotic-like properties. | Zhongtang Li Fan Fang Yiyan Li Xuehui Lv Ruqiu Zheng Peili Jiao Yuxi Wang Guiwang Zhu Zefang Jin Xiangqing Xu Yinli Qiu Guisen Zhang Zhongjun Li Zhenming Liu Liangren Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，11： | 0 |
| 11 | In vitro selection of G-rich RNA aptamers that target HIV-1 integrase显示文摘Aptamers that interact with various HIV-1 proteins,such as reverse transcriptase,Rev,Tat protein,and nuclear capsule protein,have been prepared through SELEX (systematic evolution of ligands by ex-ponential enrichment) technique. However,there are few reports about the DNA or RNA aptamers that target HIV-1 integrase. In this investigation,we selected alternative RNA aptamers specific for the HIV-1 integrase by using a different binding buffer containing 10 mmol·L-1 MgCl2 and 100 mmol·L-1 KCl. Aptamer IN1,IN2,IN3 had similar and the highest Kd values from 145 to 239 nmol·L-1. Structural studies showed that they formed similar stem-loop structure. Deletion of any stem structure resulted in diminished affinity. In addition,structure probing study with antisense DNA indicated that the stem-loop structure in the random region was critical for integrase binding. Although aptamer IN1 failed to form G-quartet structure,it might directly interact with the DDE motif of integrase,which is the virus DNA-binding site,because G-quadruplex T40214 competitively inhibited the interaction between IN1 and integrase. Together,this study generated a novel RNA aptamer IN1,which could be useful in basic research and anti-HIV drug screening. | LIU YingChun ZHANG Yan YE GuoZhu YANG ZhenJun ZHANG LiangRen ZHANG LiHe | 2008 | Science China Chemistry2008，51，5： | 0 |
| 12 | Clinical characteristics of testicular non-seminomatous germ cell tumor from West China: a 10-year experience显示文摘To the Editor:Testicular tumor represents 1%of male neoplasms and 5%of urogenital tumors.Non-seminomatous germ cell tumor(NSGCT)accounts for nearly 40%of all testicular cancers.The survival of patients with NSGCT has been improved because of advanced multimodal therapies(orchiectomy,and if necessary,subsequent chemotherapy).[1]However,to the best of our knowledge,survival of NSGCT patients has not been studied in a large Chinese cohort yet.Therefore,this study assessed the clinical characteristics,treatments,and outcomes of patients with NSGCT. | Zeyu Chen Xingyuan Wang Dehong Cao Shi Qiu Jin Li Bo Chen Yin Huang Yige Bao Liangren Liu Qiang Wei | 2022 | Chinese Medical Journal2022，，13： | 0 |
| 13 | 3D-QSAR and docking studies on 2-arylbenzoxazole and linker-Y transthyretin amyloidogenesis inhibitors显示文摘Transthyretin(TTR),a plasma protein with a tetramer structure,could form amyloid fibril associated with several human diseases through the dissociation of tetramer and the misfolding of monomer.These amyloidogenesis can be inhibited by small molecules which bind to the central channel of TTR.A number of small molecules like 2-arylbenzoxazoles(ABZ)analogues are proposed as promising therapeutic strategy to treat amyloidosis.In this work,comparative molecular field analysis(CoMFA)and comparative molecular similarity indices analysis(CoMSIA)three-dimensional quantitative structure-activity relationship(3D-QSAR)and docking studies were performed on series of 2-arylbenzoxazoles(ABZ)and linker-Y analogues to investigate the inhibitory activities of TTR amyloidogenesis at atomic level.Significant correlation coefficients for ABZ series(CoMFA,r2=0.877,q2=0.431;CoMSIA,r2=0.836,q2=0.447)and those for linker-Y series(CoMFA,r2=0.828,q2=0.522;CoMSIA,r2=0.800,q2=0.493)were obtained,and the generated models were validated using test sets.In addition,docking studies on 6 compounds binding to TTR were performed to analyze the forward or reverse binding mode and interactions between molecules and TTR.These results from 3D-QSAR and docking studies have great significance for designing novel TTR amyloidogenesis inhibitors in the future. | ZHAO LiJun ZHANG LiangRen LEI Ming | 2013 | Science China Chemistry2013，56，11： | 0 |
| 14 | Investigation of the effect of 2'-substitution of NMN analogues on CD38 NADase inhibitory activity显示文摘CD38是一种烟酰胺腺嘌呤二核苷酸(NAD)代谢酶,可以催化生成不同的钙信号信使。它的酶抑制剂对于CD38调控的信号通路和生理功能的进一步研究有重要作用。为了深入了解2'位取代基对烟酰胺单核苷酸(NMN)类似物抑制CD38酶活性的影响,本文研究了一种2'位有两个取代基的新NMN类似物,同时使用分子动力学模拟和量子化学计算方法探索2'位取代基影响活性的原因。结果表明2'位有两个取代基时,会干扰核苷酸C1'与CD38之间共价键的形成。本研究将有助于全面理清NMN类似物作为CD38酶抑制剂的构效关系。 | Jianguo Li Fen Pei Wenjie Zhu Hongwei Jin Yongjuan Zhao Liangren Zhang Honcheung Lee Lihe Zhang | 2015 | Journal of Chinese Pharmaceutical Sciences2015，24，8： | 0 |
| 15 | Comparative assessment of efficacy and safety of different treatment for de novo overactive bladder children: A systematic review and network meta-analysis显示文摘Objective:To compare these managements focusing on the efficacy and safety to treat overactive bladder(OAB)in children through network meta-analysis(NMA).Methods:We searched PubMed,Embase,the Cochrane Library Central Register of Controlled Trials(CENTRAL)and the reference lists up to May 1st,2017.Data from eligible randomized controlled trails(RCT)studies including three different treatment options were extracted.The primary outcome was maximal voiding volume(MVV).We performed pairwise metaanalyses by random effects model and NMA by Bayesian model.We used the Grading of Recommendations,Assessment,Development and Evaluations(GRADE)framework to assess the quality of evidence contributing to each network estimate.Results:Six RCTs(462 patients)comparing three different interventions fulfilled the inclusion criteria.A low risk of bias was shown for the majority of the study items.The results of NMA showed that compared with antimuscarinic drugs,Parasacral transcutaneous electrical nerve stimulation was associated with significant improvement in the MVV(mean difference[MD]=58.50,95% confidential interval[CI]:45.95-69.52),followed by urotherapy group(MD=21.03,95%CI:11.85-29.97).When it comes to the constipation,antimuscarinic drugs exerted significant benefit than PTENS(odds ratio[OR]:0.22,95%CI:0.01-0.46).No significant difference was found between other treatments.Conclusion:Compared with antimuscarinic drugs,PTENS was associated with significant better efficacy considering MVV,but more constipation events in de novo OAB children.Antimuscarinic drugs showed remarkably better efficacy considering MVV and comparable safety profile compared with urotherapy.Clinicians should take all known safety and compliance of patients into account when choosing an optimal strategy. | Shi Qiu Siwei Bi Tianhai Lin Zhuheng Wu Qi’an Jiang Jiwen Geng Liangren Liu Yige Bao Xiang Tu Mingjing He Lu Yang Qiang Wei | 2019 | Asian Journal of Urology2019，6，4： | 0 |
| 16 | Design, Synthesis and Preliminary Biological Evaluation of Purine-2,6-diamine Derivatives as Cyclin-dependent Kinase (CDK) Inhibitors显示文摘新奇 purine-2,6-diamine 衍生物作为 cyclin 依赖的 kinase (CDK ) 被设计并且综合禁止者。根据初步的生物评估,大多数混合物在一些肿瘤房间线在 CDK1 酶试金和有势力 antiproliferative 活动显示出好禁止的活动。特别,加重 11a (IC50=0. | Junhua Wang Quande Wang Liangren Zhang Hao Fang | 2013 | Chinese Journal of Chemistry2013，31，9： | 0 |
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