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| 1 | Rapeseed research and production in China显示文摘Rapeseed(Brassica napus L.) is the largest oilseed crop in China and accounts for about 20% of world production.For the last 10 years,the production,planting area,and yield of rapeseed have been stable,with improvement of seed quality and especially seed oil content.China is among the leading countries in rapeseed genomic research internationally,having jointly with other countries accomplished the whole genome sequencing of rapeseed and its two parental species,Brassica oleracea and Brassica rapa.Progress on functional genomics including the identification of QTL governing important agronomic traits such as yield,seed oil content,fertility regulation,disease and insect resistance,abiotic stress,nutrition use efficiency,and pod shattering resistance has been achieved.As a consequence,molecular markers have been developed and used in breeding programs.During 2005–2014,215 rapeseed varieties were registered nationally,including 210 winter-and 5 spring-type varieties.Mechanization across the whole process of rapeseed production was investigated and operating instructions for all relevant techniques were published.Modern techniques for rapeseed field management such as high-density planting,controlled-release fertilizer,and biocontrol of disease and pests combined with precision tools such as drones have been developed and are being adopted in China.With the application of advanced breeding and production technologies,in the near future,the oil yield and quality of rapeseed varieties will be greatly increased,and more varieties with desirable traits,especially early maturation,high yield,high resistance to biotic and abiotic stress,and suitability for mechanized harvesting will be developed.Application of modern technologies on the mechanized management of rapeseed will greatly increase grower profit. | Qiong Hu Wei Hua Yan Yin Xuekun Zhang Lijiang Liu Jiaqin Shi Yongguo Zhao Lu Qin Chang Chen Hanzhong Wang | 2017 | The Crop Journal2017，5，2： | 25 |
| 2 | Expression of survivin in primary and metastatic gastric cancer cells obtained by laser capture microdissection显示文摘AIM:Survivin, a recently identified member of the inhibitor of apoptosis protein family, is expressed during development and in various human cancers. However, its expression in normal tissues and clinical relevance in cancers are still debated. In the present study, we analyzed the expression of the survivin gene in human primary and metastatic gastric cancer cells as well as in paired epithelial cells from normal gastric mucosa by means of a novel laser capture microdissection (LCM) technique coupled with reverse transcription -polymerase chain reaction (RT-PCR).METHODS: Thirty patients who had undergone gastrectomy with lymph node dissection for gastric cancer without preoperative treatments were included. Neoplastic tissue, metastatic lymph nodes, and apparently uninvolved normal tissue were collected from each patient. LCM-captured 'pure' cell groups were respectively subjected to RT-PCR analysis with primers specific for the survivin gene.RESULTS: Of the paired samples from 30 gastric cancer patients studied, 24 (80%) primary gastric cancer cell groups and 7 (23%) adjacent morphologically 'normal' gastric epithelial cell groups were shown to have a detectable survivin expression. There was a statistically significant difference in suvivin expression between these two groups (P<0.01). Meanwhile, 95% (19/20) of the metastatic gastric cancer cell groups from lymph nodes had a clear expression of the survivin gene. However, no significant correlation between survivin expression and clinicopathological features of gastric cancer was observed in the present study. CONCLUSION: Survivin expression is present in the majority of gastric cancer cell groups obtained by LCM techniques. The high expression rate in metastatic lesions suggests a possible role of survivin in cancer invasiveness and metastasis. It may contribute to the detection of gastric cancer micrometastasis as a potential molecular marker. In addition, the high expression percentage renders survivin a potential target in the therapy for gastric cancer. | Zhen-NingWang Hui-MianXu LiJiang XinZhou ChongLu XueZhang | 2004 | World Journal of Gastroenterology2004，10，21： | 23 |
| 3 | Characterization of the Rice Floral Organ Number Mutantfon3显示文摘A spontaneous rice mutant named floral organ number 3 (fon3) had major mutations in floral organ numbers. Genetic analysis indicated thatfon3 acted as a single recessive gene. Microscopic observation showed that the number of floral organs infon3 increased centripetally. For example, the number of pistils was the more frequently increased than organs in the outer whorls. Homeotic conversion of lodicules and glumes into palea/lemma-like organs was observed in some flowers. Scanning electron microscopy observation showed that the size of flower meristems was maintained the same or similar until the lemma primordium started to differentiate, at which time the floral meristem became enlarged, suggesting abnormal development of the inner whorls of rice florets. The relationship offon3 with other similar rice mutants is discussed. | LiJIANG QianQIAN LongMAO Qing-YuanZHOU Wen-XueZHAI | 2005 | Journal of Integrative Plant Biology2005，47，1： | 21 |
| 4 | Porous CuO nanowires as the anode of rechargeable Na-ion batteries显示文摘 | Lijiang Wang Kai Zhang Zhe Hu Wenchao Duan Fangyi Cheng Jun Chen | 2014 | Nano Research2014，7，2： | 21 |
| 5 | Association of Fas-670 gene polymorphism with inflammatory bowel disease in Chinese patients显示文摘AIM: Recent studies suggest that Fas-mediated apoptosis is involved in the pathogenesis of inflammatory bowel disease (IBD). It has been hypothesized that either increased apoptosis of intestinal epithelium or decreased apoptosis of lamina propria lymphocytes may induce inflammation of gut. The aim of this study was to determine whether the Fas gene promoter polymorphism at position-670 was associated with IBD in Chinese patients.METHODS: Fifty unrelated Chinese patients with IBD (38patients with ulcerative colitis and 12 with Crohn's disease)and 124 healthy controls were genotyped for the Fas-670polymorphism by PCR-restriction fragment length polymorphism method. The PCR product was digested by Mva I restriction enzyme.RESULTS: Distribution of the Fas-670 gene polymorphism was 33% for the AA genotype, 52% for the AG genotype and 15% for the GG genotype in 124 healthy subjects. In patients with IBD, 30% was for the AA genotype, 42% for the AG genotype and 28% for the GG genotype respectively. However, there was no significant difference in the genotype (P= 0.1498), allele frequencies (P= 0.3198)and carriage frequencies (P = 0.4133) between healthy controls and IBD patients. Furthermore, we did not find any difference between the left-sided colitis and total colitis (P = 0.8242).CONCLUSION: Fas-670 polymorphism is not associated with IBD in Chinese patients. | BingXia Yu-HongYu Qiu-ShaGuo Xiang-YinLi LiJiang JinLi | 2005 | World Journal of Gastroenterology2005，11，3： | 15 |
| 6 | Resistance to rice blast (Pyricularia oryzae) caused by the expression of trichosanthin gene in transgenic rice plants transferred through agrobacterium method显示文摘The gene of trichosanthin has been transferred into rice plants through agrobacterium method. The single copy insertion and the expression of foreign gene have been proved in regenerated plants. In antifungal assay the degrees of rice blast (Pyricularia oryzae) infection of the transgenic plants expressing trichosanthin and expressing GUS gene as control have been evaluated. The differences such as the time of disease symptom observed, the number of infected plants and damaged leaves, the growth of infected plants of the two transgenic plants after being inoculated by rice blast (Pyricularia oryzae) are significant. The transgenic plants with trichosanthin gene grew faster than the plants with GUS gene, even when humidity environment was removed. The results show that the transgenic plants that expressed trichosanthin are able to delay the infection of rice blast compared with the plants as control. In addition, no damage caused by the expression of trichosanthin gene in transgenic plants has been | Xiaotian Ming Lijiang Wang Chengcai An Huayi Yuan Zhangliang Chen | 2000 | Chinese Science Bulletin2000，45，19： | 12 |
| 7 | DISCUSSING ON SOLID ABRASIVE LAPPING PATH显示文摘DISCUSSINGONSOLIDABRASIVELAPPINGPATHYangJiandong,WenXuehengChangchunInstituteofOpticsandFineMechanicsZhuYanqiu,WangLijiangJil... | Yang Jiandong ,Wen XuehengChangchun Institute of Optics and Fine MechanicsZhu Yanqiu, Wang Lijiang Jilin University of Technology | 1997 | Chinese Journal of Mechanical Engineering1997，10，2： | 11 |
| 8 | Heritable/conditional genome editing in C. elegans using a CRISPR-Cas9 feeding system显示文摘 | Pengpeng Liu Lijiang Long Kai Xiong Bo Yu Nannan Chang Jing-Wei Xiong Zuoyan Zhu Dong Liu | 2014 | Cell Research2014，24，7： | 8 |
| 9 | Regulation of transcriptionally active genes via the catalytically inactive Cas9 in C. elegans and D. rerio显示文摘 | Lijiang Long Hong Guo Di Yao Kai Xiong Yongjun Li Pengpeng Liu Zuoyan Zhu Dong Liu | 2015 | Cell Research2015，25，5： | 7 |
| 10 | An assessment of arctic sea ice concentration retrieval based on “HY-2” scanning radiometer data using field observations during CHINARE-2012 and other satellite instruments显示文摘A retrieval algorithm of arctic sea ice concentration(SIC) based on the brightness temperature data of 'HY-2' scanning microwave radiometer has been constructed. The tie points of the brightness temperature were selected based on the statistical analysis of a polarization gradient ratio and a spectral gradient ratio over open water(OW), first-year ice(FYI), and multiyear ice(MYI) in arctic. The thresholds from two weather filters were used to reduce atmospheric effects over the open ocean. SIC retrievals from the 'HY-2' radiometer data for idealized OW, FYI, and MYI agreed well with theoretical values. The 2012 annual SIC was calculated and compared with two reference operational products from the National Snow and Ice Data Center(NSIDC) and the University of Bremen. The total ice-covered area yielded by the 'HY-2' SIC was consistent with the results from the reference products. The assessment of SIC with the aerial photography from the fifth Chinese national arctic research expedition(CHINARE) and six synthetic aperture radar(SAR) images from the National Ice Service was carried out. The 'HY-2' SIC product was 16% higher than the values derived from the aerial photography in the central arctic. The root-mean-square(RMS) values of SIC between 'HY-2' and SAR were comparable with those between the reference products and SAR, varying from 8.57% to 12.34%. The 'HY-2' SIC is a promising product that can be used for operational services. | SHI Lijiang LU Peng CHENG Bin KARVONEN Juha WANG Qimao LI Zhijun HAN Hongwei | 2015 | Acta Oceanologica Sinica2015，34，3： | 6 |
| 11 | Hierarchical-structure anatase TiO2 with conductive network for high-rate and high-loading lithium-ion battery显示文摘Titanium dioxides have been extensively investigated as promising anodes for Lithium ion batteries(LIBs)because of the high–rate capacity and cyclability,as well as the improved safety over graphite anode(1,2)However,as a typical insertion–type anode,anatase TiO2 exhibits low conductivity(10–12S cm-1 for electron conductivity[3]and 10–17–10–10 cm2 s1 for Li+ion diffusion coefficient[4])and poor specific capacity(only accommodate<0.5 Li per bulk TiO2 unit[5]),severely limiting its practical applications. | Xinghua Liu Lijiang Zhao Shitong Wang Meng Chao Yutong Li Jin Leng Junying Zhang Zilong Tang | 2019 | Science Bulletin2019，64，16： | 6 |
| 12 | The progress of olfactory transduction and biomimetic olfactory-based biosensors显示文摘Olfaction is a very important sensation for all animals. Recently great progress has been made in the research of olfactory transduction. Especially the novel finding of the gene superfamily encoding olfactory receptors has led to rapid advances in olfactory transduction. These advances also promoted the research of biomimetic olfactory-based biosensors and some obvious achievements have been obtained due to their potential commercial prospects and promising industrial applications. This paper briefly introduces the biological basis of olfaction, summarizes the progress of olfactory signal transduction in the olfactory neuron, the olfactory bulb and the olfactory cortex, outlines the latest devel- opments and applications of biomimetic olfactory-based biosensors. Finally, the olfactory biosensor based on light addressable potentiometric sensor (LAPS) is addressed in detail based on our recent work and the research trends of olfactory biosensors in future are discussed. | WU ChunSheng WANG LiJiang ZHOU Jun ZHAO LuHang WANG Ping | 2007 | Chinese Science Bulletin2007，52，14： | 5 |
| 13 | A quantum-chemical study on the discharge reaction mechanism of lithium-sulfur batteries显示文摘Lithium-sulfur batteries have attracted a great interest in electrochemical energy conversion and storage, but their discharge mechanism remains not well understood up to now. Here, we report density functional theory (DFT) calculation study of the discharge mechanism for lithium-sulfur batteries which are based on the structure of S8 and Li2S x (1≤x≤8) clusters. The results show that for Li2S x (1≤x≤8) clusters, the most stable geometry is chainlike when x = 1 and 6, while the minimal-energy structure is found to be cyclic when x = 2-5, 7,8. The stability of Li2S x (1≤x≤8) clusters increases with the decreasing x value, indicating a favorable thermodynamic tendency of transition from S8 to Li2S. A three-step reaction route has been proposed during the discharge process, that is, S8 →Li2S4 at about 2.30 V, Li2S4 →Li2S2 at around 2.22 V, and Li2S2 → Li2S at 2.18 V. Furthermore, the effect of the electrolyte on the potential platform has been also investigated. The discharge potential is found to increase with the decrease of dielectric constant of the electrolyte. The computational results could provide insights into further understanding the discharge mechanism of lithium-sulfur batteries. | Lijiang Wang Tianran Zhang Siqi Yang Fangyi Cheng Jing Liang Jun Chen | 2013 | Journal of Energy Chemistry2013，22，1： | 4 |
| 14 | Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC显示文摘AIM: To verify the effectiveness of denaturing highperformance liquid chromatography (DHPLC) in detecting somatic mutation of p53 gene in gastric carcinoma tissues.The superiority of this method has been proved in the detection of germline mutations, but it was not very affirmative with respect to somatic mutations in tumor specimens. ST7 gene, a candidate tumor suppressor gene identified recently at human chromosome 7q31.1, was also detected because LOH at this site has also been widely reported in stomach cancer.METHODS: DNA was extracted from 39 cases of surgical gastric carcinoma specimen and their correspondent normal mucosa. Seven fragments spanning the 11 exons were used to detect the mutation of p53 gene and the four exons reported to have mutations in ST7 gene were amplified by PCR and directly analyzed by DHPLC without mixing with wild-type allele.RESULTS: In the analysis of p53 gene mutation, 9 aberrant DHPLC chromatographies were found in tumor tissues, while their normal-adjacent counterparts running in parallel showed a normal shape. Subsequent sequencing revealed nine sequence variations, 1 polymorphism and 8 mutations including 3 mutations not reported before. The mutation rate of p53 gene (21%) was consistent with that previously reported. Furthermore, no additional aberrant chromatography was found when wild-type DNA was added into the DNA of other 30 tumor samples that showed normal shapes previously. The positivity of p53 mutations was significantly higher in intestinal-type carcinomas (40 %) than that in diffuse-type (8.33 %) carcinomas of the stomach. No mutation of ST7 gene was found.CONCLUSION: DHPLC is a very convenient method for the detection of somatic mutations in gastric carcinoma. The amount of wild type alleles supplied by the non-tumorous cells in gastric tumor specimens is enough to form heteroduplex with mutant alleles for DHPLC detection. ST7 gene may not be the target gene of inactivation at 7q31 site in gastric carcinoma. | ChongLu Hui-MianXu QunRen YangAo Zhen-NingWang XueAo LiJiang YangLuo XueZhang | 2003 | World Journal of Gastroenterology2003，9，12： | 4 |
| 15 | The Escherichia coli O157:H7 DNA detection on a gold nanoparticle-enhanced piezoelectric biosensor显示文摘This paper presents development of a quartz crystal microbalance (QCM) biosensor for real-time de- tection of E. coli O157:H7 DNA based on nanogold particles amplification. Many inner Au nanoparticles were immobilized onto the thioled surface of the Au electrode, then more specific thiolated sin- gle-stranded DNA (ssDNA) probes could be fixed through Au-SH bonding. The hybridization was in- duced by exposing the ssDNA probe to the complementary target DNA of E. coli O157:H7 gene eaeA, then resulted in a mass change and corresponding frequency shifts ( △f ) of the QCM. The outer avidin-coated Au nanoparticles could combine with the target DNA to increase the mass. The electro- chemical techniques, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were adopted to manifest and character each step. The target DNA corresponding to 2.0×103 colony forming unit (CFU)/mL E. coli O157:H7 cells can be detected by this biosensor, so it is practical to develop a sensitive and effective QCM biosensor for pathogenic bacteria detection based on specific DNA analy- sis. The piezoelectric biosensing system has potential for further applications, such as food safety and environment monitoring, and this approach lays the groundwork for incorporating the method into an integrated system for in-field bacteria detection. | WANG LiJiang WEI QingShan WU ChunSheng HU ZhaoYing JI Jian WANG Ping | 2008 | Chinese Science Bulletin2008，53，8： | 4 |
| 16 | Methane adsorption-induced coal swelling measured with an optical method显示文摘In order to quantify the effect of matrix shrinkage on reservoir permeability during coalbed methane production, coal samples from Huozhou, Changzhi and Jincheng areas in Shanxi province(classified as high-volatile bituminous coal, low-volatile bituminous coal and anthracite, respectively) were collected,and adsorption-induced coal swelling in methane were determined by an optical method at 40 °C and pressure up to 12 MPa. All three coals showed similar behavior-that swelling increased as a function of pressure up to about 10 MPa but thereafter no further increase in swelling was observed. Swelling in the direction perpendicular to the bedding plane is greater than that parallel to the bedding plane,and the differences are about 7.77–8.33%. The maximum volumetric swelling ranges from 2.73% to3.21%-increasing with increasing coal rank. The swelling data can be described by a modified DR model.In addition, swelling increases with the amount of adsorption. However, the increase shows a relatively slower stage followed by a relatively faster stage instead of a linear increase. Based on the assumption that sorption-induced swelling/shrinkage of coal in methane is reversible, the permeability increases induced by coal shrinkage during methane desorption was analyzed, and the results indicate that the permeability change is larger for higher rank coal in the same unit of pressure depletion. | Tang Shuheng Wan Yi Duan Lijiang Xia Zhaohui Zhang Songhang | 2015 | International Journal of Mining Science and Technology2015，25，6： | 3 |
| 17 | Mutation of the PHYTOENE DESATURASE 3 gene causes yellowish-white petals in Brassica napus显示文摘Oilseed rape (Brassica napus) with yellow flowers is an attractive ornamental landscape plant during the flowering period,and the development of different petal colors has become a breeding objective.Although yellowish flower color is a common variant observed in field-grown oilseed rape,the genetics behind this variation remains unclear.We obtained a yellowish-white flower (ywf) mutant from Zhongshuang 9 (ZS9) by ethyl methanesulfonate mutagenesis (EMS) treatment.Compared with ZS9,ywf exhibited a lower carotenoid content with a reduced and defective chromoplast ultrastructure in the petals.Genetic analysis revealed that the yellowish-white trait was controlled by a single recessive gene.Using bulked-segregant analysis sequencing (BSA-seq) and kompetitive allele-specific PCR(KASP),we performed map-based cloning of the ywf locus on chromosome A08 and found that ywf harbored a C-to-T substitution in the coding region,resulting in a premature translation termination.YWF,encoding phytoene desaturase 3 (PDS3),was highly expressed in oilseed rape petals and involved in carotenoid biosynthesis.Pathway enrichment analysis of the transcriptome profiles from ZS9 and ywf indicated the carotenoid biosynthesis pathway to be highly enriched.Further analyses of differentially expressed genes and carotenoid components revealed that the truncated Bna A08.PDS3 resulted in decreased carotenoid biosynthesis in the mutant.These results contribute to an understanding of the carotenoid biosynthesis pathway and manipulation of flower-color variation in B.napus. | Chuanji Zhao Luqman Bin Safdar Meili Xie Meijuan Shi Zhixue Dong Li Yang Xiaohui Cheng Yueying Liu Zetao Bai Yang Xiang Chaobo Tong Junyan Huang Lijiang Liu Shengyi Liu | 2021 | The Crop Journal2021，9，5： | 3 |
| 18 | STAT1 and Survivin Expression in Full Lymph Node Examined Gastric Cancer by Using Tissue Microarray Technique显示文摘客观:描绘在之间的关系 STAT1 和 Survivinexpression,和在他们和淋巴节点转移之间的关系,在完整的淋巴节点的侵略和预后的深度检查了中国的胃的癌症病人。方法:在 1988 和 2003 之间的药品解剖的标本从 JianghanUniversity 的隶属于的医院被收集。所有 140 个病人有完全的考试数据。所有淋巴结被清除胖方法发现。打断的连续剧染色 andimmunohistochemical 方法的 4 μ m 节,平淡的苏木精和曙红被用来检测淋巴节点转移。胃的癌症 tissuemicroarray 被形成,在胃的癌症的 survivin 和 STAT1 的表示是检测 byimmunohistochemical 方法。所有数据多用枪兵等级相关分析, Kaplan-Meyer 木头等级方法和考克斯被处理变量分析(社会科学统计套装软体 12.0 软件) 。结果:在微数组构造了的 140gastric 癌症织物之中, 110 能被使用(利用率是 78.6%) 。7079lymph 节点在 110 种情况(64.4/case ) 中被发现。转移在 89 种情况和 1679 个淋巴节点中被发现。survivin 和 STAT1 的积极表示率是 52.7%(58/110 ) 并且 40%(44/110 ) 分别地。在 STAT1 表示和 survivinexpression 之间有重要否定关联(r=-0.19, P=0.04 ) 。STAT1 表示与侵略的深度有否定关联(r=-0.21, P=0.04 ) 。Survivin 表示与 UICC N 舞台有否定关联(r=-0.24, P=0.01 ) 并且组织学的分类(r=-0.21, P=0.03 ) 由枪兵等级相关分析。Butsurvivin 和 STAT1 表示没与预后被联系。在淋巴节点转移和预后之间的重要关联被考克斯多表明变量分析(χ ~ 2=4.85, P=0.028 ) 。结论:STAT1 在胃的癌症与 survivin 表示有否定关联。他们俩没在胃的癌症与预后有关联。STAT1 表示能是一个分子的标记预言先进胃的癌症和 survivin 在胃的癌症的淋巴节点转移的一个分子的标记。UICC N 舞台是在在中国的胃的 caner 的最重要的预示的因素。 | DENG Hao WU Renliang CHEN Ying LIU Lijiang | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，4： | 3 |
| 19 | Effect of cyclin G2 on proliferative ability of SGC-7901 cell显示文摘AIM: To study the effect of cyclin G2 on proliferation of gastric adenocarcinoma cell line-SGC-7901 cell in vitro.METHODS: By use of cation lipofectamine transfection reagent,the pIRES-G2 and pIRESneo plasmids were transferred into SGC-7901cell line. Anticlones were selected by G418. Positive clones were observed and counted using Giemsa staining.Cell proliferative ability was assayed by Ml-r.RESULTS: (1) The done number of pIRES-G2 group decreased,clone volume reduced. The number of cell clones in pIRESneo group was 87+3, that of pIRES-G2 group was 53+4,occupying 60.1% of pIRESneo group, there was significant difference obviously (P<0.01, t=15.45). (2) The average absorbance of clone cell obtained by stable transfection of pIRES-G2 at 570 nm was 1.6966+0.2125, the average absorbance of clone cell obtained by stable transfection of pIRESneo at 570 nm was 2.1182+0.3675, there was significant difference between them (P<0.01, t=3.412).CONCLUSION: Cyclin G2 can inhibit SGC-7901cell proliferative ability obviously, it may be a negative regulator in cell cycle regulation. | JieLiu Ze-ShiCui YangLuo LiJiang Xiao-HuiMan XueZhang | 2004 | World Journal of Gastroenterology2004，10，9： | 3 |
| 20 | Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders in mice显示文摘Both immunosuppressants and antibiotics (ABX) are indispensable for transplant patients. However, the former increases the risk of new-onset diabetes, whereas the latter impacts intestinal microbiota (IM). It is still unclear whether and how the interaction between immunosuppressants and ABX alters the IM and thus leads to glucose metabolism disorders. This study examined the alterations of glucose and lipid metabolism and IM in mice exposed to tacrolimus (TAC) with or without ABX. We found that ABX further aggravated TAC-induced glucose tolerance and increased insulin secretion. Combined treatment resulted in exacerbated lipid accumulation in the liver. TAC-altered microbial community was further amplified by ABX administration, as characterized by reductions in phylum Firmicutes, family Lachnospiraceae, and genus Copyococcus. Analyses based on the metagenomic profiles revealed that ABX augmented the effect of TAC on microbial metabolic function mostly related to lipid metabolism. The altered components of gut microbiome and predicted microbial functional profiles showed significant correlation with hepatic lipid accumulation and glucose disorders. In conclusion, ABX aggravated the effect of TAC on the microbiome and its metabolic capacities, which might contribute to hepatic lipid accumulation and glucose disorders. These findings suggest that the ABX-altered microbiome can amplify the diabetogenic effect of TAC and could be a novel therapeutic target for patients. | Yuqiu Han Xiangyang Jiang Qi Ling Li Wu Pin Wu Ruiqi Tang Xiaowei Xu Meifang Yang Lijiang Zhang Weiwei Zhu Baohong Wang Lanjuan Li | 2019 | Frontiers of Medicine2019，13，4： | 3 |
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