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| 1 | Diagnosis of gastrointestinal bleeding: A practical guide for clinicians显示文摘Gastrointestinal bleeding is a common problem encountered in the emergency department and in the primary care setting. Acute or overt gastrointestinal bleeding is visible in the form of hematemesis, melena or hematochezia. Chronic or occult gastrointestinal bleeding is notapparent to the patient and usually presents as positive fecal occult blood or iron deficiency anemia. Obscure gastrointestinal bleeding is recurrent bleeding when the source remains unidentified after upper endoscopy and colonoscopic evaluation and is usually from the small intestine. Accurate clinical diagnosis is crucial and guides definitive investigations and interventions. This review summarizes the overall diagnostic approach to gastrointestinal bleeding and provides a practical guide for clinicians. | Bong Sik Matthew Kim Bob T Li Alexander Engel Jaswinder S Samra Stephen Clarke Ian D Norton Angela E Li | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 13 |
| 2 | Calcium signaling and T-type calcium channels in cancer cell cycling显示文摘Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers. | James T Taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang Stephenie G Yi lennifer A S Scruggs Suresh S Sikka Ming Li | 2008 | World Journal of Gastroenterology2008，14，32： | 12 |
| 3 | 肠道微生态失调与高血压的关系显示文摘新出现的证据表明,肠道菌群是维持生理动态平衡的关键,该研究旨在验证微生态失衡的肠道菌群与高血压相关这一假设,因为遗传、环境和膳食因素对肠道菌群和血压有很大影响。方法:从2种高血压模型大鼠和一个小队列患者人群的粪便样本中提取细菌DNA,用于细菌基因组的分析. | 刘莉 叶鹏 Yang T Santisteban MM Rodriguez V Li E Ahmari N Carvajal JM Zadeh M Gong M Qi Y Zubcevic J Sahay B Pepine CJ Raizada MK Mohamadzadeh M | 2015 | 中华高血压杂志2015，23，5： | 4 |
| 4 | In vivo anti-tumor activity of murine hematopoietic stem cells expressing a p185HER2-specific chimeric T-cell receptor gene显示文摘We have confirmed efficient anti-tumor activities of the peripheral lymphocytes transduced with a p185HER2-specific chimeric T-cell receptor gene both in murine and in human in our previous studies. To further test the feasibility of chimeric T-cell receptor in a bone marrow transplantation model, we first, made two murine tumor cell lines: MT901 and MCA-205, to express human p185HER2 by retroviral gene transduction. Murine bone marrow cells were retrovirally transduced to express the chimeric T-cell receptor and gene-modified bone marrow cells were transplanted into lethally irradiated mouse. Six months post transplantation, p185HER2-positive tumor cells:MT-901/HER2 or MCA-205/ HER2 was subcutaneously or intravenously injected to make mouse models simulating primary breast cancer or pulmonary metastasis. The in vivo anti-tumor effects were monitored by the size of the subcutaneous tumor or counting the tumor nodules in the lungs after India ink staining. The size of the subcutaneous tumor was significantly inhibited and the number of pulmonary nodules were significantly decreased in mouse recipients transplanted with chimeric T-cell receptor modified bone marrow cells compared with the control group. Our results suggest the efficient in vivo anti-tumor activities of chimeric T-cell receptor gene modified bone marrow cells. | JIAN MIN YANG MICHAEL S FRIEDMAN MARIANNE T HUBEN JENNIFER FULLER QIAO LI ALFRED E CHANG JAMES J MULE KEVIN T MCDONAGH | 2006 | Journal of Microbiology and Immunology2006，4，2： | 3 |
| 5 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 6 | Effect of selective thermal denaturation of seybean proteins on soymilk viscosity and tofu's physical properties显示文摘 | Liu Z S Chang S K C Li L T Tatsumi E | 2004 | Food Research International2004，37，： | 1 |
| 7 | Production of Normal Mice From Spermatozoa Denatured with High Alkali Treatment before ICSI显示文摘 | Li C Mizutani E Ono T | 2009 | Reproduction2009，137，5： | 1 |
| 8 | 4D-Var or ensemble Kalman filter?显示文摘 | Kalnay E Li H Miyoshi T | 2007 | Fellus A2007，59，5： | 1 |
| 9 | Carbon nanotube/ carbon fiber hybrid multiscale composites 显示文摘 | Thostenson E T Li W Z Wang D Z | 2002 | J Appl Phys2002，91，9： | 1 |
| 10 | Business network -based value creation in electronic commerce显示文摘 | Kauffman R J Li T Heck E | | 0，，01： | 1 |
| 11 | Integration of ep- idemiology and animal neurotoxlcity data for risk assessment 显示文摘 | LI A A LEVINE T E BURNS C J | 2012 | Neurotoxieology2012，33，4： | 1 |
| 12 | Targeted mutation of the DNA methyltransferase gene results in embryonic lethality显示文摘 | LI E BESTOR T H JAENISCH R | 1992 | Cell1992，69，： | 1 |
| 13 | A Simple fluorometric method for fat - binding capacity as an index of hydrophobicity of proteins显示文摘 | T Tsutsui Li - Chart E S Nakai | 1986 | Food Science1986，51，5： | 1 |
| 14 | Visual contour tracking based on particle filters显示文摘 | Li P H Zhang T W Arthur E C P | 2003 | Image and Vision Computing2003，21，1： | 1 |
| 15 | 查看详情显示文摘 | Khaykovich B Zeldov E Majer D Li T W Kes P H Konczykowski M | | 0，，： | 1 |
| 16 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 17 | The IGF1 pathway genes and their association with age of puber- ty in cattle显示文摘 | FORTES M R S LI Y T COLLIS E | 2015 | Animal Genetics2015，44，1： | 1 |
| 18 | Enhanced root-to-shoot translocation of cadmium in the hyperaccumulating ecotype of Sedum alfredii 显示文摘 | Lu L L Tian S K Yang X E Wang X C Brown P Li T Q He Z L | 2008 | Journal of Experimental Botany2008，59，11： | 1 |
| 19 | The compressive viscoplastie response of an A359/SiCe metal - matrix composite and the A359 aluminum alloy matrix显示文摘 | Li Y Ramesh K T Chin E S C | 2000 | International Journal of Solids and Structures2000，37，： | 1 |
| 20 | The Impact of Specific Supplier Development Efforts on Buyer Competitive Advantage: An Empirical Model 显示文摘 | Li W L Humphreys P K Yeung A C L Cheng T C E | 2007 | International Journal of Production Economics2007，106，1： | 1 |
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