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| 1 | Task space control of free-floating space robots using constrained adaptive RBF-NTSM显示文摘Trajectory tracking control of space robots in task space is of great importance to space missions,which require on-orbit manipulations.This paper focuses on position and attitude tracking control of a free-floating space robot in task space.Since neither the nonlinear terms and parametric uncertainties of the dynamic model,nor the external disturbances are known,an adaptive radial basis function network based nonsingular terminal sliding mode(RBF-NTSM)control method is presented.The proposed algorithm combines the nonlinear sliding manifold with the radial basis function to improve control performance.Moreover,in order to account for actuator physical constraints,a constrained adaptive RBF-NTSM,which employs a RBF network to compensate for the limited input is developed.The adaptive updating laws acquired by Lyapunov approach guarantee the global stability of the control system and suppress chattering problems.Two examples are provided using a six-link free-floating space robot.Simulation results clearly demonstrate that the proposed constrained adaptive RBF-NTSM control method performs high precision task based on incomplete dynamic model of the space robots.In addition,the control errors converge faster and the chattering is eliminated comparing to traditional sliding mode control. | GUO ShengPeng LI DongXu MENG YunHe FAN CaiZhi | 2014 | Science China(Technological Sciences)2014，57，4： | 11 |
| 2 | Global Dynamic Molecular Profiling of Stomatal Lineage Cell Development by Single-Cell RNA Sequencing显示文摘The regulation of stomatal lineage cell development has been extensively investigated.However,a comprehensive characterization of this biological process based on single-cell transcriptome analysis has not yet been reported.In this study,we performed RNA sequencing on 12844 individual cells from the cotyledons of 5-day-old Arabidopsis seedlings.We identified 11 cell clusters corresponding mostly to cells at specific stomatal developmental stages using a series of marker genes.Comparative analysis of genes with the highest variable expression among these cell clusters revealed transcriptional networks that regulate development from meristemoid mother cells to guard mother cells.Examination of the developmental dynamics of marker genes via pseudo-time analysis revealed potential interactions between these genes.Collectively,our study opens the door for understanding how the identified novel marker genes participate in the regulation of stomatal lineage cell development. | Zhixin Liu Yaping Zhou Jinggong Guo Jiaoai Li Zixia Tian Zhinan Zhu Jiajing Wang Rui Wu Bo Zhang Yongjian Hu Yijing Sun Yan Shangguan Weiqiang Li Tao Li Yunhe Hu Chenxi Guo Jean-David Rochaix Yuchen Miao Xuwu Sun | 2020 | Molecular Plant2020，13，8： | 11 |
| 3 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 4 | Cotton bollworm resistance to Bt transgenic cotton: A case analysis显示文摘Cotton bollworm (Helicoverpa armigera) is one of the most serious insect pests of cotton. Transgenic cotton expressing Cry toxins derived from a soil bacterium, Bacillus thuringiensis (Bt), has been produced to target this pest. Bt cotton has been widely planted around the world, and this has resulted in efficient control of bollworm populations with reduced use of synthetic insecticides. However, evolution of resistance by this pest threatens the continued success of Bt cotton. To date, no field populations of bollworm have evolved significant levels of resistance; however, several laboratory-selected Cry-resistant strains of H. armigera have been obtained, which suggests that bollworm has the capacity to evolve resistance to Bt. The development of resistance to Bt is of great concern, and there is a vast body of research in this area aimed at ensuring the continued success of Bt cotton. Here, we review studies on the evolution of Bt resistance in H. armigera, focusing on the biochemical and molecular basis of Bt resistance. We also discuss resistance management strategies, and monitoring programs implemented in China, Australia, and India. | LIU ChenXi, LI YunHe, GAO YuLin, NING ChangMing & WU KongMing State Key Laboratory of Plant Disease and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Science, Beijing 100193, China | 2010 | Science China(Life Sciences)2010，53，8： | 10 |
| 5 | An Effective SDN Controller Scheduling Method to Defence DDoS Attacks显示文摘Distributed Denial of Service(DDoS)attack is a difficult issue which needs to be addressed in Software defined networking(SDN). In order to help the controller to weather out the DDoS attack, an efficient controller scheduling method is proposed. The proposed controller scheduling method uses the normalized waiting time, length and extent of the switch being attacked to choose the request that needs to be processed by the controller. The evaluation results validate that compared with the polling based controller scheduling method, the proposed one can significantly reduce the connection failure ratio and delay. | LI Saifei CUI Yunhe NI Yongfeng YAN Lianshan | 2019 | Chinese Journal of Electronics2019，28，2： | 5 |
| 6 | Effect of preoperative nutrition therapy type and duration on short-time outcomes in gastric cancer patient with gastric outlet obstruction显示文摘Objective:To avoid perioperative complications caused malnutrition,nutrition therapy is necessary in gastric outlet obstruction(GOO)patients.Compared to parenteral nutrition(PN),enteral nutrition(EN)is associated with many advantages.This study aimed to investigate whether preoperative EN has beneficial clinical effects compared to preoperative PN in gastric cancer patients with GOO undergoing surgery.Methods:According to the methods of preoperative nutrition therapy,143 patients were divided into EN group(n=42)and PN group(n=101)between January 2013 and December 2017 at the Chinese People’s Liberation Army General Hospital.Multiple logistic regression models were used to assess the association between the methods of preoperative nutrition therapy and postoperative day of flatus passage.The generalized additive model and twopiecewise linear regression model were used to calculate the inflection point of the preoperative nutritional therapy time on the postoperative day of flatus passage in the PN group.Results:EN shortened the postoperative day of flatus passage in gastric cancer patients with GOO,which is a protective factor,especially in patients who underwent non-radical operations and the postoperative day of flatus passage reduced when the preoperative PN therapy was up to 3 d and a longer PN therapy(>3 d)did not accelerate the postoperative recovery of gastrointestinal functions.Conclusions:Preoperative EN therapy would benefit gastric cancer patients with GOO by accelerating postoperative recovery.For patients with absolute obstruction,no more than 3-day PN therapy is recommended if patients can tolerate general anesthesia and surgery. | Jiyang Li Shaoqing Li Hongqing Xi Peifa Liu Wenquan Liang Yunhe Gao Chuang Wang Bo Wei Lin Chen Yun Tang Zhi Qiao | 2021 | Chinese Journal of Cancer Research2021，33，2： | 4 |
| 7 | 0Interacting model of new agegraphic dark energy:observational constraints and age problem显示文摘Many dark energy models fail to pass the cosmic age test because of the old quasar APM 08279+5255 at redshift z=3.91,the ΛCDMmodel and holographic dark energy models being no exception.Inthis paper,we focus onthe topic of the age problem inthe new agegraphic dark energy(NADE)model.We determine the age of the universe in the NADE model by fitting the observational data,including type Ia supernovae(SNIa),baryon acoustic oscillations(BAO)and the cosmic microwave background(CMB).We find that the NADE model also faces the challenge of the age problem caused by the old quasar APM 08279+5255.In order to overcome such a difficulty,we consider the possible interaction between dark energy and dark matter.We show that this quasar can be successfully accommodated in the interacting new agegraphic dark energy(INADE)model at the 2σlevel under the current observational constraints. | LI YunHe MA JingZhe CUI JingLei WANG Zhuo ZHANG Xin | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，8： | 3 |
| 8 | Monochromatic green light stimulation during incubation shortened the hatching time via pineal function in White Leghorn eggs显示文摘Background:Effect of monochromatic green light illumination on embryo development has been reported in chickens.The avian pineal gland is an important photo-endocrine organ formed by a mediodorsal protrusion during embryonic development.However,the involvement of pineal gland in the light transduction process remains to be elucidated.In the present study,we investigated the influence of monochromatic green light on hatching time and explored the possible mechanism via pineal function.Results:A total of 600 eggs of White Leghorn(Shaver strain)were incubated under photoperiods of either 12 h of light and 12 h of darkness using monochromatic green light(12L:12D group)or 24 h of darkness(0L:24D group)for 18 d.Compared to 0L:24D group,the green light stimulation shortened the hatching time without extending the hatch window or impairing hatchability.The liver of embryos incubated in the 12L:12D light condition was heavier than those of the 0L:24D group on d 21 post incubation which may be linked to the observed increase in the serum concentration of insulin-like growth factor 1(IGF-1);primary secretion of the liver.Histological structure analysis of pineal gland demonstrated that the light stimulation increased follicle area,wall thickness and lumen area on d 10 and d 12 post incubation.Rhythmic function analysis demonstrated that three clock related genes(brain and muscle ARNT-like-1,BMAL1;circadian locomotor output cycles kaput,CLOCK;and cryptochrome-1,CRY1)and a melatonin rate-limiting enzyme related gene(arylalkylamine N-acetyltransferase,AANAT)were rhythmically expressed in the pineal gland of the 12L:12D group,but not in the 0L:24D group.Simultaneously,the light stimulation also increased the concentration of melatonin(MT),which was linked to hepatocyte proliferation and IGF-1 secretion in previous studies.Conclusions:The 12L:12D monochromatic green light stimulation during incubation shortened hatching time without impairing hatching performance.Pineal gland’s early histological development and maturation of its rhythmic function were accelerated by the light stimulation.It may be the key organ in the photo-endocrine axis that regulates embryo development,and the potential mechanism could be through enhanced secretion of MT in the 12L:12D group which promotes the secretion of IGF-1. | Panlin Wang Yanyan Sun Yunlei Li Jing Fan Yunhe Zong Adamu Mani Isa Lei Shi Yuanmei Wang Aixin Ni Pingzhuang Ge Linlin Jiang Shixiong Bian Hui Ma Zhengdong Yuan Xiaolin Liu Jilan Chen | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 3 |
| 9 | Mitochondria targeting drugs for neurodegenerative diseases——Design, mechanism and application显示文摘Neurodegenerative diseases(NDDs) such as Alzheimer’s disease(AD) and Parkinson ’s disease(PD) are a heterogeneous group of disorders characterized by progressive degeneration of neurons.NDDs threaten the lives of millions of people worldwide and regretfully remain incurable.It is well accepted that dysfunction of mitochondria underlies the pathogenesis of NDDs.Dysfunction of mitochondria results in energy depletion,oxidative stress,calcium overloading,caspases activation,which dominates the neuronal death of NDDs.Therefore,mitochondria are the preferred target for intervention of NDDs.So far various mitochondria-targeting drugs have been developed and delightfully some of them demonstrate promising outcome,though there are still some obstacles such as targeting specificity,delivery capacity hindering the drugs development.In present review,we will elaborately address 1) the strategy to design mitochondria targeting drugs,2) the rescue mechanism of respective mitochondria targeting drugs,3) how to evaluate the therapeutic effect.Hopefully this review will provide comprehensive knowledge for understanding how to develop more effective drugs for the treatment of NDDs. | Jiajia Xu Wei Du Yunhe Zhao Kahleong Lim Li Lu Chengwu Zhang Lin Li | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 2 |
| 10 | The evolution of China’s regulation of agricultural biotechnology显示文摘To ensure safe use of genetically modified organisms(GMOs),since 1993,China has made great efforts to establish and improve the safety regulatory system for GMOs.Here,we summarize and analyze the regulatory framework of agricultural GMOs,and the progress in regulatory approval of GM crops in China.In general,the development of GMO safety regulations underwent four stages:exploration(1993–2000),development(2001–2010),improvement(2011–2020)and current(2021-present)stage.The first formal regulation was promulgated in 1993,which provided a basis for further development of the regulations,during the exploration stage,when insect-resistant GM cotton,expressing genes from Bacillus thuringiensis(Bt),was approved for cultivation.During the development stage,the Chinese government issued a series of administrative measures,which covered almost all the fields relative to GMO safety when the basic regulatory system was established.Along with the controversy over GMO safety,the regulations have been further,and greatly improved,during improvement stage.From 2021,a few additional revisions have been made,and meanwhile,the new regulation on gene-edited crops was introduced with the development of biotechnology,forming a relative complete regulation and law system for China.The well-developed GMO regulations establishes a firm basis for safe use of GM crops in China.Currently,GM cotton and GM papaya have been widely grown on a large scale in China that have brought great economic and ecological benefits.In addition,12 corn events,3 soybean events,and 2 rice events have also obtained biosafety certification,but presently,these lines have yet to enter commercial production.However,several GM soybean and corn events have entered pilot industrialization,and can soon be expected to be commercially grown in China.In addition to planting,six GM crops,including soybean,corn,cotton,canola,papaya and sugar beet,with a total of 64 events,have been approved for import as processing material in China. | Jingang Liang Xiaowei Yang Yue Jiao Danxia Wang Qiang Zhao Yu Sun Yunhe Li Kongming Wu | 2022 | aBIOTECH2022，3，4： | 2 |
| 11 | X-ray analysis of pigments in the wall paintings and painted sculptures at Mogao Grottoes显示文摘 | Xu Weiye Zhou Guoxin Li Yunhe | 1983 | Dunhuang Research1983，，1： | 1 |
| 12 | Cloning of a gene encoding an acidophilic endo-β-1,4-xylanase obtained from Aspergillus niger CGMCC1067 and constitutive expression in Pichia pastoris显示文摘 | Ping Deng Defa Li Yunhe Can | 2006 | Enzyme and Microbial Te- chnology2006，39，： | 1 |
| 13 | Cloning of a gene enconding an acidophilic endo-p-1,4-xylanase obtained from Aspergillus niger CGMCC 1067 and constitutive expression in Pichia pastoris 显示文摘 | Deng Ping Li Defa Cao Yunhe | 2006 | Enzyme and Microbial Technology2006，39，： | 1 |
| 14 | Cloning of a gene encoding an acidophilic endo-β-1,4-xylanase obtained from Aspergillus niger CGMCC 1067 and constitutive expression in Pichia pastoris显示文摘 | Li Defa Cao Yunhe | 2006 | Enzyme Microb Technol2006，39，： | 1 |
| 15 | MiR-378a-3p acts as a tumor suppressor in gastric cancer via directly targeting RAB31 and inhibiting the Hedgehog pathway proteins GLI1/2显示文摘Objective:To improve the prognosis of patients with gastric cancer(GC),more effective therapeutic targets are urgently needed.Increasing evidence indicates that miRNAs are involved in the progression of various tumors,and RAS-associated protein in the brain 31(RAB31)is upregulated and promotes the progression of multiple malignant tumors.Here,we focused on identifying RAB31-targeted miRNAs and elucidating their potential mechanism in the progression of GC.Methods:RAB31 and miR-378a-3p expression levels were detected in paired fresh GC tissues and GC cell lines.Bioinformatics analysis was used to predict the miRNAs targeting RAB31 and the relationships between RAB31 and other genes.Dual-luciferase reporter assays were applied to verify the targeted interaction relationship.CCK-8,colony formation,flow cytometry,wound healing,and Transwell assays were performed to assess the proliferation,apoptosis,migration,and invasion of GC cells.Tumorsphere formation assays were performed to assess the stemness of gastric cancer stem cells.Related proteins were detected by Western blot.Xenograft assays in nude mice were performed to explore the effect of miR-378a-3p in vivo.Results:We report the first evidence that miR-378a-3p is downregulated in GC,whereas its overexpression inhibits proliferation,invasion,and migration as well as promotes apoptosis in GC cells.Mechanistically,miR-378a-3p inhibits the progression of GC by directly targeting RAB31.Restoring RAB31 expression partially offsets the inhibitory effect of miR-378a-3p.Further research revealed that miR-378a-3p inhibits GLI1/2 in the Hedgehog signaling pathway and attenuates the stemness of gastric cancer stem cells.Finally,xenograft assays showed that miR-378a-3p inhibits GC tumorigenesis in vivo.Conclusions:MiR-378a-3p inhibits GC progression by directly targeting RAB31 and inhibiting the Hedgehog signaling pathway proteins GLI1/2. | Xinxin Xu Yang Li Guoxiao Liu Kai Li Peng Chen Yunhe Gao Wenquan Liang Hongqing Xi Xinxin Wang Bo Wei Hongtao Li Lin Chen | 2022 | Cancer Biology & Medicine2022，19，12： | 1 |
| 16 | Human mobility data in the COVID-19 pandemic:characteristics,applications,and challenges显示文摘The COVID-19 pandemic poses unprecedented challenges around the world.Many studies have applied mobility data to explore spatiotemporal trends over time,investigate associations with other variables,and predict or simulate the spread of COVID-19.Our objective was to provide a comprehensive overview of human mobility open data to guide researchers and policymakers in conducting data-driven evaluations and decision-making for the COVID-19 pandemic and other infectious disease outbreaks.We summarized the mobility data usage in COVID-19 studies by reviewing recent publications on COVID-19 and human mobility from a data-oriented perspective.We identified three major sources of mobility data:public transit systems,mobile operators,and mobile phone applications.Four approaches have been commonly used to estimate human mobility:public transit-based flow,social activity patterns,index-based mobility data,and social media-derived mobility data.We compared mobility datasets’characteristics by assessing data privacy,quality,space–time coverage,high-performance data storage and processing,and accessibility.We also present challenges and future directions of using mobility data.This review makes a pivotal contribution to understanding the use of and access to human mobility data in the COVID-19 pandemic and future disease outbreaks. | Tao Hu Siqin Wang Bing She Mengxi Zhang Xiao Huang Yunhe Cui Jacob Khuri Yaxin Hu Xiaokang Fu Xiaoyue Wang Peixiao Wang Xinyan Zhu Shuming Bao Wendy Guan Zhenlong Li | 2021 | International Journal of Digital Earth2021，14，9： | 1 |
| 17 | Bt maize expressing Cry3Bbl does not harm the spider mite, Tetranychus urtieae, or its ladybird beetle predator, Stethoms punctillurn显示文摘 | Yunhe Li Jrg Romeis | 2010 | Biological Control2010，53，3： | 1 |
| 18 | Dietary supplementation with zinc oxide decreases expression of the stem cell factor in the small intestine of weanling pigs显示文摘 | Deyuan Ou Defa Li Yunhe Cao Xilong Li Jingdong Yin Shiyan Qiao Guoyao Wu | 2007 | The Journal of Nutritional Biochemistry2007，，12： | 1 |
| 19 | 2-O-(2- hydroxybutyl)-β-cyclodextrin as a chiral selector for the capillary electrophoretic separation of chiral drugs显示文摘 | Yunhe Wei Jian Li Cherdu Zhu | 2005 | Analytical Sciences2005，21，： | 1 |
| 20 | Preparation of core–shell structural single ionic conductor SiO 2 @Li + and its application in PVDF–HFP-based composite polymer electrolyte显示文摘 | Wei Xiao Xinhai Li Huajun Guo Zhixing Wang Yunhe Zhang Xiaoping Zhang | 2012 | Electrochimica Acta2012，，： | 1 |
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