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5篇 您的检索式：作者名="Li Rumin"

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		题名	作者	年代	出处	被引量
	1	The rare B0d →φγ decays in Standard Model and as a probe of R-parity violation显示文摘	Li Xinqiang Lu Gongru Wang Rumin	2004	Eur Phys J2004，36，：	1
	2	Progress in preparation methods of ultrafine M-type ferrite powders显示文摘	Zhang Milin Zhao Hua Li Rumin	1996	Journal of Functional Materials1996，27，3：	1
	3	Decomposition of wavelet filtering layer adaptive determination method 显示文摘	DU Wenliao ZHU Rumin LI Yanming	2010	Laser Optoelectronies2010，7，9：	1
	4	The progress of preparation of solid state electrolyte membrane for SOFC 显示文摘	Jing Xiaoyan Li Rumin Zhang Milin	2000	Applied Science and technology2000，27，2：	1
	5	Attenuation of Telomerase Activity by siRNA Targeted Telomerase RNA Leads to Apoptosis and Inhibition of Proliferation in Human Renal Carcinoma Cells显示文摘OBJECTIVE Telomerase is an attractive molecular target for cancer therapy because the activation of telomerase is one of the key steps in cell immortalization and carcinogenesis. RNA interference using small-interfering RNA (siRNA) has been demonstrated to be an effective method for inhibiting the expression of a given gene in human cells. The aim of the present study was to investigate whether inhibition of telomerase activity by siRNA targeted against human telomerase RNA (hTR) can inhibit proliferation and induce apoptotic cell death in human renal carcinoma cells (HRCCs). METHODS The siRNA duplexes for hTR were synthesized and 786-0 HRCCs were transfected with different concentrations of hTR-siRNA. The influence on the hTR mRNA level, telomerase activity, as well as the effect on cell proliferation and apoptosis was examined. RESULTS Anti-hTR siRNA treatment of HRCCs resulted in specific reduction of hTR mRNA and inhibition of telomerase activity. Additionally, significant inhibition of proliferation and induction of apoptosis were observed. CONCLUSION siRNA against the hTR gene can inhibit proliferation and induce apoptosis by blocking telomerase activity of HRCCs. Specific hTR inhibition by siRNA represents a promising new option for renal cancer treatment.	Rumin Wen Junjie Liu Wang Li Wenfa Yang Lijun Mao Junnian Zheng	2006	Chinese Journal of Clinical Oncology2006，3，5：	0

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