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| 1 | Laparoscopic liver resection under hemihepatic vascular inflow occlusion using the lowering of hilar plate approach显示文摘BACKGROUND: With advances in technology, laparoscopic liver resection is widely accepted. Laparoscopic liver resection under hemihepatic vascular inflow occlusion has advantages over the conventional total hepatic inflow occlusion using the Pringle's maneuver, especially in patients with cirrhosis.METHOD: From November 2011 to August 2012, eight consecutive patients underwent laparoscopic liver resection under hemihepatic vascular inflow occlusion using the lowering of hilar plate approach with biliary bougie assistance.RESULTS: The types of liver resection included right hepatectomy(n1), right posterior sectionectomy(n1), left hepatectomy and common bile duct exploration(n1), segment 4b resection(n1), left lateral sectionectomy(n2), and wedge resection(n2). Four patients underwent right and 4 left hemihepatic vascular inflow occlusion. Four patients had cirrhosis. The mean operation time was 176.3 minutes. The mean time taken to achieve hemihepatic vascular inflow occlusion was 24.3minutes. The mean duration of vascular inflow occlusion was54.5 minutes. The mean intraoperative blood loss was 361 mL.No patient required blood transfusion. Postoperatively, one patient developed bile leak which healed with conservative treatment. No postoperative liver failure and mortality occurred. The mean hospital stay of the patients was 7 days.CONCLUSION: Our technique of hemihepatic vascular inflow vascular occlusion using the lowering of hilar plate approachwas safe, and it improved laparoscopic liver resection by minimizing blood loss during liver parenchymal transection. | Ying-Jun Chen Zuo-Jun Zhen Huan-Wei Chen Eric CH Lai Fei-Wen Deng Qing-Han Li Wan Yee Lau | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，5： | 23 |
| 2 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 3 | Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography显示文摘Endoscopic retrograde cholangiopancrea tography(ERCP) is the most complex gastrointestinal procedure,which needs patients’ cooperation. The aim of this study was to observe the quality and safey of sedation with propofol in patients undergoing therapeutic ERCP. METHODS:Seventy patients who had undergone therapeutic ERCP were randomly divided into two groups.One group, given intravenously propofol, and the other sedated with routine method, served as the control. Blood pressure, heart rate,oxygen saturation were monitored and cardiorespiratory event was observed. Patient cooperation,performance, recovery time and amnesia served as variables postoperation. RESULTS:Blood pressure elevated in four patients in the propofol group, less than in the control group(P<0.01). Seven patients showed decreased blood pressure after administration of propofol,but none in the control group (P<0.01). Twelve patients in the control group showed mild or significant resistance, but none in the propofol group (P<0.01). The time for performance in the propofol group(P<0.05) was shorter than in the control group. Patient recovery was quicker in the propofol group than in the control group (P<0.01). The degree of amnesia better in the propofol group than in the control group ( P<0.01). The degree of amnesia was also better in the propofol group than in the control group (P<0.01). CONCLUSIONS:Propofol proves to be an excellent sedative for therapeutic ERCP. Being effective and safe, it shows a shorter ERCP duration but quick recovery and better amnesia. It is better than other routine sedatives. | Digestive Department (Chen WX, Lin HJ, Gu Q, Zhong XQ, Yu CH, Li YM and Gu ZY) and Department of Intensive Care Unit (Zhang WF), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 10 |
| 4 | Association of nonalcoholic fatty liver disease with type 2 diabetes: clinical features and independent risk factors in diabetic fatty liver patients显示文摘Nonalcoholic fatty liver disease(NAFLD) is a common chronic liver disease in China, of which diabetic fatty liver (DFL) accounts for a large proportion in clinic. DFL is a disease without specific clinical features and lacking of confirmatory laboratory tests, and the etiology of hepatic steatosis remains poorly understood. The aim of this paper was to explore the clinical characteristics and to determine associated risk factors in type 2 diabetes patients with fatty liver. METHODS: A total of 166 patients, 53 in DFL group and 113 in NDFL(diabetes without fatty liver) group participated in this study. Serum fasting blood glucose (FBG), alanine aminotransferase(ALT), aspartate aminotransferase (AST), alkaline phosphate (AKP), gamma glutamyl transpeptidase (GGT), total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) were measured in both groups. And these variables were analyzed by using Student’ s t test and logistic regression model. RESULTS:A progressive increase in the level of FBG, ALT, AST, AKP, GGT, TG( P<0.05) and a decrease of HDL-C(P<0.01)were observed from DFL group to NDFL group. And there was no statistical difference in the level of TC between the two groups. CONCLUSIONS:Dyslipidemia, dysglycemia and elevation of liver enzyme can be seen more frequently in the DFL patients than in the NDFL patients. The successive escalation of serum ALT and TG levels and the lower HDL-C level are the independent risk factors of DFL. | Department of Digestive Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Jin HB, Gu ZY, Yu CH and Li YM) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 9 |
| 5 | Effects of partial portal vein arterialization on the hilar bile duct in a rat model显示文摘BACKGROUND: Liver revascularization is frequently required during the enlarged radical operation for hilar cholangio carcinoma involving the hepatic artery. Researchers have carried out a number of experiments applying partial porta vein arterialization (PVA) in clinical practice. In this study we aimed to establish a theoretical basis for clinical application o partial PVA and to investigate the effects of partial PVA on ra hilar bile duct and hepatic functions. METHODS: Thirty rats were randomly and equally assigned into 3 groups: control (group A), hepatic artery ligation+bile duct recanalization (group B), and partial PVA+bile duc recanalization (group C). Proliferation and apoptosis o rat hilar bile duct epithelial cells, arteriolar counts of the peribiliary plexus (PBP) of the bile duct wall, changes in serum biochemistry, and pathologic changes in the bile duc were assessed 1 month after operation. RESULTS: The proliferation of hilar bile duct epithelial cells in group B was greater than in groups A and C (P<0.01). No apoptotic hilar bile duct epithelial cells were detected in any of the groups. The PBP arteriolar counts of the hilar bile duc wall were similar in groups A and C (P>0.05), but the coun was lower in group B than in group A (P<0.01). No statistically significant differences in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and albumin were found in the 3 groups. The gamma-glutamyltransferase value was higher in group B than in groups A and C (P<0.01) The hepatic tissues of groups A and C showed no significan abnormality. Chronic inflammatory changes in the hilar bile duct walls were observed only in group B. CONCLUSION: Partial PVA can restore the arterial blood supply of the hilar bile duct and significantly extenuate the injury to hilar bile duct epithelial cells resulting from hepatic artery ligation. | Shao-Hua Guo, Chong-Hui Li,Yong-Liang Chen, Jian-Ning Song,Ai-Qun Zhang and Cheng Zhou Department of Hepatobiliary Surgery (Guo SH, Li CH, Chen YL, Song JN, Zhang AQ and Zhou C) and Department of Surgical Oncology (Guo SH), General Hospital of PLA, Beijing 100853, China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 8 |
| 6 | Effect of Qinling granule in treatment of 102 patients with chronic hepatitis B显示文摘EfectofQinlinggranuleintreatmentof102patientswithchronichepatitisBHUANGZhengMing1,YANGXinBo1,CAOWenBin1,ZHOUYiJun2andLULi... | HUANG Zheng Ming 1, YANG Xin Bo 1, CAO Wen Bin 1, ZHOU Yi Jun 2 and LU Li Yan 2 1Department of Pharmacology, Chinese PLA Beijing Medical School, Beijing 100071, China 2Chinese PLA 184 Hospital, Yingtan 350000, Jiangxi Province, Ch | 1998 | World Journal of Gastroenterology1998，4，1： | 7 |
| 7 | Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance显示文摘有非小的房间肺癌症(NSCLC ) 的最对待 gefitinib 的病人将最后开发抵抗。从 LC Hemsl 的 Lysimachia capillipes (LC ) capilliposide 摘录。在 vitro 并且在 vivo 反癌症效果出现。在这研究,我们调查了在有 gefitinib 的联合的 LC capilliposide 是否能克服 NSCLC 房间的抵抗到 gefitinib 并且识别包含的发信号的小径。有 LC capilliposide 的治疗独自禁止了 NSCLC 房间线(PC-9, H460, H1975, H1299 和 PC-9-GR ) 的一块面板的生长对有在 g/mL 的范围的 IC 50 价值的 gefitinib 敏感或抵抗。在 gefitinib 抵抗的 PC-9-GR 房间(它有一个 T790M EGFR 变化) , LC capilliposide (在 IC30, i.e.1.2 g/mL ) 显著地与它的 IC50 价值提高了 gefitinib 的禁止的效果从 6.80 | Shi-rong ZHANG Ya-si XU Er JIN Lu-cheng ZHU Bing XIA Xu-feng CH EN Fan-zhu LI Sheng-lin MA | 2017 | Acta Pharmacologica Sinica2017，38，1： | 7 |
| 8 | Zircon U-Pb dating of Shuiquangou alkaline complex intrusives, northwestern Hebei Province显示文摘SUPER large gold deposits related to alkaline intrusions have been found in America,Canada,Australia,Papua New Guinea and elsewhere.Dongping gold deposit with superlarge potentialhas also been found in Shuiquangou alkaline complex intrusions,northwestern Hebei Province,China.One of the keys to resolving the possible genetic relationship between gold deposits andore-host alkaline intrusions is to determine their formation ages.This note dates the Shuiquan-gou intrusions with zircon U-Pb method. | Mo, CH Liang, HY Wang, XZ Cheng, JP Li, HM | 1997 | Chinese Science Bulletin1997，42，9： | 6 |
| 9 | Phase Evolution during the Sintering of Submicron Ti(C,N)-Based Cermets显示文摘The submicron powder mixtures of TiC-TiN-WC-Mo-C-Ni sintered at 1400℃ or below in vacuum were studied by X-ray diffration (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses. The results showed that Mo2C fOrmed at 800℃ or below. Both WC and Mo2C disappeared at 1200 ℃, and TiN disappeared at 1250℃. In addihon, the variahons of lanice constans of the htanium carbonitride and nickel binder phase with sintering temperature were experimentally obtained, and the reason was analyzed. | Li, CH Xiong, WH Yu, LX | 2001 | Rare Metals2001，20，4： | 4 |
| 10 | Split liver transplantation: a reliable approach to expand donor pool显示文摘Orthotopic liver transplantation as a successful treatment of end-stage liver disease is hampered by a persistent lack of cadaveric organs. Split liver transplantation, which was first successfully performed by Medical School of Hannover in 1988, has become a mature surgical technique to expand the donor pool. Between 1993 and 1999, split liver transplantation activities have increased in Europe from 1. 2% to 10. 4% in all performed liver transplantations. Current data have strongly supported that the survival rate of patients after split liver transplantation is not significantly different from that of patients after whole-size orthotopic liver transplantation. The most important step of donor graft selection is surgeon’ s observation judged by the experience of individual transplant center. The paper aims to provide the guideline of donor selection, hepatic graft splitting, and recipient management as well. DATA SOURCES: Medical School of Hannover has accumulated plentiful experience of split liver transplantation for more than 10 cases ever since 1998. Besides that, we also reviewed a variety of literatures from other famous European and American centers specialized in this field for many years. RESULTS:According to our experience combined with the view points of others, the donor should meet the following criteria as well: (1) age less than 50 years; (2) hemodynamics stable; (3) ICU less than 5 days; (4) Na less than 170 mmol/L or better if less than 150 mmol/L. In 1996 and 1997, the Hamburg group and the UCLA group separately introduced a breakthrough technique performing split liver transplantation in situ. Evidently, the in situ technique has been limited by prolonged time of donor organ procurement , coordination with other organ procurement teams, and even extra burden on donor hospital. Some groups, therefore, have restored the ex situ or bench splitting technique , and fortunately the transplant outcomes of the ex situ technique are equivalent to those of the in situ one. Recently some new techniques have been introduced to split the liver for two adult patients, including the split-cava technique. CONCLUSIONS:It is clear that the most important factor for determining the prognosis of the patient is the time of receiving liver transplantation, not the type of liver transplantation. We still need to pay close attention to the graft to recipient weight ratio (GRWR) and the UNOS classification or MELD score before the patient is subjected to split liver transplantation. | Ji-Qi Yan, Thomas Becker, Cheng-Hong Peng, Hong-Wei Li and Juergen Klempnauer Department of Surgery, Ruijin Hospital Affiliated to Shanghai Second Medical University, Shanghai 200025, China ( Yan JQ, Peng CH and Li HW) Department of Abdominal and Transplant Surgery, Medical School of Hannover, Carl-Neuberg-Str. 1 , 30625 Hannover, Germany | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 3 |
| 11 | Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells显示文摘 | Zhang,W Ge,W Li,CH You,SG Liao,LM Han,Q Deng,WM Zhao,RCH | 2005 | 中国生物学文摘2005，19，3： | 3 |
| 12 | NMR imaging studies of coal swollen with pyridine显示文摘NMR imaging is a new NMR technique which appeared in these twenty years. The most important difference from the traditional NMR technique is that it can distinguish what signals will be provided by which part of the sample. Since Lauterbur reported the first NMR imaging in 1973, this technique has been widely used in biological, medical, geological, and material studies. NMR imaging technique has also been used in the study of coal structure in | Ma, ZR Zhang, PZ Ding, GL Li, LY Ye, CH | 1997 | Chinese Science Bulletin1997，42，16： | 2 |
| 13 | The Crosstalk of mTOR/S6K1 and Hedgehog Pathways显示文摘 | Yan Wang Qingqing Ding Chia-Jui Yen Weiya Xia Julie G. Izzo Jing-Yu Lang Chia-Wei Li Jennifer L. Hsu Stephanie A. Miller Xuemei Wang Dung-Fang Lee Jung-Mao Hsu Longfei Huo Adam M. LaBaff Dongping Liu Tzu-Hsuan Huang Chien-Chen Lai Fuu-Jen Tsai Wei-Chao Ch | 2012 | Cancer Cell2012，，3： | 2 |
| 14 | Healing effects of heparin on acetic acid-induced gastric ulcers in rats显示文摘HealingefectsofheparinonaceticacidinducedgastriculcersinratsYangLi,QiBingMeiandChiHinChoDepartmentofPharmacology,FacultyofMe... | Yang Li, Qi Bing Mei and Chi Hin Cho Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, 5 Sassoon Road, Hong Kong (Li Y, Mei QB and Cho CH) | 1998 | Chinese Medical Journal1998，，1： | 2 |
| 15 | MoO_(x) and V_(2)O_(x) as hole and electron transport layers through functionalized intercalation in normal and inverted organic optoelectronic devices显示文摘To achieve fabrication and cost competitiveness in organic optoelectronic devices that include organic solar cells(OSCs)and organic light-emitting diodes(OLEDs),it is desirable to have one type of material that can simultaneously function as both the electron and hole transport layers(ETLs and HTLs)of the organic devices in all device architectures(i.e.,normal and inverted architectures).We address this issue by proposing and demonstrating Cs-intercalated metal oxides(with various Cs mole ratios)as both the ETL and HTL of an organic optoelectronic device with normal and inverted device architectures.Our results demonstrate that the new approach works well for widely used transition metal oxides of molybdenum oxide(MoOx)and vanadium oxide(V_(2)O_(x)).Moreover,the Cs-intercalated metaloxide-based ETL and HTL can be easily formed under the conditions of a room temperature,water-free and solution-based process.These conditions favor practical applications of OSCs and OLEDs.Notably,with the analyses of the Kelvin Probe System,our approach of Cs-intercalated metal oxides with a wide mole ratio range of transition metals(Mo or V)/Cs from 1:0 to 1:0.75 can offer significant and continuous work function tuning as large as 1.31 eV for functioning as both an ETL and HTL.Consequently,our method of intercalated metal oxides can contribute to the emerging large-scale and low-cost organic optoelectronic devices. | Xinchen Li Fengxian Xie Shaoqing Zhang Jianhui Hou Wallace CH Choy | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 16 | Genistein stimulates the osteoblastic differentiation via NO/cGMP in bone marrow culture显示文摘 | Pan W Quarles LD Song LH Yu YH Jiao C Tang HB Jiang CH Deng HW Li YJ Zhou HH Xiao ZS | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 17 | Power density distribution simulation and relevant heat effect calculation of a high-power CO2 laser with low order modes显示文摘 | MA K FAN Z B | 2002 | Chinese Journal of Laser2002，11，5： | 1 |
| 18 | The effect of excess Zn on mineral nutrition and antioxidative response in rapeseed seedlings显示文摘 | WANG CH ZHANG S H WANG P F HOU J ZHANG W J LI W LIN ZH P | 2009 | Chemosphere2009，75，： | 1 |
| 19 | Semi-wild wheat from Xi zang(Tibet)显示文摘 | Shao Q Q Li Ch S Basang C R | 1980 | Acta Genet Sin1980，7，2： | 1 |
| 20 | Regulation of hepatic microRNA expression in response to ischemic preconditioning following ischemia/reperfusion injury in mice显示文摘 | Xu CF Yu CH Li YM | 2009 | OMICS2009，13，6： | 1 |
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