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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Combination of Morphologic Criteria and α-Fetoprotein in Selection of Patients With Hepatocellular Carcinoma for Liver Transplantation Minimizes the Problem of Posttransplant Tumor Recurrence显示文摘 | Micha? Gr?t Oskar Kornasiewicz Zbigniew Lewandowski Wac?aw Ho?ówko Karolina Gr?t Konrad Kobryń Waldemar Patkowski Krzysztof Zieniewicz Marek Krawczyk | 2014 | World Journal of Surgery2014，，10： | 2 |
| 4 | Simulating microbiologi- cally influenced corrosion by depositing extracellular biopoly- mers on mild steel surfaces 显示文摘 | Roe F L Lewandowski Z Funk T | 1996 | Corrosion Science1996，52，： | 1 |
| 5 | A- cute myocardial infarction as the first presentation of thyrotoxieosis in a 31-year old woman-case report显示文摘 | Lewandowski KC Rechcifiski T Krzemiftska-Pakula M | 2010 | Thyroid Res2010，3，1： | 1 |
| 6 | Blockade of GABAAreceptors disrupts isoperiodic neuronal oscillations in the intergeniculate leaflet of the rat显示文摘 | Blasiak T Lewandowski MH | 2004 | Brain Research2004，1009，12： | 1 |
| 7 | C4d complement split product in diagnosis of immnunological activity of chronic allograft nephrovathy显示文摘 | Mroz A Lewandowski Z Cieciura T | 2006 | Transplant Proc2006，38，1： | 1 |
| 8 | Membrane fouling due to dynamic particle size changes in the aerated hybrid PAC - MF system 显示文摘 | Khan M Md T Takizawa S Lewandowski Z | 2011 | Membrane Science2011，371，12： | 1 |
| 9 | Dynamic Deformation Behavior of Al-Zn-Mg-Cu Alloy Matrix Composites Reinforced with 20vol% SiC显示文摘 | Hong S L Grayiii G T Lewandowski J J | 1993 | Acta Metal1993，41，8： | 1 |
| 10 | Onset of variable-range hopping at ferromagnetic phase nucleation in amorphous paramagnetic LaSrMnO films显示文摘 | OKUNEV V D SAMOILENKO Z A PAFOMOV N N D'YACHENKO T A PLEHOV A L SZYMCZAK R BARAN M SZYMCZAK H LEWANDOWSKI S J | 2005 | Phys Lett A2005，346，： | 1 |
| 11 | Dietary fish oil supplements increase tissue n-3 fatty acid composition and expression of delta-6 desaturase and elongase-2 in Jade Tiger hybrid abalone显示文摘 | Mateos H T Lewandowski P A Su X Q | 2011 | Lipids2011，46，8： | 1 |
| 12 | Evidence for organosulfates in secondary organic aerosol 显示文摘 | Surratt J D Kroll J H Kleindienst T E Edney E O Claeys M Sorooshian A Ng N L Offenberg J H Lewandowski M Jaoui M Flagan R C Seinfeld J H | 2007 | Environ Sci Technol2007，41，2： | 1 |
| 13 | Simulating microbiologically Influenced corrosion by depositing extracellular biopolymer on mild steel surfaces显示文摘 | Roe FL Lewandowski Z Funk T | 1996 | Corrosion1996，52，10： | 1 |
| 14 | Hydroxydicarboxylic acids: Markers for secondary organic aerosols from the photooxidation of α-pinene 显示文摘 | Claeys M Szmigielski R Kourtchev I Van der Veken P Vermeylen R Maenhaut W Jaoui M Kleindienst T E Lewandowski M Offenberg J H Edney E O | 2007 | Environ Sci Technol2007，41，5： | 1 |
| 15 | Secondary organic carbon and aerosol yields from the irradiations of isoprene and α-pinene in the presence of NOx and SO2 显示文摘 | Kleindienst T E Edney E O Lewandowski M Offenberg J H Jaoui M | 2006 | Environ Sci Technol2006，40，12： | 1 |
| 16 | Simultaneous laparoscopic adrenalectomy and laparoscopic nephron-sparing surgerynew experience with port placement显示文摘 | Panek W Szydelko T Lewandowski J | 2013 | Wideochir Inne Tech Malo Inwazyjne2013，8，4： | 1 |
| 17 | An evaluation of the in vitro cytotoxicities of 50 chemicals by using an electrical current exclusion method versus the neutral red uptake and MTT assays显示文摘 | Lindl T Lewandowski B Schreyogg S | 2005 | Altern Lab Anim2005，33，6： | 1 |
| 18 | Estimates of the contributions of biogenic and anthropogenic hydrocarbons tosecondary organic aerosol at a southeastern US location 显示文摘 | Kleindienst T E Jaoui M Lewandowski M | 2007 | Atmospheric Environment2007，41，37： | 1 |
| 19 | Amplification of hTERT and hTERC genes in leukemic cells with high expression and activity of telomerase显示文摘 | Nowak T Januszkiewicz D Zawada M Pemak M Lewandowski K Rembowska J | 2006 | Oncol Rep2006，16，2： | 1 |
| 20 | Dietary fish oil supplements increase tissue n-3 fatty acid composition and expression of delta-6 desaturase and elongase-2 in Jade Tiger hybrid abalone显示文摘 | Mateos H T Lewandowski P A Su X | 2011 | Lipids2011，46，8： | 1 |
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