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| 1 | Bacterial biota in reflux esophagitis and Barrett's esophagus显示文摘AIM: To identify the bacterial flora in conditions such as Barrett's esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora.METHODS: Using broad-range 16S rDNA PCR,esophageal biopsies were examined from 24 patients [9with normal esophageal mucosa, 12 with gastroesophageal reflux disease (GERD), and 3 with Barrett's esophagus].Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned.In one patient with Barrett's esophagus, g9 PCR clones were analyzed.RESULTS: Two separate clones were recovered from each patient (total = 48), representing 24 different species, with 14 species homologous to known bacteria,5 homologous to unidentified bacteria, and 5 were not homologous (<97% identity) to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett's esophagus patients, and 10 in normal esophagus patients.Further analysis concentrating on a single biopsy from an individual with Barrett's esophagus revealed the presence of 21. distinct bacterial species. Members of four phyla were represented, including Bacteroidetes,Firmicutes, Proteobacteria, and Actinobacteria.Microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory.CONCLUSION: These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations. | Zhiheng Pei Liying Yang Richard M Peek Jr Steven M Levine David T Pride Martin J Blaser | 2005 | World Journal of Gastroenterology2005，11，46： | 11 |
| 2 | 2型糖尿病患者及其一级亲属和非糖尿病者骨骼肌的胰岛素信号传导显示文摘2型糖尿病与骨骼肌和其他组织的葡萄糖利用能力下降有关。胰岛素抵抗可能与遗传因素和糖尿病本身的代谢异常如高血糖或非脂化脂肪酸(NEFA)升高有关。遗传因素和继发的胰岛素抵抗代谢异常可能是由于调节葡萄糖代谢的胰岛素受体和受体后信号传导的改变引起。胰岛素与其受体结合后,受体自身磷酸化,受体激酶活化,一些细胞间的底物磷酸化,其中在骨骼肌细胞中胰岛素受体底物-1(IRS-1)最重要。酪氨酸磷酸化的IRS与脂肪激酶磷脂酚肌醇3’(PI3’) | Meyer MM Levin K Grimmsmann T Beck-Nielsen H Klein HH Diabetologia 叶华 | 2003 | 中国糖尿病杂志2003，11，2： | 3 |
| 3 | Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients:a national study显示文摘 | Block G A Hulbert-Shearon T E Levin N W | | 0，，： | 2 |
| 4 | Finance and sources of growth 显示文摘 | BECK T LEVINE R LOAYZA N 2000 | 2000 | Journal of Financial Economics2000，58，： | 1 |
| 5 | Relationships between soil properties and vegetation at the Northern Experimental Forest, Howland, Maine显示文摘 | LEVINE L R KNOX R G AND LAWRENCE W T | 1994 | Remote Sensing of Environment1994，47，： | 1 |
| 6 | Lipid-like materials for low-dose,in vivo gene silencing显示文摘 | Love K T Mahon K P Levins C G | 2010 | Proc Natl Acad Sci2010，107，5： | 1 |
| 7 | Effects of high- flux hemodialysis on clinical outcomes: results of the HEMO study显示文摘 | Cheung A K Levin N W Greene T | 2003 | J Am Soc Nephrol2003，14，12： | 1 |
| 8 | Financial Intermediation and Growth:Causality and Causes 显示文摘 | Levine R Loayza N Beck T | 2000 | Journal of Monetary Economics2000，，01： | 1 |
| 9 | Integration of ep- idemiology and animal neurotoxlcity data for risk assessment 显示文摘 | LI A A LEVINE T E BURNS C J | 2012 | Neurotoxieology2012，33，4： | 1 |
| 10 | Financial Intermediation and Growth: Causality and Causes 显示文摘 | Levine R Loayza N Beck T | 2000 | Journal of Monetary Economics2000，46，8： | 1 |
| 11 | Ghrelin stim- ulates motility in the small intestine of rats through intrinsic cho- linergic neurons显示文摘 | EDHOLM T LEVIN F HELLSTROM PM | 2004 | Regul Pept2004，121，13： | 1 |
| 12 | Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure显示文摘 | COHN J N LEVINE T B OLIVARI M T | 1984 | N Engl J Med1984，311，： | 1 |
| 13 | Mitochondrial DNA and the origins of the domestic horse显示文摘 | JANSEN T FORSTER P LEVINE M A | 2002 | Proc Natl Acad Sci USA2002，99，10： | 1 |
| 14 | MPL515 mutations in myeloproliferative and other myeloid disorders:a study of 1182patients显示文摘 | Pardanani AD Levine RL Lasho T | | 0，，10： | 1 |
| 15 | MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients显示文摘 | Pardanani AD Levine RL Lasho T | 2006 | Blood2006，108，10： | 1 |
| 16 | Methods in mammalian autophagy research 显示文摘 | Mizushima N Yoshimori T Levine B | 2010 | Cell2010，140，3： | 1 |
| 17 | Telomerase activity is sufficient to allow transformed cells to escape from crisis显示文摘 | HALVORSEN T L LEIBOWITZ G LEVINE F | 1999 | Mol Cell Biol1999，19，： | 1 |
| 18 | Comparison of Orthogonal Radiography and 3D CT-based treatment planning in HDR brachytherapy of cervix cancer显示文摘 | Alezra D Rabin T Levine D | 2006 | Int J Radiat Oncol Biol Phys2006，66，： | 1 |
| 19 | Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells显示文摘 | Marson A Levine S S Cole M F Frampton G M Brambrink T Johnstone S | 2008 | Cell2008，134，： | 1 |
| 20 | Intraoperative gamma detection of 125I-lanreotide in women with primary breast cancer显示文摘 | Cuntz M C Levine E A O'Dorisio T M | 1999 | Ann Surg Oncol1999，6，4： | 1 |
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