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| 1 | Experimental demonstration of linear and spinning Janus dipoles for polarisation-and wavelength-selective near-field coupling显示文摘The electromagnetic field scattered by nano-objects contains a broad range of wavevectors and can be efficiently coupled to waveguided modes.The dominant contribution to scattering from subwavelength dielectric and plasmonic nanoparticles is determined by electric and magnetic dipolar responses.Here,we experimentally demonstrate spectral and phase selective excitation of Janus dipoles,sources with electric and magnetic dipoles oscillating out of phase,in order to control near-field interference and directional coupling to waveguides.We show that by controlling the polarisation state of the dipolar excitations and the excitation wavelength to adjust their relative contributions,directionality and coupling strength can be fully tuned.Furthermore,we introduce a novel spinning Janus dipole featuring cylindrical symmetry in the near and far field,which results in either omnidirectional coupling or noncoupling.Controlling the propagation of guided light waves via fast and robust near-field interference between polarisation components of a source is required in many applications in nanophotonics and quantum optics. | Michela F.Picardi Martin Neugebauer Jorg S.Eismann Gerd Leuchs Peter Banzer Francisco J.Rodriguez-Fortuno Anatoly V.Zayats | 2019 | Light(Science & Applications)2019，8，1： | 4 |
| 2 | Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors. | Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 3 | Entangling fiber solitons-quantum noise engineering for interferometry and communication显示文摘 | Korolkova N Leuchs G | 2002 | Optics and Photonics News2002，2，： | 1 |
| 4 | Sharper focus for a radially polarized light beam显示文摘 | DORN R QUABIS S LEUCHS G | 2003 | Physical Review Letters2003，91，23： | 1 |
| 5 | Life expectancy of head injured men with and without epilepsy显示文摘 | Waker AE Leuchs HK Gruter HL | 1971 | Arch Neurol1971，24，： | 1 |
| 6 | Retargeting of rat parvovirus H-1PV to cancer cells through genetic engineering of the viral capsid显示文摘 | Allaume X E1-Andaloussi N Leuchs B | 2012 | J Virol2012，86，7： | 1 |
| 7 | The role of water and surface acidity on the reactive adsorption of ammonia on modified activated carbons显示文摘 | Le Leuch L M Bandosz T J | 2007 | Carbon2007，45，3： | 1 |
| 8 | Unconditional Quantum Cloning of Coherent States with Linear 显示文摘 | ANDERSEN U L JOSSE V LEUCHS G | 2005 | Phys Rev Lett2005，94，24： | 1 |
| 9 | Intranasal vaccination with recombinant adeno-associated virus type 5 against human papiLloma-virus type 16 LI显示文摘 | Kuck D Lau T Leuchs B | | 0，，06： | 1 |
| 10 | Sharper focus for a radially polarized light beam 显示文摘 | R Dorn S Quabis G Leuchs | 2003 | Phys Rev Lett2003，91，23： | 1 |
| 11 | AngiotensionConverting enzyme inhibitors and betablockers in long-term treatment of dilated cardiomyopathy显示文摘 | Leuchs B Krulls-Munch J | 1995 | Am Heart J1995，129，： | 1 |
| 12 | Sharper focus for a radially polarized light beam显示文摘 | R Dorn S Quabis G Leuchs | 2003 | Phys Rev Lett2003，91，23： | 1 |
| 13 | Sharper focus for a radially polarized light beam 显示文摘 | R Dorn S Quabis G Leuchs | 2003 | Phys Rev Lett2003，91，23： | 1 |
| 14 | Unconditional Quantum C|o- ning of Coherent States with Linear Optics 显示文摘 | Andersen U L Josse V Leuchs G | 2005 | Phys Rev Lett2005，94，24： | 1 |
| 15 | 查看详情显示文摘 | Dorn R Quabis S Leuchs G | | 0，，： | 1 |
| 16 | Intranasal vaccination with recombinant adeno-associated virus type 5 against human papillomavirus type 16 L1显示文摘 | Kuck D Lau T Leuchs B | 2006 | J Viroi2006，80，6： | 1 |
| 17 | Continuous biocatalytic synthesis of (R)-2-octanol with integrated product separation 显示文摘 | Kohlmann C Leuchs S Greiner L | 2011 | Green Chem2011，13，： | 1 |
| 18 | New generation antipsychotics versus low-potency conventional antipsychotics: a systematic review and meta-analysis显示文摘 | Leuch S Wahlbeck K HamannJ | 2003 | Lancet2003，362，9393： | 1 |
| 19 | Polarization squeezing and continuous-variable polarization entanglement显示文摘 | Leuchs G Loudon R | 2002 | Phys Rev A2002，65，05： | 1 |
| 20 | Quantum key distribution with bright entangled beams 显示文摘 | KOROLKOVA N LEUCHS G | 2002 | Phys Rev Lett2002，88，16： | 1 |
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