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| 1 | Prediction of atrial fibrillation development and progression:current perspectives显示文摘Atrial fibrillation(AF) is the most common arrhythmia in clinical practice. Several conventional and novel predictors of AF development and progression(from paroxysmal to persistent and permanent types) have been reported. The most important predictor of AF progression is possibly the arrhythmia itself. The electrical, mechanical and structural remodeling determines the perpetuation of AF and the progression from paroxysmal to persistent and permanent forms. Common clinical scores such as the hypertension, age ≥ 75 years, transient ischemic attack or stroke, chronic obstructive pulmonary disease, and heart failure and the congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke/transient ischemic attack, vascular disease, age 65-74 years, sex category scores as well as biomarkers related to inflammation may also add important information on this topic. There is now increasing evidence that even in patients with so-called lone or idiopathic AF, the arrhythmia is the manifestation of a structural atrial disease which has recently been defined and described as fibrotic atrial cardiomyopathy. Fibrosis results from a broad range of factors related to AF inducing pathologies such as cell stretch, neurohumoral activation, and oxidative stress. The extent of fibrosis as detected either by late gadolinium enhancement-magnetic resonance imaging or electroanatomic voltage mapping may guide the therapeutic approach based on the arrhythmia substrate. The knowledge of these risk factors may not only delay arrhythmia progression, but also reduce the arrhythmia burden in patients with first detected AF. The present review highlights on the conventional and novel risk factors of development and progression of AF. | Konstantinos Vlachos Konstantinos P Letsas Panagiotis Korantzopoulos Tong Liu Stamatis Georgopoulos Athanasios Bakalakos Nikolaos Karamichalakis Sotirios Xydonas Michael Efremidis Antonios Sideris | 2016 | World Journal of Cardiology2016，8，3： | 16 |
| 2 | Catheter ablation of atrial fibrillation in the elderly显示文摘BackgroundAtrial 纤维性颤动(AF ) 导管脱离为 AF 作为有希望的治疗策略出现了,但是广泛地没在老人口被采用。试图在老 population.Methods 和 ResultsThe 学习人口决定 AF 导管脱离的安全和功效的现在的学习与发作性的 AF 由 316 个病人组成了经历了左 atrial 脱离。95 个病人是 ≥65 年(48 男性,意味着年龄 68.9 ±3.0 岁) 并且 221 个病人是 <65 岁(130 男性,意味着年龄 52.5 ±10.4 岁) 。在 34.0 ± 的一个吝啬的后续时期以后;15.1 个月, 55 (57.9%) 在老组的病人与 149 相比从心律不齐复发是自由的(67.4%) 在更年轻的组的病人(P = 0.169 ) 。程序的复杂并发症在两个学习组是不平常的。在逻辑回归分析,离开了 atrial 直径( P = 0.003 ),高血压( P = 0.001 ), dyslipidemia ( P = 0.039 ),并且冠的动脉疾病( P = 0.018 )在 AF 的老 population.ConclusionsCatheter 脱离的 AF 复发的独立预言者在更老的病人安全、有效。侵略策略应该与 AF 在征兆的老病人被看作一种其他的选择。 | Louiza Lioni Konstantinos P. Letsas Michael Efremidis Konstantinos Vlachos Georgios Giannopoulos Vasileios Kareliotis Spyridon Deftereos Antonios Sideris | 2014 | Journal of Geriatric Cardiology2014，11，4： | 5 |
| 3 | Simple hematological predictors of AF recurrence in patients undergoing atrial fibrillation ablation显示文摘Backgound Red cell distribution width(RDW) and neutrophil-to-lymphocyte ratio(NLR) are simple hematologic indices that have been used to predict adverse outcomes in different clinical settings. The aim of our study is to determine whether RDW and NLR can predict atrial fibrillation(AF) recurrence in patients undergoing AF ablation. Methods Consecutive patients, without known hematological disorders, who underwent AF catheter ablation between January 2014 and April 2017 were enrolled into this study. Blood samples were taken one day before and five hours after the ablation procedure. Results A total of 346 patients(224 males(65%), mean age: 59 ± 11 years old) were included. After a mean follow up of 26.2 ± 12.1 months, 80(23.1%) patients experienced late AF recurrence(defined as any recurrence after the blanking period of three months), while 97(28%) patients experienced early AF recurrence during the blanking period. Univariate analysis showed that early arrhythmia recurrence, type of AF and NLR after the procedure were significantly associated with late AF recurrence, while early arrhythmia recurrence and NLR remained significant in multivariate analysis. RDW was not associated with late AF recurrence. None of the parameters above predicted early arrhythmia recurrence. Conclusions Simple and inexpensive hematological indices such as NLR should be evaluated for their ability to predict AF recurrence in patients undergoing catheter ablation in larger prospective studies. | George Bazoukis Konstantinos P Letsas Konstantinos Vlachos Athanasios Saplaouras Dimitrios Asvestas Konstantinos Tyrovolas Aikaterini Rokiza Eirini Pagkalidou Gary Tse Stavros Stavrakis Antonios Sideris Michael Efremidis | 2019 | Journal of Geriatric Cardiology2019，16，9： | 4 |
| 4 | Ibutilide and novel indexes of ventricular repolarization in persistent atrial fibrillation patients显示文摘AIM: To examine the effect of ibutilide on novel indexes of repolarization in patients with persistent atrial fibrillation (AF). METHODS: We studied consecutive patients scheduled for elective electrical cardioversion. Intravenous ibutilide (1+1mg) was administered before the electrical cardioversion while close electrocardiographic (ECG) monitoring was performed. ECG indexes such as corrected QT interval (QTc), the interval from the peak until the end of T wave (Tpe), and the Tpe/QT ratio were measured before ibutilide infusion and 10 min after the end of infusion. RESULTS: The final study population consisted of 20 patients (mean age: 67.1±9.9 years, 10 men). Six patients were cardioverted pharmacologically and did not proceed to electrical cardioversion. Two patientsdeveloped short non-sustained episodes of torsades de pointes ventricular tachycardia. All but one of the aforementioned ECG indexes increased significantly after ibutilide administration. In specific, the QTc interval increased from 442 ± 29 to 471 ± 37 ms (P=0.037), the Tpe interval in precordial leads from 96 ms (range 80-108 ms) to 101 ms (range 91-119 ms) (P=0.021), the Tpe interval in lead Ⅱ from 79 ms (range 70-88 ms) to 100 ms (range 87-104 ms) (P<0.001), the Tpe/QT ratio in precordial leads from 0.23 ms (range 0.18-0.26 ms) to 0.26 ms (range 0.23-0.28 ms) (P=0.028), and the Tpe interval dispersion from 25 ms (range 23-30 ms) to 35 ms (range 27-39 ms) (P=0.012). However, the Tpe/QT ratio in lead II did not change significantly. CONCLUSION: Ibutilide increases the duration and dispersion of ventricular repolarization. The prognostic value of Tpe and Tpe/QT in the setting of drug-induced proarrhythmia needs further study. | Panagiotis Korantzopoulos Konstantinos P Letsas Anna Kotsia Giannis Baltogiannis Kallirroi Kalantzi Konstantinos Kyrlas John A Goudevenos | 2013 | World Journal of Cardiology2013，5，7： | 3 |
| 5 | Headache:An unusual presentation of acute myocardial infraction显示文摘Acute myocardial infarction should be diagnosed as early as possible for the appropriate management to salvage ischemic myocardium. Accurate diagnosis is typically based on the typical symptoms of angina. Headache is an unusual symptom in patients with acute myocardial infraction. We report a patient with ST-segment elevation acute myocardial infarction who presented to the emergency department complaining of severe occipital headache without chest discomfort. | Dimitrios Asvestas Konstantinos Vlachos Anastasios Salachas Konstantinos P Letsas Antonios Sideris | 2014 | World Journal of Cardiology2014，6，6： | 3 |
| 6 | Efficacy and safety of novel anticoagulants in the elderly显示文摘Atrial 纤维性颤动和静脉的 thromboembolism (VTE ) 是与有害 thrombotic 事件联系的普通混乱,特别地在老病人。Polypharmacy,合作病态,和改变的 pharmacokinetics,在这些病人经常在场,使抗凝剂的使用变为相当挑战性。新奇口头的抗凝剂(NOAC ) 最近作为维生素 K 对手(VKA ) 的选择出现了并且主要因为他们的更少药和食物相互作用和容易使用,逐渐地正在增加他们的流行。他们的有效性和安全在一般人口是生长得很好的但是在利益和伤害在之间的平衡老仍然是不清楚的。在这些病人的平淡的使用是不平常的。积累的数据证明了 NOAC 的利益在所有年龄组之中是一致的,展示在阻止 thrombotic 事件的相等或更大的功效。过量流血与与 VKA 相比的 NOAC 是更低的,但是为模式放血在他们之中并且面对面是迥异的比较不是可得到的。在老人口的新奇抗凝剂的功效和安全上的现在的评论热点。 | Nikolaos Karamichalakis Stamatis Georgopoulos Konstantinos Vlachos Ioarmis Liatakis Michael Efremidis Antonios Sideris Konstantinos P Letsas | 2016 | Journal of Geriatric Cardiology2016，13，8： | 3 |
| 7 | Mechanisms of drug-induced proarrhythmia in clinical practice显示文摘Drug-induced proarrhythmia represents a great challenge for those involved in the development of novel pharmaceuticals and in the regulatory bodies for drug approval as well as for the prescribing clinicians.Our understanding of the mechanisms that underlie druginduced proarrhythmia has grown dramatically over the last two decades.A growing number of cardiac and non-cardiac agents have been shown to alter cardiac repolarization predisposing to fatal cardiac arrhythmias such as ventricular tachycardia or ventricular fibrillation and sudden cardiac death.These agents may induce the phenotype of long QT syndrome and less commonly of short QT syndrome and Brugada syndrome(BS).Although,genetic susceptibility underlie drug-induced proarrhythmia in certain cases,current data are limited regarding this topic.The present review surveys the current published literature on the mechanisms and the offending medical agents that predispose to drug-induced long QT syndrome,short QT syndrome and BS.Drug-induced proarrhythmia should be considered as a predictor of sudden cardiac death and should prompt critical re-evaluation of the risks and benefits of the suspicious medication.Survivors of drug-induced proarrhythmia and family members require careful examination and possibly genetic testing for the presence of a channelopathy.Treating physicians are advised to follow the lists of agents implicated in drug-induced proarrhythmia in order to minimize the risk of arrhythmia and sudden cardiac death. | Arkadia Konstantopoulou Spyros Tsikrikas Dimitrios Asvestas Panagiotis Korantzopoulos Konstantinos P Letsas | 2013 | World Journal of Cardiology2013，5，6： | 2 |
| 8 | Drug-induced QT interval prolongation after ciprofloxaxin administration in a patient receiving olanzapine显示文摘 | Letsas KP Sideris A Kounas SP | 2006 | Intern J Cardiol2006，109，： | 1 |
| 9 | Deterrainants of plasma NT- pm-BNP levels in patients with atrial fibrillation and preserved left ventricular ejection fraction 显示文摘 | Letsas KP Filippatos GS Pappas LK | 2009 | Clin Res Cardiol2009，98，2： | 1 |
| 10 | Antieoagulation and antiplatelet therapy in implantation of electrophysiological devices显示文摘 | Korantzopoulos P Letsas KP Liu T | 2011 | Europace2011，13，12： | 1 |
| 11 | Tpeak-Tend interval and Tpeak-Tend / QT ratio as markers of ventricular tachycardia inducibility in subjects with Brugada ECG phenotype显示文摘 | Letsas KP Weber R Astheimer K | | 0，，： | 1 |
| 12 | Uric acid elevation in atrial fibrillation显示文摘 | Letsas KP Korantzopoulos P Filippatos GS | 2010 | Hellenic J Cardiol2010，51，20： | 1 |
| 13 | Tpeak-Tend interval and Tpeak-Tend/QT ratio as markers of ventricular tachyear dia inducibility in subjects with Brugada ECG phenotype显示文摘 | Letsas K P Weber R Astheimer K | 2010 | Europace2010，12，2： | 1 |
| 14 | QT inter- val prolongation associated with venlafaxine administration 显示文摘 | Letsas K Korantzopoulos P Pappas L | 2006 | Int J Cardiol2006，109，1： | 1 |
| 15 | Catheter ablation of persistent atrial fibrillation:The importance of substrate modification显示文摘Accumulating data have shown that elimination of atrial fibrillation(AF) sources should be the goal in persistent AF ablation. Pulmonary vein isolation, linear lesions and complex fractionated atrial electrograms(CFAEs) ablation have shown limited efficacy in patients with persistent AF. A combined approach using voltage, CFAEs and dominant frequency(DF) mapping may be helpful for the identification of AF sources and subsequent focal substrate modification. The fibrillatory activity is maintained by intramural reentry centered on fibrotic patches. Voltage mapping may assist in the identification of fibrotic areas. Stable rotors display the higher DF and possibly drive AF. Furthermore, the single rotor is usually consistent with organized AF electrograms without fractionation. It is therefore quite possible that rotors are located at relatively 'healthy islands' within the patchy fibrosis. This is supported by the fact that high DF sites have been negatively correlated to the amount of fibrosis. CFAEs are located in areas adjacent to high DF. In conclusion, patchy fibrotic areas displaying the maximum DF along with high organization index and the lower fractionation index are potential targets of ablation. Prospective studies are required to validate the efficacy of substrate modification in left atrial ablation outcomes. | Konstantinos P Letsas Michael Efremidis Nikolaos P Sgouros Konstantinos Vlachos Dimitrios Asvestas Antonios Sideris | 2015 | World Journal of Cardiology2015，7，3： | 1 |
| 16 | Uric acid elevation in atrial fibrillation显示文摘 | Letsas KP Korantzopoulos P Filippatos GS | 2010 | Hellenic J Cardiol2010，51，3： | 1 |
| 17 | Tpeak-Tend interval and Tpeak-Tend/QT ratio as markers of ventricular tachycardia indue- ibility in subjects with Brugada ECG phenotype显示文摘 | Letsas KP Weber R Astheimer K | 2010 | Europace2010，12，2： | 1 |
| 18 | Acute myocardial infarction with normal coronary arteries in a patient with Hodgkin's disease: a late complication of irradiation and chemotherapy 显示文摘 | Letsas KP Korantzopoulos P Evangelou D | 2006 | Tex Heart Inst J2006，33，4： | 1 |
| 19 | Uric acid elevation in atrial fibrillation显示文摘 | Letsas KP Korantzopoulos P Filippatos GS | 2010 | Hellenic J Cardiol2010，51，20： | 1 |
| 20 | Tpeak-Tend interval and Tpeak-Tend/QT ratio as markers of ventricular tachycardia inducibility in subjects with Brugada ECG phenotype显示文摘 | Letsas K P Weber R Astheimer K | 2010 | Europace2010，12，2： | 1 |
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