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7篇 您的检索式：作者名="Letoha T"

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		题名	作者	年代	出处	被引量
	1	Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis.	Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács	2007	World Journal of Gastroenterology2007，13，33：	5
	2	The proteasome inhibitor MG132 protects against acute pancreatitis显示文摘	Letoha T Somlai C Takacs T	2005	Free Radio Biol Med2005，39，9：	1
	3	The proteasome inhibitor MG132 protects against acute pancreatitis显示文摘	Letoha T Somlai C Takács T	2005	Free Radical Biol Med2005，39，9：	1
	4	The proteasome inhibitor MG- 132 protects against acute pancreatitis 显示文摘	Letoha T Somlai C Takacs T	2005	Free Radio Biol Med2005，39，9：	1
	5	In vitro and in vivo nuclear factor-kappaB inhibitory effects of the cell-penetrating penetratin peptide显示文摘	Letoha T Kusz E Papai G	2006	Mol Pharmacol2006，69，6：	1
	6	The proteasome inhibitor MG-132 protects against acute pancreatitis 显示文摘	Letoha T Somlai C Takacs T	2005	Free Radical Biol Med2005，39，9：	1
	7	The proteasome inhibitor MG 132 protects against acute pancreatitis显示文摘	Letoha T Somlai C Takacs T	2005	Free Radic Biol Med2005，39，9：	1

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