|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification显示文摘AIM:To compare noninvasive methods presently used for steatosis detection and quantification in nonalcoholic fatty liver disease(NAFLD).METHODS:Cross-sectional study of subjects from the general population,a subgroup from the First Israeli National Health Survey,without excessive alcohol consumption or viral hepatitis.All subjects underwent anthropometric measurements and fasting blood tests.Evaluation of liver fat was performed using four noninvasive methods:the SteatoTest;the fatty liver index(FLI);regular abdominal ultrasound(AUS);and the hepatorenal ultrasound index(HRI).Two of the noninvasive methods have been validated vs liver biopsy and were considered as the reference methods:the HRI,the ratio between the median brightness level of the liver and right kidney cortex;and the SteatoTest,a biochemical surrogate marker of liver steatosis.The FLI is calculated by an algorithm based on triglycerides,body mass index,γ-glutamyl-transpeptidase and waist circumference,that has been validated only vs AUS.FLI < 30 rules out and FLI ≥ 60 rules in fatty liver.RESULTS:Three hundred and thirty-eight volunteers met the inclusion and exclusion criteria and had valid tests.The prevalence rate of NAFLD was 31.1% according to AUS.The FLI was very strongly correlated with SteatoTest(r = 0.91,P < 0.001) and to a lesser but significant degree with HRI(r = 0.55,P < 0.001).HRI and SteatoTest were significantly correlated(r = 0.52,P < 0.001).The κ between diagnosis of fatty liver by SteatoTest(≥ S2) and by FLI(≥ 60) was 0.74,which represented good agreement.The sensitivity of FLI vs SteatoTest was 85.5%,specificity 92.6%,positive predictive value(PPV) 74.7%,and negative predictive value(NPV) 96.1%.Most subjects(84.2%) with FLI < 60 had S0 and none had S3-S4.The κ between diagnosis of fatty liver by HRI(≥ 1.5) and by FLI(≥ 60) was 0.43,which represented only moderate agreement.The sensitivity of FLI vs HRI was 56.3%,specificity 86.5%,PPV 57.0%,and NPV 86.1%.The diagnostic accuracy of FLI for steatosis > 5%,as predicted by SteatoTest,yielded an area under the receiver operating characteristic curve(AUROC) of 0.97(95% CI:0.95-0.98).The diagnostic accuracy of FLI for steatosis> 5%,as predicted by HRI,yielded an AUROC of 0.82(95% CI:0.77-0.87).The κ between diagnosis of fatty liver by AUS and by FLI(≥ 60) was 0.48 for the entire sample.However,after exclusion of all subjects with an intermediate FLI score of 30-60,the κ between diagnosis of fatty liver by AUS and by FLI either ≥ 60 or < 30 was 0.65,representing good agreement.Excluding all the subjects with an intermediate FLI score,the sensitivity of FLI was 80.3% and the specificity 87.3%.Only 8.5% of those with FLI < 30 had fatty liver on AUS,but 27.8% of those with FLI ≥ 60 had normal liver on AUS.CONCLUSION:FLI has striking agreement with SteatoTest and moderate agreements with AUS or HRI.However,if intermediate values are excluded FLI has high diagnostic value vs AUS. | Shira Zelber-Sagi Muriel Webb Nimer Assy Laurie Blendis Hanny Yeshua Moshe Leshno Vlad Ratziu Zamir Halpern Ran Oren Erwin Santo | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 2 | Older age, longer procedures and tandem endoscopic-ultrasound as risk factors for post-endoscopic retrograde cholangiopancreatography bacteremia显示文摘BACKGROUND Clinically significant post-endoscopic retrograde cholangiopancreatography(ERCP) bacteremia(PEB) occurs in up to 5% of cases, while antibiotic prophylaxis is recommended only when an ERCP is unlikely to achieve complete biliary drainage. However, the current recommendations may not cover all potential risk factors for PEB.AIM To identify novel risk factors for PEB and evaluate appropriateness of antibiotic prophylaxis.METHODS A retrospective study of 1082 ERCP procedures performed between January 2012-December 2013 in a single tertiary medical center. Data collection included: Demographic and clinical characteristics such as pre and post procedure antibiotic treatment and bacterial blood cultures. Exclusion criteria were:(1) Age < 18 years;(2) Positive bacterial blood culture before ERCP;(3) Scheduled antibiotic treatment prior to ERCP;(4) Hospitalization longer than 14 d before ERCP;and(5) missing critical data. Stepwise Logistic Regression analysis and Decision Tree algorithms were used for prediction modeling of PEB.RESULTS A total of 626 ERCPs performed in 434 patients were included. Mean age 66.49 ± 15.4 years and 46.5% were males. PEB prevalence was 3.7%. Antibiotic prophylaxis was administrated in 139/626(22.2%) cases but was indicated according to the guidelines only in 44/626(7%) cases. In all the PEB cases, prophylaxis was deemed not indicated. A stepwise logistic regression [receiver operating characteristic(ROC), 0.766], identified 3 variables as independent risk factors for PEB: Age at ERCP ≥ 75 years(OR, 3.780, 95%CI: 1.519-9.408, P = 0.004);Tandem EUS/ERCP with fine needle aspiration(FNA)(OR, 14.528, 95%CI: 3.571-59.095, P < 0.001);ERCP duration longer than 60 min(OR, 5.396, 95%CI: 1.86-15.656, P = 0.002). In a decision tree model(ROC, 0.778) the probability for PEB without any risk factors was 1% regardless of prophylaxis administration.CONCLUSION The prevalence of PEB in our study is similar to previous reports, despite the fact that antibiotic prophylaxis was administrated more readily than recommended. ERCP duration longer than 60 min, tandem EUS-ERCP with FNA and age above 75 years are significant risk factors for PEB. These factors should be further evaluated as indications for prophylactic antibiotic treatment before ERCP. | Liat Deutsch Shay Matalon Adam Phillips Moshe Leshno Oren Shibolet Erwin Santo | 2020 | World Journal of Gastroenterology2020，26，41： | 3 |
| 3 | Increased fibrosis progression rates in hepatitis C patients carrying the prothrombin G20210A mutation显示文摘AIM: To examine whether hepatitis C virus (HCV)-infected patients who carry hypercoagulable mutationssuffer from increased rates of liver fi brosis. METHODS: We analyzed DNA samples of 168 HCV patients for three common hypercoagulable gene mutations: prothrombin 20210 (PT20210), factor V Leiden (FV Leiden) and methylene tetrahydrofolate reductase (MTHFR). The patients were consecutively recruited as part of the prospective 'Fibroscore Study' in France. The effect of the various mutations on the rate of fi-brosis was analyzed statistically and was correlated with epidemiological, clinical and biochemical data such as grade and stage of liver biopsies, patients' risk factors for liver cirrhosis, and timing of infection. RESULTS: Fifty two of the patients were categorized as 'fast fi brosers' and 116 as 'slow fi brosers'; 13% of the 'fast fi brosers' carried the PT20210 mutation as compared with 5.5% of the 'slow fi brosers', with an odds ratio of 4.76 (P = 0.033; 95% CI: 1.13-19.99) for 'fast' liver fibrosis. Carriage of MTHFR or FV Leiden mutations was not associated with enhanced liver fi brosis. CONCLUSION: Carriage of the PT20210 mutation is related to an increased rate of liver fi brosis in HCV patients. | Nitsan Maharshak Philippe Halfon Varda Deutsch Hava Peretz Shlomo Berliner Sigal Fishman Shira Zelber-Sagi Uri Rozovski Moshe Leshno Ran Oren | 2011 | World Journal of Gastroenterology2011，17，45： | 2 |
| 4 | Multilayer feedforward networks with a non-polynomial activation can Approximate any function 显示文摘 | Leshno M Lin V Y Pinkus A | 1993 | Neural Network1993，6，： | 1 |
| 5 | Re-evaluation of se-rum alanine aminotransferase upper normal limit and itsmodulating factors in a large-scale popu-lation study显示文摘 | Kariv R Leshno M Beth-Or A | 2006 | Liver Int2006，26，4： | 1 |
| 6 | Stochastic Dominance and Medical Decision Making显示文摘 | Moshe Leshno Haim Levy | 2004 | Health Care Management Science2004，，3： | 1 |
| 7 | Muhilayer feed forward networks with a no polynomial activation function can approximate any func- tion显示文摘 | LESHNO M LIN V Y PINKUS A | 1993 | Neural networks1993，6，6： | 1 |
| 8 | Cost - effectiveness of colorectal cancer screening in the average risk population 显示文摘 | Leshno M Halpern Z Arber N | 2003 | Health Care Management Science2003，6，3： | 1 |
| 9 | Multilayer feedforward networks with a nonpolynomial activation function can approximate any function显示文摘 | Leshno M Lin V Y Pinkus A | 1993 | Neural Networks1993，6，： | 1 |
| 10 | Halitosis and gastroe-sophageal reflux disease: a possible association 显示文摘 | Moshkowitz M Horowitz N Leshno M | 2007 | Oral Dis2007，13，6： | 1 |
| 11 | Multilayer feedforward networks with a nonpolynomial activation function can approximate any function显示文摘 | Leshno M Lin V Y Pinkus A | | 0，，06： | 1 |
| 12 | The prevalence rate and anatomic location of eolorectal adenoma and cancer detected by colonoscopy in average-risk individuals aged 40--80 years显示文摘 | Strul H Kariv R Leshno M | 2006 | Am J Gastroenterol2006，101，2： | 1 |
| 13 | The prevalence rate and anatomic location of colorectal adenoma and cancer detected by colonoscopy in average - risk individuals aged 40 - 80 years 显示文摘 | Strul H Kariv R Leshno M | 2006 | Am J Gastroen- terol2006，101，2： | 1 |
| 14 | Muhilayer Feedorward Networks with a Nonpolynomial Activation Function can Approximate any Function显示文摘 | Leshno M Lin V Y Schocken S | 1992 | Neural Networks1992，6，6： | 1 |
| 15 | Re-evaluation of serum alanine aminotransferase upper normal limit and its modulating factors in a large-scale population study 显示文摘 | Kariv R Leshno M Beth-Or A Strul H Blendis L Kokia E | 2006 | Liver Int2006，26，44： | 1 |
| 16 | The impact of EHR and HIE on reducing avoidable admissions: controlling main differ- ential diagnoses 显示文摘 | Ben - Assuli O Shabtai I Leshno M | 2013 | BMC Med Inform Decis Mak2013，13，： | 1 |
| 17 | The prevalence rete and anatomic location of colorectal adenoma and cancer detected by colonoscopy in average-risk individuals aged 40 -80 years显示文摘 | Strul H Kariv R Leshno M | 2006 | Am J Gastroenterel2006，101，2： | 1 |
| 18 | Neural network predic- tion analysis: The bankruptcy case 显示文摘 | Leshno M Spector Y | 1996 | Neuro- computing1996，10，2： | 1 |
| 19 | Point/Counterpoint: Aspirin is clinically effective in chemoprevention of colorectal neoplasia point 显示文摘 | Leshno M Moshkowitz M Arber N | 2008 | Cancer Epidemiol Biomarkers Prev2008，17，7： | 1 |
| 20 | prevalence of colorectal neoplasms in young, average risk individuals: A turning tide between East and West显示文摘AIM To determine the prevalence of colorectal neoplasia in average risk persons 40-59 years of age in Israel and to compare the results with other populations. METHODS We reviewed the results of asymptomatic average-risk subjects, aged 40 to 59 years, undergoing their first screening colonoscopy between April 1994 and January 2014. The detection rates of adenoma, advanced adenoma(AA) and colorectal cancer(CRC) were determined in the 40's and 50's age groups by gender. The prevalence of lesions was compared between age groups. After meticulous review of the literature, these results were compared to published studies addressing the prevalence of colorectal neoplasia in similar patient groups, in a variety of geographical locations.RESULTS We included first screening colonoscopy results of 1750 individuals. The prevalence of adenomas, AA and CRC was 8.3%, 1.0% and 0.2% in the 40-49 age group and 13.7%, 2.4% and 0.2% in the 50-59 age group, respectively. Age-dependent differences in adenoma and AA rates were significant only among men(p < 0.005). Literature review disclosed 17 relevant studies. As expected, in both Asian and Western populations, the risks for overall adenoma and advanced adenoma was significantly higher in the 50's age group as compared to the 40's age group in a similar fashion. The result of the current study were similar to previous studies on Western populations. A substantially higher rate of adenoma, was observed in studies conducted among Asian populations in both age groups.CONCLUSION The higher rate of colorectal neoplasia in Asian populations requires further investigation and reconsideration as to the starting age of screening in that population. | Ari Leshno Menachem Moshkowitz Maayan David Lior Galazan Alfred I Neugut Nadir Arber Erwin Santo | 2016 | World Journal of Gastroenterology2016，22，32： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员