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| 1 | Effects of glutamine supplementation on gut barrier,glutathione content and acute phase response in malnourished rats during inflammatory shock显示文摘AIM: To evaluate the effect of glutamine on intestinal mucosa integrity,glutathione stores and acute phase response in protein-depleted rats during an inflammatory shock. METHODS: Plasma acute phase proteins (APP),jejunal APP mRNA levels,liver and jejunal glutathione concentrations were measured before and one,three and seven days after turpentine injection in 4 groups of control,protein-restricted,protein-restricted rats supplemented with glutamine or protein powder. Bacterial translocation in mesenteric lymph nodes and intestinal morphology were also assessed. RESULTS: Protein deprivation and turpentine injection significantly reduced jejunal villus height,and crypt depths. Mucosal glutathione concentration significantly decreased in protein-restricted rats. Before turpentine oil,glutamine supplementation restored villus heights and glutathione concentration (3.24 ± 1.05 vs 1.72 ± 0.46 μmol/g tissue,P < 0.05) in the jejunum,whereas in the liver glutathione remained low. Glutamine markedly increased jejunal α1-acid glycoprotein mRNA level after turpentine oil but did not affect its plasma concentration. Bacterial translocation in protein-restricted rats was not prevented by glutamine or protein powder supplementation. CONCLUSION: Glutamine restored gut glutathione stores and villus heights in malnourished rats but had no preventive effect on bacterial translocation in our model. | Liliana Belmonte Mose Co■ffier Florence Le Pessot Olga Miralles-Barrachina Martine Hiron Antony Leplingard Jean-Franois Lemeland Bernadette Hecketsweiler Maryvonne Daveau Philippe Ducrotté Pierre Déchelotte | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 2 | Lactobacillus casei DN-114 001 inhibits the ability of adherent-invasive Eschefiehia coli isolated from Crohn's disease patients to adhere to and to invade intestinal epithelial ceils显示文摘 | INGRASSIA I LEPLINGARD A DARFEUILLE-MICHAUD A | 2005 | Appl Environ Microbiol2005，71，6： | 1 |
| 3 | Glutamine decreases interleukin-8 and interleukin-6 but not nitric oxide and prostaglandins e (2) production by human gut in-vitro 显示文摘 | Coeffier M Marion R Leplingard A | 2002 | Cytokine2002，18，2： | 1 |
| 4 | Glutamine decreases interleukin-8 and interleukin-6 but not nitric oxide and prostaglandins e (2) production by human gut in-vitro 显示文摘 | Coeffier M Marion R Leplingard A | 2002 | Cytokine2002，18，2： | 1 |
| 5 | Cytokine-stimulated nitric oxide production and inducible NO-synthase mRNA level in human intestinal cells: lack of modulation by glutamine显示文摘 | Marion R Coeffier M Leplingard A | 2003 | Clin Nutr2003，22，6： | 1 |
| 6 | 48% power conversion efficiency in single pump gain - shifted thuliumdoped fiber amplifier 显示文摘 | ROY F LEPLINGARD F | 2001 | Electronics Letters2001，37，15： | 1 |
| 7 | Glutamine decreased interleukin-8 and interleukin-6 but not nitric oxide and prostaglandins E2 production by human gut in-vitro 显示文摘 | Coeffier M Marion R Leplingard A Lerebours E Ducrotte P Dechelotte P | 2002 | Cytokine2002，18，： | 1 |
| 8 | QoT function and A*routing:an optimi-zed combination for connection search in translucent net-works显示文摘 | Annalisa Morea Nicolas Brogard Florence Leplingard Jean-Christophe Antona Thierry Zami Bruno Lavigne and Dominique Bayart | | 0，，： | 1 |
| 9 | A Lactobacillus casei DN-114 001 inhibits the ability of adherent-invasive Escherichia coli isolated from Crohn's disease patients to adhere to and to invade intestinal epithelial cells 显示文摘 | INGRASSIA I LEPLINGARD A DARFEUILLE M | 2005 | Appl Environ Microbiol2005，71，6： | 1 |
| 10 | Lactobacillus casei DN-114 001 inhibits the ability of ad-herent-invasive Escherichia coli isolated from Crohnf s diseasepatients to adhere to and to invade intestinal epithelial cells显示文摘 | INGRASSIA I LEPLINGARD A DARFEUILLEMICHAUDA | 2005 | Appl Environ Microbiol2005，71，6： | 1 |
| 11 | QoT function and A* routing an optimized combination for connection search in translucent networks显示文摘 | MOREA A BROGARD N LEPLINGARD F | 2008 | Journal of Optical Networking2008，7，1： | 1 |
| 12 | Acute enteral glutamine infusion enhances heme oxygenase-1 expression in human duodenal mucosa显示文摘 | Coeffier M Le Pessot F Leplingard A | 2002 | J Nutr2002，132，9： | 1 |
| 13 | 48% power conversion efficiency in single pump gain-shifted thulium-doped fibre amplifier显示文摘 | ROY F LEPLINGARD F LORCY L | 2001 | Electron Lett2001，37，15： | 1 |
| 14 | Cytokine-stimulated nitric oxide production and inducible NO-synthase mRNA level in human intestinal cells:lack of modulation by glutamine显示文摘 | Marion R Coeffier M Leplingard A | 2003 | Clinical Nutrition2003，22，6： | 1 |
| 15 | Acute enteral glutamine infusion enhances heme oxygenase-1 expression in human duodenal mueosa显示文摘 | Coeffier M Le Pessot F Leplingard A | 2002 | J Nutr2002，132，9： | 1 |
| 16 | Cytokine-stimulated nitric oxide production and inducible NO-synthase mRNA level in human intestinal cells:lack of modulation by glutamine显示文摘 | Marion R Coeffier M Leplingard A | 2003 | Clini Nutrit2003，22，6： | 1 |
| 17 | Glutamine decreases interleukin-8 and interleukin-6 but not nitric oxide and prostaglandinse (2) production by human gut in-vitro显示文摘 | Coeffier M Marion R Leplingard A | 2002 | Cytokine2002，18，2： | 1 |
| 18 | Glutamine decreases interleukin-8 and interleukin-6 but not nitric oxide and prostaglandins e (2) production by human gut in-vitro 显示文摘 | Coeffier M Marion R Leplingard A | 2002 | Cytokine2002，18，2： | 1 |
| 19 | 48% power conversion efficiency in single pump gain-shifted thulium-doped fibre amplifier显示文摘 | LEPLINGARD F | 2001 | Electronics Letters2001，37，15： | 1 |
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