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| 1 | From histology to micro-CT:Measuring and modeling resorption cavities and their relation to bone competence显示文摘The process of bone remodelling plays an essential role in the emergence and maintenance of bone geometry and its internal structure.Osteoclasts are one of the three main bone cell types that play a crucial role in the bone remodelling cycle.At the microstructural level,osteoclasts create bone deficits by eroding resorption cavities.Understanding how these cavities impair the mechanical quality of the bone is not only relevant in quantifying the impact of resorption cavities in healthy bone and normal aging,but maybe even more so in quantifying their role in metabolic bone diseases.Meta-bolic bone diseases and their treatment are both known to affect the bone remodelling cycle;hence,the bone mechanical competence can and will be affected.How-ever,the current knowledge of the precise dimensions of these cavities and their effect on bone competence is rather limited.This is not surprising considering the difficulties in deriving three-dimensional(3D)properties from two-dimensional(2D)histological sections.The measurement difficulties are reflected in the evalua-tion of how resorption cavities affect bone competence.Although detailed 3D models are generally being used to quantify the mechanical impact of the cavities,the representation of the cavities themselves has basicallybeen limited to simplified shapes and averaged cavityproperties.Qualitatively,these models indicate that cav-ity size and location are important,and that the effectof cavities is larger than can be expected from simplebone loss.In summary,the dimensions of osteoclastresorption cavities were until recently estimated from2D measures;hence,a careful interpretation of resorp-tion cavity dimensions is necessary.More effort needsto go into correctly quantifying resorption cavities usingmodern 3D imaging techniques like micro-computedtomography(micro-CT)and synchrotron radiation CT.Osteoclast resorption cavities affect bone competence.The structure-function relationships have been ana-lysed using computational models that,on one hand,provide rather detailed information on trabecular bonestructure,but on the other incorporate rather crudeassumptions on cavity dimensions.The use of high-resolution representations and parametric descriptionscould be potential routes to improve the quantitativefidelity of these models. | Jef Vanderoost G Harry van Lenthe | 2014 | World Journal of Radiology2014，6，9： | 3 |
| 2 | Environmental correlates of physical activity in youth – a review and update显示文摘 | I.Ferreira K.Van Der Horst W.Wendel‐Vos S.Kremers F. J.Van Lenthe J.Brug | 2006 | Obesity Reviews2006，，2： | 2 |
| 3 | A simultaneous analysis of neighborhood and childhood socio-economic environment with self-assessed health and health-related behaviors显示文摘 | Monden CW van Lenthe FJ Mackenbach JP | 2006 | Health and Place2006，，12： | 1 |
| 4 | Effects of mechanical forces on maintenance and adaptation of form in trabecular bone显示文摘 | Huiskes R Ruimerman R Van Lenthe G H | 2000 | Nature2000，405，6787： | 1 |
| 5 | Determination of 5-fluorouracil in plasma with HPEC-tandem mass spectrometry 显示文摘 | van Kuilenburg A B van Lenthe H Maring J G | 2006 | Nucleosides Nucleotides Nucleic Acids2006，25，911： | 1 |
| 6 | Quantitative analysis of arsenic in mine tailing soils using double pulse-laser induced breakdown spectroscopy显示文摘 | Kwak J Lenth C Salb C | 2009 | Spectrochimica Acta Part B2009，64，10： | 1 |
| 7 | Hydrogen Storage in Magnesium Clusters: Quantum Chemical Study 显示文摘 | Wagemans R W P Van Lenthe J H De Jongh P E | 2005 | JAmChemSoc2005，127，16： | 1 |
| 8 | Quantification of bone structuralparameters and mechanical competence at the distal radius显示文摘 | van Lenthe GH Mueller TL Wirth AJ | 2008 | J Orthop Trauma2008，22，8： | 1 |
| 9 | Effects of mechanical forces on maintenance and adaptation of form in trabecular bone显示文摘 | Huiskes R Ruimerman R van Lenthe GH | 2000 | Nature2000，405，6787： | 1 |
| 10 | New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid? 显示文摘 | Van Kuilenburg AB Stroomer AE Van Lenthe H | 2004 | Biochem J2004，，： | 1 |
| 11 | Green infrared-pumped erbium up-conversion laser 显示文摘 | Ailversmith A J Lenth W Macfarlane R M | 1987 | Applied Physics Letters1987，51，： | 1 |
| 12 | Theoretical Description of Frequency Modulation and Wavelength Modulation Spectroscopy显示文摘 | Supplee J M Whittaker E A and Lenth W | 1994 | Applied Optics1994，33，27： | 1 |
| 13 | A randomized clinical trial comparing the effect of basal insulin and inhaled mealtime insulin on glucose variability and oxidative stress显示文摘 | Siegelaar SE Kulik W van Lenthe H | | 0，，07： | 1 |
| 14 | Importance of individual rods and plates in the assessment of bone quality and their contribution to bone stiffness显示文摘 | Stauber M Rapillard L van Lenthe GH | 2006 | J Bone Miner Res2006，21，4： | 1 |
| 15 | Liquid chromatographic determination of olaquindox in medicated feeds and in contents of porcine gastrointestinal tract显示文摘 | Spierenburg T J Van Lenthe H De Graaf G J | 1988 | J Assoc off Anal Chem1988，71，6： | 1 |
| 16 | Process Evaluation of a Dutch Community Intervention to improve Health Related Behaviour in deprived neighbourhoods 显示文摘 | Kloek GC van Lenthe FJ Meertens YMG | 2006 | Soz Praventiv Med2006，51，： | 1 |
| 17 | Quick and Easy Analysis of Un -replicated Factorials 显示文摘 | LENTH R V | 1989 | Techno metrics1989，，31： | 1 |
| 18 | The effect of chemical composition and structure on XPS binding energies in zeolites 显示文摘 | Gijzeman O L J Mens A J M van Lenthe J H Mortier W J Weckhuysen B M | 2003 | J Phys Chem B2003，107，3： | 1 |
| 19 | Speed of sound reflects Young's modulus as assessed by microstructural finite element analysis 显示文摘 | Van den Bergh JP van Lenthe GH Hermus AR | 2000 | Bone2000，26，5： | 1 |
| 20 | A multilevel study of socio-economic inequalities in food choice behaviour and dietary intake among the Dutch population:the GLOBE study显示文摘 | GISKES K TURRELL G VAN LENTHE F J | 2006 | Public Health Nutr2006，9，1： | 1 |
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