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| 1 | 与HBeAg阴性慢性乙型肝炎患者成功停药相关的病毒和免疫因素显示文摘【据Journal of Hepatology 2020年12月报道】与HBeAg阴性慢性乙型肝炎患者成功停药相关的病毒和免疫因素(作者García-López M等)目前,与HBeAg阴性慢性乙型肝炎(CHB)患者成功停用核苷(酸)类似物(NA)治疗的相关因素尚未阐明。为了分析停用NA患者的HBV特异性T淋巴细胞反应以及外周和肝内病毒参数,来自西班牙巴塞罗那大学的García-López等对27例病毒完全抑制(>3年)HBeAg阴性CHB非肝硬化患者进行了前瞻性研究。在基线时定量检测肝内HBV DNA(iHBV DNA)、肝内HBV RNA(iHBV RNA)和共价闭合环状DNA(cccDNA)。此外,在基线和整个随访过程中,对血清标志物(HBV DNA、HBsAg、HBcrAg和HBV RNA)和HBV特异性T淋巴细胞反应进行了分析。 | GARCIA-LOPEZ M LENS S PALLETT LJ 孟方园 高沿航 | 2021 | 临床肝胆病杂志2021，37，2： | 8 |
| 2 | Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications. | Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns | 2015 | World Journal of Gastroenterology2015，21，17： | 4 |
| 3 | Identification of a no?vel subpopulation of germinal center B cells characterized by expres?sion of IgD and CD70 显示文摘 | Lens S M Keehnen R M van Oers M H | 1996 | Eur J Immunol1996，26，5： | 1 |
| 4 | Anti-CTLA4 monoclonal antibody Ipilimumab in the treatment of metastatic melanoma:recent findings显示文摘 | Lens M Ferrucci PF Testori A | | 0，，2： | 1 |
| 5 | Control of lymphocyte function through CD27-CD70 interactions显示文摘 | Lens S M Tesselaar K Van Oers M H etal | 1998 | Semin Immunol1998，10，： | 1 |
| 6 | An efficient integration of algorithms to evaluate the quality of free form surfaces显示文摘 | Lennings A F Peters J G Vergeest J S M | 1995 | Computer & Graphics1995，19，6： | 1 |
| 7 | Examining the motivational impact of intrinsic versus extrinsic goal framing and autonomy supportive versus internally controlling communication style on early adolescents' academic achievement显示文摘 | Vansteenkiste M Simons J Lens W | 2005 | Child Development2005，76，： | 1 |
| 8 | Prevalence of malnutrition in a mid-long term stay unit显示文摘 | Argente Pla M Garc侏a Malpartida K Len De Zayas B | 2014 | NutrHosp2014，31，2： | 1 |
| 9 | Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation显示文摘 | Hintzen R Q Lens S M Lammers K | 1995 | J Immunol1995，154，： | 1 |
| 10 | Ultraviolet spectrophotometric characterization and bactericidal properties of electrolyzed oxidizing water as influenced by amperage and pH显示文摘 | Len SV Hung YC Erickson M | 2000 | Journal of Food Protection2000，63，： | 1 |
| 11 | Evaporation and canopy characteristics of coniferous forests and grasslands显示文摘 | Kelliher F M Lenning R Schulze E D | 1993 | Oecologia1993，95，： | 1 |
| 12 | The contact characteristics of rough surfaces in line contact during running-in process显示文摘 | HORNG J H LEN M L LEE J S | 2002 | Wear2002，253，： | 1 |
| 13 | Effect of staging on volatile fatty acid degradation in a sulfidogenic granular sludge reactor显示文摘 | Lens P N L Bosch M C V D Pol L W H | 1998 | Water Research1998，32，4： | 1 |
| 14 | Aberrant expression and reverse signalling of CD70 on malignantBcells显示文摘 | Lens S M Drillenburg P Den Drijver B F etal | 1999 | BrJ Haematol1999，106，： | 1 |
| 15 | The results of surgical excision and adjuvantirradiation for therapy-resistant keloids:a prospective clinieal outcome study显示文摘 | Vandekar AL Kreu len M Vanzuijlen | 2007 | Plast Reconstr Surg2007，119，7： | 1 |
| 16 | Whole-cell biocatalysis in organic media 显示文摘 | Len R Femandes P Pinheiro H M | 1998 | Enzyme Microb Technol1998，23，： | 1 |
| 17 | Long-term outcome of aleohol septal ablation in patients with obstructive hypertrophic eardiomyopathy: a word of caution 显示文摘 | Len Cate FJ Soliman OI Michels M | 2010 | Cire Heart Fail2010，3，3： | 1 |
| 18 | Human gliosarcoma-associated ganglioside compo- sition is complex and distinctive as evidenced by high perform- ance mass spectrometric determination and structural charac- terization显示文摘 | VukelieZ Kalanj-Bognar S Froesch M Bindila L Radie B Al- len M | 2007 | Glyeobiology2007，17，： | 1 |
| 19 | Com-prehensive analysis of exported proteins from Mycobacteriumtuberculosis H37Rv显示文摘 | IWA M LEN H BERVEN F S FLADMARK K E | 2007 | Proteomics2007，7，10： | 1 |
| 20 | The role of vaccine therapy in the treatment of melanoma显示文摘 | Lens M | 2008 | Expert Opin Biol Ther2008，8，3： | 1 |
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