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| 1 | Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain显示文摘Background: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation(LDLT) is presented. Methods: A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29(45.3%) females and 35(54.7%) males was 50.2 years(interquartile range, IQR 32.9–57.5). Twenty-two(34.4%) recipients had no portal hypertension. Three(4.7%) patients had a benign and 33(51.6%) a malignant tumor [19(29.7%) hepatocellular cancer, 11(17.2%) secondary cancer and one(1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months(IQR 41–159) and 39 months(22–91), respectively. Results: Right and left hemi-livers were implanted in 39(60.9%) and 25(39.1%) cases, respectively. Median weights of right-and left-liver were 810 g(IQR 730–940) and 454 g(IQR 394–534), respectively. Graft-to-recipient weight ratios(GRWRs) were 1.17%(right, IQR 0.98%-1.4%) and 0.77%(left, 0.59%-0.95%). One-and five-year patient survivals were 85% and 71%(right) vs. 84% and 58%(left), respectively. Oneand five-year graft survivals were 74% and 61%(right) vs. 76% and 53%(left), respectively. The patient and graft survival of right and left grafts and of very small( < 0.6%), small(0.6%–0.79%) and large( ≥0.8%) GRWR were similar. Survival of very small grafts was 86% and 86% at 3-and 12-month. No donor died while five(7.8%) developed a Clavien–Dindo complication IIIa, IIIb or IV. Recipient morbidity consisted mainly of biliary and vascular complications; three(4.7%) recipients developed a small-for-size syndrome according to the Kyushu criteria. Conclusions: Adult-to-adult LDLT is a demanding procedure that widens therapeutic possibilities of many hepatobiliary diseases. The donor procedure can be done safely with low morbidity. The recipient operation carries a major morbidity indicating an important learning curve. Shifting the risk from the donor to the recipient, by moving from the larger right-liver to the smaller left-liver grafts, should be further explored as this policy makes donor hepatectomy safer and may stimulate the development of transplant oncology. | Samuele Iesari Milton Eduardo Inostroza Nú?ez Juan Manuel Rico Juri Olga Ciccarelli Eliano Bonaccorsi-Riani Laurent Coubeau Pierre-Fran?ois Laterre Pierre Goffette Chantal De Reyck Beno?t Lengelé Pierre Gianello Jan Lerut | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 5 |
| 2 | Phage engineering: how advances in molecular biology and synthetic biology are being utilized to enhance the therapeutic potential of bacteriophages显示文摘自从他们的第一隔离和描述,抗菌素的治疗学的潜力在 20 年初 th 世纪。然而,在申请和观察功效的一致性的缺乏在快速减缓的噬菌体治疗的领域里在抗菌素混合物研究的发现之上在他们的早使用期间意味着那。特别在小病毒的染色体的上下文,在细菌的抗菌素抵抗和处于我们修改并且操作 DNA 的能力的改进的上升导致了对作为抗菌剂治疗学利用噬菌体的兴趣的最近的苏醒。在从瞄准了到的文学的很多结果探讨的这篇文章的结果作为利用分子的生物学和合成生物学途径愿望的抗菌剂治疗学关于噬菌体的实用程序和功效给问题调音被介绍并且讨论,在这个领域里给最近的进步的一个一般看法。在分子的生物学和合成生物学的结论进展在噬菌体工程的领域里启用了快速的进步,与加亮开发优化为细菌的疾病的处理的噬菌体的很多有希望的策略的这篇文章。虽然许多仍然历史上作为治疗学限制了噬菌体的使用的一样的问题存在,这些修正,或它的联合,可以形成未来进展能在之上被造的一个基础。的一个焦点在 vivo 为答应候选人噬菌体可以被要求让这域真正成熟,但是有噬菌体治疗的潜在的好处可以最后被认识到的更新的希望在临床的选拔赛测试和投资严密。 | Russell Brown Andreas Lengeling Baojun Wang | 2017 | Frontiers of Electrical and Electronic Engineering in China2017，5，1： | 2 |
| 3 | Organizational Information Requirements, Media Richness and Structural Design 显示文摘 | Daft R L Lengel R H | 1986 | Management Science1986，32，5： | 1 |
| 4 | Media Symbolism, Media Richness, and Media Choice in Organizations: A Symbolic lnteractionist Perspective 显示文摘 | Trevino L K Daft R L Lengel R H | 1987 | Communication Research1987，14，5： | 1 |
| 5 | Mating-type-specific and nonspecific PAK kinases play shared and divergent role in cytokinesis,differentiation and virulence of Cryptococcus neoformans显示文摘 | Wang P Nichols CS Lengeler KB Cardenas ME Cox GM Perfect JR Heitman J | 2002 | Eukaryot Cell2002，1，2： | 1 |
| 6 | Data-driven design and complexity control of time-frequency detectors显示文摘 | CEDRIC RICHARD REGIS LENGELLE | 1999 | Signal Processing1999，77，： | 1 |
| 7 | First human face allograft: early report显示文摘 | Devauchelle B Badet L Lengele B | 2006 | Lancet2006，368，9531： | 1 |
| 8 | Enbloc and standard esophagectomies bythomeoscopy显示文摘 | Collard JM Lengele B | 1993 | Ann Thorac Surg1993，56，3： | 1 |
| 9 | Non-suicidal self-in- jury:the contribution of general personality functioning显示文摘 | Mullins-Sweatt SN Lengel GJ Grant D M | 2013 | Personality and Mental Health2013，7，1： | 1 |
| 10 | Heller- Dor procedure for achalasia: from conventional to video- endoscopic surgery显示文摘 | Romagnoli R Lengele B | 1996 | Acta Chir Belg1996，96，2： | 1 |
| 11 | Organizational Information Requirements, Media Richness and Structural Design 显示文摘 | DAFT R L LENGEL R H | 1986 | Management Science1986，32，5： | 1 |
| 12 | The banana(Musa acuminata)genome andthe evolution of monocotyledonous plants显示文摘 | HONT A D DENOEUD F AURY J M BAURENSF C CARREELF GARSMEUR O NOEL B BOCS S DROC G ROUARD M SILVA C D JABBARI K CARDI C POULAIN J SOUQUET M LABADIEK JOURDA C LENGELLE J MARGUERITE R G ALBERTI A BERNARD M CORREA M AYYAMPALAYAM S MCKAIN M R JIM L M | 2012 | Nature2012，488，： | 1 |
| 13 | Organizational Infor- mation Requirements,Media Riehness and Structural Design显示文摘 | DMt R.L Lengel R.H | | 0，，： | 1 |
| 14 | Exafs studies of calcined and sulfided CO-Mo HDS catalysts显示文摘 | CLAUSEN B S LENGELER B CANDIA R | 1981 | Bulletin des Soci6t6s Chimiques Belges1981，90，12： | 1 |
| 15 | Phosphoenolpyru- vate:carbohydrate phosphotrans{erase systems of bacteria显示文摘 | Postma P W Lengeler J W Jaeobson G R | 1993 | Microbiol Rev1993，57，54： | 1 |
| 16 | Length of the styloid process of the temporal bone显示文摘 | Lengele BG Dhem AJ | 1988 | Arch Otolaryngol Head Neck Surg1988，114，9： | 1 |
| 17 | Organizational information requirements,media richness and structural design显示文摘 | Darer R L Lengel R H | 1986 | Managment Science1986，32，5： | 1 |
| 18 | Cloning and characterization of the promoter region of the human keratinocyte growth factor gene显示文摘 | Finch PW Lengel C Chedid M | 1995 | J Bio Chem1995，270，11： | 1 |
| 19 | Enbloc and standard esophagec- tomies by thoracoscopy 显示文摘 | Collard J M Lengele B | 1993 | Ann Thorac Surg1993，56，3： | 1 |
| 20 | Enbloc and standard esophagectomies by thoracoscopy显示文摘 | Collard JM Lengele B | 1993 | Ann Thorac Surg1993，56，3： | 1 |
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