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| 1 | Age-related changes in the kinetics of human lenses:prevention of the cataract显示文摘The crystalline lens is a transparent,biconvex structure in the eye that,along with the cornea,helps to refract light to be focused on the retina and,by changing shape,it adjusts focal distance(accommodation).The three classes of structural proteins found in the lens areα,β,and γ crystallins.These proteins make up more than 90% of the total dry mass of the eye lens.Other components which can be found are sugars,lipids,water,several antioxidants and low weight molecules.When ageing changes occur in the lens,it causes a gradual reduction in transparency,presbyopia and an increase in the scattering and aberration of light waves as well as a degradation of the optical quality of the eye.The main changes that occur with aging are: 1) reduced diffusion of water from the outside to the inside of the lens and from its cortical to its nuclear zone; 2)crystalline change due to the accumulation of high molecular weight aggregates and insoluble proteins; 3)production of advanced glycation end products(AGEs),lipid accumulation,reduction of reduced glutathione content and destruction of ascorbic acid.Even if effective strategies in preventing cataract onset are not already known,good results have been reached in some cases with oral administration of antioxidant substances such as caffeine,pyruvic acid,epigallocatechin gallate(EGCG),α-lipoic acid and ascorbic acid.Furthermore,methionine sulfoxide reductase A(MSRA) over expression could protect lens cells both in presence and in absence of oxidative stress-induced damage.Nevertheless,promising results have been obtained by reducing ultraviolet-induced oxidative damage. | Nicola Pescosolido Andrea Barbato Rossella Giannotti Chiara Komaiha Fiammetta Lenarduzzi | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 13 |
| 2 | Importance of grouting to enhance the performance of earth energy systems 显示文摘 | Lenarduzzi Frank J Cragg Chris B H Radhakrishna H S | 2000 | ASHRAE Transactions2000，106，： | 1 |
| 3 | Comprehensive MicroRNA profiling for head and neck squamous cell carcinomas显示文摘 | Hui AH Lenarduzzi M Krushel T | 2010 | Clin Cancer Res2010，16，4： | 1 |
| 4 | Comprehensive MicroR- NA profiling for head and neck squamous cell carcinomas显示文摘 | Hui AB Lenarduzzi M Krushel T | 2010 | Clin Cancer Res2010，16，4： | 1 |
| 5 | Comprehensive MicroRNA profiling for head and neck squamous cell carcinomas显示文摘 | Hui AB Lenarduzzi M Krushel T | | 0，，04： | 1 |
| 6 | MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway显示文摘 | Alajez NM Lenarduzzi M Ito E | 2011 | Cancer Res2011，71，： | 1 |
| 7 | Comprehensive MicroRNA profiling for head and neck squamous cell carcinomas显示文摘 | Hui AB Lenarduzzi M Krushel T | 2010 | Clin Cancer Res2010，16，4： | 1 |
| 8 | Comprehensive MicroRNA profiling for head and neck squamous cell carcinomas 显示文摘 | Hui AB Lenarduzzi M Krushel T | 2010 | Clin Cancer Res2010，16，4： | 1 |
| 9 | MiR-218 suppresses nasopharyngeal cancer progression through downregulation of sur- vivin and the SLIT2-ROBO1 pathway显示文摘 | Alajez NM Lenarduzzi M Ito E | 2011 | Cancer Res2011，71，6： | 1 |
| 10 | Importance of grouting to enhance the performance of earth energy systems显示文摘 | Lenarduzzi F J Cragg C B H Radhakrishna H S | 2000 | ASHRAE Transactions2000，106，： | 1 |
| 11 | Comprehensive MicroR NA profiling for head and neck squamous cell carcinomas显示文摘 | Hui A B Lenarduzzi M Krushel T | 2010 | Clin Cancer Res2010，16，： | 1 |
| 12 | n/R-218 supprses nasopl cancer prcwession through downregulation of survivin andthe SLIT2- ROBO1 pathway显示文摘 | Alajez NM Lenarduzzi M ho E | 2011 | Cancer Res2011，71，6： | 1 |
| 13 | MiR-218 suppresses na- sopharyngeal cancer progression through downregulation of sur vivin and the SLIT2-ROBO1 pathway显示文摘 | Alajez NM Lenarduzzi M Ito E | 2011 | Cancer Res2011，71，6： | 1 |
| 14 | The importance ofgrouting to enhance the performance of earth energysystem显示文摘 | Lenarduzzi F J Radhakrishna H S | 2000 | ASHRAE Trans2000，106，1： | 1 |
| 15 | Compre- hensive MicroRNA profiling for head and neck squa- mous cell carcinomas显示文摘 | I-Iui A B Lenarduzzi M Krushel T | 2010 | Clin Cancer Res2010，16，4： | 1 |
| 16 | Comprehensive MicroRNA profiling for head and neck squamous cell carcinomas显示文摘 | Hui AB Lenarduzzi M Krushel T | 2010 | Clin Cancer Res2010，16，4： | 1 |
| 17 | Comprehensive microRNA profiling for head and neck squamous cell carcinomas 显示文摘 | Hui A B Lenarduzzi M Krushel T | 2010 | Clin Cancer Res2010，16，： | 1 |
| 18 | miR-218 suppres- ses nasopharyngeal cancer progression through downregula- tion of survivin and the SLIT2-ROBO1 pathway显示文摘 | Alajez NM Lenarduzzi M ho E | 2011 | Canc- er Res2011，71，6： | 1 |
| 19 | Localized Denoising Filtering Using the Wavelet Transform显示文摘 | M. Fedi L. Lenarduzzi R. Primiceri T. Quarta | 2000 | Pure and Applied Geophysics2000，，9： | 1 |
| 20 | Importance of grouting to enhance the performance of earth energy systems显示文摘 | LENARDUZZI F J CRAGG C B H RADHAKRISHNA H S | 2000 | ASHRAE Trans2000，106，： | 1 |
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