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| 1 | Crohn’s and colitis in children and adolescents显示文摘Crohn's disease and ulcerative colitis can be grouped as the inflammatory bowel diseases(IBD).These conditions have become increasingly common in recent years,including in children and young people.Although much is known about aspects of the pathogenesis of these diseases,the precise aetiology is not yet understood,and there remains no cure.Recent data has illustrated the importance of a number of genes-several of these are important in the onset of IBD in early life,including in infancy.Pain,diarrhoea and weight loss are typical symptoms of paediatric Crohn's disease whereas bloody diarrhoea is more typical of colitis in children.However,atypical symptoms may occur in both conditions:these include isolated impairment of linear growth or presentation with extra-intestinal manifestations such as erythema nodosum.Growth and nutrition are commonly compromised at diagnosis in both Crohn's disease and colitis.Consideration of possible IBD and completion of appropriate investi-gations are essential to ensure prompt diagnosis,thereby avoiding the consequences of diagnostic delay.Patterns of disease including location and progression of IBD in childhood differ substantially from adultonset disease.Various treatment options are available for children and adolescents with IBD.Exclusive enteral nutrition plays a central role in the induction of remission of active Crohn's disease.Medical and surgical therapies need to considered within the context of a growing and developing child.The overall management of these chronic conditions in children should include multi-disciplinary expertise,with focus upon maintaining control of gut inflammation,optimising nutrition,growth and quality of life,whilst preventing disease or treatment-related complications. | Andrew S Day Oren Ledder Steven T Leach Daniel A Lemberg | 2012 | World Journal of Gastroenterology2012，18，41： | 4 |
| 2 | Campylobacter concisus and inflammatory bowel disease显示文摘Investigation of the possible role of Campylobacter concisus(C. concisus) in inflammatory bowel disease(IBD) is an emerging research area. Despite the association found between C. concisus and IBD, it has been difficult to explain how C. concisus, a bacterium that is commonly present in the human oral cavity, may contribute to the development of enteric diseases. The evidence presented in this review shows that some C. concisus strains in the oral cavity acquired zonula occludens toxin(zot) gene from a virus(prophage) and that C. concisus Zot shares conserved motifs with both Vibrio cholerae Zot receptor binding domain and human zonulin receptor binding domain. Both Vibrio cholerae Zot and human zonulin are known to increase intestinal permeability by affecting the tight junctions. Increased intestinal permeability is a feature of IBD. Based on these data, we propose that a primary barrier function defect caused by C. concisus Zot is a mechanism by which zot-positive C. concisus strains may trigger the onset and relapse of IBD. | Li Zhang Hoyul Lee Michael C Grimm Stephen M Riordan Andrew S Day Daniel A Lemberg | 2014 | World Journal of Gastroenterology2014，20，5： | 4 |
| 3 | Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered显示文摘AIM: To study the blood-brain barrier integrity in prehe-patic portal hypertensive rats induced by partial portal vein ligation, at 14 and 40 d after ligation when portal pressure is spontaneously normalized. METHODS: Adult male Wistar rats were divided into four groups: GroupⅠ: Sham14d, sham operated; GroupⅡ: PH14d, portal vein stenosis; (both groups were used 14 days after surgery); GroupⅢ: Sham40d, Sham operated and GroupⅣ: PH40d Portal vein stenosis (GroupsⅡandⅣused 40 d after surgery). Plasma ammonia, plasma and cerebrospinal fluid protein and liver enzymes concentrations were determined. Trypan and Evans blue dyes, systemically injected, were investigated in hippocampus to study blood-brain barrier integrity. Portal pressure was periodically recorded. RESULTS: Forty days after stricture, portal pressure was normalized, plasma ammonia was moderately high, and both dyes were absent in central nervous system parenchyma. All other parameters were reestablished. When portal pressure was normalized and ammonia level was lowered, but not normal, the altered integrity of blood-brain barrier becomes reestablished. CONCLUSION: The impairment of blood-brain barrier and subsequent normalization could be a mechanism involved in hepatic encephalopathy reversibility, Hemo-dynamic changes and ammonia could trigger blood-brain barrier alterations and its reestablishment. | Francisco Eizayaga Camila Scorticati Juan P Prestifilippo Salvador Romay Maria A Fernandez José L Castro Abraham Lemberg Juan C Perazzo | 2006 | World Journal of Gastroenterology2006，12，9： | 3 |
| 4 | Diffuse axonal injury:analysis of 100 patients wish radiological signs显示文摘 | Guiburd J N Lemberger A | 1990 | Neurosurgery1990，27，3： | 1 |
| 5 | Identification of signal peptide peptidase, a presenilin-type aspartic protease显示文摘 | Weihofen A Binns K Lemberg M K | 2002 | Science2002，296，： | 1 |
| 6 | Diffuse axonal injury:analysis of 100 patients with radiological signs显示文摘 | Levi L Guilburd JN Lemberger A | 1990 | Neurosurgery1990，27，： | 1 |
| 7 | Mechanical fatigue as a mechanism of water tree propagation in TR-XLPE显示文摘 | Wang Z Marcolongo P Lemberg J A | 2012 | IEEE Transactions on Dielectrics and Electrical Insulation2012，19，1： | 1 |
| 8 | Diffuse axonal injury:Analysis of 100 patients with radiological signs显示文摘 | Levi L Guiburd J N Lemberger A | 1990 | Neurosurgery1990，27，3： | 1 |
| 9 | Diffuse axonal injury:analysis of 100 patients with radiological signs显示文摘 | Levil Guiburd JN Lemberger A | 1990 | Neurosurg1990，27，3： | 1 |
| 10 | True view blade improves laryngeal view when compared to Macintosh blade显示文摘 | Lieberman N Hakim A R Lemberg L Berkenstadt H | 2003 | Anesthesiology2003，99，： | 1 |
| 11 | Diffuse exonal injury:analysis of 100 patients with radiological signs显示文摘 | Levil Guilburd JN Lemberger A | | 0，，： | 1 |
| 12 | MOCVD of tantalum nitride thin films from TBTEMT single source precursor as metal electrodes in CMOS applications显示文摘 | Lemberger M Thiemann S Baunemann A | 2007 | Surf Coat Teehn2007，201，2223： | 1 |
| 13 | An asymmetry of conduction mechanisms and charge trapping in thin high-k HfxTiySi2O films 显示文摘 | PASKALEVA A BAUER A J LEMBERGER M | 2005 | J Appl Phys2005，98，5： | 1 |
| 14 | Water vapor permeation of selected cellulose ester films显示文摘 | Patel M Patel J M Lemberger A P | 1964 | J Pharm Sci1964，53，3： | 1 |
| 15 | Diffuse axonal injury: Analysis of 100 pafiens with radiological sign显示文摘 | Levi L Ouiburd YN Lemberger A | 1990 | Neurosurgery1990，27，3： | 1 |
| 16 | Electrical characterization and reliability aspects of zirconium silicate films obtained from novel MOCVD precursors 显示文摘 | LEMBERGER M PASKALEVA A ZURCHER S | 2004 | Microelectronic Engineering2004，72，： | 1 |
| 17 | Diffuse axonal injury:analysis of 100 patients with radiological signs显示文摘 | Levi L Guiburd JN Lemberger A | 1990 | Neurosurgery1990，27，3： | 1 |
| 18 | Dffuseaxonal injury:anal-ysis of 100 patients with radiological signs显示文摘 | Levi L Guilburd JN Lemberger A | 1990 | Neurology1990，27，： | 1 |
| 19 | Diffuse axonal injury: analysis of 100 patients with radiological signs显示文摘 | Levi L Guiburd J N Lemberger A | 1990 | Neurosurgery1990，27，3： | 1 |
| 20 | Diffuse axonal injury:analysis of 100 patients with radiological signs显示文摘 | Levi L Guiburd JN Lemberger A | 1990 | Neurosurgery1990，27，3： | 1 |
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